Madd (MAP-kinase activating death domain) - Rat Genome Database

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Gene: Madd (MAP-kinase activating death domain) Rattus norvegicus
Analyze
Symbol: Madd
Name: MAP-kinase activating death domain
RGD ID: 619922
Description: Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of growth hormone secretion and negative regulation of pancreatic amylase secretion. Located in cytosol; nucleus; and synaptic vesicle. Is active in synapse. Biomarker of transient cerebral ischemia. Orthologous to human MADD (MAP kinase activating death domain); PARTICIPATES IN ceramide signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MAP kinase-activating death domain protein; rab3 GDP/GTP exchange factor; Rab3 GDP/GTP exchange protein; RabGEF; RabGEP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Maddm1Mcwi  
Genetic Models: FHH-Maddm1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,114,330 - 77,157,865 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl379,960,301 - 80,003,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0379,960,301 - 80,003,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0386,669,054 - 86,711,776 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,498,321 - 75,541,073 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,408,586 - 75,437,445 (-)NCBI
Celera376,323,258 - 76,366,073 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8988362   PMID:9115275   PMID:11577081   PMID:14735464   PMID:15007167   PMID:18849981   PMID:20937701   PMID:22871113   PMID:25931508   PMID:29476059   PMID:30053369  


Genomics

Comparative Map Data
Madd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,114,330 - 77,157,865 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl379,960,301 - 80,003,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0379,960,301 - 80,003,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0386,669,054 - 86,711,776 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,498,321 - 75,541,073 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,408,586 - 75,437,445 (-)NCBI
Celera376,323,258 - 76,366,073 (-)NCBICelera
Cytogenetic Map3q24NCBI
MADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1147,269,161 - 47,330,031 (+)EnsemblGRCh38hg38GRCh38
GRCh381147,269,188 - 47,330,031 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371147,290,739 - 47,351,582 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,247,535 - 47,308,158 (+)NCBINCBI36hg18NCBI36
Build 341147,248,259 - 47,308,157NCBI
Celera1147,430,145 - 47,490,862 (+)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1146,989,904 - 47,050,670 (+)NCBIHuRef
CHM1_11147,290,116 - 47,350,822 (+)NCBICHM1_1
Madd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,967,705 - 91,013,404 (-)NCBIGRCm39mm39
GRCm39 Ensembl290,967,705 - 91,014,182 (-)Ensembl
GRCm38291,137,360 - 91,184,006 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,137,360 - 91,183,837 (-)EnsemblGRCm38mm10GRCm38
MGSCv37290,977,517 - 91,024,025 (-)NCBIGRCm37mm9NCBIm37
MGSCv36290,938,200 - 90,984,657 (-)NCBImm8
Celera292,522,135 - 92,568,708 (-)NCBICelera
Cytogenetic Map2E1NCBI
Madd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422902,969 - 940,201 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955422902,969 - 940,201 (-)NCBIChiLan1.0ChiLan1.0
MADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11147,769,863 - 47,829,240 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,773,733 - 47,828,360 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01147,216,006 - 47,276,422 (+)NCBIMhudiblu_PPA_v0panPan3
MADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,290,226 - 42,332,237 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,290,754 - 42,328,586 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,019,254 - 41,060,604 (-)NCBI
ROS_Cfam_1.01842,944,691 - 42,986,383 (-)NCBI
UMICH_Zoey_3.11842,430,983 - 42,472,278 (-)NCBI
UNSW_CanFamBas_1.01841,986,221 - 42,027,872 (-)NCBI
UU_Cfam_GSD_1.01842,715,501 - 42,756,968 (-)NCBI
Madd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,779,478 - 19,825,054 (-)NCBI
SpeTri2.0NW_0049365621,891,120 - 1,936,559 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,270,788 - 15,326,202 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,270,783 - 15,315,459 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,477,477 - 16,538,588 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,987,573 - 18,041,317 (-)NCBI
ChlSab1.1 Ensembl117,986,860 - 18,042,266 (-)Ensembl
Vero_WHO_p1.0NW_023666038115,287,755 - 115,344,365 (-)NCBI
Madd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247671,421,603 - 1,459,738 (-)NCBI

Position Markers
D3Wox32  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,115,056 - 77,115,198 (+)MAPPERmRatBN7.2
Rnor_6.0379,960,382 - 79,960,523NCBIRnor6.0
Rnor_5.0386,669,135 - 86,669,276UniSTSRnor5.0
RGSC_v3.4375,498,402 - 75,498,543UniSTSRGSC3.4
Celera376,323,339 - 76,323,480UniSTS
Cytogenetic Map3q24UniSTS
STS-U22662  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,158,984 - 77,159,214 (+)MAPPERmRatBN7.2
Rnor_6.0380,004,307 - 80,004,536NCBIRnor6.0
Rnor_5.0386,713,060 - 86,713,289UniSTSRnor5.0
RGSC_v3.4375,542,357 - 75,542,586UniSTSRGSC3.4
Celera376,367,357 - 76,367,586UniSTS
Cytogenetic Map3q24UniSTS
AI548269  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,158,931 - 77,159,087 (+)MAPPERmRatBN7.2
Rnor_6.0380,004,254 - 80,004,409NCBIRnor6.0
Rnor_5.0386,713,007 - 86,713,162UniSTSRnor5.0
RGSC_v3.4375,542,304 - 75,542,459UniSTSRGSC3.4
Celera376,367,304 - 76,367,459UniSTS
Cytogenetic Map3q24UniSTS
BE102504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,115,017 - 77,115,192 (+)MAPPERmRatBN7.2
Rnor_6.0379,960,343 - 79,960,517NCBIRnor6.0
Rnor_5.0386,669,096 - 86,669,270UniSTSRnor5.0
RGSC_v3.4375,498,363 - 75,498,537UniSTSRGSC3.4
Celera376,323,300 - 76,323,474UniSTS
Cytogenetic Map3q24UniSTS
RH139546  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,157,990 - 77,158,204 (+)MAPPERmRatBN7.2
Rnor_6.0380,003,313 - 80,003,526NCBIRnor6.0
Rnor_5.0386,712,066 - 86,712,279UniSTSRnor5.0
RGSC_v3.4375,541,363 - 75,541,576UniSTSRGSC3.4
Celera376,366,363 - 76,366,576UniSTS
Cytogenetic Map3q24UniSTS
PMC33205P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,159,202 - 77,159,438 (+)MAPPERmRatBN7.2
Rnor_6.0380,004,525 - 80,004,760NCBIRnor6.0
Rnor_5.0386,713,278 - 86,713,513UniSTSRnor5.0
RGSC_v3.4375,542,575 - 75,542,810UniSTSRGSC3.4
Celera376,367,575 - 76,367,810UniSTS
Cytogenetic Map3q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3195176874Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31009408193415837Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)330114912123700444Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33347735481136227Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333477354108914061Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)334394121103141944Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)339248391140271184Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)34042292185422921Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)34052359392654473Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)34052359392654473Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)343295930108914061Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34540605894467785Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)345406058127023997Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)351821836124513579Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)351822008120917851Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)354630948119830094Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35463104693415673Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35524527695176874Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35524527695176874Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35524527695176874Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)356735995101735995Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)362922868127023997Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36304905092654302Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)366711607119830094Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)366711607119830094Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)372672290127023997Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)372973445127023997Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)378700444123700444Rat


Genetic Models
This gene Madd is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:53
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000017360
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 9 2 18 2 74 12 20 9
Low 1 43 48 39 1 39 8 11 23 21 2 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000017360   ⟹   ENSRNOP00000017360
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl379,960,301 - 80,003,032 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079394   ⟹   ENSRNOP00000075233
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl379,960,359 - 80,000,091 (-)Ensembl
RefSeq Acc Id: NM_053585   ⟹   NP_446037
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,976 - 77,157,701 (-)NCBI
Rnor_6.0379,960,301 - 80,003,023 (-)NCBI
Rnor_5.0386,669,054 - 86,711,776 (-)NCBI
RGSC_v3.4375,498,321 - 75,541,073 (-)RGD
Celera376,323,258 - 76,366,073 (-)RGD
Sequence:
RefSeq Acc Id: XM_039106005   ⟹   XP_038961933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106006   ⟹   XP_038961934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,115,233 - 77,157,865 (-)NCBI
RefSeq Acc Id: XM_039106007   ⟹   XP_038961935
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,115,233 - 77,157,574 (-)NCBI
RefSeq Acc Id: XM_039106008   ⟹   XP_038961936
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106009   ⟹   XP_038961937
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106010   ⟹   XP_038961938
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106011   ⟹   XP_038961939
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106012   ⟹   XP_038961940
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106014   ⟹   XP_038961942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106015   ⟹   XP_038961943
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106016   ⟹   XP_038961944
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106017   ⟹   XP_038961945
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106018   ⟹   XP_038961946
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106019   ⟹   XP_038961947
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106020   ⟹   XP_038961948
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106021   ⟹   XP_038961949
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106022   ⟹   XP_038961950
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106023   ⟹   XP_038961951
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106024   ⟹   XP_038961952
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106025   ⟹   XP_038961953
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,115,233 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106026   ⟹   XP_038961954
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106027   ⟹   XP_038961955
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106028   ⟹   XP_038961956
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106029   ⟹   XP_038961957
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106030   ⟹   XP_038961958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106031   ⟹   XP_038961959
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106032   ⟹   XP_038961960
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106033   ⟹   XP_038961961
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106034   ⟹   XP_038961962
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106035   ⟹   XP_038961963
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106036   ⟹   XP_038961964
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106037   ⟹   XP_038961965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106038   ⟹   XP_038961966
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106039   ⟹   XP_038961967
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106040   ⟹   XP_038961968
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106041   ⟹   XP_038961969
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106042   ⟹   XP_038961970
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106043   ⟹   XP_038961971
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106044   ⟹   XP_038961972
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106045   ⟹   XP_038961973
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106046   ⟹   XP_038961974
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,154,435 (-)NCBI
RefSeq Acc Id: XM_039106047   ⟹   XP_038961975
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,114,330 - 77,147,207 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446037 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961933 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961934 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961935 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961936 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961937 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961938 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961939 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961940 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961942 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961943 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961944 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961945 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961946 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961947 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961948 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961949 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961950 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961951 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961952 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961953 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961954 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961955 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961956 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961957 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961958 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961959 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961960 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961961 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961962 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961963 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961964 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961965 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961966 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961967 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961968 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961969 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961970 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961971 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961972 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961973 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961974 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961975 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53149 (Get FASTA)   NCBI Sequence Viewer  
  EDL79509 (Get FASTA)   NCBI Sequence Viewer  
  EDL79510 (Get FASTA)   NCBI Sequence Viewer  
  EDL79511 (Get FASTA)   NCBI Sequence Viewer  
  EDL79512 (Get FASTA)   NCBI Sequence Viewer  
  O08873 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446037   ⟸   NM_053585
- UniProtKB: O08873 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075233   ⟸   ENSRNOT00000079394
RefSeq Acc Id: ENSRNOP00000017360   ⟸   ENSRNOT00000017360
RefSeq Acc Id: XP_038961961   ⟸   XM_039106033
- Peptide Label: isoform X26
RefSeq Acc Id: XP_038961960   ⟸   XM_039106032
- Peptide Label: isoform X25
RefSeq Acc Id: XP_038961973   ⟸   XM_039106045
- Peptide Label: isoform X38
RefSeq Acc Id: XP_038961955   ⟸   XM_039106027
- Peptide Label: isoform X20
RefSeq Acc Id: XP_038961959   ⟸   XM_039106031
- Peptide Label: isoform X24
RefSeq Acc Id: XP_038961972   ⟸   XM_039106044
- Peptide Label: isoform X37
RefSeq Acc Id: XP_038961974   ⟸   XM_039106046
- Peptide Label: isoform X39
RefSeq Acc Id: XP_038961958   ⟸   XM_039106030
- Peptide Label: isoform X23
RefSeq Acc Id: XP_038961957   ⟸   XM_039106029
- Peptide Label: isoform X22
RefSeq Acc Id: XP_038961971   ⟸   XM_039106043
- Peptide Label: isoform X36
RefSeq Acc Id: XP_038961951   ⟸   XM_039106023
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038961970   ⟸   XM_039106042
- Peptide Label: isoform X35
RefSeq Acc Id: XP_038961950   ⟸   XM_039106022
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038961948   ⟸   XM_039106020
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038961968   ⟸   XM_039106040
- Peptide Label: isoform X33
RefSeq Acc Id: XP_038961947   ⟸   XM_039106019
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038961945   ⟸   XM_039106017
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038961967   ⟸   XM_039106039
- Peptide Label: isoform X32
RefSeq Acc Id: XP_038961943   ⟸   XM_039106015
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038961956   ⟸   XM_039106028
- Peptide Label: isoform X21
RefSeq Acc Id: XP_038961969   ⟸   XM_039106041
- Peptide Label: isoform X34
RefSeq Acc Id: XP_038961949   ⟸   XM_039106021
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038961946   ⟸   XM_039106018
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038961966   ⟸   XM_039106038
- Peptide Label: isoform X31
RefSeq Acc Id: XP_038961942   ⟸   XM_039106014
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038961954   ⟸   XM_039106026
- Peptide Label: isoform X19
RefSeq Acc Id: XP_038961952   ⟸   XM_039106024
- Peptide Label: isoform X17
RefSeq Acc Id: XP_038961965   ⟸   XM_039106037
- Peptide Label: isoform X30
RefSeq Acc Id: XP_038961940   ⟸   XM_039106012
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038961964   ⟸   XM_039106036
- Peptide Label: isoform X29
RefSeq Acc Id: XP_038961939   ⟸   XM_039106011
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038961938   ⟸   XM_039106010
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038961963   ⟸   XM_039106035
- Peptide Label: isoform X28
RefSeq Acc Id: XP_038961936   ⟸   XM_039106008
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961944   ⟸   XM_039106016
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038961962   ⟸   XM_039106034
- Peptide Label: isoform X27
RefSeq Acc Id: XP_038961937   ⟸   XM_039106009
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038961933   ⟸   XM_039106005
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961975   ⟸   XM_039106047
- Peptide Label: isoform X40
RefSeq Acc Id: XP_038961934   ⟸   XM_039106006
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961935   ⟸   XM_039106007
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961953   ⟸   XM_039106025
- Peptide Label: isoform X18
Protein Domains
cDENN   dDENN   Death   uDENN

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692208
Promoter ID:EPDNEW_R2733
Type:single initiation site
Name:Madd_1
Description:MAP-kinase activating death domain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0380,003,037 - 80,003,097EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619922 AgrOrtholog
Ensembl Genes ENSRNOG00000012568 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017360 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000075233 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017360 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000079394 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.11500 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cDENN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dDENN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DENN_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MADD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  uDENN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:94193 UniProtKB/Swiss-Prot
NCBI Gene 94193 ENTREZGENE
PANTHER PTHR13008 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  uDENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Madd PhenoGen
PROSITE DENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART dDENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  uDENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KA27_RAT UniProtKB/TrEMBL
  MADD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Madd  MAP-kinase activating death domain      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Madd  MAP-kinase activating death domain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all tissues, enriched in brain 633238
gene_protein 1,602 amino acids; 178 kDa 633238