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Gene: Madd (MAP-kinase activating death domain) Rattus norvegicus

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Symbol:

Madd

Name:

MAP-kinase activating death domain

RGD ID:

619922

Description:

Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of growth hormone secretion and negative regulation of pancreatic amylase secretion. Located in synaptic vesicle. Is active in synapse. Biomarker of transient cerebral ischemia. Orthologous to human MADD (MAP kinase activating death domain); PARTICIPATES IN ceramide signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MAP kinase-activating death domain protein; rab3 GDP/GTP exchange factor; Rab3 GDP/GTP exchange protein; RabGEF; RabGEP

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MADD (MAP kinase activating death domain)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):	Madd (MAP-kinase activating death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Madd (MAP kinase activating death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MADD (MAP kinase activating death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MADD (MAP kinase activating death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Madd (MAP kinase activating death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MADD (MAP kinase activating death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MADD (MAP kinase activating death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Madd (MAP kinase activating death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MADD (MAP kinase activating death domain)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Madd (MAP-kinase activating death domain)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	madd (MAP-kinase activating death domain)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	aex-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rab3-GEF	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Allele / Splice:

Madd^m1Mcwi

Genetic Models:

FHH-Madd^m1Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	97,570,141 - 97,613,688 (-)	NCBI		GRCr8
mRatBN7.2	3	77,114,330 - 77,157,865 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	77,114,314 - 77,157,701 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	80,593,357 - 80,636,039 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	89,192,364 - 89,235,046 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	87,043,634 - 87,086,083 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	79,960,301 - 80,003,023 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	79,960,301 - 80,003,032 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	86,669,054 - 86,711,776 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	75,498,321 - 75,541,073 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	75,408,586 - 75,437,445 (-)	NCBI
Celera	3	76,323,258 - 76,366,073 (-)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

congenital disorder of glycosylation type IIc (ISO)

DEEAH Syndrome (ISO)

fetal akinesia deformation sequence syndrome 1 (ISO)

genetic disease (ISO)

hypertrophic cardiomyopathy (ISO)

hypertrophic cardiomyopathy 4 (ISO)

intellectual disability (ISO)

multiple acyl-CoA dehydrogenase deficiency (ISO)

NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES, IMPAIRED SPEECH, AND HYPOTONIA (ISO)

transient cerebral ischemia (IEP)

type 2 diabetes mellitus (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-naphthylamine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acetylsalicylic acid (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

atrazine (ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

carbon nanotube (ISO)

Cardanol (ISO)

chlorpyrifos (ISO)

choline (ISO)

ciguatoxin CTX1B (ISO)

corosolic acid (ISO)

coumarin (ISO)

dexamethasone (ISO)

diazinon (EXP)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

genistein (ISO)

indometacin (ISO)

L-methionine (ISO)

maneb (ISO)

N-ethyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP)

nickel dichloride (EXP)

nicotine (ISO)

ozone (ISO)

p-menthan-3-ol (ISO)

paclitaxel (ISO)

paracetamol (EXP)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phorbol 13-acetate 12-myristate (ISO)

pinostrobin (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

resveratrol (ISO)

scopolamine (EXP)

silver atom (ISO)

silver(0) (ISO)

Soman (EXP)

sunitinib (ISO)

titanium dioxide (ISO)

trichostatin A (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

tungsten (ISO)

undecane (EXP)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterograde synaptic vesicle transport (ISO)

apoptotic process (IEA)

execution phase of apoptosis (ISO)

negative regulation of apoptotic signaling pathway (ISO)

negative regulation of growth hormone secretion (IDA)

negative regulation of pancreatic amylase secretion (IMP)

positive regulation of MAPK cascade (ISO,ISS)

regulation of apoptotic process (IBA,ISO)

regulation of cell cycle (ISO,ISS)

regulation of extrinsic apoptotic signaling pathway (ISO)

regulation of extrinsic apoptotic signaling pathway via death domain receptors (ISO,ISS)

regulation of Rab protein signal transduction (IBA,ISO)

Cellular Component

axon (IEA)

axon cytoplasm (IEA)

cell projection (IEA)

cytoplasm (IEA)

cytosol (IBA,ISO)

membrane (IEA,ISO,ISS)

plasma membrane (IEA,ISO)

synapse (IDA,IEP)

synaptic vesicle (IDA)

Molecular Function

guanyl-nucleotide exchange factor activity (IBA,IDA,IEA,ISO,ISS)

protein binding (IPI,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ceramide signaling pathway (ISO)

tumor necrosis factor mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells.	Imai A, etal., Arch Biochem Biophys. 2013 Aug 1;536(1):31-7. doi: 10.1016/j.abb.2013.05.002. Epub 2013 May 20.
3.	A novel function of the C-terminal lipid moieties of Rab3A small G protein implicated in Ca2+-dependent exocytosis--inhibition of interaction with GTP and reduction of this inhibition by phospholipid.	Jin-no Y, etal., Genes Cells. 1997 Apr;2(4):273-88.
4.	A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)-dependent exocytosis of neurotransmitter.	Kawabe H, etal., Genes Cells 2003 Jun;8(6):537-46.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Localization of the Rab3 small G protein regulators in nerve terminals and their involvement in Ca2+-dependent exocytosis.	Oishi H, etal., J Biol Chem. 1998 Dec 18;273(51):34580-5.
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Purification and properties of Rab3 GEP (DENN/MADD).	Sakisaka T and Takai Y, Methods Enzymol. 2005;403:254-61.
14.	The onset of apoptosis of neurons induced by ischemia-reperfusion injury is delayed by transient period of hypertension in rats.	Smrcka M, etal., Physiol Res. 2003;52(1):117-22.
15.	Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins.	Wada M, etal., J Biol Chem 1997 Feb 14;272(7):3875-8.

Additional References at PubMed

PMID:8988362	PMID:9115275	PMID:11577081	PMID:14735464	PMID:15007167	PMID:18849981	PMID:20937701	PMID:22871113	PMID:25931508	PMID:29476059	PMID:30053369

Genomics

Comparative Map Data

Madd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	97,570,141 - 97,613,688 (-)	NCBI		GRCr8
mRatBN7.2	3	77,114,330 - 77,157,865 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	77,114,314 - 77,157,701 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	80,593,357 - 80,636,039 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	89,192,364 - 89,235,046 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	87,043,634 - 87,086,083 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	79,960,301 - 80,003,023 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	79,960,301 - 80,003,032 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	86,669,054 - 86,711,776 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	75,498,321 - 75,541,073 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	75,408,586 - 75,437,445 (-)	NCBI
Celera	3	76,323,258 - 76,366,073 (-)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

MADD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	47,269,188 - 47,330,031 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	47,269,161 - 47,330,031 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	47,290,739 - 47,351,582 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	47,247,535 - 47,308,158 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	47,248,259 - 47,308,157	NCBI
Celera	11	47,430,145 - 47,490,862 (+)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	46,989,904 - 47,050,670 (+)	NCBI		HuRef
CHM1_1	11	47,290,116 - 47,350,822 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	47,425,958 - 47,486,853 (+)	NCBI		T2T-CHM13v2.0

Madd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	90,967,705 - 91,013,404 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	90,967,705 - 91,014,182 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	91,137,360 - 91,184,006 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	91,137,360 - 91,183,837 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	90,977,517 - 91,024,025 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	90,938,200 - 90,984,657 (-)	NCBI		MGSCv36	mm8
Celera	2	92,522,135 - 92,568,708 (-)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.46	NCBI

Madd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	902,969 - 940,201 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	902,969 - 940,201 (-)	NCBI	ChiLan1.0	ChiLan1.0

MADD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	49,471,009 - 49,531,167 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	49,490,871 - 49,550,962 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	47,216,006 - 47,276,422 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	47,769,863 - 47,829,240 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	47,773,733 - 47,828,360 (+)	Ensembl	panpan1.1		panPan2

MADD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	42,290,226 - 42,332,237 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	42,290,754 - 42,328,586 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	41,019,254 - 41,060,604 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	42,944,691 - 42,986,383 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	42,944,691 - 42,986,478 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	42,430,983 - 42,472,278 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	41,986,221 - 42,027,872 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	42,715,501 - 42,756,968 (-)	NCBI		UU_Cfam_GSD_1.0

Madd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	19,779,478 - 19,825,054 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	1,892,033 - 1,932,418 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936562	1,891,120 - 1,936,559 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MADD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	15,270,783 - 15,315,459 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	15,270,783 - 15,315,459 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	16,477,477 - 16,538,588 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MADD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	17,987,573 - 18,041,317 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	17,986,860 - 18,042,266 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	115,287,755 - 115,344,365 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Madd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	1,421,603 - 1,459,507 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	1,421,603 - 1,459,738 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Madd
172 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	69
Count of miRNA genes:	53
Interacting mature miRNAs:	67
Transcripts:	ENSRNOT00000017360
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	78196190	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	61134348	89115068	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat

Markers in Region

D3Wox32

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	97,570,867 - 97,571,009 (+)	Marker Load Pipeline
mRatBN7.2	3	77,115,056 - 77,115,198 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	79,960,382 - 79,960,523	NCBI	Rnor6.0
Rnor_5.0	3	86,669,135 - 86,669,276	UniSTS	Rnor5.0
RGSC_v3.4	3	75,498,402 - 75,498,543	UniSTS	RGSC3.4
Celera	3	76,323,339 - 76,323,480	UniSTS
Cytogenetic Map	3	q24	UniSTS

STS-U22662

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	77,158,984 - 77,159,214 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	80,004,307 - 80,004,536	NCBI	Rnor6.0
Rnor_5.0	3	86,713,060 - 86,713,289	UniSTS	Rnor5.0
RGSC_v3.4	3	75,542,357 - 75,542,586	UniSTS	RGSC3.4
Celera	3	76,367,357 - 76,367,586	UniSTS
Cytogenetic Map	3	q24	UniSTS

AI548269

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	77,158,931 - 77,159,087 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	80,004,254 - 80,004,409	NCBI	Rnor6.0
Rnor_5.0	3	86,713,007 - 86,713,162	UniSTS	Rnor5.0
RGSC_v3.4	3	75,542,304 - 75,542,459	UniSTS	RGSC3.4
Celera	3	76,367,304 - 76,367,459	UniSTS
Cytogenetic Map	3	q24	UniSTS

BE102504

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	77,115,017 - 77,115,192 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	79,960,343 - 79,960,517	NCBI	Rnor6.0
Rnor_5.0	3	86,669,096 - 86,669,270	UniSTS	Rnor5.0
RGSC_v3.4	3	75,498,363 - 75,498,537	UniSTS	RGSC3.4
Celera	3	76,323,300 - 76,323,474	UniSTS
Cytogenetic Map	3	q24	UniSTS

RH139546

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	77,157,990 - 77,158,204 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	80,003,313 - 80,003,526	NCBI	Rnor6.0
Rnor_5.0	3	86,712,066 - 86,712,279	UniSTS	Rnor5.0
RGSC_v3.4	3	75,541,363 - 75,541,576	UniSTS	RGSC3.4
Celera	3	76,366,363 - 76,366,576	UniSTS
Cytogenetic Map	3	q24	UniSTS

PMC33205P3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	97,615,010 - 97,615,246 (+)	Marker Load Pipeline
mRatBN7.2	3	77,159,202 - 77,159,438 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	80,004,525 - 80,004,760	NCBI	Rnor6.0
Rnor_5.0	3	86,713,278 - 86,713,513	UniSTS	Rnor5.0
RGSC_v3.4	3	75,542,575 - 75,542,810	UniSTS	RGSC3.4
Celera	3	76,367,575 - 76,367,810	UniSTS
Cytogenetic Map	3	q24	UniSTS

Genetic Models

This gene Madd is modified in the following models/strains:

FHH-Madd^m1Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001429606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_053585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284759	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284760	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284769	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284770	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284774	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284780	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284787	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U72995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017360 ⟹ ENSRNOP00000017360

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,114,976 - 77,157,701 (-)	Ensembl
Rnor_6.0 Ensembl	3	79,960,301 - 80,003,032 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079394 ⟹ ENSRNOP00000075233

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,114,976 - 77,157,701 (-)	Ensembl
Rnor_6.0 Ensembl	3	79,960,359 - 80,000,091 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103435 ⟹ ENSRNOP00000084938

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,138,063 - 77,157,701 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104046 ⟹ ENSRNOP00000081884

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,114,976 - 77,157,701 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111515 ⟹ ENSRNOP00000087537

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,114,314 - 77,157,701 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111613 ⟹ ENSRNOP00000076460

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,114,314 - 77,157,701 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112841 ⟹ ENSRNOP00000081476

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,114,314 - 77,157,701 (-)	Ensembl

RefSeq Acc Id:

NM_053585 ⟹ NP_446037

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,787 - 97,613,509 (-)	NCBI
mRatBN7.2	3	77,114,976 - 77,157,701 (-)	NCBI
Rnor_6.0	3	79,960,301 - 80,003,023 (-)	NCBI
Rnor_5.0	3	86,669,054 - 86,711,776 (-)	NCBI
RGSC_v3.4	3	75,498,321 - 75,541,073 (-)	RGD
Celera	3	76,323,258 - 76,366,073 (-)	RGD

Sequence:

show sequence

GAATTCTCGCACGAGGCGCCGGCTCGCCGCGGCGCTGGGCTAGGAAGCGACGGGCGCTTCGCGG
TTCGGAGACGTCCGGCGGGCCTGGCAGGTTCCTCGGAGAGTAGATTTTATCAAGATTCCTCCCT
GGAACGCTGGCTCCTTGCTCAGTGCCCTGAAGTCTCTCTGCGATGAACTGATACATTGGAACCA
TGGTGCAAAAGAAGTTCTGCCCTCGGTTACTTGACTATCTAGTGATCGTAGGGGCCAGGCATCC
AAGCAGTGACAGTGTGGCTCAGACTCCTGAACTTCTGCGGAGGTACCCACTAGAGGACCACCCG
GAGTTTCCCCTGCCCCCAGATGTGGTGTTCTTCTGCCAGCCAGAGGGATGTCTGAGCGTGCGGC
AACGGCGCATGAGCCTCCGAGATGATACCTCTTTTGTCTTCACCCTAACCGATAAGGACACTGG
AGTCACCCGTTATGGCATCTGTGTCAACTTCTACCGTTCCTTTCAAAAGCGAATGCCAAAGGAA
AAGGCGGAAGGCGGAGCAGGACCCCGTGGGAAGGAAGGAGCTCATGCCCCCTGTGCCTCAGAAG
AGGCCGCCACCGAGAGCTCAGAGAGTGGCTCAACCTTGCAGCCTCCTAGTGCTGACTCCACTCC
TGACGTAAACCAGTCTCCTCGGGGCAAACGTAGGGCAAAAGCAGGCAACCGCTCCCGAAACAGT
ACCCTGACATCCCTGTGTGTGCTTAGCCACTACCCTTTCTTCTCTACCTTCAGAGAGTGTCTGT
ATACTCTCAAACGTCTGGTAGACTGCTGTAGTGAACGGCTCCTAGGCAAGAAACCGGGCATCCC
TCGAGGTGTACAAAGGGACACCATGTGGCGAATCTTTACTGGATCACTGCTAGTGGAGGAGAAG
TCCAGTGCCCTTCTGCATGACCTTCGAGAGATCGAGGCCTGGATCTATCGGTTGCTACGCTCCC
CGGTGCCTGTCTCTGGGCAGAAGCGAGTGGACATTGAGGTCCTACCCCAGGAAGTGCAGCAGGC
CCTGACATTTGCTCTTCCAGATCCATCCCGGTTCACCCTAGTAGATTTCCCTCTTCACCTTCCC
TTGGAACTTCTGGGTGTAGATGCTTGTCTTCAGGTGCTAACCTGCATCCTGTTGGAGCACAAGG
TGGTGCTACAGTCTCGAGACTACAACGCACTCTCCATGTCTGTGATGGCGTTTGTGGCAATGAT
CTACCCCCTGGAGTACATGTTCCCTGTCATCCCGCTGCTTCCCACCTGCATGGCTTCGGCAGAG
CAGCTACTCTTGGCTCCAACCCCATATATCATTGGAGTCCCTGCCAGCTTTTTCCTCTATAAGC
TAGACTTCAAAATGCCTGATGACGTGTGGCTGGTGGATCTGGACAGCAACAGGGTGATTGCCCC
CACCAATGCAGAAGTGCTACCCATCCTGCCAGAACCGGAATCATTAGAGCTGAAAAAACACTTA
AAGCAGGCTCTAGCCAGCATGAGTCTCAACACCCAGCCCATTCTTAATCTGGAGAAATTCCATG
AGGGCCAGGAGACACCACTTCTCTTGGGAAGGTTTTCTAATGACCTTCAGTCTACACCTTCCAC
TGAATTCAACCCACTCATTTATGGCAATGATGTAGATTCAGTCGATGTTGCAACGAGAGTGGCC
ATGGTTCGTTTCTTCAACTCTGCTAACGTGCTGCAGGGCTTTCAGATGCACACACGTACCCTGC
GACTCTTCCCCCGGCCCGTGGTTGCCTTCCAAGCTGGCTCCTTTCTGGCCTCACGCCCCCGGCA
GACCCCCTTTGCTGAGAAACTGGCCAGGACTCAAGCCGTGGAGTACTTTGGAGAATGGATCCTG
AACCCTTCTAACTATGCCTTCCAGCGGATTCACAACAATACGTTTGATCCAGCCCTCATTGGTG
ACAAGCCTAAGTGGTACGCTCACCAGCTGCAGCCCATTCACTATCGAGTCTATGACAGCAATTC
TCAGCTGGCTGAGGCCCTGAGTGTGCCACCGGAGCGTGATTCTGAGTCTGACCCCACTGATGAC
AGTGGCAGTGACAGCATGGACTATGATGACTCAAGCTCTTCTTACTCCTCCCTGGGGGACTTCG
TCAGTGAAATGATGAAGTGTGACATCAATGGCGACACTCCCAATGTGGATCCTCTGACGCATGC
GGCCCTGGGAGACGCCAGTGAAGTGGAGATTGATGAGCTGCAGCCCCAGAAGGAGGGAGAGGAG
CCTGGCCCAGACAGTGAGAACTCTCAGGAGAACCTTCCCCTGCGCTCCAGCTCCAGCACCACTG
CCAGCAGTAGCCCTAGCACCATCGTCCACGGCGCCCACTCTGAACCTGCTGATTCTACAGAGGT
GGGAGATAAGGCAGCAACAGGCATCTCCAAGCCCCTCCCTCCTGTGCCTCCCAGCATTTGCAAA
TCTACTGTGGACAGGAGACAGACAGAGACTGGAGAGGGGTCAGTGTGCCAGCGAACCTACGACC
ATCCATATTTTGAGCCCCAATATGGCTCCCCCGCTGAGGAAGATGATGACGAGCAGGGAGAGAG
CTACACGCCCCGGTTCAGCCAACATGCCAGTGGCAGTCGGGCTCAAAAGCTGCTGCGGCCCAAC
AGCTTGAAGCTGGCCAGTGACTCAGACGCAGAGTCAGACTCCCGAGCAAGCTCTCCCAACTCCA
CCGTCTCTAACAACAGCACCGAGGGCTTCGGGGGCATCATGTCTTTTGCTAGCAGCCTGTATCG
GAACCATAGTACAAGCTTCAGCCTTTCAAACCTCACACTGCCCACCAAAGGTGCCCGAGAGAAG
ACTACACCATTCCCCAGCCTGAAAGGAAACAGGAGGGCCTTAGTGGACCAGAAATCATCTGTCA
TTAAACACAGCCCAACTGTGAAAAGAGAACCTCCATCACCGCAGGGCCGGTCCAGCAATTCTAG
CGAGAACCAACAGTTCCTGAAGGAGGTGGTCCACAGTGTGCTGGATGGCCAGGGAGTCGGCTGG
CTCAACATGAAAAAGGTGCGCCGGCTGCTGGAGAGTGAGCAGCTCCGAGTCTTTGTACTGAGCA
AGCTGAGTCGTGCAGTGCAGTCAGAGGATGATGCCCGACAGGATGTCATCCAGGATGTGGAGAT
CAGTCGGAAGGTGTACAAGGGAATGCTAGACCTCCTCAAGTGCACAGTCCTCAGCCTCGAGCAG
TCCTATGCCCATGCTGGTCTGGGTGGCATGGCCAGCATCTTTGGGCTTTTGGAGATTGCCCAGA
CCCATTACTATAGTAAAGAACCAGACAAACGCAAGAGAAGTCCAACAGAGAATGTAAATACCCC
AGTTGGCAAGGATCCTGGTCTGGCTGGGCGGGGGGACCCAAAGGCAATGGCTCAGCTAAGGGTC
CCTCAGCTGGGTCCTCGGGCACCAAGTGCTACAGGAAGGGGTCCTAAAGAACTGGACACCAGAA
GTTTAAAGGAAGAGAATTTTGTAGCGTCTGTGGGACCAGAGGTCATCAAGCCTGTCTTTGACCT
GGGTGAGACTGAGGAGAAAAAGTCCCAGATCAGCGCAGACAGTGGTGTGAGCCTGGCATCTGCT
TCCCAGAGGACTGATCAAGACTCTGTCATCGGTGTGAGTCCAGCTGTTATGATCCGAAGCTCAA
GTCAGGATTCTGAAGTGAGTAACAGTTCAGGAGAGACCCTCGGAGCAGACAGTGACCTGAGCAG
CAATGCAGGTGATGGGCCAGGAGGCGAAGGCAGTGCCCACTTGGCAAGTTCTCGGGCTACTCTG
TCTGACAGTGAAATTGAAACCAATTCTGCTACAAGCACCATCTTTGGTAAAGCCCATAGCTTGA
AGCCAAAGGAGAAGCCGGCTAGTAGTCCAGTTCGCTCTTCCGAAGATGTAAGCCAGCGAGTCTA
TCTCTATGAGGGACTACTAGGAAGGGACAAAGGATCCATGTGGGACCAGTTAGAGGATGCTGCT
ATGGAGACCTTTTCTATAAGCAAAGAGCGGTCTACTTTATGGGACCAAATGCAGTTCTGGGAAG
ATGCGTTCCTAGATGCTGTGATGTTGGAAAGAGAAGGAATGGGTATGGACCAGGGCCCTCAGGA
AATGATCGACAGGTACCTGTCCCTAGGAGAGCATGACCGGAAGCGCCTGGAGGATGATGAAGAT
CGCTTACTGGCCACACTCTTACACAACCTCATATCCTATATGCTCCTGATGAAGGTGAACAAGA
ACGACATCAGGAAGAAAGTACGGCGCCTAATGGGAAAGTCCCACGTTGGGCTGGTGTACAGTCA
ACAAATCAATGAGGTGCTCGATCAGCTGACCAACCTGAATGGGCGTGATCTCTCCATCCGATCC
AGTGGCAGCAGGCACATGAAGAAGCAGACGTTCGTTGTGCACGCAGGGACGGACACAAATGGAG
ATATCTTTTTCATGGAAGTGTGTGACGACTGTGTGGTCTTACGTAGTAACATCGGGACAGTGTA
CGAGCGCTGGTGGTATGAGAAGCTTATCAACATGACCTACTGTCCCAAGACCAAGGTCCTGTGC
TTATGGCGTAGAAATGGCTCTGAGACGCAGCTCAACAAGTTCTATACCAAGAAGTGTCGGGAGC
TGTACTACTGTGTGAAGGACAGCATGGAGCGTGCGGCTGCCCGGCAACAAAGCATCAAACCCGG
GCCTGAACTAGGTGGTGAGTTCCCTGTGCAGGACATGAAGACTGGAGAGGGCGGCTTGCTTCAG
GTCACCCTGGAAGGGATCAATCTCAAGTTCATGCATAACCAGGTTTTCATAGAGCTGAATCACA
TTAAAAAGTGCAATACAGTTCGAGGCGTCTTTGTCCTGGAAGAATTTGTTCCTGAAATTAAAGA
AGTGGTGAGCCACAAGTACAAGACTCCAATGGCCCACGAGATCTGCTATTCTGTGTTGTGTCTC
TTCTCGTATGTGGCCGCAGTTCGTAGCAGTGAAGAAGACCTCCGAACCCCACCTCGGCCTGTCT
CTAGCTGATAGAGAGGGGTTACACAGCTGGGCCAGCCCAGGGGTCACCCCTCACCTCTTGCTGC
TCCTAAGCGCTGAAGCTGCCTCGACTGAGACAGAGACTCTGTGTGTGTGTGTGTGTGTGTTCTC
TGCAAGGTGTTCTCTGCAAGCTCCTTCCTGCGGTTGAGCTGGTTTCGTTTTATGTCTGAGTGTG
TCCTTGTGTTCATCTGTCATGGGGCTAAGCTAGTCTCATTACCTTCTCTTCCTACAATAGCAGA
C

hide sequence

RefSeq Acc Id:

XM_039106011 ⟹ XP_038961939

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,675 (-)	NCBI
mRatBN7.2	3	77,114,330 - 77,154,435 (-)	NCBI

RefSeq Acc Id:

XM_039106019 ⟹ XP_038961947

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,674 (-)	NCBI
mRatBN7.2	3	77,114,330 - 77,154,435 (-)	NCBI

RefSeq Acc Id:

XM_039106021 ⟹ XP_038961949

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,674 (-)	NCBI
mRatBN7.2	3	77,114,330 - 77,154,435 (-)	NCBI

RefSeq Acc Id:

XM_039106022 ⟹ XP_038961950

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,674 (-)	NCBI
mRatBN7.2	3	77,114,330 - 77,154,435 (-)	NCBI

RefSeq Acc Id:

XM_039106028 ⟹ XP_038961956

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,674 (-)	NCBI
mRatBN7.2	3	77,114,330 - 77,154,435 (-)	NCBI

RefSeq Acc Id:

XM_039106031 ⟹ XP_038961959

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,673 (-)	NCBI
mRatBN7.2	3	77,114,330 - 77,154,435 (-)	NCBI

RefSeq Acc Id:

XM_063284751 ⟹ XP_063140821

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,677 (-)	NCBI

RefSeq Acc Id:

XM_063284752 ⟹ XP_063140822

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,140 (-)	NCBI

RefSeq Acc Id:

XM_063284753 ⟹ XP_063140823

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,286 (-)	NCBI

RefSeq Acc Id:

XM_063284754 ⟹ XP_063140824

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,678 (-)	NCBI

RefSeq Acc Id:

XM_063284755 ⟹ XP_063140825

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,677 (-)	NCBI

RefSeq Acc Id:

XM_063284756 ⟹ XP_063140826

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,676 (-)	NCBI

RefSeq Acc Id:

XM_063284757 ⟹ XP_063140827

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,677 (-)	NCBI

RefSeq Acc Id:

XM_063284758 ⟹ XP_063140828

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,676 (-)	NCBI

RefSeq Acc Id:

XM_063284759 ⟹ XP_063140829

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,677 (-)	NCBI

RefSeq Acc Id:

XM_063284760 ⟹ XP_063140830

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,676 (-)	NCBI

RefSeq Acc Id:

XM_063284761 ⟹ XP_063140831

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,674 (-)	NCBI

RefSeq Acc Id:

XM_063284762 ⟹ XP_063140832

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,676 (-)	NCBI

RefSeq Acc Id:

XM_063284763 ⟹ XP_063140833

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,675 (-)	NCBI

RefSeq Acc Id:

XM_063284764 ⟹ XP_063140834

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,676 (-)	NCBI

RefSeq Acc Id:

XM_063284765 ⟹ XP_063140835

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,677 (-)	NCBI

RefSeq Acc Id:

XM_063284766 ⟹ XP_063140836

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,675 (-)	NCBI

RefSeq Acc Id:

XM_063284767 ⟹ XP_063140837

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,676 (-)	NCBI

RefSeq Acc Id:

XM_063284768 ⟹ XP_063140838

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,673 (-)	NCBI

RefSeq Acc Id:

XM_063284769 ⟹ XP_063140839

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,138 (-)	NCBI

RefSeq Acc Id:

XM_063284770 ⟹ XP_063140840

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,674 (-)	NCBI

RefSeq Acc Id:

XM_063284771 ⟹ XP_063140841

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,675 (-)	NCBI

RefSeq Acc Id:

XM_063284772 ⟹ XP_063140842

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,675 (-)	NCBI

RefSeq Acc Id:

XM_063284773 ⟹ XP_063140843

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,673 (-)	NCBI

RefSeq Acc Id:

XM_063284774 ⟹ XP_063140844

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,673 (-)	NCBI

RefSeq Acc Id:

XM_063284775 ⟹ XP_063140845

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,673 (-)	NCBI

RefSeq Acc Id:

XM_063284776 ⟹ XP_063140846

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,675 (-)	NCBI

RefSeq Acc Id:

XM_063284777 ⟹ XP_063140847

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,673 (-)	NCBI

RefSeq Acc Id:

XM_063284778 ⟹ XP_063140848

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,688 (-)	NCBI

RefSeq Acc Id:

XM_063284779 ⟹ XP_063140849

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,674 (-)	NCBI

RefSeq Acc Id:

XM_063284780 ⟹ XP_063140850

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,675 (-)	NCBI

RefSeq Acc Id:

XM_063284781 ⟹ XP_063140851

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,675 (-)	NCBI

RefSeq Acc Id:

XM_063284782 ⟹ XP_063140852

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,673 (-)	NCBI

RefSeq Acc Id:

XM_063284783 ⟹ XP_063140853

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,674 (-)	NCBI

RefSeq Acc Id:

XM_063284784 ⟹ XP_063140854

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,673 (-)	NCBI

RefSeq Acc Id:

XM_063284785 ⟹ XP_063140855

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,674 (-)	NCBI

RefSeq Acc Id:

XM_063284786 ⟹ XP_063140856

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,674 (-)	NCBI

RefSeq Acc Id:

XM_063284787 ⟹ XP_063140857

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,674 (-)	NCBI

RefSeq Acc Id:

XM_063284788 ⟹ XP_063140858

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,673 (-)	NCBI

RefSeq Acc Id:

XM_063284789 ⟹ XP_063140859

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,673 (-)	NCBI

RefSeq Acc Id:

XM_063284790 ⟹ XP_063140860

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,673 (-)	NCBI

RefSeq Acc Id:

XM_063284791 ⟹ XP_063140861

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,571,468 - 97,613,672 (-)	NCBI

RefSeq Acc Id:

XM_063284792 ⟹ XP_063140862

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,603,012 (-)	NCBI

RefSeq Acc Id:

XM_063284793 ⟹ XP_063140863

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,570,141 - 97,613,673 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001416535	(Get FASTA)	NCBI Sequence Viewer
	NP_001416536	(Get FASTA)	NCBI Sequence Viewer
	NP_001416537	(Get FASTA)	NCBI Sequence Viewer
	NP_001416538	(Get FASTA)	NCBI Sequence Viewer
	NP_001416539	(Get FASTA)	NCBI Sequence Viewer
	NP_001416540	(Get FASTA)	NCBI Sequence Viewer
	NP_001416541	(Get FASTA)	NCBI Sequence Viewer
	NP_001416542	(Get FASTA)	NCBI Sequence Viewer
	NP_001416543	(Get FASTA)	NCBI Sequence Viewer
	NP_446037	(Get FASTA)	NCBI Sequence Viewer
	XP_038961939	(Get FASTA)	NCBI Sequence Viewer
	XP_038961947	(Get FASTA)	NCBI Sequence Viewer
	XP_038961949	(Get FASTA)	NCBI Sequence Viewer
	XP_038961950	(Get FASTA)	NCBI Sequence Viewer
	XP_038961956	(Get FASTA)	NCBI Sequence Viewer
	XP_038961959	(Get FASTA)	NCBI Sequence Viewer
	XP_063140821	(Get FASTA)	NCBI Sequence Viewer
	XP_063140822	(Get FASTA)	NCBI Sequence Viewer
	XP_063140823	(Get FASTA)	NCBI Sequence Viewer
	XP_063140824	(Get FASTA)	NCBI Sequence Viewer
	XP_063140825	(Get FASTA)	NCBI Sequence Viewer
	XP_063140826	(Get FASTA)	NCBI Sequence Viewer
	XP_063140827	(Get FASTA)	NCBI Sequence Viewer
	XP_063140828	(Get FASTA)	NCBI Sequence Viewer
	XP_063140829	(Get FASTA)	NCBI Sequence Viewer
	XP_063140830	(Get FASTA)	NCBI Sequence Viewer
	XP_063140831	(Get FASTA)	NCBI Sequence Viewer
	XP_063140832	(Get FASTA)	NCBI Sequence Viewer
	XP_063140833	(Get FASTA)	NCBI Sequence Viewer
	XP_063140834	(Get FASTA)	NCBI Sequence Viewer
	XP_063140835	(Get FASTA)	NCBI Sequence Viewer
	XP_063140836	(Get FASTA)	NCBI Sequence Viewer
	XP_063140837	(Get FASTA)	NCBI Sequence Viewer
	XP_063140838	(Get FASTA)	NCBI Sequence Viewer
	XP_063140839	(Get FASTA)	NCBI Sequence Viewer
	XP_063140840	(Get FASTA)	NCBI Sequence Viewer
	XP_063140841	(Get FASTA)	NCBI Sequence Viewer
	XP_063140842	(Get FASTA)	NCBI Sequence Viewer
	XP_063140843	(Get FASTA)	NCBI Sequence Viewer
	XP_063140844	(Get FASTA)	NCBI Sequence Viewer
	XP_063140845	(Get FASTA)	NCBI Sequence Viewer
	XP_063140846	(Get FASTA)	NCBI Sequence Viewer
	XP_063140847	(Get FASTA)	NCBI Sequence Viewer
	XP_063140848	(Get FASTA)	NCBI Sequence Viewer
	XP_063140849	(Get FASTA)	NCBI Sequence Viewer
	XP_063140850	(Get FASTA)	NCBI Sequence Viewer
	XP_063140851	(Get FASTA)	NCBI Sequence Viewer
	XP_063140852	(Get FASTA)	NCBI Sequence Viewer
	XP_063140853	(Get FASTA)	NCBI Sequence Viewer
	XP_063140854	(Get FASTA)	NCBI Sequence Viewer
	XP_063140855	(Get FASTA)	NCBI Sequence Viewer
	XP_063140856	(Get FASTA)	NCBI Sequence Viewer
	XP_063140857	(Get FASTA)	NCBI Sequence Viewer
	XP_063140858	(Get FASTA)	NCBI Sequence Viewer
	XP_063140859	(Get FASTA)	NCBI Sequence Viewer
	XP_063140860	(Get FASTA)	NCBI Sequence Viewer
	XP_063140861	(Get FASTA)	NCBI Sequence Viewer
	XP_063140862	(Get FASTA)	NCBI Sequence Viewer
	XP_063140863	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC53149	(Get FASTA)	NCBI Sequence Viewer
	EDL79509	(Get FASTA)	NCBI Sequence Viewer
	EDL79510	(Get FASTA)	NCBI Sequence Viewer
	EDL79511	(Get FASTA)	NCBI Sequence Viewer
	EDL79512	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017360
	ENSRNOP00000075233
	ENSRNOP00000076460
	ENSRNOP00000087537
GenBank Protein	O08873	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446037 ⟸ NM_053585

- UniProtKB:

O08873 (UniProtKB/Swiss-Prot), A6HNA9 (UniProtKB/TrEMBL), A0A8L2Q8M9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVQKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVR
QRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKAEGGAGPRGKEGAHAPCASE
EAATESSESGSTLQPPSADSTPDVNQSPRGKRRAKAGNRSRNSTLTSLCVLSHYPFFSTFRECL
YTLKRLVDCCSERLLGKKPGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRS
PVPVSGQKRVDIEVLPQEVQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK
VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYK
LDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFH
EGQETPLLLGRFSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTL
RLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIG
DKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSESDPTDDSGSDSMDYDDSSSSYSSLGDF
VSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQPQKEGEEPGPDSENSQENLPLRSSSSTT
ASSSPSTIVHGAHSEPADSTEVGDKAATGISKPLPPVPPSICKSTVDRRQTETGEGSVCQRTYD
HPYFEPQYGSPAEEDDDEQGESYTPRFSQHASGSRAQKLLRPNSLKLASDSDAESDSRASSPNS
TVSNNSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKTTPFPSLKGNRRALVDQKSSV
IKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLS
KLSRAVQSEDDARQDVIQDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQ
THYYSKEPDKRKRSPTENVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGRGPKELDTR
SLKEENFVASVGPEVIKPVFDLGETEEKKSQISADSGVSLASASQRTDQDSVIGVSPAVMIRSS
SQDSEVSNSSGETLGADSDLSSNAGDGPGGEGSAHLASSRATLSDSEIETNSATSTIFGKAHSL
KPKEKPASSPVRSSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWE
DAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNK
NDIRKKVRRLMGKSHVGLVYSQQINEVLDQLTNLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNG
DIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRE
LYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQVFIELNH
IKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVRSSEEDLRTPPRPV
SS

hide sequence

Ensembl Acc Id:

ENSRNOP00000075233 ⟸ ENSRNOT00000079394

Ensembl Acc Id:

ENSRNOP00000017360 ⟸ ENSRNOT00000017360

RefSeq Acc Id:	XP_038961959 ⟸ XM_039106031
- Peptide Label:	isoform X31
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038961950 ⟸ XM_039106022
- Peptide Label:	isoform X22
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038961947 ⟸ XM_039106019
- Peptide Label:	isoform X19
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038961956 ⟸ XM_039106028
- Peptide Label:	isoform X29
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038961949 ⟸ XM_039106021
- Peptide Label:	isoform X21
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038961939 ⟸ XM_039106011
- Peptide Label:	isoform X14
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000084938 ⟸ ENSRNOT00000103435

Ensembl Acc Id:

ENSRNOP00000081884 ⟸ ENSRNOT00000104046

Ensembl Acc Id:

ENSRNOP00000087537 ⟸ ENSRNOT00000111515

Ensembl Acc Id:

ENSRNOP00000081476 ⟸ ENSRNOT00000112841

Ensembl Acc Id:

ENSRNOP00000076460 ⟸ ENSRNOT00000111613

RefSeq Acc Id:	XP_063140848 ⟸ XM_063284778
- Peptide Label:	isoform X32

RefSeq Acc Id:	XP_063140824 ⟸ XM_063284754
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140829 ⟸ XM_063284759
- Peptide Label:	isoform X7
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140827 ⟸ XM_063284757
- Peptide Label:	isoform X5
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140835 ⟸ XM_063284765
- Peptide Label:	isoform X13
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140825 ⟸ XM_063284755
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140821 ⟸ XM_063284751
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140834 ⟸ XM_063284764
- Peptide Label:	isoform X12
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140828 ⟸ XM_063284758
- Peptide Label:	isoform X6
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140832 ⟸ XM_063284762
- Peptide Label:	isoform X10
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140837 ⟸ XM_063284767
- Peptide Label:	isoform X16
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140826 ⟸ XM_063284756
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140830 ⟸ XM_063284760
- Peptide Label:	isoform X8
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140846 ⟸ XM_063284776
- Peptide Label:	isoform X28
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140842 ⟸ XM_063284772
- Peptide Label:	isoform X24
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140836 ⟸ XM_063284766
- Peptide Label:	isoform X15
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140841 ⟸ XM_063284771
- Peptide Label:	isoform X23
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140833 ⟸ XM_063284763
- Peptide Label:	isoform X11
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140840 ⟸ XM_063284770
- Peptide Label:	isoform X20
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140831 ⟸ XM_063284761
- Peptide Label:	isoform X9

RefSeq Acc Id:	XP_063140847 ⟸ XM_063284777
- Peptide Label:	isoform X30

RefSeq Acc Id:	XP_063140843 ⟸ XM_063284773
- Peptide Label:	isoform X25

RefSeq Acc Id:	XP_063140845 ⟸ XM_063284775
- Peptide Label:	isoform X27
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140863 ⟸ XM_063284793
- Peptide Label:	isoform X47
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140844 ⟸ XM_063284774
- Peptide Label:	isoform X26

RefSeq Acc Id:	XP_063140838 ⟸ XM_063284768
- Peptide Label:	isoform X17
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140823 ⟸ XM_063284753
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140822 ⟸ XM_063284752
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140839 ⟸ XM_063284769
- Peptide Label:	isoform X18
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140862 ⟸ XM_063284792
- Peptide Label:	isoform X46

RefSeq Acc Id:	XP_063140851 ⟸ XM_063284781
- Peptide Label:	isoform X35
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140850 ⟸ XM_063284780
- Peptide Label:	isoform X34
- UniProtKB:	A0A8I5Y5V9 (UniProtKB/TrEMBL), A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140857 ⟸ XM_063284787
- Peptide Label:	isoform X41
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140855 ⟸ XM_063284785
- Peptide Label:	isoform X39
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140856 ⟸ XM_063284786
- Peptide Label:	isoform X40
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140853 ⟸ XM_063284783
- Peptide Label:	isoform X37
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140849 ⟸ XM_063284779
- Peptide Label:	isoform X33
- UniProtKB:	A0A8I5ZTV3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140860 ⟸ XM_063284790
- Peptide Label:	isoform X44

RefSeq Acc Id:	XP_063140859 ⟸ XM_063284789
- Peptide Label:	isoform X43
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140858 ⟸ XM_063284788
- Peptide Label:	isoform X42

RefSeq Acc Id:	XP_063140854 ⟸ XM_063284784
- Peptide Label:	isoform X38

RefSeq Acc Id:	XP_063140852 ⟸ XM_063284782
- Peptide Label:	isoform X36

RefSeq Acc Id:	XP_063140861 ⟸ XM_063284791
- Peptide Label:	isoform X45
- UniProtKB:	A0A8L2Q8M9 (UniProtKB/TrEMBL)

Protein Domains

cDENN dDENN Death uDENN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O08873-F1-model_v2	AlphaFold	O08873	1-1602	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692208

Promoter ID:

EPDNEW_R2733

Type:

single initiation site

Name:

Madd_1

Description:

MAP-kinase activating death domain

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	80,003,037 - 80,003,097	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619922	AgrOrtholog
BioCyc Gene	G2FUF-48747	BioCyc
Ensembl Genes	ENSRNOG00000012568	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000017360	ENTREZGENE
	ENSRNOT00000079394	ENTREZGENE
	ENSRNOT00000111515	ENTREZGENE
	ENSRNOT00000111613	ENTREZGENE
Gene3D-CATH	3.30.450.200	UniProtKB/Swiss-Prot
	3.40.50.11500	UniProtKB/Swiss-Prot
InterPro	cDENN_dom	UniProtKB/Swiss-Prot
	dDENN_dom	UniProtKB/Swiss-Prot
	DENN_C	UniProtKB/Swiss-Prot
	MADD	UniProtKB/Swiss-Prot
	Tripartite_DENN	UniProtKB/Swiss-Prot
	uDENN_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:94193	UniProtKB/Swiss-Prot
NCBI Gene	94193	ENTREZGENE
PANTHER	MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN	UniProtKB/Swiss-Prot
	PTHR13008	UniProtKB/Swiss-Prot
Pfam	DENN	UniProtKB/Swiss-Prot
	uDENN	UniProtKB/Swiss-Prot
PhenoGen	Madd	PhenoGen
PROSITE	DENN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000012568	RatGTEx
SMART	dDENN	UniProtKB/Swiss-Prot
	DENN	UniProtKB/Swiss-Prot
	uDENN	UniProtKB/Swiss-Prot
UniProt	A0A0G2KA27	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5Y5V9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZSL5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZTV3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A266_RAT	UniProtKB/TrEMBL
	A0A8I6A7E5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2Q8M9	ENTREZGENE, UniProtKB/TrEMBL
	A6HNA8_RAT	UniProtKB/TrEMBL
	A6HNA9	ENTREZGENE, UniProtKB/TrEMBL
	A6HNB0_RAT	UniProtKB/TrEMBL
	A6HNB1_RAT	UniProtKB/TrEMBL
	MADD_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Madd	MAP-kinase activating death domain			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Madd	MAP-kinase activating death domain			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in all tissues, enriched in brain	633238
gene_protein	1,602 amino acids; 178 kDa	633238

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)