Dpp4 (dipeptidylpeptidase 4) - Rat Genome Database

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Gene: Dpp4 (dipeptidylpeptidase 4) Rattus norvegicus
Symbol: Dpp4
Name: dipeptidylpeptidase 4
RGD ID: 2515
Description: Enables several functions, including collagen binding activity; dipeptidyl-peptidase activity; and identical protein binding activity. Involved in B-1a B cell differentiation; protein catabolic process; and regulation of lymphocyte mediated immunity. Located in cell surface. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4); INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bile canaliculus domain-specific membrane glycoprotein; CD26; Dipeptidyl peptidase 4; dipeptidyl peptidase IV; DPP IV; DPPIV; GP110 glycoprotein; T-cell activation antigen CD26
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Dpp4DPPIV  
Genetic Models: DA.F344-Dpp4DPPIV/SvH F344-Dpp4DPPIV-/DchcHsdRrrc
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8367,370,794 - 67,452,422 (-)NCBIGRCr8
mRatBN7.2346,962,233 - 47,043,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl346,962,243 - 47,043,901 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,316,895 - 50,398,506 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0358,900,415 - 58,982,044 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0356,673,443 - 56,755,068 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,291,055 - 48,372,672 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,291,055 - 48,372,672 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0354,957,146 - 55,038,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,279,255 - 44,360,283 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1344,175,626 - 44,256,655 (-)NCBI
Celera346,603,336 - 46,685,074 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
adenosine  (ISO)
aflatoxin B1  (ISO)
alogliptin  (EXP,ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
amphetamine  (EXP)
anagliptin  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenic acid  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
azoxystrobin  (EXP)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
Chikusetsusaponin-V  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
ciprofibrate  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
columbamine  (ISO)
copper(II) sulfate  (ISO)
coptisine  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
flutamide  (EXP)
formaldehyde  (EXP,ISO)
fructose  (ISO)
gentamycin  (EXP)
Ginsenoside Rg5  (ISO)
Ginsenoside Rh4  (ISO)
Ginsenoside-Rk3  (ISO)
glafenine  (EXP)
glyphosate  (EXP)
Heptachlor epoxide  (ISO)
hydrazine  (ISO)
imidacloprid  (EXP)
isoflavones  (ISO)
Kukoamine B  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
linagliptin  (EXP)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
Panaxadiol  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
Phytolaccoside E  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
pyrroles  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
rimonabant  (ISO)
rotenone  (EXP,ISO)
Salvianolic acid C  (ISO)
saxagliptin  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tectoridin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
venlafaxine hydrochloride  (EXP)
vildagliptin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
Voglibose  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component


References - curated
# Reference Title Reference Citation
1. Elevated Human Dipeptidyl Peptidase 4 Expression Reduces the Susceptibility of hDPP4 Transgenic Mice to Middle East Respiratory Syndrome Coronavirus Infection and Disease. Algaissi A, etal., J Infect Dis. 2019 Feb 15;219(5):829-835. doi: 10.1093/infdis/jiy574.
2. Upregulated expression and activation of membrane‚ÄĎassociated proteases in esophageal squamous cell carcinoma. Augoff K, etal., Oncol Rep. 2014 Jun;31(6):2820-6. doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.
3. Roles of cysteines in rat dipeptidyl peptidase IV/CD26 in processing and proteolytic activity. Dobers J, etal., Eur J Biochem. 2000 Aug;267(16):5093-100.
4. Domain-specific N-glycosylation of the membrane glycoprotein dipeptidylpeptidase IV (CD26) influences its subcellular trafficking, biological stability, enzyme activity and protein folding. Fan H, etal., Eur J Biochem. 1997 May 15;246(1):243-51.
5. Efficacy and Safety Comparison Between the DPP-4 Inhibitor Vildagliptin and the Sulfonylurea Gliclazide After Two Years of Monotherapy in Drug-naive Patients with Type 2 Diabetes. Foley JE and Sreenan S, Horm Metab Res. 2009 Aug 24.
6. Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions. Frerker N, etal., Clin Chem Lab Med. 2009;47(3):275-87. doi: 10.1515/CCLM.2009.064.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. cDNA cloning for a bile canaliculus domain-specific membrane glycoprotein of rat hepatocytes. Hong W and Doyle D, Proc Natl Acad Sci U S A 1987 Nov;84(22):7962-6.
10. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
11. Extreme reduction of dipeptidyl peptidase IV activity in F344 rat substrains is associated with various behavioral differences. Karl T, etal., Physiol Behav. 2003 Oct;80(1):123-34.
12. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
13. Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Kim SJ, etal., Diabetes. 2009 Mar;58(3):641-51. Epub 2008 Dec 10.
14. Activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats with dopamine deficiency-dependent MPTP-induced depressive syndrome. Krupina NA, etal., Bull Exp Biol Med. 2006 Nov;142(5):554-6.
15. CD26 (dipeptidyl-peptidase IV)-dependent recruitment of T cells in a rat asthma model. Kruschinski C, etal., Clin Exp Immunol. 2005 Jan;139(1):17-24.
16. The cysteine-rich region of dipeptidyl peptidase IV (CD 26) is the collagen-binding site. Loster K, etal., Biochem Biophys Res Commun. 1995 Dec 5;217(1):341-8.
17. The 3D structure of rat DPPIV/CD26 as obtained by cryo-TEM and single particle analysis. Ludwig K, etal., Biochem Biophys Res Commun. 2003 Apr 25;304(1):73-7.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes. Mu J, etal., Eur J Pharmacol. 2009 Sep 16.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Primary structure of rat liver dipeptidyl peptidase IV deduced from its cDNA and identification of the NH2-terminal signal sequence as the membrane-anchoring domain. Ogata S, etal., J Biol Chem 1989 Feb 25;264(6):3596-601.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. Richard E, etal., J Biol Chem 2002 May 31;277(22):19720-6.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Improvement of high fat-diet-induced insulin resistance in dipeptidyl peptidase IV-deficient Fischer rats. Yasuda N, etal., Life Sci 2002 May 31;71(2):227-38.
Additional References at PubMed
PMID:1347701   PMID:1970322   PMID:1974258   PMID:3182821   PMID:7594462   PMID:7905271   PMID:8100523   PMID:8101391   PMID:8798518   PMID:10593948   PMID:10900005   PMID:11487543  
PMID:11772392   PMID:12068294   PMID:12675219   PMID:12675233   PMID:12716896   PMID:14684150   PMID:15052268   PMID:15448155   PMID:15584901   PMID:16478473   PMID:16651416   PMID:16670267  
PMID:16712972   PMID:16802131   PMID:16962474   PMID:17010607   PMID:17175274   PMID:17287217   PMID:17549790   PMID:17583752   PMID:17897319   PMID:18047624   PMID:18077600   PMID:18538760  
PMID:18931022   PMID:18940185   PMID:18978811   PMID:19056867   PMID:19199708   PMID:19501934   PMID:19540879   PMID:19804410   PMID:19876009   PMID:19946888   PMID:20153005   PMID:20458337  
PMID:20560982   PMID:20887754   PMID:21139073   PMID:21362503   PMID:21423176   PMID:21982785   PMID:22001206   PMID:22373413   PMID:22802229   PMID:22918684   PMID:23033273   PMID:23035207  
PMID:23184393   PMID:23359639   PMID:23361237   PMID:23376485   PMID:23408696   PMID:23486063   PMID:23533145   PMID:23535306   PMID:23677473   PMID:23832365   PMID:23894014   PMID:24357522  
PMID:24416433   PMID:24874705   PMID:25122001   PMID:25635612   PMID:25656369   PMID:25823534   PMID:25936515   PMID:26187356   PMID:26259714   PMID:26359413   PMID:26399925   PMID:27083282  
PMID:27198182   PMID:27238050   PMID:27525674   PMID:28372289   PMID:28895067   PMID:29472575   PMID:29677638   PMID:30977110   PMID:31089745   PMID:32542696   PMID:33162819   PMID:34310895  
PMID:34738744   PMID:35014677  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8367,370,794 - 67,452,422 (-)NCBIGRCr8
mRatBN7.2346,962,233 - 47,043,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl346,962,243 - 47,043,901 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,316,895 - 50,398,506 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0358,900,415 - 58,982,044 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0356,673,443 - 56,755,068 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,291,055 - 48,372,672 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,291,055 - 48,372,672 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0354,957,146 - 55,038,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,279,255 - 44,360,283 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1344,175,626 - 44,256,655 (-)NCBI
Celera346,603,336 - 46,685,074 (-)NCBICelera
Cytogenetic Map3q21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382161,992,245 - 162,074,215 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2161,992,245 - 162,074,394 (-)EnsemblGRCh38hg38GRCh38
GRCh372162,848,755 - 162,930,725 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,557,001 - 162,639,298 (-)NCBINCBI36Build 36hg18NCBI36
Build 342162,674,263 - 162,756,559NCBI
Celera2156,458,999 - 156,541,354 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2154,730,637 - 154,813,409 (-)NCBIHuRef
CHM1_12162,854,656 - 162,936,956 (-)NCBICHM1_1
T2T-CHM13v2.02162,448,837 - 162,530,851 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39262,160,417 - 62,242,635 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl262,160,417 - 62,242,575 (-)EnsemblGRCm39 Ensembl
GRCm38262,330,073 - 62,412,315 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl262,330,073 - 62,412,231 (-)EnsemblGRCm38mm10GRCm38
MGSCv37262,168,130 - 62,250,288 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36262,132,579 - 62,212,921 (-)NCBIMGSCv36mm8
Celera264,022,145 - 64,102,355 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map235.85NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495544911,795,536 - 11,875,412 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544911,795,994 - 11,873,408 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21364,684,314 - 64,766,927 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B64,698,715 - 64,781,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B49,285,685 - 49,368,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B166,654,659 - 166,736,588 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B166,654,659 - 166,736,588 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1367,398,713 - 7,472,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl367,399,643 - 7,454,204 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha367,540,277 - 7,619,076 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0367,528,186 - 7,606,978 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl367,529,163 - 7,606,652 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1367,543,394 - 7,622,160 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0367,588,175 - 7,666,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0367,695,776 - 7,774,177 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303124,555,518 - 124,638,558 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646916,979,410 - 17,061,159 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646916,979,220 - 17,062,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1568,660,521 - 68,743,663 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11568,661,764 - 68,742,961 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21576,153,602 - 76,234,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap15q21NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11047,396,605 - 47,481,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1047,394,093 - 47,480,893 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040152,044,113 - 152,128,336 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247323,460,118 - 3,535,249 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247323,460,529 - 3,535,252 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Dpp4
475 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:33
Interacting mature miRNAs:36
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)33819223350749747Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)33871036550302886Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)33945463753296578Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2346,964,111 - 46,964,311 (+)MAPPERmRatBN7.2
Rnor_6.0348,292,924 - 48,293,123NCBIRnor6.0
Rnor_5.0354,959,015 - 54,959,214UniSTSRnor5.0
RGSC_v3.4344,281,124 - 44,281,323UniSTSRGSC3.4
Celera346,605,205 - 46,605,404UniSTS
Cytogenetic Map3q21UniSTS

Genetic Models
This gene Dpp4 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 2 39 29 19 29 31 14 11
Low 1 41 18 12 12 8 10 64 4 25 8
Below cutoff 1 10 2


RefSeq Acc Id: ENSRNOT00000040482   ⟹   ENSRNOP00000045536
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl346,962,243 - 47,043,901 (-)Ensembl
Rnor_6.0 Ensembl348,293,617 - 48,372,583 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077788   ⟹   ENSRNOP00000072092
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl346,962,243 - 47,019,280 (-)Ensembl
Rnor_6.0 Ensembl348,292,739 - 48,372,609 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085426   ⟹   ENSRNOP00000068881
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl346,962,243 - 47,043,775 (-)Ensembl
Rnor_6.0 Ensembl348,291,055 - 48,372,672 (-)Ensembl
RefSeq Acc Id: NM_012789   ⟹   NP_036921
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8367,370,794 - 67,452,422 (-)NCBI
mRatBN7.2346,962,233 - 47,043,870 (-)NCBI
Rnor_6.0348,291,055 - 48,372,672 (-)NCBI
Rnor_5.0354,957,146 - 55,038,628 (-)NCBI
RGSC_v3.4344,279,255 - 44,360,283 (-)RGD
Celera346,603,336 - 46,685,074 (-)RGD
Protein Sequences
Protein RefSeqs NP_036921 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41096 (Get FASTA)   NCBI Sequence Viewer  
  AAA41272 (Get FASTA)   NCBI Sequence Viewer  
  EDL79005 (Get FASTA)   NCBI Sequence Viewer  
  EDL79006 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045536.5
GenBank Protein P14740 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036921   ⟸   NM_012789
- UniProtKB: P14740 (UniProtKB/Swiss-Prot),   A6HLV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068881   ⟸   ENSRNOT00000085426
RefSeq Acc Id: ENSRNOP00000072092   ⟸   ENSRNOT00000077788
RefSeq Acc Id: ENSRNOP00000045536   ⟸   ENSRNOT00000040482
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14740-F1-model_v2 AlphaFold P14740 1-767 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692100
Promoter ID:EPDNEW_R2623
Type:initiation region
Description:dipeptidylpeptidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0348,372,675 - 48,372,735EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2515 AgrOrtholog
BioCyc Gene G2FUF-49593 BioCyc
Ensembl Genes ENSRNOG00000030763 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040482.5 UniProtKB/TrEMBL
  ENSRNOT00000077788.2 UniProtKB/TrEMBL
  ENSRNOT00000085426.2 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dipeptidylpeptidase IV, N-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DPPIV_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_S9_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25253 UniProtKB/Swiss-Prot
Pfam DPPIV_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DPPIV_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dpp4 PhenoGen
RatGTEx ENSRNOG00000030763 RatGTEx
Superfamily-SCOP DPP6 N-terminal domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229485
  A0A0G2K238_RAT UniProtKB/TrEMBL
  DPP4_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Dpp4  Dipeptidyl peptidase 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_other genetic deficiency of dipeptidyl peptidase IV is noted in the F344/DuCrj strain 728469