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Gene: Dpp4 (dipeptidylpeptidase 4) Rattus norvegicus
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Symbol: Dpp4
Name: dipeptidylpeptidase 4
Description: Exhibits several functions, including collagen binding activity; dipeptidyl-peptidase activity; and protein homodimerization activity. Involved in establishment of localization; proteolysis; and regulation of T cell mediated immunity. Localizes to the cell surface; cytoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4); INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: bile canaliculus domain-specific membrane glycoprotein; CD26; Dipeptidyl peptidase 4; dipeptidyl peptidase IV; DPP IV; DPPIV; GP110 glycoprotein; T-cell activation antigen CD26
Orthologs:
Homo sapiens (human) : DPP4 (dipeptidyl peptidase 4)  HGNC  Alliance
Mus musculus (house mouse) : Dpp4 (dipeptidylpeptidase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dpp4 (dipeptidyl peptidase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DPP4 (dipeptidyl peptidase 4)
Canis lupus familiaris (dog) : DPP4 (dipeptidyl peptidase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dpp4 (dipeptidyl peptidase 4)
Sus scrofa (pig) : DPP4 (dipeptidyl peptidase 4)
more info ...
Allele / Splice: Dpp4DPPIV-  
Genetic Models: F344-Dpp4DPPIV-/DchcHsdRrrc
Is Marker For: Strains:   F344-Dpp4DPPIV-/DchcHsdRrrc  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0348,291,055 - 48,372,672 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0354,957,146 - 55,038,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,279,255 - 44,360,283 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1344,175,626 - 44,256,655 (-)NCBI
Celera346,603,336 - 46,685,074 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Dpp4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2515
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.