DPP4 (dipeptidyl peptidase 4) - Rat Genome Database

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Gene: DPP4 (dipeptidyl peptidase 4) Sus scrofa
Analyze
Symbol: DPP4
Name: dipeptidyl peptidase 4
RGD ID: 14032485
Description: ENCODES a protein that exhibits collagen binding (ortholog); dipeptidyl-peptidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN B-1a B cell differentiation (ortholog); behavioral fear response (ortholog); endothelial cell migration (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Coronavirus infectious disease (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cell surface (ortholog); endocytic vesicle (ortholog); lamellipodium (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ADABP; CD26; dipeptidyl peptidase IV; dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2); dipeptidyl-peptidase iv; DPP IV; DPPIV; T-cell activation antigen CD26
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1568,660,521 - 68,743,663 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11568,661,764 - 68,742,961 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21576,153,602 - 76,234,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap15q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:1675855   PMID:7903569   PMID:12690074   PMID:14681463   PMID:14719797   PMID:16025254   PMID:16700514   PMID:17145712   PMID:21093607   PMID:22301074   PMID:25828735   PMID:30032202  


Genomics

Comparative Map Data
DPP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1568,660,521 - 68,743,663 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11568,661,764 - 68,742,961 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21576,153,602 - 76,234,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap15q21NCBI
DPP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382161,992,245 - 162,074,215 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2161,992,245 - 162,074,394 (-)EnsemblGRCh38hg38GRCh38
GRCh372162,848,755 - 162,930,725 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,557,001 - 162,639,298 (-)NCBINCBI36Build 36hg18NCBI36
Build 342162,674,263 - 162,756,559NCBI
Celera2156,458,999 - 156,541,354 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2154,730,637 - 154,813,409 (-)NCBIHuRef
CHM1_12162,854,656 - 162,936,956 (-)NCBICHM1_1
T2T-CHM13v2.02162,448,837 - 162,530,851 (-)NCBIT2T-CHM13v2.0
Dpp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39262,160,417 - 62,242,635 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl262,160,417 - 62,242,575 (-)EnsemblGRCm39 Ensembl
GRCm38262,330,073 - 62,412,315 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl262,330,073 - 62,412,231 (-)EnsemblGRCm38mm10GRCm38
MGSCv37262,168,130 - 62,250,288 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36262,132,579 - 62,212,921 (-)NCBIMGSCv36mm8
Celera264,022,145 - 64,102,355 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map235.85NCBI
Dpp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8367,370,794 - 67,452,422 (-)NCBIGRCr8
mRatBN7.2346,962,233 - 47,043,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl346,962,243 - 47,043,901 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,316,895 - 50,398,506 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0358,900,415 - 58,982,044 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0356,673,443 - 56,755,068 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,291,055 - 48,372,672 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,291,055 - 48,372,672 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0354,957,146 - 55,038,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,279,255 - 44,360,283 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1344,175,626 - 44,256,655 (-)NCBI
Celera346,603,336 - 46,685,074 (-)NCBICelera
Cytogenetic Map3q21NCBI
Dpp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544911,795,536 - 11,875,412 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544911,795,994 - 11,873,408 (+)NCBIChiLan1.0ChiLan1.0
DPP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21364,684,314 - 64,766,927 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B64,698,715 - 64,781,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B49,285,685 - 49,368,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B166,654,659 - 166,736,588 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B166,654,659 - 166,736,588 (-)Ensemblpanpan1.1panPan2
DPP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1367,398,713 - 7,472,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl367,399,643 - 7,454,204 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha367,540,277 - 7,619,076 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0367,528,186 - 7,606,978 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl367,529,163 - 7,606,652 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1367,543,394 - 7,622,160 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0367,588,175 - 7,666,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0367,695,776 - 7,774,177 (-)NCBIUU_Cfam_GSD_1.0
Dpp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303124,555,518 - 124,638,558 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646916,979,410 - 17,061,159 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646916,979,220 - 17,062,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11047,396,605 - 47,481,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1047,394,093 - 47,480,893 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040152,044,113 - 152,128,336 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dpp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247323,460,118 - 3,535,249 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247323,460,529 - 3,535,252 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DPP4
1540 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 19 1 2 5 14 12 19 3 4 3

Sequence


Ensembl Acc Id: ENSSSCT00000017306   ⟹   ENSSSCP00000016843
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1568,660,863 - 68,743,663 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000033784   ⟹   ENSSSCP00000029093
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1568,660,852 - 68,743,607 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000035225   ⟹   ENSSSCP00000028692
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1568,660,852 - 68,720,479 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000067722   ⟹   ENSSSCP00000059750
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1568,660,853 - 68,743,663 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000073154   ⟹   ENSSSCP00000068875
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1568,660,521 - 68,706,520 (-)Ensembl
RefSeq Acc Id: NM_214257   ⟹   NP_999422
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11568,661,764 - 68,742,961 (-)NCBI
Sequence:
RefSeq Acc Id: NP_999422   ⟸   NM_214257
- UniProtKB: Q866G2 (UniProtKB/Swiss-Prot),   P22411 (UniProtKB/Swiss-Prot),   A0A480UDQ9 (UniProtKB/TrEMBL),   A0A4X1VQ49 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000028692   ⟸   ENSSSCT00000035225
Ensembl Acc Id: ENSSSCP00000016843   ⟸   ENSSSCT00000017306
Ensembl Acc Id: ENSSSCP00000059750   ⟸   ENSSSCT00000067722
Ensembl Acc Id: ENSSSCP00000068875   ⟸   ENSSSCT00000073154
Ensembl Acc Id: ENSSSCP00000029093   ⟸   ENSSSCT00000033784
Protein Domains
Dipeptidyl peptidase 4 low complexity region   Dipeptidylpeptidase IV N-terminal   Peptidase S9 prolyl oligopeptidase catalytic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015894 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005043469 UniProtKB/Swiss-Prot
  ENSSSCG00015012166 UniProtKB/TrEMBL
  ENSSSCG00025055400 UniProtKB/TrEMBL
  ENSSSCG00030019104 UniProtKB/TrEMBL
  ENSSSCG00035020335 UniProtKB/TrEMBL
  ENSSSCG00040073443 UniProtKB/TrEMBL
  ENSSSCG00045003116 UniProtKB/TrEMBL
  ENSSSCG00050022353 UniProtKB/TrEMBL
  ENSSSCG00055020012 UniProtKB/TrEMBL
  ENSSSCG00060010002 UniProtKB/TrEMBL
  ENSSSCG00065077465 UniProtKB/TrEMBL
  ENSSSCG00070025527 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000017306 ENTREZGENE
  ENSSSCT00000017306.4 UniProtKB/TrEMBL
  ENSSSCT00000017306.5 UniProtKB/Swiss-Prot
  ENSSSCT00000033784.4 UniProtKB/TrEMBL
  ENSSSCT00000035225.3 UniProtKB/TrEMBL
  ENSSSCT00000067722.2 UniProtKB/TrEMBL
  ENSSSCT00000073154.2 UniProtKB/TrEMBL
  ENSSSCT00005069919.1 UniProtKB/Swiss-Prot
  ENSSSCT00015016577.1 UniProtKB/TrEMBL
  ENSSSCT00025077401.1 UniProtKB/TrEMBL
  ENSSSCT00030026458.1 UniProtKB/TrEMBL
  ENSSSCT00030026577.1 UniProtKB/TrEMBL
  ENSSSCT00035026487.1 UniProtKB/TrEMBL
  ENSSSCT00035026576.1 UniProtKB/TrEMBL
  ENSSSCT00040101465.1 UniProtKB/TrEMBL
  ENSSSCT00045005119.1 UniProtKB/TrEMBL
  ENSSSCT00045005341.1 UniProtKB/TrEMBL
  ENSSSCT00050030274.1 UniProtKB/TrEMBL
  ENSSSCT00055039999.1 UniProtKB/TrEMBL
  ENSSSCT00055040986.1 UniProtKB/TrEMBL
  ENSSSCT00060013003.1 UniProtKB/TrEMBL
  ENSSSCT00060013028.1 UniProtKB/TrEMBL
  ENSSSCT00065107304.1 UniProtKB/TrEMBL
  ENSSSCT00065107382.1 UniProtKB/TrEMBL
  ENSSSCT00070051059.1 UniProtKB/Swiss-Prot
  ENSSSCT00070051062.1 UniProtKB/TrEMBL
  ENSSSCT00070051064.1 UniProtKB/TrEMBL
  ENSSSCT00070051073.1 UniProtKB/TrEMBL
  ENSSSCT00070051075.1 UniProtKB/TrEMBL
  ENSSSCT00070051076.1 UniProtKB/TrEMBL
  ENSSSCT00070051081.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dipeptidylpeptidase IV, N-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DPPIV_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_S9_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serine_Prot_S9B/DPPIV_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397492 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene DPP4 ENTREZGENE
PANTHER DIPEPTIDYL PEPTIDASE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DPPIV_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DPPIV_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PRO_ENDOPEP_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP DPP6 N-terminal domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2C9F3H7_PIG UniProtKB/TrEMBL
  A0A480UDQ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VMD6_PIG UniProtKB/TrEMBL
  A0A4X1VMY6_PIG UniProtKB/TrEMBL
  A0A4X1VNU6_PIG UniProtKB/TrEMBL
  A0A4X1VQ49 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2Q7G7_PIG UniProtKB/TrEMBL
  A0A5G2QXK4_PIG UniProtKB/TrEMBL
  A0A5S6GG63_PIG UniProtKB/TrEMBL
  A0A8D0M1I1_PIG UniProtKB/TrEMBL
  A0A8D0M239_PIG UniProtKB/TrEMBL
  DPP4_PIG UniProtKB/Swiss-Prot
  K7GMK0_PIG UniProtKB/TrEMBL
  P22411 ENTREZGENE
  Q866G2 ENTREZGENE
UniProt Secondary Q866G2 UniProtKB/Swiss-Prot
VGNC ID VGNC:96236 ENTREZGENE