DPP4 (dipeptidyl peptidase 4) - Rat Genome Database

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Gene: DPP4 (dipeptidyl peptidase 4) Canis lupus familiaris
Analyze
Symbol: DPP4
Name: dipeptidyl peptidase 4
RGD ID: 12098393
Description: ENCODES a protein that exhibits collagen binding (ortholog); dipeptidyl-peptidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN B-1a B cell differentiation (ortholog); behavioral fear response (ortholog); locomotory exploration behavior (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Coronavirus infectious disease (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1367,398,713 - 7,472,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl367,399,643 - 7,454,204 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha367,540,277 - 7,619,076 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0367,528,186 - 7,606,978 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl367,529,163 - 7,606,652 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1367,543,394 - 7,622,160 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0367,588,175 - 7,666,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0367,695,776 - 7,774,177 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:16700514   PMID:18538760   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DPP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1367,398,713 - 7,472,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl367,399,643 - 7,454,204 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha367,540,277 - 7,619,076 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0367,528,186 - 7,606,978 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl367,529,163 - 7,606,652 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1367,543,394 - 7,622,160 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0367,588,175 - 7,666,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0367,695,776 - 7,774,177 (-)NCBIUU_Cfam_GSD_1.0
DPP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382161,992,245 - 162,074,215 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2161,992,245 - 162,074,394 (-)EnsemblGRCh38hg38GRCh38
GRCh372162,848,755 - 162,930,725 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,557,001 - 162,639,298 (-)NCBINCBI36Build 36hg18NCBI36
Build 342162,674,263 - 162,756,559NCBI
Celera2156,458,999 - 156,541,354 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2154,730,637 - 154,813,409 (-)NCBIHuRef
CHM1_12162,854,656 - 162,936,956 (-)NCBICHM1_1
T2T-CHM13v2.02162,448,837 - 162,530,851 (-)NCBIT2T-CHM13v2.0
Dpp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39262,160,417 - 62,242,635 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl262,160,417 - 62,242,575 (-)EnsemblGRCm39 Ensembl
GRCm38262,330,073 - 62,412,315 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl262,330,073 - 62,412,231 (-)EnsemblGRCm38mm10GRCm38
MGSCv37262,168,130 - 62,250,288 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36262,132,579 - 62,212,921 (-)NCBIMGSCv36mm8
Celera264,022,145 - 64,102,355 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map235.85NCBI
Dpp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8367,370,794 - 67,452,422 (-)NCBIGRCr8
mRatBN7.2346,962,233 - 47,043,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl346,962,243 - 47,043,901 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,316,895 - 50,398,506 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0358,900,415 - 58,982,044 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0356,673,443 - 56,755,068 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,291,055 - 48,372,672 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,291,055 - 48,372,672 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0354,957,146 - 55,038,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,279,255 - 44,360,283 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1344,175,626 - 44,256,655 (-)NCBI
Celera346,603,336 - 46,685,074 (-)NCBICelera
Cytogenetic Map3q21NCBI
Dpp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544911,795,536 - 11,875,412 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544911,795,994 - 11,873,408 (+)NCBIChiLan1.0ChiLan1.0
DPP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21364,684,314 - 64,766,927 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B64,698,715 - 64,781,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B49,285,685 - 49,368,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B166,654,659 - 166,736,588 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B166,654,659 - 166,736,588 (-)Ensemblpanpan1.1panPan2
Dpp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303124,555,518 - 124,638,558 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646916,979,410 - 17,061,159 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646916,979,220 - 17,062,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1568,660,521 - 68,743,663 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11568,661,764 - 68,742,961 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21576,153,602 - 76,234,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap15q21NCBI
DPP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11047,396,605 - 47,481,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1047,394,093 - 47,480,893 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040152,044,113 - 152,128,336 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dpp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247323,460,118 - 3,535,249 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247323,460,529 - 3,535,252 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DPP4
922 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000016527   ⟹   ENSCAFP00000015290
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl367,399,643 - 7,454,204 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053256   ⟹   ENSCAFP00845041821
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl367,529,163 - 7,606,652 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053407   ⟹   ENSCAFP00845041956
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl367,529,163 - 7,606,344 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053417   ⟹   ENSCAFP00845041965
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl367,529,163 - 7,606,179 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053476   ⟹   ENSCAFP00845042017
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl367,529,163 - 7,602,116 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053506   ⟹   ENSCAFP00845042040
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl367,531,034 - 7,606,179 (-)Ensembl
RefSeq Acc Id: XM_038446895   ⟹   XP_038302823
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0367,528,186 - 7,606,978 (-)NCBI
RefSeq Acc Id: XM_038446896   ⟹   XP_038302824
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0367,529,224 - 7,606,148 (-)NCBI
RefSeq Acc Id: XM_038463398   ⟹   XP_038319326
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha367,540,277 - 7,619,076 (-)NCBI
RefSeq Acc Id: XM_038463399   ⟹   XP_038319327
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha367,541,315 - 7,618,249 (-)NCBI
RefSeq Acc Id: XM_038520970   ⟹   XP_038376898
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1367,543,394 - 7,622,160 (-)NCBI
RefSeq Acc Id: XM_038584662   ⟹   XP_038440590
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0367,695,776 - 7,774,177 (-)NCBI
RefSeq Acc Id: XM_038584663   ⟹   XP_038440591
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0367,696,814 - 7,773,347 (-)NCBI
RefSeq Acc Id: XM_038649084   ⟹   XP_038505012
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0367,588,175 - 7,666,856 (-)NCBI
RefSeq Acc Id: XM_038649085   ⟹   XP_038505013
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0367,589,213 - 7,666,082 (-)NCBI
Ensembl Acc Id: ENSCAFP00000015290   ⟸   ENSCAFT00000016527
RefSeq Acc Id: XP_038376898   ⟸   XM_038520970
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038505012   ⟸   XM_038649084
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038505013   ⟸   XM_038649085
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038302823   ⟸   XM_038446895
- Peptide Label: isoform X1
- UniProtKB: A0A8I3Q2I8 (UniProtKB/TrEMBL),   A0A8P0TPI1 (UniProtKB/TrEMBL),   A0A8C0NNA1 (UniProtKB/TrEMBL),   A0A8I3Q8D4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038302824   ⟸   XM_038446896
- Peptide Label: isoform X2
- UniProtKB: A0A8P0TPI1 (UniProtKB/TrEMBL),   A0A8I3Q2I8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038319326   ⟸   XM_038463398
- Peptide Label: isoform X1
- UniProtKB: A0A8I3Q2I8 (UniProtKB/TrEMBL),   A0A8P0TPI1 (UniProtKB/TrEMBL),   A0A8C0NNA1 (UniProtKB/TrEMBL),   A0A8I3Q8D4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038319327   ⟸   XM_038463399
- Peptide Label: isoform X2
- UniProtKB: A0A8I3Q2I8 (UniProtKB/TrEMBL),   A0A8P0TPI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038440590   ⟸   XM_038584662
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NNA1 (UniProtKB/TrEMBL),   A0A8I3Q2I8 (UniProtKB/TrEMBL),   A0A8I3Q8D4 (UniProtKB/TrEMBL),   A0A8P0TPI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038440591   ⟸   XM_038584663
- Peptide Label: isoform X2
- UniProtKB: A0A8I3Q2I8 (UniProtKB/TrEMBL),   A0A8P0TPI1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845042040   ⟸   ENSCAFT00845053506
Ensembl Acc Id: ENSCAFP00845041965   ⟸   ENSCAFT00845053417
Ensembl Acc Id: ENSCAFP00845042017   ⟸   ENSCAFT00845053476
Ensembl Acc Id: ENSCAFP00845041956   ⟸   ENSCAFT00845053407
Ensembl Acc Id: ENSCAFP00845041821   ⟸   ENSCAFT00845053256
Protein Domains
Dipeptidyl peptidase 4 low complexity region   Dipeptidylpeptidase IV N-terminal   Peptidase S9 prolyl oligopeptidase catalytic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000025002 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015521 UniProtKB/TrEMBL
  ENSCAFG00040022543 UniProtKB/TrEMBL
  ENSCAFG00845030056 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016527.6 UniProtKB/TrEMBL
  ENSCAFT00000098952.1 UniProtKB/TrEMBL
  ENSCAFT00000098986.1 UniProtKB/TrEMBL
  ENSCAFT00000102037.1 UniProtKB/TrEMBL
  ENSCAFT00000107414.1 UniProtKB/TrEMBL
  ENSCAFT00030028596.1 UniProtKB/TrEMBL
  ENSCAFT00030028842.1 UniProtKB/TrEMBL
  ENSCAFT00030028999.1 UniProtKB/TrEMBL
  ENSCAFT00030029130.1 UniProtKB/TrEMBL
  ENSCAFT00040041981.1 UniProtKB/TrEMBL
  ENSCAFT00845053256 ENTREZGENE
  ENSCAFT00845053256.1 UniProtKB/TrEMBL
  ENSCAFT00845053407 ENTREZGENE
  ENSCAFT00845053407.1 UniProtKB/TrEMBL
  ENSCAFT00845053417.1 UniProtKB/TrEMBL
  ENSCAFT00845053476.1 UniProtKB/TrEMBL
  ENSCAFT00845053506.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
  Dipeptidylpeptidase IV, N-terminal domain UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  DPPIV_rep UniProtKB/TrEMBL
  Pept_S9_AS UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/TrEMBL
  Peptidase_S9B_N UniProtKB/TrEMBL
  Serine_Prot_S9B/DPPIV_sf UniProtKB/TrEMBL
NCBI Gene DPP4 ENTREZGENE
PANTHER DIPEPTIDYL PEPTIDASE 4 UniProtKB/TrEMBL
  PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED UniProtKB/TrEMBL
Pfam DPPIV_N UniProtKB/TrEMBL
  DPPIV_rep UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/TrEMBL
PROSITE PRO_ENDOPEP_SER UniProtKB/TrEMBL
Superfamily-SCOP DPP6 N-terminal domain-like UniProtKB/TrEMBL
  SSF53474 UniProtKB/TrEMBL
UniProt A0A8C0NCU9_CANLF UniProtKB/TrEMBL
  A0A8C0NE23_CANLF UniProtKB/TrEMBL
  A0A8C0NE60_CANLF UniProtKB/TrEMBL
  A0A8C0NNA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TJP6_CANLF UniProtKB/TrEMBL
  A0A8I3Q2I8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q2N1_CANLF UniProtKB/TrEMBL
  A0A8I3Q8D4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q958_CANLF UniProtKB/TrEMBL
  A0A8I3QMA9_CANLF UniProtKB/TrEMBL
  A0A8P0NCM4_CANLF UniProtKB/TrEMBL
  A0A8P0TKS8_CANLF UniProtKB/TrEMBL
  A0A8P0TPI1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40074 ENTREZGENE