Dpp4<sup>DPPIV</sup> (dipeptidylpeptidase 4; DPPIV mutant)

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Gene: Dpp4^DPPIV (dipeptidylpeptidase 4; DPPIV mutant) Rattus norvegicus

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Symbol:	Dpp4^DPPIV
Name:	dipeptidylpeptidase 4; DPPIV mutant
RGD ID:	12792942
Description:	The DPP4 mutant allele was a spontaneous mutation found in Fischer 344 rats, which caused a deficiency in Dpp4. The mutant allele has a G to A change at nucleotide 1897 (in exon 22), which results in an amino acid change of Gly (WT; GGA) to Arg (Mut; AGA). ASSOCIATED WITH decreased anxiety-related response; decreased circulating adrenocorticotropin level; decreased circulating alanine transaminase level
Type:	allele of Dpp4
Previously known as:	Dpp4^DPPIV-; Dpp4DPPIV-
Is Marker For:	Strains: F344-Dpp4^DPPIV-/DchcHsdRrrc DA.F344-Dpp4^DPPIV/SvH
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased anxiety-related response (IAGP)

decreased circulating adrenocorticotropin level (IAGP)

decreased circulating alanine transaminase level (IAGP)

decreased circulating alkaline phosphatase level (IAGP)

decreased circulating aspartate transaminase level (IAGP)

decreased circulating corticosterone level (IAGP)

decreased circulating interleukin-6 level (IAGP)

decreased circulating triglyceride level (IAGP)

decreased eosinophil cell number (IAGP)

decreased interleukin-6 secretion (IAGP)

decreased lymphocyte cell number (IAGP)

decreased response to stress-induced hyperthermia (IAGP)

decreased susceptibility to diet-induced obesity (IAGP)

decreased susceptibility to weight gain (IAGP)

impaired natural killer cell mediated cytotoxicity (IAGP)

improved glucose tolerance (IAGP)

increased B-1 B cell number (IAGP)

increased blood urea nitrogen level (IAGP)

increased circulating glucagon level (IAGP)

increased circulating phosphate level (IAGP)

increased exploration in new environment (IAGP)

increased NK cell number (IAGP)

weight loss (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions.	Frerker N, etal., Clin Chem Lab Med. 2009;47(3):275-87. doi: 10.1515/CCLM.2009.064.

Genomics

Related Rat Strains

The following Strains have been annotated to Dpp4^DPPIV

DA.F344-Dpp4^DPPIV/SvH

F344-Dpp4^DPPIV-/DchcHsdRrrc

Expression

Sequence

Nucleotide Sequences

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-02-09	Dpp4^DPPIV	dipeptidylpeptidase 4; DPPIV mutant	Dpp4^DPPIV-	dipeptidylpeptidase 4; DPPIV mutant	Symbol changed	629549	APPROVED

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype