Nckap1 (NCK-associated protein 1) - Rat Genome Database

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Gene: Nckap1 (NCK-associated protein 1) Rattus norvegicus
Analyze
Symbol: Nckap1
Name: NCK-associated protein 1
RGD ID: 61939
Description: Predicted to contribute to small GTPase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; cortical actin cytoskeleton organization; and positive regulation of cellular component organization. Predicted to act upstream of or within several processes, including apical protein localization; embryonic morphogenesis; and segmentation. Predicted to be located in lamellipodium and ruffle. Predicted to be part of SCAR complex and filamentous actin. Predicted to be active in postsynapse. Orthologous to human NCKAP1 (NCK associated protein 1); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: membrane-associated protein HEM-2; NAP 1; p125Nap1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8385,824,333 - 85,898,748 (-)NCBIGRCr8
mRatBN7.2365,417,450 - 65,491,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl365,417,453 - 65,492,217 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx368,763,734 - 68,838,101 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0377,347,303 - 77,421,669 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0375,110,005 - 75,184,226 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0367,725,180 - 67,804,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl367,725,947 - 67,787,990 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0374,284,277 - 74,361,208 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4363,191,700 - 63,274,021 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1363,099,188 - 63,170,297 (-)NCBI
Celera364,863,664 - 64,938,000 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
calciol  (ISO)
carboplatin  (EXP)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
diuron  (EXP)
ethanol  (ISO)
flutamide  (EXP)
glafenine  (EXP)
graphite  (EXP)
ivermectin  (ISO)
L-glutamic acid  (EXP)
lead(0)  (ISO)
mechlorethamine  (ISO)
Mesaconitine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methylparaben  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
propiconazole  (EXP,ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck. Kitamura T, etal., Biochem Biophys Res Commun 1996 Feb 15;219(2):509-14.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7643388   PMID:12477932   PMID:14765121   PMID:16831833   PMID:18560548   PMID:19056867   PMID:21107423   PMID:21423176   PMID:22871113   PMID:24050404   PMID:26296893   PMID:27927633  
PMID:30053369   PMID:32357304  


Genomics

Comparative Map Data
Nckap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8385,824,333 - 85,898,748 (-)NCBIGRCr8
mRatBN7.2365,417,450 - 65,491,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl365,417,453 - 65,492,217 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx368,763,734 - 68,838,101 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0377,347,303 - 77,421,669 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0375,110,005 - 75,184,226 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0367,725,180 - 67,804,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl367,725,947 - 67,787,990 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0374,284,277 - 74,361,208 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4363,191,700 - 63,274,021 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1363,099,188 - 63,170,297 (-)NCBI
Celera364,863,664 - 64,938,000 (-)NCBICelera
Cytogenetic Map3q24NCBI
NCKAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382182,909,115 - 183,038,457 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2182,909,115 - 183,038,858 (-)EnsemblGRCh38hg38GRCh38
GRCh372183,773,843 - 183,903,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362183,497,850 - 183,611,474 (-)NCBINCBI36Build 36hg18NCBI36
Build 342183,615,110 - 183,728,735NCBI
Celera2177,385,839 - 177,499,386 (-)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2175,647,499 - 175,761,404 (-)NCBIHuRef
CHM1_12183,795,489 - 183,909,486 (-)NCBICHM1_1
T2T-CHM13v2.02183,398,094 - 183,527,479 (-)NCBIT2T-CHM13v2.0
Nckap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39280,330,856 - 80,411,526 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl280,330,856 - 80,411,724 (-)EnsemblGRCm39 Ensembl
GRCm38280,500,512 - 80,581,182 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl280,500,512 - 80,581,380 (-)EnsemblGRCm38mm10GRCm38
MGSCv37280,341,452 - 80,421,122 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36280,302,134 - 80,381,804 (-)NCBIMGSCv36mm8
Celera282,167,966 - 82,247,538 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map248.21NCBI
Nckap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540314,480,162 - 14,554,702 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540314,476,689 - 14,554,380 (+)NCBIChiLan1.0ChiLan1.0
NCKAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21385,580,366 - 85,697,222 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B85,595,344 - 85,712,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B70,193,950 - 70,308,442 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B188,003,235 - 188,116,704 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B188,003,235 - 188,116,710 (-)Ensemblpanpan1.1panPan2
NCKAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13625,965,243 - 26,054,775 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3625,965,938 - 26,054,760 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3625,862,726 - 25,966,235 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03626,119,068 - 26,222,536 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3626,119,080 - 26,222,514 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13626,245,261 - 26,348,621 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03626,176,339 - 26,279,633 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03626,318,225 - 26,421,624 (-)NCBIUU_Cfam_GSD_1.0
Nckap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303142,971,863 - 143,070,930 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650911,524,556 - 11,624,621 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650911,525,764 - 11,624,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCKAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1588,425,142 - 88,528,326 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11588,425,861 - 88,528,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21597,930,698 - 98,032,893 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCKAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11068,434,839 - 68,546,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1068,433,258 - 68,545,990 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040130,996,820 - 131,108,402 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nckap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248444,676,741 - 4,773,538 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248444,679,840 - 4,773,617 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nckap1
316 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:370
Count of miRNA genes:208
Interacting mature miRNAs:247
Transcripts:ENSRNOT00000064851
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat

Markers in Region
RH127961  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2365,417,576 - 65,417,796 (+)MAPPERmRatBN7.2
Rnor_6.0367,725,307 - 67,725,526NCBIRnor6.0
Rnor_5.0374,284,404 - 74,284,623UniSTSRnor5.0
Celera364,863,791 - 64,864,010UniSTS
Cytogenetic Map3q24UniSTS
BE105526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2365,438,922 - 65,439,128 (+)MAPPERmRatBN7.2
Rnor_6.0367,746,592 - 67,746,797NCBIRnor6.0
Rnor_5.0374,305,749 - 74,305,954UniSTSRnor5.0
RGSC_v3.4363,220,926 - 63,221,131UniSTSRGSC3.4
Celera364,885,213 - 64,885,418UniSTS
RH 3.4 Map5688.49UniSTS
Cytogenetic Map3q24UniSTS
G67007  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2365,420,913 - 65,421,439 (+)MAPPERmRatBN7.2
Rnor_6.0367,728,587 - 67,729,112NCBIRnor6.0
Rnor_5.0374,287,744 - 74,288,269UniSTSRnor5.0
RGSC_v3.4363,202,919 - 63,203,444UniSTSRGSC3.4
Celera364,867,206 - 64,867,731UniSTS
Cytogenetic Map3q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000064851   ⟹   ENSRNOP00000059233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl365,418,217 - 65,481,531 (-)Ensembl
Rnor_6.0 Ensembl367,725,947 - 67,787,990 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094898   ⟹   ENSRNOP00000081784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl365,417,453 - 65,492,217 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099995   ⟹   ENSRNOP00000083834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl365,417,453 - 65,481,531 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114653   ⟹   ENSRNOP00000079055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl365,417,453 - 65,491,695 (-)Ensembl
RefSeq Acc Id: NM_031618   ⟹   NP_113806
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,824,333 - 85,898,574 (-)NCBI
mRatBN7.2365,417,450 - 65,491,695 (-)NCBI
Rnor_6.0367,725,180 - 67,804,680 (-)NCBI
Rnor_5.0374,284,277 - 74,361,208 (-)NCBI
RGSC_v3.4363,191,700 - 63,274,021 (-)RGD
Celera364,863,664 - 64,938,000 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105741   ⟹   XP_038961669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,824,333 - 85,898,748 (-)NCBI
mRatBN7.2365,417,541 - 65,491,769 (-)NCBI
RefSeq Acc Id: XM_039105742   ⟹   XP_038961670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,824,333 - 85,898,635 (-)NCBI
mRatBN7.2365,417,541 - 65,491,769 (-)NCBI
RefSeq Acc Id: XM_039105743   ⟹   XP_038961671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,824,333 - 85,898,667 (-)NCBI
mRatBN7.2365,417,541 - 65,491,769 (-)NCBI
RefSeq Acc Id: XM_063284423   ⟹   XP_063140493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,824,333 - 85,888,044 (-)NCBI
RefSeq Acc Id: XM_063284424   ⟹   XP_063140494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,824,333 - 85,879,371 (-)NCBI
RefSeq Acc Id: NP_113806   ⟸   NM_031618
- UniProtKB: P55161 (UniProtKB/Swiss-Prot),   A0A8I5ZLZ9 (UniProtKB/TrEMBL),   A6HMN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059233   ⟸   ENSRNOT00000064851
RefSeq Acc Id: XP_038961671   ⟸   XM_039105743
- Peptide Label: isoform X3
- UniProtKB: P55161 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038961670   ⟸   XM_039105742
- Peptide Label: isoform X2
- UniProtKB: P55161 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038961669   ⟸   XM_039105741
- Peptide Label: isoform X1
- UniProtKB: P55161 (UniProtKB/Swiss-Prot),   A0A8I5ZSX9 (UniProtKB/TrEMBL),   A6HMN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083834   ⟸   ENSRNOT00000099995
RefSeq Acc Id: ENSRNOP00000081784   ⟸   ENSRNOT00000094898
RefSeq Acc Id: ENSRNOP00000079055   ⟸   ENSRNOT00000114653
RefSeq Acc Id: XP_063140493   ⟸   XM_063284423
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063140494   ⟸   XM_063284424
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55161-F1-model_v2 AlphaFold P55161 1-1128 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61939 AgrOrtholog
BioCyc Gene G2FUF-49224 BioCyc
Ensembl Genes ENSRNOG00000007518 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064851.4 UniProtKB/TrEMBL
  ENSRNOT00000094898.1 UniProtKB/TrEMBL
  ENSRNOT00000099995.1 UniProtKB/TrEMBL
  ENSRNOT00000114653 ENTREZGENE
  ENSRNOT00000114653.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7305552 IMAGE-MGC_LOAD
  IMAGE:7310896 IMAGE-MGC_LOAD
InterPro Nck-associated_protein-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58823 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109251 IMAGE-MGC_LOAD
  MGC:125130 IMAGE-MGC_LOAD
NCBI Gene 58823 ENTREZGENE
PANTHER NCK-ASSOCIATED PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12093 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Nckap1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nckap1 PhenoGen
RatGTEx ENSRNOG00000007518 RatGTEx
TIGR TC204490
UniProt A0A8I5ZLZ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXW3_RAT UniProtKB/TrEMBL
  A6HMN0 ENTREZGENE, UniProtKB/TrEMBL
  A6HMN1 ENTREZGENE, UniProtKB/TrEMBL
  F1LSM5_RAT UniProtKB/TrEMBL
  NCKP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q32PY0_RAT UniProtKB/TrEMBL
  Q562B3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nckap1  NCK-associated protein 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the Hem family 61669
gene_protein 125-kDa protein 61669