Ifih1 (interferon induced with helicase C domain 1) - Rat Genome Database

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Gene: Ifih1 (interferon induced with helicase C domain 1) Rattus norvegicus
Analyze
Symbol: Ifih1
Name: interferon induced with helicase C domain 1
RGD ID: 1560496
Description: Predicted to enable several functions, including ATP hydrolysis activity; RNA binding activity; and nucleoside phosphate binding activity. Predicted to be involved in several processes, including MDA-5 signaling pathway; antiviral innate immune response; and positive regulation of cytokine production. Predicted to act upstream of or within protein complex oligomerization and type I interferon-mediated signaling pathway. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Orthologous to human IFIH1 (interferon induced with helicase C domain 1); PARTICIPATES IN influenza A pathway; measles pathway; Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interferon-induced helicase C domain-containing protein 1; LOC499801; RGD1560496; similar to HELICARD
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2347,228,980 - 47,275,403 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl347,227,364 - 47,275,456 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,583,733 - 50,630,163 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0359,167,264 - 59,213,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0356,940,461 - 56,986,897 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,557,696 - 48,604,097 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,557,696 - 48,604,097 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0355,221,682 - 55,269,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,547,092 - 44,593,969 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera346,870,143 - 46,916,330 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
Genipin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
inulin  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
ketoconazole  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
metam  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
mitochondrion  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. Noçon AL, etal., J Virol. 2014 Jan;88(1):679-89. doi: 10.1128/JVI.02094-13. Epub 2013 Oct 30.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:17600090   PMID:17942531   PMID:19211564   PMID:19380577   PMID:19531363   PMID:19656871   PMID:19881509   PMID:21156324   PMID:21478870   PMID:21957149   PMID:22160685  
PMID:25865883   PMID:28146100  


Genomics

Comparative Map Data
Ifih1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2347,228,980 - 47,275,403 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl347,227,364 - 47,275,456 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,583,733 - 50,630,163 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0359,167,264 - 59,213,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0356,940,461 - 56,986,897 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,557,696 - 48,604,097 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,557,696 - 48,604,097 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0355,221,682 - 55,269,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,547,092 - 44,593,969 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera346,870,143 - 46,916,330 (-)NCBICelera
Cytogenetic Map3q21NCBI
IFIH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382162,267,074 - 162,318,684 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2162,267,074 - 162,318,684 (-)EnsemblGRCh38hg38GRCh38
GRCh372163,123,584 - 163,175,194 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,831,835 - 162,883,285 (-)NCBINCBI36Build 36hg18NCBI36
Build 342162,949,096 - 163,000,546NCBI
Celera2156,733,905 - 156,785,356 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2155,005,887 - 155,057,529 (-)NCBIHuRef
CHM1_12163,129,475 - 163,181,104 (-)NCBICHM1_1
T2T-CHM13v2.02162,723,727 - 162,775,351 (-)NCBIT2T-CHM13v2.0
Ifih1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39262,426,137 - 62,476,599 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl262,426,142 - 62,476,599 (-)EnsemblGRCm39 Ensembl
GRCm38262,595,618 - 62,646,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl262,595,798 - 62,646,255 (-)EnsemblGRCm38mm10GRCm38
MGSCv37262,433,850 - 62,484,312 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36262,398,289 - 62,451,864 (-)NCBIMGSCv36mm8
Celera264,286,036 - 64,336,570 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map235.85NCBI
Ifih1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544911,538,889 - 11,593,349 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544911,538,869 - 11,596,502 (+)NCBIChiLan1.0ChiLan1.0
IFIH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B64,974,193 - 65,025,670 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B49,560,620 - 49,612,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B166,928,994 - 166,980,170 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B166,928,994 - 166,980,170 (-)Ensemblpanpan1.1panPan2
IFIH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1367,668,925 - 7,727,040 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl367,649,727 - 8,261,048 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha367,812,658 - 7,870,597 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0367,800,592 - 7,858,795 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl367,799,925 - 7,859,590 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1367,819,125 - 7,877,043 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0367,860,049 - 7,918,195 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0367,967,525 - 8,025,700 (-)NCBIUU_Cfam_GSD_1.0
Ifih1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303124,839,500 - 124,896,682 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646916,721,677 - 16,774,903 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493646916,721,306 - 16,778,249 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFIH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1568,928,254 - 68,985,083 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11568,930,998 - 68,985,145 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21576,422,958 - 76,477,124 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IFIH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11047,676,799 - 47,732,310 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1047,676,920 - 47,732,264 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040151,800,300 - 151,852,344 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ifih1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247323,187,791 - 3,250,981 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247323,187,791 - 3,248,795 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ifih1
329 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:258
Count of miRNA genes:183
Interacting mature miRNAs:215
Transcripts:ENSRNOT00000009620
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)33819223350749747Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)33871036550302886Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)33945463753296578Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
D3Rat113  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2347,242,842 - 47,242,983 (+)MAPPERmRatBN7.2
Rnor_6.0348,571,559 - 48,571,699NCBIRnor6.0
Rnor_5.0355,237,161 - 55,237,301UniSTSRnor5.0
RGSC_v3.4344,560,954 - 44,561,095RGDRGSC3.4
RGSC_v3.4344,560,955 - 44,561,095UniSTSRGSC3.4
RGSC_v3.1344,457,326 - 44,457,467RGD
Celera346,884,006 - 46,884,146UniSTS
SHRSP x BN Map332.8199UniSTS
SHRSP x BN Map332.8199RGD
Cytogenetic Map3q21UniSTS
D3Rat130  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2347,233,211 - 47,233,430 (+)MAPPERmRatBN7.2
Rnor_6.0348,561,928 - 48,562,146NCBIRnor6.0
Rnor_5.0355,227,530 - 55,227,748UniSTSRnor5.0
RGSC_v3.4344,551,324 - 44,551,542UniSTSRGSC3.4
RGSC_v3.4344,551,252 - 44,551,542RGDRGSC3.4
RGSC_v3.1344,447,696 - 44,447,914RGD
Celera346,874,375 - 46,874,593UniSTS
RH 3.4 Map3601.73RGD
RH 3.4 Map3601.73UniSTS
RH 2.0 Map3376.6RGD
SHRSP x BN Map332.8199RGD
FHH x ACI Map332.74RGD
Cytogenetic Map3q21UniSTS
D3Rat184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2347,270,455 - 47,270,670 (+)MAPPERmRatBN7.2
Rnor_6.0348,599,150 - 48,599,364NCBIRnor6.0
Rnor_5.0355,264,634 - 55,264,848UniSTSRnor5.0
RGSC_v3.4344,589,021 - 44,589,236RGDRGSC3.4
RGSC_v3.4344,589,022 - 44,589,236UniSTSRGSC3.4
RGSC_v3.1344,485,393 - 44,485,608RGD
Celera346,911,383 - 46,911,597UniSTS
SHRSP x BN Map334.4498UniSTS
SHRSP x BN Map334.4498RGD
Cytogenetic Map3q21UniSTS
RH134948  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2347,228,646 - 47,228,836 (+)MAPPERmRatBN7.2
Rnor_6.0348,557,363 - 48,557,552NCBIRnor6.0
Rnor_5.0355,222,965 - 55,223,154UniSTSRnor5.0
RGSC_v3.4344,546,759 - 44,546,948UniSTSRGSC3.4
Celera346,869,810 - 46,869,999UniSTS
Cytogenetic Map3q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 24 11 18 11 9 11
Low 3 41 33 30 1 30 8 10 64 35 25 8
Below cutoff 2 1 10 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009620   ⟹   ENSRNOP00000009621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,227,364 - 47,275,456 (-)Ensembl
Rnor_6.0 Ensembl348,557,696 - 48,604,097 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104914   ⟹   ENSRNOP00000077601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,227,364 - 47,275,456 (-)Ensembl
RefSeq Acc Id: NM_001109199   ⟹   NP_001102669
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2347,228,980 - 47,275,403 (-)NCBI
Rnor_6.0348,557,696 - 48,604,097 (-)NCBI
Rnor_5.0355,221,682 - 55,269,581 (-)NCBI
RGSC_v3.4344,547,092 - 44,593,969 (-)RGD
Celera346,870,143 - 46,916,330 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105671   ⟹   XP_038961599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2347,229,379 - 47,272,507 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102669 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961599 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68680 (Get FASTA)   NCBI Sequence Viewer  
  EDL79011 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001102669   ⟸   NM_001109199
- UniProtKB: G3V6W5 (UniProtKB/TrEMBL),   A6HLW0 (UniProtKB/TrEMBL),   A0A8I5Y1S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009621   ⟸   ENSRNOT00000009620
RefSeq Acc Id: XP_038961599   ⟸   XM_039105671
- Peptide Label: isoform X1
- UniProtKB: B5DEI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077601   ⟸   ENSRNOT00000104914
Protein Domains
Helicase ATP-binding   Helicase C-terminal   RLR CTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6W5-F1-model_v2 AlphaFold G3V6W5 1-1027 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560496 AgrOrtholog
BioCyc Gene G2FUF-49585 BioCyc
Ensembl Genes ENSRNOG00000006227 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009621 ENTREZGENE
  ENSRNOP00000009621.2 UniProtKB/TrEMBL
  ENSRNOP00000077601.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009620 ENTREZGENE
  ENSRNOT00000009620.4 UniProtKB/TrEMBL
  ENSRNOT00000104914.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  1.20.1320.30 UniProtKB/TrEMBL
  2.170.150.30 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro CARD_dom UniProtKB/TrEMBL
  DEAD-like_helicase UniProtKB/TrEMBL
  DEATH-like_dom UniProtKB/TrEMBL
  Helicase/UvrB_dom UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RIG-I_C UniProtKB/TrEMBL
  RIG-I_C-RD UniProtKB/TrEMBL
  RLR_C_sf UniProtKB/TrEMBL
KEGG Report rno:499801 UniProtKB/TrEMBL
NCBI Gene 499801 ENTREZGENE
PANTHER HELICASE WITH DEATH DOMAIN-RELATED UniProtKB/TrEMBL
  INTERFERON-INDUCED HELICASE C DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam CARD_2 UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  ResIII UniProtKB/TrEMBL
  RIG-I_C UniProtKB/TrEMBL
  RIG-I_C-RD UniProtKB/TrEMBL
PhenoGen Ifih1 PhenoGen
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  RLR_CTR UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5Y1S7 ENTREZGENE, UniProtKB/TrEMBL
  A6HLW0 ENTREZGENE, UniProtKB/TrEMBL
  B5DEI3 ENTREZGENE, UniProtKB/TrEMBL
  G3V6W5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Ifih1  interferon induced with helicase C domain 1  RGD1560496_predicted  similar to HELICARD (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560496_predicted  similar to HELICARD (predicted)  LOC499801  similar to HELICARD  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499801  similar to HELICARD      Symbol and Name status set to provisional 70820 PROVISIONAL