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Gene: Nfe2l2 (nuclear factor, erythroid 2-like 2) Rattus norvegicus
Symbol: Nfe2l2
Name: nuclear factor, erythroid 2-like 2
RGD ID: 620360
Description: Exhibits transcription cofactor binding activity and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; and regulation of cell migration. Localizes to cytoplasm and nucleus. Used to study several diseases, including diabetic retinopathy; liver cirrhosis; middle cerebral artery infarction; non-alcoholic fatty liver disease; and visual epilepsy. Biomarker of several diseases, including chronic obstructive pulmonary disease; extrahepatic cholestasis; kidney failure (multiple); neurodegenerative disease (multiple); and non-alcoholic steatohepatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; and macular degeneration. Orthologous to human NFE2L2 (nuclear factor, erythroid 2 like 2); PARTICIPATES IN oxidative stress response pathway; nuclear factor, erythroid 2 like 2 signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-alpha-tocopherol; (-)-selegiline; (R)-lipoic acid.
Type: protein-coding
Also known as: NF-E2-related factor 2; NFE2-related factor 2; nrf2; nuclear factor erythroid 2-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor, erythroid derived 2, like 2
Homo sapiens (human) : NFE2L2 (nuclear factor, erythroid 2 like 2)  HGNC  Alliance
Mus musculus (house mouse) : Nfe2l2 (nuclear factor, erythroid derived 2, like 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfe2l2 (nuclear factor, erythroid 2 like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NFE2L2 (nuclear factor, erythroid 2 like 2)
Canis lupus familiaris (dog) : NFE2L2 (nuclear factor, erythroid 2 like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfe2l2 (nuclear factor, erythroid 2 like 2)
Sus scrofa (pig) : NFE2L2 (nuclear factor, erythroid 2 like 2)
Chlorocebus sabaeus (African green monkey) : NFE2L2 (nuclear factor, erythroid 2 like 2)
Heterocephalus glaber (naked mole-rat) : Nfe2l2 (nuclear factor, erythroid 2 like 2)
more info ...
Allele / Splice: Nfe2l2em1Mcwi   Nfe2l2em1Kyo   Nfe2l2em2Kyo  
Genetic Models: F344-Nfe2l2em2Kyo F344-Nfe2l2em1Kyo SD-Nfe2l2em1Mcwi SD-Nfe2l2em1Mcwi-/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0362,497,568 - 62,525,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl362,497,571 - 62,524,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0369,041,641 - 69,069,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4358,366,693 - 58,394,116 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1358,263,064 - 58,290,488 (-)NCBI
Celera360,095,041 - 60,122,464 (-)NCBICelera
Cytogenetic Map3q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)