Nfe2l2 (nuclear factor, erythroid 2-like 2) - Rat Genome Database

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Gene: Nfe2l2 (nuclear factor, erythroid 2-like 2) Rattus norvegicus
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Symbol: Nfe2l2
Name: nuclear factor, erythroid 2-like 2
RGD ID: 620360
Description: Enables transcription cis-regulatory region binding activity and transcription coregulator binding activity. Involved in several processes, including aflatoxin catabolic process; positive regulation of macromolecule metabolic process; and regulation of cell migration. Located in cytoplasm and nucleus. Used to study several diseases, including diabetic retinopathy; liver cirrhosis; middle cerebral artery infarction; non-alcoholic fatty liver disease; and visual epilepsy. Biomarker of several diseases, including extrahepatic cholestasis; kidney failure (multiple); neurodegenerative disease (multiple); non-alcoholic steatohepatitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (nuclear factor, erythroid 2 like 2); PARTICIPATES IN oxidative stress response pathway; nuclear factor, erythroid 2 like 2 signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (-)-selegiline; (R)-lipoic acid; (R)-mevalonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: NF-E2-related factor 2; NFE2-related factor 2; nrf2; nuclear factor erythroid 2-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor, erythroid derived 2, like 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nfe2l2em1Mcwi   Nfe2l2em1Kyo   Nfe2l2em2Kyo  
Genetic Models: F344-Nfe2l2em2Kyo F344-Nfe2l2em1Kyo SD-Nfe2l2em1Mcwi SD-Nfe2l2em1Mcwi-/-
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2360,594,239 - 60,621,785 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl360,594,242 - 60,621,737 (-)Ensembl
Rnor_6.0362,497,568 - 62,525,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl362,497,571 - 62,524,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0369,041,641 - 69,069,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4358,366,693 - 58,394,116 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1358,263,064 - 58,290,488 (-)NCBI
Celera360,095,041 - 60,122,464 (-)NCBICelera
Cytogenetic Map3q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model