Nfe2l2 (NFE2 like bZIP transcription factor 2) - Rat Genome Database

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Gene: Nfe2l2 (NFE2 like bZIP transcription factor 2) Rattus norvegicus
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Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
RGD ID: 620360
Description: Enables transcription cis-regulatory region binding activity and transcription coregulator binding activity. Involved in several processes, including aflatoxin catabolic process; positive regulation of macromolecule biosynthetic process; and regulation of cell migration. Located in nucleus. Used to study several diseases, including diabetic retinopathy; liver disease (multiple); middle cerebral artery infarction; pulmonary fibrosis; and visual epilepsy. Biomarker of several diseases, including extrahepatic cholestasis; kidney failure (multiple); metabolic dysfunction-associated steatohepatitis; neurodegenerative disease (multiple); and traumatic brain injury. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2); PARTICIPATES IN oxidative stress response pathway; nuclear factor, erythroid 2 like 2 signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-taxifolin; (-)-selegiline; (R)-carnitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NF-E2-related factor 2; NFE2-related factor 2; nrf2; nuclear factor erythroid 2-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor, erythroid 2-like 2; nuclear factor, erythroid derived 2, like 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nfe2l2em1Mcwi   Nfe2l2em1Kyo   Nfe2l2em2Kyo  
Genetic Models: SD-Nfe2l2em1Mcwi SD-Nfe2l2em1Mcwi-/- F344-Nfe2l2em2Kyo F344-Nfe2l2em1Kyo
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8381,001,529 - 81,031,165 (-)NCBIGRCr8
mRatBN7.2360,594,239 - 60,621,712 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl360,594,242 - 60,621,737 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx363,968,507 - 63,995,961 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0372,552,163 - 72,579,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0370,318,419 - 70,345,871 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0362,497,568 - 62,525,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl362,497,571 - 62,524,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0369,041,641 - 69,069,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4358,366,693 - 58,394,116 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1358,263,064 - 58,290,488 (-)NCBI
Celera360,095,041 - 60,122,464 (-)NCBICelera
Cytogenetic Map3q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acidoses  (ISO)
acute kidney failure  (IEP,ISO)
Acute Lung Injury  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Disease Models  (ISO)
asthma  (ISO)
Brain Injuries  (IEP)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
Cardiac Fibrosis  (IEP)
Cardiac Output, Low  (ISO)
Cardiomegaly  (IEP)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
cholestasis  (ISO)
Chromosome Breakage  (ISO)
chronic kidney disease  (IEP)
chronic obstructive pulmonary disease  (IEP,ISO)
Chronic Tubulointerstitial Nephropathy  (IEP)
colitis  (ISO)
colorectal cancer  (IEP,ISO)
congestive heart failure  (IEP,ISO)
Diabetic Cardiomyopathies  (IEP,ISO)
Diabetic Nephropathies  (IDA,IEP,ISO)
diabetic retinopathy  (IDA)
Disease Progression  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Emphysema  (ISO)
Endometrial Neoplasms  (ISO)
Endotoxemia  (IEP)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (IEP)
extrahepatic cholestasis  (IEP,ISO)
Fetal Death  (ISO)
Fetal Growth Retardation  (IEP,ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
genital herpes  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hepatic Insufficiency  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
Huntington's disease  (IEP)
hyperglycemia  (ISO)
Hyperplasia  (ISO)
hypertension  (IEP,ISO)
IMMUNODEFICIENCY, DEVELOPMENTAL DELAY, AND HYPOHOMOCYSTEINEMIA  (ISO)
Insulin Resistance  (ISO)
keratosis  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IEP)
liver cirrhosis  (IDA,ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (IEP)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
macular degeneration  (ISO)
metabolic dysfunction-associated steatohepatitis  (IEP)
metabolic dysfunction-associated steatotic liver disease  (IDA,ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (IDA)
myocardial infarction  (IDA,ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
pancreatic ductal carcinoma  (ISO)
pleurisy  (ISO)
Premature Aging  (ISO)
primary biliary cholangitis  (ISO)
primary ovarian insufficiency  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IDA,ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
sickle cell anemia  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IDA)
Splenomegaly  (ISO)
split hand-foot malformation 5  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (ISO)
Subarachnoid Hemorrhage  (IEP)
Sunburn  (ISO)
toxic encephalopathy  (ISO)
transitional cell carcinoma  (ISO)
traumatic brain injury  (IEP)
tuberculosis  (ISO)
type 2 diabetes mellitus  (IEP)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular System Injuries  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)
visceral leishmaniasis  (ISO)
visual epilepsy  (IDA,ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (ISO)
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-isoborneol  (ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(+)-taxifolin  (EXP,ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-selegiline  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-naringenin  (ISO)
(S)-ropivacaine  (ISO)
(Z)-ligustilide  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,2,3-Trichloropropane  (ISO)
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,2-naphthoquinone  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,4,7-triazonane  (ISO)
1,4-benzoquinone  (ISO)
1,4-dichlorobenzene  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-Amino-2,4-dibromoanthraquinone  (ISO)
1-benzofuran  (ISO)
1-bromopropane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
1-tert-Butoxy-2-propanol  (ISO)
13,14-dihydro-Delta(12)-prostaglandin J2  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-Bis(bromomethyl)propane-1,3-diol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrobromobenzene  (ISO)
2,4-dinitroiodobenzene  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-di-tert-butylbenzene-1,4-diol  (ISO)
2,5-dihydroxybenzoic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-(chloromethyl)pyridine  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-3-hydroxypyridine  (ISO)
2-aminoethoxydiphenylborane  (ISO)
2-chloroethanol  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-hydroxyethyl methacrylate  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
20-hydroxyecdysone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3,6-diaminoacridine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methoxycatechol  (ISO)
3-methylcatechol  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,6-dioxoheptanoic acid  (ISO)
4-hydroxy-TEMPO  (EXP)
4-Hydroxybenzyl isothiocyanate  (EXP)
4-hydroxyestrone  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylcatechol  (ISO)
4-nitrobenzaldehyde  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (EXP,ISO)
[6]-Shogaol  (ISO)
abamectin  (EXP)
acetic acid  (EXP)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
AL 8810  (ISO)
alachlor  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
allicin  (ISO)
alloxan  (EXP)
allyl isothiocyanate  (EXP,ISO)
alpha-D-galactose  (EXP,ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-pinene  (ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
aminoguanidine  (ISO)
amiodarone  (ISO)
amitraz  (EXP)
amlexanox  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP,ISO)
Ammothamnine  (EXP,ISO)
amphetamine  (EXP)
andrographolide  (EXP,ISO)
anethole  (EXP)
angelica lactone  (ISO)
angiotensin II  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthranilic acid  (ISO)
antimycin A  (ISO)
apigenin  (EXP)
apocynin  (EXP,ISO)
aprepitant  (EXP)
arachidonic acid  (EXP)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asperuloside  (ISO)
astaxanthin  (EXP,ISO)
astilbin  (ISO)
astragaloside IV  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
auraptene  (ISO)
aureusidin  (EXP)
azathioprine  (ISO)
bafilomycin A1  (ISO)
baicalin  (ISO)
BAPTA  (ISO)
Bardoxolone methyl  (EXP,ISO)
bathocuproine disulfonic acid  (ISO)
bendiocarb  (ISO)
benfotiamine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
benzopyran  (EXP)
benzoquinones  (ISO)
benzyl isothiocyanate  (EXP,ISO)
beraprost  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP,ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (ISO)
beta-propiolactone  (ISO)
beta-tocopherol  (EXP)
Betanin  (EXP)
betulin  (EXP)
bezafibrate  (ISO)
bifenthrin  (EXP,ISO)
bilirubin IXalpha  (ISO)
biochanin A  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bixin  (ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
bortezomib  (EXP,ISO)
brefeldin A  (ISO)
bromobenzene  (ISO)
Bromochloroacetonitrile  (ISO)
bromocriptine  (ISO)
bromosulfophthalein  (ISO)
Brusatol  (EXP,ISO)
bucladesine  (ISO)
buspirone  (EXP)
busulfan  (ISO)
but-2-en-4-olide  (ISO)
butane-2,3-dione  (EXP)
butein  (ISO)
butylated hydroxyanisole  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cafestol  (EXP,ISO)
caffeine  (EXP)
calciol  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
calycosin  (EXP)
calyculin a  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbendazim  (EXP,ISO)
carbon disulfide  (EXP)
carbon monoxide  (EXP,ISO)
carfilzomib  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
Carnosol  (ISO)
carrageenan  (EXP)
carteolol  (ISO)
catalpol  (ISO)
CCCP  (ISO)
cefuroxime  (ISO)
celastrol  (EXP,ISO)
ceric oxide  (ISO)
cerium  (ISO)
ceruletide  (ISO)
chalcone  (ISO)
chalcones  (EXP)
chenodeoxycholic acid  (ISO)
chitosan  (EXP,ISO)
chlorambucil  (ISO)
chlormidazole  (ISO)
chloroacetaldehyde  (ISO)
Chloroacetonitrile  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
cholic acid  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (EXP,ISO)
cidofovir anhydrous  (ISO)
cilostazol  (EXP,ISO)
cinnamyl alcohol  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
citraconic acid  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
clorgyline  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
colistin  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corilagin  (ISO)
corn oil  (ISO)
cortisol  (EXP,ISO)
cortisone  (EXP,ISO)
corynoline  (ISO)
coumarin  (ISO)
creatinine  (ISO)
crocin-1  (EXP)
crotonaldehyde  (ISO)
cumene hydroperoxide  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanidin cation  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
Cynaropicrin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (ISO)
cyproterone acetate  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP)
dapagliflozin  (EXP)
dazomet  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
delta-tocopherol  (EXP)
demethoxycurcumin  (ISO)
Dendrobine  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibenzofurans  (ISO)
Dibromoacetonitrile  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
Dichloroacetonitrile  (ISO)
dichloroacetyl chloride  (ISO)
dichloromethane  (ISO)
dichlorvos  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP,ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dihydroactinidiolide  (ISO)
dihydroartemisinin  (ISO)
dihydrolipoic acid  (EXP)
dihydroxyacetone  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimerumic acid  (ISO)
dimethomorph  (ISO)
dimethyl fumarate  (EXP,ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioscin  (EXP)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
dithionite(2-)  (ISO)
diuron  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
echinacoside  (EXP,ISO)
edaravone  (EXP,ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
emodin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP)
epalrestat  (ISO)
epoxiconazole  (ISO)
epoxomicin  (ISO)
erastin  (EXP,ISO)
erdosteine  (EXP,ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
eriodictyol  (EXP,ISO)
erythromycin A  (ISO)
esculetin  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethionamide  (ISO)
ethoxyquin  (ISO)
Ethyl phenylglycidate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylene glycol dimethacrylate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
falcarindiol  (EXP)
farrerol  (ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
ferroheme b  (ISO)
ferrostatin-1  (ISO)
ferulic acid  (ISO)
fisetin  (ISO)
flufenacet  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluoxastrobin  (ISO)
fluoxetine  (ISO)
flutamide  (EXP,ISO)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
formetanate  (ISO)
formononetin  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (ISO)
furazolidone  (ISO)
furosemide  (ISO)
Fusaric acid  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP,ISO)
galangin  (EXP,ISO)
gallic acid  (EXP,ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (EXP,ISO)
Gastrodin  (EXP,ISO)
gemcitabine  (ISO)
Genipin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
Geraniin  (ISO)
geraniol  (EXP,ISO)
Gingerenone A  (ISO)
ginkgolide B  (ISO)
Ginkgolide C  (EXP)
ginsenoside Rb1  (ISO)
ginsenoside Rg1  (ISO)
Ginsenoside Rh4  (EXP,ISO)
gliclazide  (EXP)
glucoraphanin  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glyburide  (EXP)
glycogen  (ISO)
glycyrrhetinate  (EXP,ISO)
glycyrrhetinic acid  (EXP,ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (EXP)
guggulsterone  (ISO)
GW 501516  (ISO)
harman  (ISO)
heme b  (ISO)
hemin  (EXP,ISO)
heparin  (ISO)
hesperetin  (ISO)
hesperidin  (EXP)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
homoeriodictyol  (ISO)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroquinones  (ISO)
hydroxysafflor yellow A  (ISO)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
iberin  (EXP)
ibuprofen  (ISO)
ifosfamide  (EXP,ISO)
Ile(5)-angiotensin II  (ISO)
imperatorin  (ISO)
indirubin  (EXP)
indole-3-methanol  (EXP,ISO)
indolin-2-one  (ISO)
indoline  (EXP)
indometacin  (EXP,ISO)
inositol  (EXP)
iodoform  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
iron(III) citrate  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoflurane  (EXP,ISO)
isoimperatorin  (EXP)
isoniazide  (EXP,ISO)
isophorone diisocyanate  (ISO)
isoprenaline  (EXP)
isorhamnetin  (ISO)
Isosorbide  (ISO)
isothiocyanate  (ISO)
kaempferol  (EXP,ISO)
kahweol  (EXP,ISO)
kainic acid  (ISO)
ketamine  (EXP)
ketanserin  (ISO)
ketoconazole  (EXP,ISO)
kresoxim-methyl  (ISO)
KT 5823  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
lactacystin  (EXP,ISO)
lactulose  (EXP)
lansoprazole  (EXP)
lapatinib  (ISO)
lawsone  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (EXP,ISO)
leflunomide  (EXP,ISO)
lenvatinib  (EXP)
Leonurine  (EXP)
letrozole  (EXP)
levetiracetam  (EXP)
levofloxacin  (EXP)
linagliptin  (EXP)
linalool  (ISO)
linoleic acid  (ISO)
linsidomine  (EXP,ISO)
lipoamide  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP)
liquiritigenin  (EXP,ISO)
liquiritin  (EXP,ISO)
liraglutide  (EXP)
lithium atom  (ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
loganin  (ISO)
loliolide  (ISO)
losartan  (EXP,ISO)
lovastatin  (ISO)
Lucidone  (ISO)
lutein  (EXP,ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
Macrosphelide B  (ISO)
magnesium dichloride  (EXP)
malathion  (ISO)
maleic acid  (EXP)
malonaldehyde  (EXP,ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP)
masoprocol  (EXP)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
meglumine amidotrizoate  (EXP)
MeIQx  (ISO)
melatonin  (EXP,ISO)
meloxicam  (ISO)
menadione  (ISO)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (EXP,ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
methyl 3,4,5-trihydroxybenzoate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylene blue  (EXP,ISO)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
Methysticin  (ISO)
metolachlor  (ISO)
metrafenone  (ISO)
mevalonic acid  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
mirtazapine  (EXP)
MK-2206  (EXP)
monascin  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
monocrotophos  (EXP,ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
Morroniside  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (ISO)
N-(1-naphthyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylnicotinate  (EXP,ISO)
N-Methylolacrylamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-phosphocreatine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
naphthalene-1,2-diol  (ISO)
naphthalene-1,5-diamine  (ISO)
naringin  (EXP,ISO)
nebivolol  (ISO)
nefazodone  (EXP)
neoastilbin  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicorandil  (EXP)
nicotinamide  (EXP,ISO)
nifedipine  (ISO)
nilotinib  (EXP)
nimesulide  (EXP,ISO)
nitrites  (EXP,ISO)
nitrofurantoin  (ISO)
nitrogen mustard  (ISO)
nitroprusside  (EXP,ISO)
nobiletin  (EXP)
Nonylphenol  (EXP)
notoginsenoside R1  (EXP,ISO)
NSC 23766  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (EXP)
oltipraz  (EXP,ISO)
omeprazole  (ISO)
Ophiopogonin D  (ISO)
orlistat  (EXP,ISO)
oxaliplatin  (EXP,ISO)
oxazepam  (ISO)
oxidopamine  (EXP,ISO)
Oxyfluorfen  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (ISO)
Palbinone  (EXP)
pallidol  (ISO)
palmatine  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion-methyl  (ISO)
pelargonidin  (ISO)
pentachloronitrobenzene  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
perillyl aldehyde  (ISO)
permethrin  (EXP)
peroxides  (ISO)
pevonedistat  (ISO)
phalloidin  (ISO)
phenacetin  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
Phenyl glycidyl ether  (ISO)
phenylarsine oxide  (ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phloretin  (ISO)
phlorizin  (ISO)
phlorizin chalcone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (ISO)
phoxim  (EXP)
phytoestrogen  (EXP)
picolinic acid  (EXP)
picoxystrobin  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
plumbagin  (EXP,ISO)
polysulfur  (ISO)
porphyrins  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
prazosin  (ISO)
prednisolone  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probucol  (EXP,ISO)
procyanidin B1  (ISO)
procyanidin B2  (EXP)
prodigiosin  (EXP)
progesterone  (EXP)
propacetamol  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
prostaglandin J2  (EXP)
psoralen  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
Punicalagin  (EXP)
pyocyanine  (EXP,ISO)
pyrethrins  (EXP)
pyridaben  (ISO)
Pyridostigmine bromide  (EXP)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
quinolinic acid  (EXP)
quinoxyfen  (ISO)
rac-1,2-dichloropropane  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
ranitidine  (EXP)
raspberry ketone  (ISO)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (EXP)
reserpine  (ISO)
resolvin D1  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Rhynchophylline  (ISO)
rifampicin  (ISO)
rimonabant  (EXP)
ritonavir  (ISO)
roflumilast  (EXP,ISO)
rosmarinic acid  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
royal jelly  (EXP)
rutin  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salvianolic acid B  (EXP,ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
SCH772984  (EXP)
scopolamine  (ISO)
sebacic acid  (ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
sertraline  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP,ISO)
Shikonin  (ISO)
silibinin  (EXP)
silicon atom  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
Siomycin A  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (EXP)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sodium selenide  (ISO)
sodium sulfide (anhydrous)  (EXP)
solanesol  (ISO)
Soman  (EXP)
spermidine  (ISO)
spermine  (ISO)
spironolactone  (EXP)
staurosporine  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfaphenazole  (ISO)
sulfasalazine  (EXP,ISO)
sulfluramid  (ISO)
sulforaphane  (EXP,ISO)
sulfur atom  (ISO)
sunitinib  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tadalafil  (EXP)
tamibarotene  (ISO)
tangeretin  (EXP,ISO)
Tanshinone I  (ISO)
taurocholic acid  (ISO)
tectorigenin  (ISO)
terbinafine  (ISO)
terephthalic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiamine(1+) chloride  (ISO)
thiazoles  (EXP)
thioacetamide  (EXP,ISO)
thymoquinone  (EXP,ISO)
tideglusib  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
toluquinol  (ISO)
torcetrapib  (ISO)
trabectedin  (ISO)
trans-anethole  (EXP)
trans-chalcone  (ISO)
trans-piceid  (ISO)
trans-rhaponticin  (EXP)
triadimefon  (ISO)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (EXP,ISO)
tricalcium bis(phosphate)  (ISO)
tricetin  (ISO)
trichlorfon  (ISO)
Trichloroacetonitrile  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trifloxystrobin  (ISO)
trifluridine  (ISO)
trilobatin  (EXP,ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (ISO)
trimethyltin  (ISO)
Triptolide  (EXP,ISO)
Tris(2,3-dibromopropyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tubastatin A  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
umbelliferone  (EXP,ISO)
undecan-2-one  (EXP,ISO)
ursodeoxycholic acid  (EXP,ISO)
usnic acid  (ISO)
valproic acid  (ISO)
verapamil  (EXP,ISO)
vinclozolin  (EXP,ISO)
vincristine  (EXP)
vitamin D  (ISO)
vitamin E  (EXP,ISO)
vitexin  (ISO)
vorinostat  (ISO)
water  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)
yttrium chloride  (EXP)
zearalenone  (ISO)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)
zoxamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aflatoxin catabolic process  (IMP)
cell redox homeostasis  (IMP,ISO,ISS)
cellular response to angiotensin  (IDA)
cellular response to copper ion  (ISO)
cellular response to fluid shear stress  (ISO,ISS)
cellular response to glucose starvation  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (IEP,ISO)
cellular response to laminar fluid shear stress  (ISO)
cellular response to oxidative stress  (IBA,IEA,ISO,ISS)
cellular response to tumor necrosis factor  (IEP,ISO)
cellular response to xenobiotic stimulus  (ISO)
endoplasmic reticulum unfolded protein response  (ISO)
inflammatory response  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cellular process  (IMP)
negative regulation of cellular response to hypoxia  (IMP)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of hematopoietic stem cell differentiation  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (IMP)
PERK-mediated unfolded protein response  (ISO)
positive regulation of angiogenesis  (IMP)
positive regulation of blood coagulation  (ISO)
positive regulation of blood vessel endothelial cell migration  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (IMP,ISO)
positive regulation of glucose import  (ISO)
positive regulation of glutathione biosynthetic process  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP,ISO,ISS)
proteasomal ubiquitin-independent protein catabolic process  (ISO,ISS)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO,ISS)
protein ubiquitination  (ISO,ISS)
regulation of cellular response to oxidative stress  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of embryonic development  (ISO)
regulation of innate immune response  (ISO,ISS)
regulation of removal of superoxide radicals  (ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA)
response to endoplasmic reticulum stress  (ISO)
response to ischemia  (IEP)
response to organic substance  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (IEP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mast cell stabilizer modulates Sirt1/Nrf2/TNF pathway and inhibits oxidative stress, inflammation, and apoptosis in rat model of cyclophosphamide hepatotoxicity. Abdelzaher WY, etal., Immunopharmacol Immunotoxicol. 2020 Feb 18:1-9. doi: 10.1080/08923973.2020.1727499.
2. The molecular mechanism underlining the preventive effect of vitamin D against hepatic and renal acute toxicity through the NrF2/ BACH1/ HO-1 pathway. Abo El-Magd NF and Eraky SM, Life Sci. 2020 Mar 1;244:117331. doi: 10.1016/j.lfs.2020.117331. Epub 2020 Jan 20.
3. Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in healthy and pathologic placentas of human and rat. Acar N, etal., Acta Histochem. 2014 Oct;116(8):1289-300. doi: 10.1016/j.acthis.2014.07.012. Epub 2014 Aug 27.
4. Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy. Aminzadeh MA, etal., Nephrol Dial Transplant. 2013 Aug;28(8):2038-45. doi: 10.1093/ndt/gft022. Epub 2013 Mar 19.
5. Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism. Arambasic J, etal., Eur J Nutr. 2013 Aug;52(5):1461-73. doi: 10.1007/s00394-012-0452-z. Epub 2012 Oct 12.
6. After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Arredondo F, etal., Free Radic Biol Med. 2010 Sep 1;49(5):738-47. doi: 10.1016/j.freeradbiomed.2010.05.020. Epub 2010 Jun 8.
7. Reduction of hippocampal apoptosis by intracerebroventricular administration of extracellular signal-regulated protein kinase and/or p38 inhibitors in amyloid beta rat model of Alzheimer's disease: involvement of nuclear-related factor-2 and nuclear factor-kappaB. Ashabi G, etal., Basic Clin Pharmacol Toxicol. 2013 Mar;112(3):145-55. doi: 10.1111/bcpt.12000. Epub 2012 Oct 5.
8. Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia. Ashino T, etal., Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):760-8. doi: 10.1161/ATVBAHA.112.300614. Epub 2013 Feb 14.
9. Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance. Azzimato V, etal., Sci Transl Med. 2020 Feb 26;12(532). pii: 12/532/eaaw9709. doi: 10.1126/scitranslmed.aaw9709.
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PMID:28464602   PMID:28480587   PMID:28497199   PMID:28585088   PMID:28588747   PMID:28636290   PMID:28686978   PMID:28744340   PMID:28844677   PMID:28854440   PMID:28928429   PMID:29018201  
PMID:29054681   PMID:29074371   PMID:29108993   PMID:29119264   PMID:29147465   PMID:29201913   PMID:29210072   PMID:29304479   PMID:29323739   PMID:29362432   PMID:29381299   PMID:29404371  
PMID:29412163   PMID:29488137   PMID:29533123   PMID:29549163   PMID:29608952   PMID:29631592   PMID:29719281   PMID:29845199   PMID:29901143   PMID:29996121   PMID:30039750   PMID:30071128  
PMID:30105650   PMID:30119254   PMID:30129387   PMID:30203709   PMID:30213522   PMID:30315936   PMID:30316779   PMID:30358118   PMID:30369549   PMID:30476502   PMID:30500779   PMID:30513452  
PMID:30569102   PMID:30578379   PMID:30592315   PMID:30599315   PMID:30724852   PMID:30818054   PMID:30840298   PMID:30841430   PMID:30949917   PMID:30962285   PMID:30978363   PMID:30989783  
PMID:31001960   PMID:31019649   PMID:31050655   PMID:31054488   PMID:31091144   PMID:31132190   PMID:31173878   PMID:31209719   PMID:31251976   PMID:31273531   PMID:31344704   PMID:31432116  
PMID:31541683   PMID:31563143   PMID:31585542   PMID:31600004   PMID:31729530   PMID:31915512   PMID:31918011   PMID:31998437   PMID:32016469   PMID:32036037   PMID:32069075   PMID:32078205  
PMID:32097614   PMID:32105681   PMID:32246423   PMID:32311231   PMID:32320433   PMID:32323734   PMID:32420373   PMID:32478470   PMID:32558131   PMID:32590729   PMID:32605461   PMID:32610255  
PMID:32633393   PMID:32643505   PMID:32657424   PMID:32685505   PMID:32697403   PMID:32838965   PMID:32894623   PMID:32945417   PMID:32964992   PMID:32993187   PMID:33003644   PMID:33006714  
PMID:33040818   PMID:33134382   PMID:33159299   PMID:33166863   PMID:33173963   PMID:33343809   PMID:33495841   PMID:33544450   PMID:33600051   PMID:33656642   PMID:33675841   PMID:33677805  
PMID:33713981   PMID:33759307   PMID:33760331   PMID:33811899   PMID:33846774   PMID:33846798   PMID:33920318   PMID:34032369   PMID:34032546   PMID:34036379   PMID:34047419   PMID:34064070  
PMID:34136984   PMID:34175407   PMID:34185425   PMID:34254317   PMID:34278476   PMID:34310894   PMID:34329667   PMID:34399353   PMID:34440619   PMID:34495404   PMID:34673854   PMID:34699317  
PMID:34699582   PMID:34881386   PMID:34914307   PMID:34918390   PMID:35026282   PMID:35038776   PMID:35075205   PMID:35109747   PMID:35159376   PMID:35360547   PMID:35498128   PMID:35596948  
PMID:35726572   PMID:35843349   PMID:36040608   PMID:36091668   PMID:36359788   PMID:36736873   PMID:36807051   PMID:36819786   PMID:36856923   PMID:36916102   PMID:36998992   PMID:37122072  
PMID:37146710   PMID:37169128   PMID:37169561   PMID:37183461   PMID:37579617   PMID:37674036   PMID:37818693   PMID:37822721   PMID:37992540   PMID:38097051   PMID:38158661   PMID:38215951  
PMID:38308640   PMID:38311279   PMID:38350966  


Genomics

Comparative Map Data
Nfe2l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8381,001,529 - 81,031,165 (-)NCBIGRCr8
mRatBN7.2360,594,239 - 60,621,712 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl360,594,242 - 60,621,737 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx363,968,507 - 63,995,961 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0372,552,163 - 72,579,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0370,318,419 - 70,345,871 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0362,497,568 - 62,525,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl362,497,571 - 62,524,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0369,041,641 - 69,069,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4358,366,693 - 58,394,116 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1358,263,064 - 58,290,488 (-)NCBI
Celera360,095,041 - 60,122,464 (-)NCBICelera
Cytogenetic Map3q23NCBI
NFE2L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382177,230,303 - 177,264,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2177,218,667 - 177,392,756 (-)EnsemblGRCh38hg38GRCh38
GRCh372178,095,031 - 178,129,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362177,803,282 - 177,837,663 (-)NCBINCBI36Build 36hg18NCBI36
Build 342177,920,542 - 177,954,924NCBI
Celera2171,697,459 - 171,732,295 (-)NCBICelera
Cytogenetic Map2q31.2NCBI
HuRef2169,966,324 - 170,001,125 (-)NCBIHuRef
CHM1_12178,100,863 - 178,135,685 (-)NCBICHM1_1
T2T-CHM13v2.02177,712,539 - 177,746,971 (-)NCBIT2T-CHM13v2.0
Nfe2l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39275,505,860 - 75,535,007 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl275,505,857 - 75,534,985 (-)EnsemblGRCm39 Ensembl
GRCm38275,675,513 - 75,704,663 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl275,675,513 - 75,704,641 (-)EnsemblGRCm38mm10GRCm38
MGSCv37275,513,576 - 75,542,698 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36275,476,358 - 75,505,480 (-)NCBIMGSCv36mm8
Celera277,336,615 - 77,365,680 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map244.75NCBI
Nfe2l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540319,532,103 - 19,535,944 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540319,510,122 - 19,536,428 (+)NCBIChiLan1.0ChiLan1.0
NFE2L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21379,896,932 - 80,058,685 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B79,911,905 - 80,073,664 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B64,509,446 - 64,544,600 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B182,214,116 - 182,248,282 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B182,214,116 - 182,248,085 (-)Ensemblpanpan1.1panPan2
NFE2L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13620,989,205 - 21,087,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3620,989,360 - 21,012,524 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3621,008,912 - 21,151,059 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03621,133,291 - 21,275,953 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3621,133,296 - 21,276,012 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13621,203,925 - 21,237,606 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03621,205,089 - 21,302,516 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03621,320,865 - 21,418,596 (-)NCBIUU_Cfam_GSD_1.0
Nfe2l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303138,036,230 - 138,177,608 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365096,590,630 - 6,620,262 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365096,589,967 - 6,621,171 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFE2L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1582,973,656 - 83,146,183 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11582,967,485 - 83,146,185 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21592,433,294 - 92,469,024 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFE2L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11062,789,647 - 62,825,651 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1062,790,124 - 62,825,339 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040136,640,202 - 136,820,663 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfe2l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478714,355,791 - 14,381,251 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478714,355,330 - 14,381,353 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nfe2l2
96 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:158
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000002114
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat

Markers in Region
RH130653  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2360,597,065 - 60,597,248 (+)MAPPERmRatBN7.2
Rnor_6.0362,500,392 - 62,500,574NCBIRnor6.0
Rnor_5.0369,044,468 - 69,044,650UniSTSRnor5.0
RGSC_v3.4358,369,514 - 58,369,696UniSTSRGSC3.4
Celera360,097,862 - 60,098,044UniSTS
Cytogenetic Map3q23UniSTS
BI284301  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2360,594,712 - 60,594,869 (+)MAPPERmRatBN7.2
Rnor_6.0362,498,039 - 62,498,195NCBIRnor6.0
Rnor_5.0369,042,115 - 69,042,271UniSTSRnor5.0
RGSC_v3.4358,367,161 - 58,367,317UniSTSRGSC3.4
Celera360,095,509 - 60,095,665UniSTS
Cytogenetic Map3q23UniSTS
RH135926  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2360,594,910 - 60,595,115 (+)MAPPERmRatBN7.2
Rnor_6.0362,498,237 - 62,498,441NCBIRnor6.0
Rnor_5.0369,042,313 - 69,042,517UniSTSRnor5.0
RGSC_v3.4358,367,359 - 58,367,563UniSTSRGSC3.4
Celera360,095,707 - 60,095,911UniSTS
Cytogenetic Map3q23UniSTS
Nfe2l2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2360,595,122 - 60,596,303 (+)MAPPERmRatBN7.2
Rnor_6.0362,498,449 - 62,499,629NCBIRnor6.0
Rnor_5.0369,042,525 - 69,043,705UniSTSRnor5.0
RGSC_v3.4358,367,571 - 58,368,751UniSTSRGSC3.4
Celera360,095,919 - 60,097,099UniSTS
Cytogenetic Map3q23UniSTS


Genetic Models
This gene Nfe2l2 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 62 35 41 11 8
Low 1 12
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001399173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF037350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000002114   ⟹   ENSRNOP00000002114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl360,594,242 - 60,621,737 (-)Ensembl
Rnor_6.0 Ensembl362,497,571 - 62,524,996 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104413   ⟹   ENSRNOP00000087804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl360,594,242 - 60,605,874 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110389   ⟹   ENSRNOP00000097870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl360,594,242 - 60,598,646 (-)Ensembl
RefSeq Acc Id: NM_001399173   ⟹   NP_001386102
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,529 - 81,028,999 (-)NCBI
mRatBN7.2360,594,239 - 60,621,712 (-)NCBI
RefSeq Acc Id: NM_031789   ⟹   NP_113977
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,529 - 81,028,999 (-)NCBI
mRatBN7.2360,594,239 - 60,621,712 (-)NCBI
Rnor_6.0362,497,571 - 62,524,994 (-)NCBI
Rnor_5.0369,041,641 - 69,069,190 (-)NCBI
RGSC_v3.4358,366,693 - 58,394,116 (-)RGD
Celera360,095,041 - 60,122,464 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234398   ⟹   XP_006234460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,532 - 81,028,809 (-)NCBI
mRatBN7.2360,594,239 - 60,621,528 (-)NCBI
Rnor_6.0362,497,568 - 62,524,157 (-)NCBI
Rnor_5.0369,041,641 - 69,069,190 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063284651   ⟹   XP_063140721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,532 - 81,031,165 (-)NCBI
RefSeq Acc Id: XM_063284652   ⟹   XP_063140722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,532 - 81,031,165 (-)NCBI
RefSeq Acc Id: XM_063284653   ⟹   XP_063140723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,001,532 - 81,028,813 (-)NCBI
RefSeq Acc Id: NP_113977   ⟸   NM_031789
- Peptide Label: isoform 2
- UniProtKB: A6HMF7 (UniProtKB/TrEMBL),   A6HMF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234460   ⟸   XM_006234398
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A7Z8 (UniProtKB/TrEMBL),   A6HMG0 (UniProtKB/TrEMBL),   A0A8I6AV20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002114   ⟸   ENSRNOT00000002114
RefSeq Acc Id: ENSRNOP00000087804   ⟸   ENSRNOT00000104413
RefSeq Acc Id: ENSRNOP00000097870   ⟸   ENSRNOT00000110389
RefSeq Acc Id: NP_001386102   ⟸   NM_001399173
- Peptide Label: isoform 1
- UniProtKB: O54968 (UniProtKB/Swiss-Prot),   Q6P7C8 (UniProtKB/Swiss-Prot),   A6HMF8 (UniProtKB/TrEMBL),   A0A8I6AV20 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140722   ⟸   XM_063284652
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140721   ⟸   XM_063284651
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140723   ⟸   XM_063284653
- Peptide Label: isoform X4
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54968-F1-model_v2 AlphaFold O54968 1-604 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692153
Promoter ID:EPDNEW_R2678
Type:initiation region
Name:Nfe2l2_1
Description:nuclear factor, erythroid 2-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0362,525,015 - 62,525,075EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620360 AgrOrtholog
BioCyc Gene G2FUF-49302 BioCyc
Ensembl Genes ENSRNOG00000001548 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002114 ENTREZGENE
  ENSRNOT00000002114.7 UniProtKB/Swiss-Prot
  ENSRNOT00000104413.1 UniProtKB/TrEMBL
  ENSRNOT00000110389.1 UniProtKB/TrEMBL
Gene3D-CATH Transcription factor, Skn-1-like, DNA-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598313 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_Maf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NFE2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83619 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72386 IMAGE-MGC_LOAD
NCBI Gene 83619 ENTREZGENE
PANTHER NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24411:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_Maf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nfe2l2 PhenoGen
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001548 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A7Z8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AV20 ENTREZGENE, UniProtKB/TrEMBL
  A6HMF7 ENTREZGENE, UniProtKB/TrEMBL
  A6HMF8 ENTREZGENE, UniProtKB/TrEMBL
  A6HMF9 ENTREZGENE, UniProtKB/TrEMBL
  A6HMG0 ENTREZGENE, UniProtKB/TrEMBL
  NF2L2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P7C8 ENTREZGENE
UniProt Secondary Q6P7C8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-22 Nfe2l2  nuclear factor, erythroid 2-like 2  Nfe2l2  nuclear factor, erythroid derived 2, like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nfe2l2  nuclear factor, erythroid derived 2, like 2    NF-E2-related factor 2  Name updated 1299863 APPROVED
2002-08-07 Nfe2l2  NF-E2-related factor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation phosphorylated on Ser-40 by protein kinase C resulting in translocation to nucleus 729231
gene_regulation translocation to the nucleus is controled by PI3-kinase signaling pathway which regulates rearrangement of actin microfilaments in response to oxidative stress 727460