Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of HSD17B12 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of HSD17B12 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | ISO | Hsd17b12 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSD17B12 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of HSD17B12 mRNA | CTD | PMID:26865667 | 17beta-estradiol | increases chemical synthesis | ISO | HSD17B12 (Homo sapiens) | 6480464 | HSD17B12 protein results in increased chemical synthesis of Estradiol | CTD | PMID:16166196 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of HSD17B12 mRNA | CTD | PMID:32145629 | 17beta-estradiol | decreases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Estradiol results in decreased expression of HSD17B12 mRNA | CTD | PMID:19484750 | 17beta-estradiol | increases chemical synthesis | ISO | Hsd17b12 (Mus musculus) | 6480464 | HSD17B12 protein results in increased chemical synthesis of Estradiol | CTD | PMID:17641292 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Hsd17b12 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSD17B12 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HSD17B12 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HSD17B12 mRNA | CTD | PMID:18796159 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of HSD17B12 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of HSD17B12 mRNA | CTD | PMID:21346803 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of HSD17B12 mRNA | CTD | PMID:19162173 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of HSD17B12 mRNA | CTD | PMID:31881176 | aflatoxin B1 | decreases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of HSD17B12 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | HSD17B12 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of HSD17B12 gene | CTD | PMID:27153756 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of HSD17B12 mRNA | CTD | PMID:16483693 | androst-4-ene-3,17-dione | increases metabolic processing | ISO | Hsd17b12 (Mus musculus) | 6480464 | HSD17B12 protein results in increased metabolism of Androstenedione | CTD | PMID:17641292 | androst-5-ene-3beta,17beta-diol | increases chemical synthesis | ISO | Hsd17b12 (Mus musculus) | 6480464 | HSD17B12 protein results in increased chemical synthesis of Androstenediol | CTD | PMID:17641292 | androstane-3,17-diol | increases chemical synthesis | ISO | Hsd17b12 (Mus musculus) | 6480464 | HSD17B12 protein results in increased chemical synthesis of Androstane-3 and 17-diol | CTD | PMID:17641292 | androsterone | increases metabolic processing | ISO | Hsd17b12 (Mus musculus) | 6480464 | HSD17B12 protein results in increased metabolism of Androsterone | CTD | PMID:17641292 | aristolochic acid A | multiple interactions | EXP | | 6480464 | [aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of HSD17B12 mRNA | CTD | PMID:23912714 | aristolochic acid A | decreases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of HSD17B12 mRNA | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD17B12 mRNA | CTD | PMID:23650126 | benzatropine | increases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Benztropine results in increased expression of HSD17B12 protein | CTD | PMID:34122009 | benzo[a]pyrene | affects expression | EXP | | 6480464 | Benzo(a)pyrene affects the expression of HSD17B12 mRNA | CTD | PMID:22960446 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:35940284 | benzo[a]pyrene diol epoxide I | multiple interactions | ISO | HSD17B12 (Homo sapiens) | 6480464 | ramelteon inhibits the reaction [7 more ... | CTD | PMID:35940284 | bexarotene | increases expression | EXP | | 6480464 | bexarotene results in increased expression of HSD17B12 mRNA | CTD | PMID:16648578 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of HSD17B12 mRNA | CTD | PMID:32619501 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of HSD17B12 mRNA | CTD | PMID:25181051 and PMID:34947998 | bisphenol A | increases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of HSD17B12 protein | CTD | PMID:34186270 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HSD17B12 mRNA | CTD | PMID:32145629 | Bisphenol B | increases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of HSD17B12 protein | CTD | PMID:34186270 | bucladesine | increases expression | EXP | | 6480464 | Bucladesine results in increased expression of HSD17B12 mRNA | CTD | PMID:21458522 | cadmium atom | multiple interactions | ISO | Hsd17b12 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSD17B12 mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | ISO | Hsd17b12 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSD17B12 mRNA | CTD | PMID:37325564 | calcitriol | multiple interactions | EXP | | 6480464 | [Calcium co-treated with Calcitriol] affects the expression of HSD17B12 mRNA | CTD | PMID:15913539 | calcium atom | multiple interactions | EXP | | 6480464 | [Calcium co-treated with Calcitriol] affects the expression of HSD17B12 mRNA | CTD | PMID:15913539 | calcium(0) | multiple interactions | EXP | | 6480464 | [Calcium co-treated with Calcitriol] affects the expression of HSD17B12 mRNA | CTD | PMID:15913539 | carbon nanotube | increases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | HSD17B12 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to HSD17B12 gene] | CTD | PMID:28238834 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of HSD17B12 protein | CTD | PMID:22023808 | clofibrate | increases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Clofibrate results in increased expression of HSD17B12 mRNA | CTD | PMID:17585979 | clofibrate | multiple interactions | ISO | Hsd17b12 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of HSD17B12 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HSD17B12 mRNA] | CTD | PMID:17585979 | clozapine | increases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Clozapine results in increased expression of HSD17B12 protein | CTD | PMID:34122009 | cobalt dichloride | increases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of HSD17B12 mRNA | CTD | PMID:19376846 | cyclosporin A | decreases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of HSD17B12 mRNA | CTD | PMID:25562108 | dehydroepiandrosterone | increases metabolic processing | ISO | Hsd17b12 (Mus musculus) | 6480464 | HSD17B12 protein results in increased metabolism of Dehydroepiandrosterone | CTD | PMID:17641292 | dexamethasone | decreases expression | EXP | | 6480464 | Dexamethasone results in decreased expression of HSD17B12 mRNA | CTD | PMID:14618091 | dorsomorphin | multiple interactions | ISO | HSD17B12 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HSD17B12 mRNA | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of HSD17B12 mRNA | CTD | PMID:29803840 | epoxiconazole | increases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | epoxiconazole results in increased expression of HSD17B12 mRNA | CTD | PMID:34182286 | estrone | increases metabolic processing | ISO | HSD17B12 (Homo sapiens) | 6480464 | HSD17B12 protein results in increased metabolism of Estrone | CTD | PMID:16166196 | estrone | increases metabolic processing | ISO | Hsd17b12 (Mus musculus) | 6480464 | HSD17B12 protein results in increased metabolism of Estrone | CTD | PMID:17641292 | ethyl methanesulfonate | increases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of HSD17B12 mRNA | CTD | PMID:23649840 | fenthion | increases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Fenthion results in increased expression of HSD17B12 mRNA | CTD | PMID:34813904 | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of HSD17B12 mRNA | CTD | PMID:34044035 | formaldehyde | increases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of HSD17B12 mRNA | CTD | PMID:23649840 | genistein | increases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Genistein results in increased expression of HSD17B12 mRNA | CTD | PMID:26865667 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of HSD17B12 mRNA | CTD | PMID:22061828 | indometacin | decreases expression | EXP | | 6480464 | Indomethacin results in decreased expression of HSD17B12 mRNA | CTD | PMID:36868495 | inulin | multiple interactions | ISO | Hsd17b12 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of HSD17B12 mRNA | CTD | PMID:36331819 | isotretinoin | decreases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Isotretinoin results in decreased expression of HSD17B12 mRNA | CTD | PMID:20436886 | ivermectin | decreases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of HSD17B12 protein | CTD | PMID:32959892 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of HSD17B12 mRNA | CTD | PMID:24136188 | methyl methanesulfonate | increases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of HSD17B12 mRNA | CTD | PMID:23649840 | NADP zwitterion | multiple interactions | ISO | HSD17B12 (Homo sapiens) | 6480464 | NADP binds to and results in increased activity of HSD17B12 protein | CTD | PMID:25526675 | NADP(+) | multiple interactions | ISO | HSD17B12 (Homo sapiens) | 6480464 | NADP binds to and results in increased activity of HSD17B12 protein | CTD | PMID:25526675 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of HSD17B12 mRNA | CTD | PMID:24136188 | ozone | decreases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Ozone results in decreased expression of HSD17B12 mRNA | CTD | PMID:16183385 | paracetamol | multiple interactions | ISO | Hsd17b12 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of HSD17B12 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HSD17B12 mRNA] | CTD | PMID:17585979 | paraquat | decreases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Paraquat results in decreased expression of HSD17B12 mRNA | CTD | PMID:21371552 | paraquat | increases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Paraquat results in increased expression of HSD17B12 mRNA | CTD | PMID:21371552 | perfluorohexanesulfonic acid | increases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of HSD17B12 mRNA | CTD | PMID:37995155 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Hsd17b12 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of HSD17B12 mRNA | CTD | PMID:36331819 | phenobarbital | decreases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of HSD17B12 protein | CTD | PMID:35881160 | phenobarbital | increases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Phenobarbital results in increased expression of HSD17B12 protein | CTD | PMID:35881160 | pirinixic acid | multiple interactions | ISO | Hsd17b12 (Mus musculus) | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of HSD17B12 mRNA] | CTD | PMID:17950772 and PMID:20059764 | pirinixic acid | increases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of HSD17B12 mRNA | CTD | PMID:17950772 more ... | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of HSD17B12 mRNA | CTD | PMID:19162173 | resveratrol | increases expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | resveratrol results in increased expression of HSD17B12 protein | CTD | PMID:25505154 | resveratrol | multiple interactions | ISO | HSD17B12 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of HSD17B12 mRNA | CTD | PMID:23557933 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of HSD17B12 mRNA | CTD | PMID:28374803 | SB 431542 | multiple interactions | ISO | HSD17B12 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 and PMID:37664457 | Tesaglitazar | increases expression | EXP | | 6480464 | tesaglitazar results in increased expression of HSD17B12 mRNA | CTD | PMID:21515302 | testosterone | increases chemical synthesis | ISO | Hsd17b12 (Mus musculus) | 6480464 | HSD17B12 protein results in increased chemical synthesis of Testosterone | CTD | PMID:17641292 | thapsigargin | increases expression | EXP | | 6480464 | Thapsigargin results in increased expression of HSD17B12 protein | CTD | PMID:35544339 | tolcapone | affects binding | EXP | | 6480464 | tolcapone binds to HSD17B12 protein | CTD | PMID:19783845 | triptonide | affects expression | ISO | Hsd17b12 (Mus musculus) | 6480464 | triptonide affects the expression of HSD17B12 mRNA | CTD | PMID:33045310 | valproic acid | affects expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HSD17B12 mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | ISO | HSD17B12 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HSD17B12 mRNA | CTD | PMID:27188386 | valproic acid | decreases expression | ISO | HSD17B12 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of HSD17B12 mRNA | CTD | PMID:26272509 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of HSD17B12 mRNA | CTD | PMID:23034163 | |