Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12) - Rat Genome Database

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Gene: Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12) Rattus norvegicus
Analyze
Symbol: Hsd17b12
Name: hydroxysteroid (17-beta) dehydrogenase 12
RGD ID: 708367
Description: Predicted to enable several functions, including fibronectin binding activity; heparin binding activity; and very-long-chain 3-oxoacyl-CoA reductase activity. Predicted to be involved in fatty acid elongation, saturated fatty acid. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to be located in extracellular matrix. Predicted to be part of fatty acid elongase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12); PARTICIPATES IN steroid hormone biosynthetic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17-beta-HSD 12; 17-beta-hydroxysteroid dehydrogenase 12; 3-ketoacyl-CoA reductase; estradiol 17-beta-dehydrogenase 12; KAR; LOC84013; smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3; very-long-chain 3-oxoacyl-CoA reductase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83100,445,393 - 100,568,898 (-)NCBIGRCr8
mRatBN7.2379,990,048 - 80,113,556 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl379,990,056 - 80,113,617 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx383,463,561 - 83,587,647 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0392,062,651 - 92,186,743 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0389,908,167 - 90,032,005 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0382,924,699 - 83,048,465 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl382,924,687 - 83,048,435 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0389,626,176 - 89,749,541 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4378,436,634 - 78,559,707 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1378,333,061 - 78,456,135 (-)NCBI
Celera379,190,922 - 79,314,232 (-)NCBICelera
Cytogenetic Map3q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (ISO)
androstane-3,17-diol  (ISO)
androsterone  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bucladesine  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
estrone  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fipronil  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
indometacin  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
methyl methanesulfonate  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
thapsigargin  (EXP)
tolcapone  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Information Derived from GenBank Report RGD, Sept. 2003
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12482854   PMID:15489334   PMID:18757743   PMID:23106098  


Genomics

Comparative Map Data
Hsd17b12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83100,445,393 - 100,568,898 (-)NCBIGRCr8
mRatBN7.2379,990,048 - 80,113,556 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl379,990,056 - 80,113,617 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx383,463,561 - 83,587,647 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0392,062,651 - 92,186,743 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0389,908,167 - 90,032,005 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0382,924,699 - 83,048,465 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl382,924,687 - 83,048,435 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0389,626,176 - 89,749,541 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4378,436,634 - 78,559,707 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1378,333,061 - 78,456,135 (-)NCBI
Celera379,190,922 - 79,314,232 (-)NCBICelera
Cytogenetic Map3q31NCBI
HSD17B12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381143,556,721 - 43,856,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1143,680,680 - 43,856,617 (+)EnsemblGRCh38hg38GRCh38
GRCh371143,702,288 - 43,878,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361143,658,719 - 43,834,745 (+)NCBINCBI36Build 36hg18NCBI36
Build 341143,658,880 - 43,834,744NCBI
Celera1143,848,404 - 44,024,379 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1143,412,072 - 43,587,812 (+)NCBIHuRef
CHM1_11143,701,792 - 43,877,827 (+)NCBICHM1_1
T2T-CHM13v2.01143,731,842 - 44,012,332 (+)NCBIT2T-CHM13v2.0
Hsd17b12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39293,863,042 - 93,988,254 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl293,863,034 - 93,988,309 (-)EnsemblGRCm39 Ensembl
GRCm38294,032,697 - 94,157,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl294,032,689 - 94,157,964 (-)EnsemblGRCm38mm10GRCm38
MGSCv37293,872,854 - 93,998,066 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36293,833,536 - 93,958,748 (-)NCBIMGSCv36mm8
Celera295,429,240 - 95,554,423 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map251.62NCBI
Hsd17b12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554223,717,666 - 3,864,801 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554223,721,452 - 3,864,801 (-)NCBIChiLan1.0ChiLan1.0
HSD17B12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2945,895,986 - 46,071,909 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11145,901,905 - 46,077,829 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01143,641,323 - 43,817,214 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11144,137,597 - 44,312,986 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1144,137,597 - 44,312,986 (+)Ensemblpanpan1.1panPan2
HSD17B12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,907,366 - 26,061,643 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,908,555 - 26,061,616 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,594,145 - 25,748,413 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,529,683 - 26,683,219 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1826,529,049 - 26,683,212 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11826,039,150 - 26,192,361 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,684,733 - 25,839,066 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01826,296,764 - 26,451,042 (-)NCBIUU_Cfam_GSD_1.0
Hsd17b12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494722,688,930 - 22,837,837 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365624,802,282 - 4,949,468 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365624,802,282 - 4,949,500 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl218,456,019 - 18,611,782 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1218,461,487 - 18,611,761 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2220,061,561 - 20,211,999 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,530,292 - 21,702,552 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,528,391 - 21,702,455 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038118,767,304 - 118,938,354 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd17b12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247674,160,053 - 4,316,370 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247674,163,452 - 4,315,827 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsd17b12
528 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:646
Count of miRNA genes:233
Interacting mature miRNAs:290
Transcripts:ENSRNOT00000012806, ENSRNOT00000047571
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat

Markers in Region
RH134631  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2379,990,143 - 79,990,352 (+)MAPPERmRatBN7.2
Rnor_6.0382,924,789 - 82,924,997NCBIRnor6.0
Rnor_5.0389,626,266 - 89,626,474UniSTSRnor5.0
RGSC_v3.4378,436,722 - 78,436,930UniSTSRGSC3.4
Celera379,191,010 - 79,191,218UniSTS
RH 3.4 Map3691.6UniSTS
Cytogenetic Map3q31UniSTS
RH138068  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2380,097,295 - 80,097,426 (+)MAPPERmRatBN7.2
Rnor_6.0383,032,055 - 83,032,185NCBIRnor6.0
Rnor_5.0389,733,310 - 89,733,440UniSTSRnor5.0
RGSC_v3.4378,543,281 - 78,543,411UniSTSRGSC3.4
Celera379,298,084 - 79,298,214UniSTS
RH 3.4 Map3694.9UniSTS
Cytogenetic Map3q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 57 41 19 41 2 2 74 35 38 11 2
Low 9 6 9 3 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000012806   ⟹   ENSRNOP00000012806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl379,990,056 - 80,113,617 (-)Ensembl
Rnor_6.0 Ensembl382,924,687 - 83,048,435 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000047571   ⟹   ENSRNOP00000041197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl379,990,058 - 80,113,549 (-)Ensembl
Rnor_6.0 Ensembl382,924,701 - 83,048,289 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111181   ⟹   ENSRNOP00000082994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl379,996,765 - 80,113,563 (-)Ensembl
RefSeq Acc Id: NM_032066   ⟹   NP_114455
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83100,445,393 - 100,568,898 (-)NCBI
mRatBN7.2379,990,048 - 80,113,556 (-)NCBI
Rnor_6.0382,924,701 - 83,048,289 (-)NCBI
Rnor_5.0389,626,176 - 89,749,541 (-)NCBI
RGSC_v3.4378,436,634 - 78,559,707 (-)RGD
Celera379,190,922 - 79,314,232 (-)RGD
Sequence:
RefSeq Acc Id: NP_114455   ⟸   NM_032066
- UniProtKB: Q6P7R8 (UniProtKB/Swiss-Prot),   Q9Z1B9 (UniProtKB/Swiss-Prot),   A6HNK4 (UniProtKB/TrEMBL),   D3ZPU3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041197   ⟸   ENSRNOT00000047571
RefSeq Acc Id: ENSRNOP00000012806   ⟸   ENSRNOT00000012806
RefSeq Acc Id: ENSRNOP00000082994   ⟸   ENSRNOT00000111181

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P7R8-F1-model_v2 AlphaFold Q6P7R8 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692236
Promoter ID:EPDNEW_R2761
Type:multiple initiation site
Name:Hsd17b12_1
Description:hydroxysteroid (17-beta) dehydrogenase 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0383,048,324 - 83,048,384EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708367 AgrOrtholog
BioCyc Gene G2FUF-48658 BioCyc
BioCyc Pathway PWY-5080 [very long chain fatty acid biosynthesis I] BioCyc
  PWY-6598 [sciadonate biosynthesis] BioCyc
  PWY-7036 [very long chain fatty acid biosynthesis II] BioCyc
  PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-7592 [arachidonate biosynthesis III (6-desaturase, mammals)] BioCyc
  PWY-7606 [docosahexaenoate biosynthesis III (6-desaturase, mammals)] BioCyc
  PWY-7619 [juniperonate biosynthesis] BioCyc
  PWY-7726 [(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)] BioCyc
  PWY-8041 [ultra-long-chain fatty acid biosynthesis] BioCyc
BioCyc Pathway Image PWY-5080 BioCyc
  PWY-6598 BioCyc
  PWY-7036 BioCyc
  PWY-7049 BioCyc
  PWY-7592 BioCyc
  PWY-7606 BioCyc
  PWY-7619 BioCyc
  PWY-7726 BioCyc
  PWY-8041 BioCyc
Ensembl Genes ENSRNOG00000009630 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065025150 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012806 ENTREZGENE
  ENSRNOT00000012806.8 UniProtKB/Swiss-Prot
  ENSRNOT00000047571.6 UniProtKB/TrEMBL
  ENSRNOT00000111181.1 UniProtKB/TrEMBL
  ENSRNOT00065043310 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6888949 IMAGE-MGC_LOAD
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84013 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72757 IMAGE-MGC_LOAD
NCBI Gene 84013 ENTREZGENE
PANTHER RH59310P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VERY-LONG-CHAIN 3-OXOACYL-COA REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd17b12 PhenoGen
PIRSF 11-beta-HSD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009630 RatGTEx
  ENSRNOG00065025150 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZVN1_RAT UniProtKB/TrEMBL
  A6HNK4 ENTREZGENE, UniProtKB/TrEMBL
  A6HNK5_RAT UniProtKB/TrEMBL
  D3ZPU3 ENTREZGENE, UniProtKB/TrEMBL
  DHB12_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z1B9 ENTREZGENE
UniProt Secondary Q9Z1B9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Hsd17b12  hydroxysteroid (17-beta) dehydrogenase 12    smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3  Name updated 1299863 APPROVED
2004-09-10 Hsd17b12  smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3  LOC84013    Symbol and Name updated 1299863 APPROVED