Mir130a (microRNA 130a) - Rat Genome Database

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Gene: Mir130a (microRNA 130a) Rattus norvegicus
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Symbol: Mir130a
Name: microRNA 130a
RGD ID: 2325385
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including negative regulation of gene expression; positive regulation of cell population proliferation; and regulation of leukocyte activation. Predicted to act upstream of or within several processes, including cellular response to forskolin; hematopoietic stem cell differentiation; and long-term synaptic potentiation. Orthologous to human MIR130A (microRNA 130a); INTERACTS WITH aflatoxin B1; atrazine; azoxystrobin.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-130a; rno-mir-130a
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,229,228 - 90,229,315 (-)NCBIGRCr8
mRatBN7.2369,822,542 - 69,822,629 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,822,542 - 69,822,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,204,341 - 73,204,428 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,803,003 - 81,803,090 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,561,913 - 79,562,000 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,141,037 - 72,141,124 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,141,037 - 72,141,124 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,661,697 - 78,661,784 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera369,178,061 - 69,178,148 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. LncRNA H19 interacted with miR-130a-3p and miR-17-5p to modify radio-resistance and chemo-sensitivity of cardiac carcinoma cells. Jia J, etal., Cancer Med. 2019 Apr;8(4):1604-1618. doi: 10.1002/cam4.1860. Epub 2019 Mar 6.
2. MicroRNA-130a Regulation of Desmocollin 2 in a Novel Model of Arrhythmogenic Cardiomyopathy. Mazurek SR, etal., Microrna. 2017;6(2):143-150. doi: 10.2174/2211536605666161109111031.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Reduced MIR130A is involved in primary immune thrombocytopenia via targeting TGFB1 and IL18. Zhao H, etal., Br J Haematol. 2014 Sep;166(5):767-73. doi: 10.1111/bjh.12934. Epub 2014 May 7.
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:16766679   PMID:17604727   PMID:20403161   PMID:20417623   PMID:20548288   PMID:20660734   PMID:21753805   PMID:21993888   PMID:23390484  
PMID:23646144   PMID:25631713   PMID:25751060   PMID:25858512   PMID:26255201   PMID:27245166   PMID:29070584   PMID:29399759   PMID:30556887   PMID:31210323   PMID:31226635   PMID:31733099  
PMID:31843527   PMID:32481647   PMID:32790238   PMID:32990844   PMID:33360969   PMID:34609952   PMID:35503135  


Genomics

Comparative Map Data
Mir130a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,229,228 - 90,229,315 (-)NCBIGRCr8
mRatBN7.2369,822,542 - 69,822,629 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,822,542 - 69,822,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,204,341 - 73,204,428 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,803,003 - 81,803,090 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,561,913 - 79,562,000 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,141,037 - 72,141,124 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,141,037 - 72,141,124 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,661,697 - 78,661,784 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera369,178,061 - 69,178,148 (-)NCBICelera
Cytogenetic Map3q24NCBI
MIR130A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,641,198 - 57,641,286 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,641,198 - 57,641,286 (+)EnsemblGRCh38hg38GRCh38
GRCh371157,408,671 - 57,408,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,165,246 - 57,165,334 (+)NCBINCBI36Build 36hg18NCBI36
Celera1154,765,156 - 54,765,244 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,757,429 - 53,757,517 (+)NCBIHuRef
CHM1_11157,274,889 - 57,274,977 (+)NCBICHM1_1
T2T-CHM13v2.01157,591,382 - 57,591,470 (+)NCBIT2T-CHM13v2.0
Mir130a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,571,459 - 84,571,522 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,571,459 - 84,571,522 (-)EnsemblGRCm39 Ensembl
GRCm38284,741,115 - 84,741,178 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,741,115 - 84,741,178 (-)EnsemblGRCm38mm10GRCm38
MGSCv37284,581,272 - 84,581,335 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera286,336,310 - 86,336,373 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
MIR130A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11838,543,618 - 38,543,679 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1838,543,618 - 38,543,681 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1838,090,020 - 38,090,081 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01839,225,427 - 39,225,488 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11838,808,515 - 38,808,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01838,381,529 - 38,381,590 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,012,290 - 39,012,351 (-)NCBIUU_Cfam_GSD_1.0
MIR130A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl213,296,695 - 13,296,773 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1213,296,695 - 13,296,773 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2212,929,884 - 12,929,962 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Acvr1rno-miR-130a-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:10564
Count of gene targets:6322
Count of transcripts:6772
Interacting mature miRNAs:rno-miR-130a-3p, rno-miR-130a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 1 3 1 6 3 7 3
Below cutoff 3 1 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000053693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl369,822,542 - 69,822,629 (-)Ensembl
Rnor_6.0 Ensembl372,141,037 - 72,141,124 (-)Ensembl
RefSeq Acc Id: NR_031876
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8390,229,228 - 90,229,315 (-)NCBI
mRatBN7.2369,822,542 - 69,822,629 (-)NCBI
Rnor_6.0372,141,037 - 72,141,124 (-)NCBI
Rnor_5.0378,661,697 - 78,661,784 (-)NCBI
Celera369,178,061 - 69,178,148 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325385 AgrOrtholog
BioCyc Gene G2FUF-49162 BioCyc
Ensembl Genes ENSRNOG00000035570 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053693 ENTREZGENE
miRBase MI0000903 ENTREZGENE
NCBI Gene 100314238 ENTREZGENE
PhenoGen Mir130a PhenoGen
RatGTEx ENSRNOG00000035570 RatGTEx
RNAcentral URS0000229ECD RNACentral
  URS0000315338 RNACentral
  URS000075D4CA RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir130a  microRNA 130a  Mir130a  microRNA mir-130a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir130a  microRNA mir-130a      Symbol and Name status set to provisional 70820 PROVISIONAL