Arhgap1 (Rho GTPase activating protein 1) - Rat Genome Database

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Gene: Arhgap1 (Rho GTPase activating protein 1) Rattus norvegicus
Analyze
Symbol: Arhgap1
Name: Rho GTPase activating protein 1
RGD ID: 1306068
Description: Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of endocytic recycling; small GTPase mediated signal transduction; and transferrin transport. Predicted to act upstream of or within regulation of GTPase activity. Located in perinuclear region of cytoplasm. Orthologous to human ARHGAP1 (Rho GTPase activating protein 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC311193; rho GTPase-activating protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,621,377 - 77,643,400 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl377,620,655 - 77,643,396 (+)Ensembl
Rnor_6.0380,555,196 - 80,576,881 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,555,196 - 80,576,856 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,254,371 - 87,275,981 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,030,806 - 76,052,736 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,931,036 - 75,947,686 (+)NCBI
Celera376,826,841 - 76,847,615 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. IGFBP-5(201-218) stimulates Cdc42GAP aggregation and filopodia formationin migrating mesangial cells. Berfield AK, etal., Kidney Int. 2000 May;57(5):1991-2003.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Wang L, etal., Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1248-53. Epub 2007 Jan 16.
Additional References at PubMed
PMID:8253717   PMID:8288572   PMID:8889548   PMID:10699171   PMID:15860730   PMID:16380373   PMID:18331715   PMID:19056867   PMID:23376485   PMID:23533145   PMID:25468996   PMID:31664016  


Genomics

Comparative Map Data
Arhgap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,621,377 - 77,643,400 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl377,620,655 - 77,643,396 (+)Ensembl
Rnor_6.0380,555,196 - 80,576,881 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,555,196 - 80,576,856 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,254,371 - 87,275,981 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,030,806 - 76,052,736 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,931,036 - 75,947,686 (+)NCBI
Celera376,826,841 - 76,847,615 (+)NCBICelera
Cytogenetic Map3q24NCBI
ARHGAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381146,677,080 - 46,700,619 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1146,677,080 - 46,700,619 (-)EnsemblGRCh38hg38GRCh38
GRCh371146,698,630 - 46,722,169 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,655,206 - 46,678,696 (-)NCBINCBI36hg18NCBI36
Build 341146,655,209 - 46,678,696NCBI
Celera1146,846,844 - 46,870,551 (-)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1146,404,665 - 46,428,254 (-)NCBIHuRef
CHM1_11146,697,036 - 46,720,625 (-)NCBICHM1_1
T2T-CHM13v2.01146,833,096 - 46,856,635 (-)NCBI
Arhgap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,480,463 - 91,502,670 (+)NCBIGRCm39mm39
GRCm39 Ensembl291,480,205 - 91,502,671 (+)Ensembl
GRCm38291,650,118 - 91,672,325 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,649,860 - 91,672,326 (+)EnsemblGRCm38mm10GRCm38
MGSCv37291,490,275 - 91,512,482 (+)NCBIGRCm37mm9NCBIm37
MGSCv36291,454,047 - 91,473,157 (+)NCBImm8
Celera293,039,665 - 93,061,789 (+)NCBICelera
Cytogenetic Map2E1NCBI
Arhgap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,378,426 - 1,396,899 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554221,378,426 - 1,395,439 (+)NCBIChiLan1.0ChiLan1.0
ARHGAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11147,185,415 - 47,209,813 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,185,415 - 47,209,765 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01146,626,174 - 46,651,308 (-)NCBIMhudiblu_PPA_v0panPan3
ARHGAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,813,580 - 42,832,054 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,813,693 - 42,830,458 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,545,991 - 41,559,181 (+)NCBI
ROS_Cfam_1.01843,469,679 - 43,488,158 (+)NCBI
ROS_Cfam_1.0 Ensembl1843,469,753 - 43,488,150 (+)Ensembl
UMICH_Zoey_3.11842,958,392 - 42,971,585 (+)NCBI
UNSW_CanFamBas_1.01842,514,027 - 42,527,216 (+)NCBI
UU_Cfam_GSD_1.01843,243,313 - 43,256,512 (+)NCBI
Arhgap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,289,302 - 20,308,993 (+)NCBI
SpeTri2.0NW_0049365622,400,983 - 2,420,635 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,834,703 - 15,854,179 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,834,285 - 15,854,181 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,185,458 - 17,205,207 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,627,534 - 18,648,984 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl118,627,611 - 18,650,706 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038115,911,102 - 115,933,286 (+)NCBIVero_WHO_p1.0
Arhgap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,905,283 - 1,922,263 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247671,905,217 - 1,922,263 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127727  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,643,044 - 77,643,235 (+)MAPPERmRatBN7.2
Rnor_6.0380,576,526 - 80,576,716NCBIRnor6.0
Rnor_5.0387,275,626 - 87,275,816UniSTSRnor5.0
RGSC_v3.4376,052,381 - 76,052,571UniSTSRGSC3.4
Celera376,847,260 - 76,847,450UniSTS
Cytogenetic Map3q24UniSTS
RH142167  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,642,779 - 77,642,964 (+)MAPPERmRatBN7.2
Rnor_6.0380,576,261 - 80,576,445NCBIRnor6.0
Rnor_5.0387,275,361 - 87,275,545UniSTSRnor5.0
RGSC_v3.4376,052,116 - 76,052,300UniSTSRGSC3.4
Celera376,846,995 - 76,847,179UniSTS
Cytogenetic Map3q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:550
Count of miRNA genes:235
Interacting mature miRNAs:290
Transcripts:ENSRNOT00000067318
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 51 35 19 35 2 5 74 35 39 11 2
Low 6 6 6 6 6 2 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA900696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK480577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO573331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN932805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV725096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV768858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000067318   ⟹   ENSRNOP00000059324
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,621,716 - 77,643,396 (+)Ensembl
Rnor_6.0 Ensembl380,555,196 - 80,576,856 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079118   ⟹   ENSRNOP00000070761
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,620,655 - 77,643,394 (+)Ensembl
Rnor_6.0 Ensembl380,556,668 - 80,575,657 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098688   ⟹   ENSRNOP00000087093
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,621,746 - 77,643,235 (+)Ensembl
RefSeq Acc Id: NM_001107747   ⟹   NP_001101217
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,621,689 - 77,643,400 (+)NCBI
Rnor_6.0380,555,196 - 80,576,881 (+)NCBI
Rnor_5.0387,254,371 - 87,275,981 (+)NCBI
RGSC_v3.4376,030,806 - 76,052,736 (+)RGD
Celera376,826,841 - 76,847,615 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234551   ⟹   XP_006234613
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,621,663 - 77,643,398 (+)NCBI
Rnor_6.0380,555,200 - 80,576,881 (+)NCBI
Rnor_5.0387,254,371 - 87,275,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234552   ⟹   XP_006234614
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,621,726 - 77,643,400 (+)NCBI
Rnor_6.0380,555,207 - 80,576,881 (+)NCBI
Rnor_5.0387,254,371 - 87,275,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234553   ⟹   XP_006234615
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,623,145 - 77,643,400 (+)NCBI
Rnor_6.0380,555,208 - 80,576,881 (+)NCBI
Rnor_5.0387,254,371 - 87,275,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234554   ⟹   XP_006234616
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,621,663 - 77,643,398 (+)NCBI
Rnor_6.0380,555,200 - 80,576,881 (+)NCBI
Rnor_5.0387,254,371 - 87,275,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234556   ⟹   XP_006234618
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,621,663 - 77,643,398 (+)NCBI
Rnor_6.0380,555,200 - 80,576,881 (+)NCBI
Rnor_5.0387,254,371 - 87,275,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234557   ⟹   XP_006234619
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,621,726 - 77,643,400 (+)NCBI
Rnor_6.0380,555,207 - 80,576,881 (+)NCBI
Rnor_5.0387,254,371 - 87,275,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234558   ⟹   XP_006234620
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,621,720 - 77,643,400 (+)NCBI
Rnor_6.0380,555,207 - 80,576,881 (+)NCBI
Rnor_5.0387,254,371 - 87,275,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234559   ⟹   XP_006234621
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,626,018 - 77,643,400 (+)NCBI
Rnor_6.0380,559,474 - 80,576,881 (+)NCBI
Rnor_5.0387,254,371 - 87,275,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234560   ⟹   XP_006234622
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,621,717 - 77,643,400 (+)NCBI
Rnor_6.0380,555,207 - 80,576,881 (+)NCBI
Rnor_5.0387,254,371 - 87,275,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591716   ⟹   XP_017447205
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,621,726 - 77,643,400 (+)NCBI
Rnor_6.0380,555,207 - 80,576,881 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104900   ⟹   XP_038960828
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,621,377 - 77,643,398 (+)NCBI
RefSeq Acc Id: XM_039104901   ⟹   XP_038960829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,621,780 - 77,643,400 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001101217   ⟸   NM_001107747
- UniProtKB: D4A6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234622   ⟸   XM_006234560
- Peptide Label: isoform X1
- UniProtKB: D4A6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234616   ⟸   XM_006234554
- Peptide Label: isoform X1
- UniProtKB: D4A6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234613   ⟸   XM_006234551
- Peptide Label: isoform X1
- UniProtKB: D4A6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234618   ⟸   XM_006234556
- Peptide Label: isoform X1
- UniProtKB: D4A6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234614   ⟸   XM_006234552
- Peptide Label: isoform X1
- UniProtKB: D4A6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234619   ⟸   XM_006234557
- Peptide Label: isoform X1
- UniProtKB: D4A6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234620   ⟸   XM_006234558
- Peptide Label: isoform X1
- UniProtKB: D4A6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234615   ⟸   XM_006234553
- Peptide Label: isoform X1
- UniProtKB: D4A6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234621   ⟸   XM_006234559
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017447205   ⟸   XM_017591716
- Peptide Label: isoform X1
- UniProtKB: D4A6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059324   ⟸   ENSRNOT00000067318
RefSeq Acc Id: ENSRNOP00000070761   ⟸   ENSRNOT00000079118
RefSeq Acc Id: XP_038960828   ⟸   XM_039104900
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038960829   ⟸   XM_039104901
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000087093   ⟸   ENSRNOT00000098688

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A6C5-F1-model_v2 AlphaFold D4A6C5 1-439 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692217
Promoter ID:EPDNEW_R2741
Type:initiation region
Name:Arhgap1_1
Description:Rho GTPase activating protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0380,555,283 - 80,555,343EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306068 AgrOrtholog
BioCyc Gene G2FUF-48722 BioCyc
Ensembl Genes ENSRNOG00000016610 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059324 ENTREZGENE
  ENSRNOP00000059324.1 UniProtKB/TrEMBL
  ENSRNOP00000070761 ENTREZGENE
  ENSRNOP00000070761.2 UniProtKB/TrEMBL
  ENSRNOP00000087093 ENTREZGENE
  ENSRNOP00000087093.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067318 ENTREZGENE
  ENSRNOT00000067318.4 UniProtKB/TrEMBL
  ENSRNOT00000079118 ENTREZGENE
  ENSRNOT00000079118.2 UniProtKB/TrEMBL
  ENSRNOT00000098688 ENTREZGENE
  ENSRNOT00000098688.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  3.40.525.10 UniProtKB/TrEMBL
InterPro CRAL-bd_TRIO_C UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
KEGG Report rno:311193 UniProtKB/TrEMBL
NCBI Gene 311193 ENTREZGENE
Pfam CRAL_TRIO_2 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
PhenoGen Arhgap1 PhenoGen
PROSITE CRAL_TRIO UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/TrEMBL
  SEC14 UniProtKB/TrEMBL
Superfamily-SCOP CRAL_TRIO_C UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
UniProt A0A0G2JYR5_RAT UniProtKB/TrEMBL
  A0A8I6A7T6_RAT UniProtKB/TrEMBL
  D4A6C5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Arhgap1  Rho GTPase activating protein 1   Arhgap1_predicted  Rho GTPase activating protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arhgap1_predicted  Rho GTPase activating protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED