(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1315706 6480464 epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TRAF6 protein] CTD PMID:27890776 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1315707 6480464 epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TRAF6 protein] CTD PMID:27890776 1,2-dichloroethane increases expression ISO RGD:1315707 6480464 ethylene dichloride results in increased expression of TRAF6 mRNA CTD PMID:28960355 17beta-estradiol increases expression ISO RGD:1315706 6480464 Estradiol results in increased expression of TRAF6 mRNA CTD PMID:16202921 17beta-estradiol multiple interactions EXP 6480464 1 more ... CTD PMID:29625166 17beta-estradiol multiple interactions ISO RGD:1315706 6480464 [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [AR protein binds to TRAF6 protein], [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [ESR1 protein binds to TRAF6 protein] CTD PMID:29625166 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1315707 6480464 Tetrachlorodibenzodioxin results in increased expression of TRAF6 mRNA CTD PMID:12167310 , PMID:15310856 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of TRAF6 mRNA CTD PMID:21346803 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO RGD:1315707 6480464 [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein], Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]] CTD PMID:28213090 2-amino-2-deoxy-D-glucopyranose multiple interactions ISO RGD:1315706 6480464 Glucosamine analog inhibits the reaction [TNF results in increased expression of TRAF6 mRNA], Glucosamine inhibits the reaction [TNF results in increased expression of TRAF6 mRNA] CTD PMID:18173918 3-phenylprop-2-enal multiple interactions ISO RGD:1315707 6480464 cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA] CTD PMID:18306459 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1315707 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of TRAF6 mRNA CTD PMID:18648102 acetylsalicylic acid increases expression ISO RGD:1315706 6480464 Aspirin results in increased expression of TRAF6 mRNA CTD PMID:11906190 aldehydo-D-glucosamine multiple interactions ISO RGD:1315706 6480464 Glucosamine analog inhibits the reaction [TNF results in increased expression of TRAF6 mRNA], Glucosamine inhibits the reaction [TNF results in increased expression of TRAF6 mRNA] CTD PMID:18173918 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1315707 6480464 [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA, crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA] CTD PMID:30580027 arsane decreases expression ISO RGD:1315707 6480464 Arsenic results in decreased expression of TRAF6 mRNA, Arsenic results in decreased expression of TRAF6 protein CTD PMID:19654921 arsenic atom decreases expression ISO RGD:1315707 6480464 Arsenic results in decreased expression of TRAF6 mRNA, Arsenic results in decreased expression of TRAF6 protein CTD PMID:19654921 arsenous acid increases expression ISO RGD:1315706 6480464 Arsenic Trioxide results in increased expression of TRAF6 mRNA CTD PMID:17530438 atorvastatin calcium multiple interactions ISO RGD:1315706 6480464 [Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA, [Atorvastatin co-treated with Telmisartan] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 benzo[a]pyrene increases expression ISO RGD:1315707 6480464 Benzo(a)pyrene results in increased expression of TRAF6 mRNA CTD PMID:22228805 benzo[a]pyrene increases expression ISO RGD:1315706 6480464 Benzo(a)pyrene results in increased expression of TRAF6 protein CTD PMID:25596431 beta-D-glucosamine multiple interactions ISO RGD:1315706 6480464 Glucosamine analog inhibits the reaction [TNF results in increased expression of TRAF6 mRNA], Glucosamine inhibits the reaction [TNF results in increased expression of TRAF6 mRNA] CTD PMID:18173918 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TRAF6 mRNA CTD PMID:25181051 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of TRAF6 mRNA CTD PMID:19167457 cadmium dichloride multiple interactions ISO RGD:1315707 6480464 [Cadmium Chloride co-treated with TNFSF11] results in increased expression of TRAF6 mRNA CTD PMID:21723911 cadmium selenide multiple interactions ISO RGD:1315706 6480464 [cadmium selenide co-treated with zinc sulfide] results in increased expression of TRAF6 mRNA CTD PMID:22342292 camptothecin decreases response to substance ISO RGD:1315706 6480464 TRAF6 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 clofibrate decreases expression ISO RGD:1315707 6480464 Clofibrate results in decreased expression of TRAF6 mRNA CTD PMID:17585979 clothianidin decreases expression ISO RGD:1315706 6480464 clothianidin results in decreased expression of TRAF6 mRNA CTD PMID:29044138 copper atom decreases expression ISO RGD:1315706 6480464 Copper results in decreased expression of TRAF6 protein CTD PMID:22692975 copper(0) decreases expression ISO RGD:1315706 6480464 Copper results in decreased expression of TRAF6 protein CTD PMID:22692975 corticosterone multiple interactions EXP 6480464 1 more ... CTD PMID:29625166 corticosterone multiple interactions ISO RGD:1315706 6480464 [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [AR protein binds to TRAF6 protein], [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [ESR1 protein binds to TRAF6 protein] CTD PMID:29625166 crocin-1 multiple interactions ISO RGD:1315707 6480464 crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA] CTD PMID:30580027 curcumin increases expression ISO RGD:1315706 6480464 Curcumin results in increased expression of TRAF6 mRNA CTD PMID:16101141 cyclosporin A increases expression ISO RGD:1315706 6480464 Cyclosporine results in increased expression of TRAF6 mRNA CTD PMID:25562108 DAPT multiple interactions ISO RGD:1315707 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 protein] CTD PMID:24223152 DAPT multiple interactions EXP 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 mRNA] CTD PMID:24223152 deoxynivalenol increases expression ISO RGD:1315706 6480464 deoxynivalenol results in increased expression of TRAF6 mRNA CTD PMID:22846391 dexamethasone decreases expression ISO RGD:1315707 6480464 Dexamethasone results in decreased expression of TRAF6 mRNA CTD PMID:21041162 diarsenic trioxide increases expression ISO RGD:1315706 6480464 Arsenic Trioxide results in increased expression of TRAF6 mRNA CTD PMID:17530438 diethylstilbestrol decreases expression ISO RGD:1315707 6480464 Diethylstilbestrol results in decreased expression of TRAF6 mRNA CTD PMID:21041162 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of TRAF6 mRNA CTD PMID:24223152 dioxygen multiple interactions EXP 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 mRNA] CTD PMID:24223152 dioxygen multiple interactions ISO RGD:1315707 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 protein] CTD PMID:24223152 dioxygen increases expression ISO RGD:1315707 6480464 Oxygen deficiency results in increased expression of TRAF6 protein CTD PMID:24223152 doxorubicin decreases expression ISO RGD:1315706 6480464 Doxorubicin results in decreased expression of TRAF6 mRNA CTD PMID:29803840 enalapril multiple interactions ISO RGD:1315706 6480464 [Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 erlotinib hydrochloride multiple interactions ISO RGD:1315706 6480464 [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of TRAF6 mRNA CTD PMID:27738319 ethanol multiple interactions ISO RGD:1315707 6480464 Fructose inhibits the reaction [Ethanol results in increased expression of TRAF6 protein], Fructose promotes the reaction [Ethanol results in increased expression of TRAF6 mRNA] CTD PMID:26858005 ethanol affects splicing ISO RGD:1315707 6480464 Ethanol affects the splicing of TRAF6 mRNA CTD PMID:30319688 ethanol increases expression EXP 6480464 Ethanol results in increased expression of TRAF6 mRNA CTD PMID:28852734 ethanol multiple interactions EXP 6480464 platycodin D inhibits the reaction [Ethanol results in increased expression of TRAF6 mRNA] CTD PMID:28852734 ethanol increases expression ISO RGD:1315707 6480464 Ethanol results in increased expression of TRAF6 mRNA, Ethanol results in increased expression of TRAF6 protein CTD PMID:26858005 flutamide multiple interactions EXP 6480464 Flutamide inhibits the reaction [Estradiol inhibits the reaction [Corticosterone results in increased expression of TRAF6 protein]] CTD PMID:29625166 folic acid affects expression ISO RGD:1315706 6480464 Folic Acid affects the expression of TRAF6 mRNA CTD PMID:16361273 formaldehyde decreases expression ISO RGD:1315706 6480464 Formaldehyde results in decreased expression of TRAF6 mRNA CTD PMID:20655997 fructose multiple interactions ISO RGD:1315707 6480464 Fructose inhibits the reaction [Ethanol results in increased expression of TRAF6 protein], Fructose promotes the reaction [Ethanol results in increased expression of TRAF6 mRNA] CTD PMID:26858005 furosemide affects expression EXP 6480464 Furosemide affects the expression of TRAF6 mRNA CTD PMID:17497460 Fusarenone X increases expression ISO RGD:1315707 6480464 fusarenon-X results in increased expression of TRAF6 mRNA CTD PMID:24983900 Fusaric acid decreases expression ISO RGD:1315706 6480464 Fusaric Acid results in decreased expression of TRAF6 protein CTD PMID:30582969 glycyrrhetinate multiple interactions ISO RGD:1315707 6480464 Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]] CTD PMID:28213090 glycyrrhetinic acid multiple interactions ISO RGD:1315707 6480464 Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]] CTD PMID:28213090 hydrogen peroxide multiple interactions ISO RGD:1315706 6480464 Hydrogen Peroxide promotes the reaction [TRAF6 protein binds to [IL1R1 protein binds to MYD88 protein]] CTD PMID:16354686 hydroxychloroquine increases expression ISO RGD:1315707 6480464 Hydroxychloroquine results in increased expression of TRAF6 mRNA CTD PMID:25321315 kaempferol multiple interactions ISO RGD:1315706 6480464 kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of TRAF6 protein] CTD PMID:30769083 lactulose multiple interactions EXP 6480464 Lactulose inhibits the reaction [Methamphetamine results in increased expression of TRAF6 protein] CTD PMID:30450033 lipoarabinomannan multiple interactions ISO RGD:1315707 6480464 lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein] CTD PMID:16263713 lipopolysaccharide affects ubiquitination ISO RGD:1315706 6480464 Lipopolysaccharides affects the ubiquitination of TRAF6 protein CTD PMID:21127049 lipopolysaccharide multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with Titanium] affects the expression of TRAF6 mRNA CTD PMID:21308757 lipopolysaccharide increases expression ISO RGD:1315707 6480464 Lipopolysaccharides results in increased expression of TRAF6 mRNA, Lipopolysaccharides results in increased expression of TRAF6 protein CTD PMID:18306459 , PMID:22925919 lipopolysaccharide multiple interactions ISO RGD:1315707 6480464 cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA] more ... CTD PMID:18306459 , PMID:22925919 lipopolysaccharide multiple interactions ISO RGD:1315706 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of TRAF6 mRNA more ... CTD PMID:21127049 , PMID:31059760 maneb multiple interactions ISO RGD:1315707 6480464 [Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA, Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA] CTD PMID:23963992 mangiferin decreases expression ISO RGD:1315707 6480464 mangiferin results in decreased expression of TRAF6 mRNA CTD PMID:15135318 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of TRAF6 protein CTD PMID:30450033 methamphetamine multiple interactions EXP 6480464 Lactulose inhibits the reaction [Methamphetamine results in increased expression of TRAF6 protein] CTD PMID:30450033 methylglyoxal multiple interactions ISO RGD:1315707 6480464 [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TRAF6 mRNA CTD PMID:30217477 methylmercury chloride decreases expression ISO RGD:1315706 6480464 methylmercuric chloride results in decreased expression of TRAF6 mRNA CTD PMID:28001369 nickel dichloride increases expression ISO RGD:1315706 6480464 nickel chloride results in increased expression of TRAF6 protein CTD PMID:21473897 Niclosamide multiple interactions ISO RGD:1315707 6480464 Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein] CTD PMID:28824321 Nonylphenol increases expression EXP 6480464 nonylphenol results in increased expression of TRAF6 protein CTD PMID:30481583 ochratoxin A decreases expression ISO RGD:1315706 6480464 ochratoxin A results in decreased expression of TRAF6 mRNA CTD PMID:30763683 p-menthan-3-ol decreases expression ISO RGD:1315706 6480464 Menthol results in decreased expression of TRAF6 mRNA CTD PMID:26760959 paracetamol affects expression ISO RGD:1315707 6480464 Acetaminophen affects the expression of TRAF6 mRNA CTD PMID:17562736 paracetamol multiple interactions ISO RGD:1315706 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of TRAF6 mRNA CTD PMID:31059760 paraquat multiple interactions ISO RGD:1315707 6480464 [Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA more ... CTD PMID:23963992 , PMID:27890776 paraquat increases expression ISO RGD:1315707 6480464 Paraquat results in increased expression of TRAF6 protein CTD PMID:27890776 paraquat increases expression ISO RGD:1315706 6480464 Paraquat results in increased expression of TRAF6 protein CTD PMID:27890776 paraquat multiple interactions ISO RGD:1315706 6480464 epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TRAF6 protein] CTD PMID:27890776 pentachlorophenol increases expression ISO RGD:1315707 6480464 Pentachlorophenol results in increased expression of TRAF6 mRNA CTD PMID:23892564 pirinixic acid multiple interactions ISO RGD:1315706 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TRAF6 mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:1315707 6480464 pirinixic acid results in decreased expression of TRAF6 mRNA CTD PMID:17950772 pirinixic acid multiple interactions ISO RGD:1315707 6480464 PPARA protein promotes the reaction [pirinixic acid results in decreased expression of TRAF6 mRNA] CTD PMID:17950772 platycodin D multiple interactions EXP 6480464 platycodin D inhibits the reaction [Ethanol results in increased expression of TRAF6 mRNA] CTD PMID:28852734 platycodin D decreases expression EXP 6480464 platycodin D results in decreased expression of TRAF6 mRNA CTD PMID:28852734 poly(I:C) multiple interactions ISO RGD:1315706 6480464 TRAF6 mutant form inhibits the reaction [Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]] CTD PMID:16399790 potassium dichromate increases expression ISO RGD:1315706 6480464 Potassium Dichromate results in increased expression of TRAF6 protein CTD PMID:23718831 progesterone increases expression ISO RGD:1315707 6480464 Progesterone results in increased expression of TRAF6 mRNA CTD PMID:21549006 progesterone increases expression EXP 6480464 Progesterone results in increased expression of TRAF6 mRNA CTD PMID:21770760 quercetin increases expression ISO RGD:1315706 6480464 Quercetin results in increased expression of TRAF6 mRNA CTD PMID:30152185 resveratrol multiple interactions ISO RGD:1315707 6480464 resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA] more ... CTD PMID:22925919 silver atom increases expression ISO RGD:1315706 6480464 Silver results in increased expression of TRAF6 mRNA CTD PMID:22342292 silver(0) increases expression ISO RGD:1315706 6480464 Silver results in increased expression of TRAF6 mRNA CTD PMID:22342292 sodium arsenite decreases expression ISO RGD:1315707 6480464 sodium arsenite results in decreased expression of TRAF6 mRNA CTD PMID:31233874 telmisartan multiple interactions ISO RGD:1315706 6480464 [Atorvastatin co-treated with Telmisartan] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 testosterone multiple interactions EXP 6480464 Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in increased ubiquitination of TRAF6 protein]] more ... CTD PMID:29625166 testosterone multiple interactions ISO RGD:1315706 6480464 [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [AR protein binds to TRAF6 protein], [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [ESR1 protein binds to TRAF6 protein] CTD PMID:29625166 titanium atom multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with Titanium] affects the expression of TRAF6 mRNA CTD PMID:21308757 titanium dioxide decreases expression ISO RGD:1315706 6480464 titanium dioxide results in decreased expression of TRAF6 mRNA CTD PMID:22342292 titanium dioxide increases expression ISO RGD:1315707 6480464 titanium dioxide analog results in increased expression of TRAF6 mRNA, titanium dioxide analog results in increased expression of TRAF6 protein CTD PMID:25111187 urethane increases expression ISO RGD:1315706 6480464 Urethane results in increased expression of TRAF6 mRNA CTD PMID:28818685 xanthohumol multiple interactions ISO RGD:1315707 6480464 xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA] CTD PMID:23994090 zinc atom increases expression ISO RGD:1315706 6480464 Zinc results in increased expression of TRAF6 mRNA CTD PMID:19071009 zinc oxide multiple interactions ISO RGD:1315707 6480464 [Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TRAF6 protein, Zinc Oxide affects the splicing of and results in increased expression of TRAF6 mRNA CTD PMID:25127755 , PMID:30500950 zinc protoporphyrin multiple interactions EXP 6480464 zinc protoporphyrin promotes the reaction [TRAF6 protein binds to MYD88 protein] CTD PMID:25780291 zinc(0) increases expression ISO RGD:1315706 6480464 Zinc results in increased expression of TRAF6 mRNA CTD PMID:19071009
Biological Process activation of NF-kappaB-inducing kinase activity ISO RGD:1315706 1624291 (PMID:15125833) RGD PMID:15125833 activation of protein kinase activity ISO RGD:1315706 1624291 (PMID:17135271) RGD PMID:17135271 animal organ morphogenesis ISO RGD:1315707 1624291 MGI:MGI:2675469 (MGI:MGI:3575245 , PMID:15705807) RGD MGI:MGI:3575245 , PMID:15705807 antigen processing and presentation of exogenous peptide antigen via MHC class II ISO RGD:1315707 1624291 MGI:MGI:2678775 (MGI:MGI:2677080 , PMID:14499111) RGD MGI:MGI:2677080 , PMID:14499111 bone remodeling ISO RGD:1315707 1624291 (MGI:MGI:2181820, PMID:10421844) RGD MGI:MGI:2181820 , PMID:10421844 bone resorption ISO RGD:1315707 1624291 (MGI:MGI:1335941, PMID:10215628) RGD MGI:MGI:1335941 , PMID:10215628 cell development ISO RGD:1315707 1624291 MGI:MGI:2675469 (MGI:MGI:3575245 , PMID:15705807) RGD MGI:MGI:3575245 , PMID:15705807 cellular response to cytokine stimulus ISO RGD:1315706 1624291 (PMID:25515214) RGD PMID:25515214 cellular response to DNA damage stimulus IEA UniProtKB-KW:KW-0227 1600115 GO_REF:0000043 UniProt GO_REF:0000043 cellular response to lipopolysaccharide ISO RGD:1315706 1624291 (PMID:23776175) RGD PMID:23776175 cytokine-mediated signaling pathway IMP 1579817 RGD I-kappaB kinase/NF-kappaB signaling ISO RGD:1315707 1624291 (MGI:MGI:4442152, PMID:17633018) RGD MGI:MGI:4442152 , PMID:17633018 immune response ISO RGD:1315707 1624291 MGI:MGI:2675469 (MGI:MGI:3575245 , PMID:15705807) RGD MGI:MGI:3575245 , PMID:15705807 in utero embryonic development ISO RGD:1315707 1624291 MGI:MGI:4840586 (MGI:MGI:5888818 , PMID:27996060) RGD MGI:MGI:5888818 , PMID:27996060 interleukin-1-mediated signaling pathway IMP 5130945 RGD interleukin-1-mediated signaling pathway ISO RGD:1315707 1624291 (MGI:MGI:2181820, PMID:10421844) RGD MGI:MGI:2181820 , PMID:10421844 interleukin-1-mediated signaling pathway IBA MGI:MGI:108072 more ... 13792537 PMID:21873635 GO_Central JNK cascade IMP 1579817 RGD myeloid dendritic cell differentiation ISO RGD:1315707 1624291 MGI:MGI:2678775 (MGI:MGI:2677080 , PMID:14499111) RGD MGI:MGI:2677080 , PMID:14499111 negative regulation of transcription by RNA polymerase II ISO RGD:1315706 1624291 (PMID:18093978) RGD PMID:18093978 negative regulation of transcription, DNA-templated ISO RGD:1315706 1624291 (PMID:18093978) RGD PMID:18093978 neural tube closure ISO RGD:1315707 1624291 (MGI:MGI:2181331, PMID:11007897) RGD MGI:MGI:2181331 , PMID:11007897 odontogenesis of dentin-containing tooth ISO RGD:1315707 1624291 MGI:MGI:2675469 (MGI:MGI:2684502 , PMID:14699584) RGD MGI:MGI:2684502 , PMID:14699584 ossification ISO RGD:1315707 1624291 MGI:MGI:1859953 (MGI:MGI:1335941 , PMID:10215628) RGD MGI:MGI:1335941 , PMID:10215628 osteoclast differentiation ISO RGD:1315707 1624291 (MGI:MGI:2181820, PMID:10421844) RGD MGI:MGI:2181820 , PMID:10421844 positive regulation of DNA-binding transcription factor activity ISO RGD:1315706 1624291 (PMID:12296995) RGD PMID:12296995 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1315706 1624291 (PMID:17135271) RGD PMID:17135271 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS UniProtKB:P70196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1315707 1624291 MGI:MGI:2444070 (MGI:MGI:3054342 more ... RGD MGI:MGI:3054342 more ... positive regulation of interleukin-12 biosynthetic process ISO RGD:1315707 1624291 MGI:MGI:2678775 (MGI:MGI:2677080 , PMID:14499111) RGD MGI:MGI:2677080 , PMID:14499111 positive regulation of interleukin-2 production ISO RGD:1315706 1624291 (PMID:15125833) RGD PMID:15125833 positive regulation of interleukin-6 biosynthetic process ISO RGD:1315707 1624291 MGI:MGI:2678775 (MGI:MGI:2677080 , PMID:14499111) RGD MGI:MGI:2677080 , PMID:14499111 positive regulation of JNK cascade IBA FB:FBgn0026319 more ... 13792537 PMID:21873635 GO_Central positive regulation of JUN kinase activity ISO RGD:1315706 1624291 (PMID:11751921) RGD PMID:11751921 positive regulation of leukocyte adhesion to vascular endothelial cell ISO RGD:1315706 1624291 (PMID:25515214) RGD PMID:25515214 positive regulation of lipopolysaccharide-mediated signaling pathway ISO RGD:1315707 1624291 (MGI:MGI:1335941, PMID:10215628) RGD MGI:MGI:1335941 , PMID:10215628 positive regulation of NF-kappaB transcription factor activity ISO RGD:1315706 1624291 (PMID:11279055), (PMID:11751921), (PMID:12296995), (PMID:16378096) RGD PMID:11279055 more ... positive regulation of NF-kappaB transcription factor activity ISS UniProtKB:P70196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of NF-kappaB transcription factor activity ISO RGD:1315707 1624291 (MGI:MGI:5499721, PMID:20345905) RGD MGI:MGI:5499721 , PMID:20345905 positive regulation of NIK/NF-kappaB signaling ISO RGD:1315706 1624291 (PMID:25515214) RGD PMID:25515214 positive regulation of osteoclast differentiation ISO RGD:1315706 1624291 (PMID:17135271) RGD PMID:17135271 positive regulation of smooth muscle cell proliferation IMP 1579817 RGD positive regulation of T cell cytokine production ISO RGD:1315706 1624291 (PMID:15125833) RGD PMID:15125833 positive regulation of T cell proliferation ISO RGD:1315707 1624291 (MGI:MGI:2181820, PMID:10421844) RGD MGI:MGI:2181820 , PMID:10421844 positive regulation of transcription by RNA polymerase II ISO RGD:1315706 1624291 (PMID:11751921) RGD PMID:11751921 positive regulation of transcription regulatory region DNA binding ISO RGD:1315706 1624291 (PMID:11751921) RGD PMID:11751921 protein autoubiquitination ISO RGD:1315706 1624291 (PMID:17135271), (PMID:18093978), (PMID:23776175) RGD PMID:17135271 more ... protein K63-linked ubiquitination ISO RGD:1315706 1624291 UniProtKB:P0CG47 (PMID:17135271), (PMID:19675569), (PMID:19713527), (PMID:21068390) RGD PMID:17135271 more ... protein K63-linked ubiquitination IBA MGI:MGI:108072 more ... 13792537 PMID:21873635 GO_Central protein K63-linked ubiquitination ISS UniProtKB:P70196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein K63-linked ubiquitination ISO RGD:1315707 1624291 (MGI:MGI:3610521, PMID:16252010) RGD MGI:MGI:3610521 , PMID:16252010 protein polyubiquitination ISO RGD:1315706 1624291 (PMID:15125833), (PMID:19675569) RGD PMID:15125833 , PMID:19675569 protein ubiquitination ISO RGD:1315707 1624291 MGI:MGI:97072 (MGI:MGI:5306181 more ... RGD MGI:MGI:5306181 more ... regulation of apoptotic process IEA InterPro:IPR012227 1600115 GO_REF:0000002 InterPro GO_REF:0000002 regulation of I-kappaB kinase/NF-kappaB signaling IBA FB:FBgn0265464 more ... 13792537 PMID:21873635 GO_Central regulation of immunoglobulin secretion ISO RGD:1315707 1624291 (MGI:MGI:2680840, PMID:12958312) RGD MGI:MGI:2680840 , PMID:12958312 response to interleukin-1 ISO RGD:1315706 1624291 (PMID:17135271) RGD PMID:17135271 signal transduction ISO RGD:1315707 1624291 (MGI:MGI:2680840, PMID:12958312) RGD MGI:MGI:2680840 , PMID:12958312 T cell receptor signaling pathway ISO RGD:1315706 1624291 (PMID:15125833) RGD PMID:15125833 T-helper 1 type immune response ISO RGD:1315707 1624291 MGI:MGI:2678775 (MGI:MGI:2677080 , PMID:14499111) RGD MGI:MGI:2677080 , PMID:14499111 tumor necrosis factor-mediated signaling pathway IBA MGI:MGI:108041 more ... 13792537 PMID:21873635 GO_Central Cellular Component CD40 receptor complex ISO RGD:1315707 1624291 (MGI:MGI:4462284, PMID:20614026) RGD MGI:MGI:4462284 , PMID:20614026 cell cortex IEA UniProtKB-SubCell:SL-0138 1600115 GO_REF:0000044 UniProt GO_REF:0000044 cytoplasm ISO RGD:1315706 1624291 (PMID:16378096), (PMID:18093978) RGD PMID:16378096 , PMID:18093978 cytoplasmic side of plasma membrane ISO RGD:1315707 1624291 (MGI:MGI:4462284, PMID:20614026) RGD MGI:MGI:4462284 , PMID:20614026 cytosol ISO RGD:1315707 1624291 (MGI:MGI:3694380, PMID:16831874) RGD MGI:MGI:3694380 , PMID:16831874 lipid droplet ISO RGD:1315707 1624291 (MGI:MGI:4943343, PMID:21435586) RGD MGI:MGI:4943343 , PMID:21435586 lipid droplet ISS UniProtKB:P70196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleus ISO RGD:1315706 1624291 (PMID:18093978) RGD PMID:18093978 perinuclear region of cytoplasm ISO RGD:1315706 1624291 (PMID:11751921) RGD PMID:11751921 plasma membrane ISO RGD:1315706 1624291 (PMID:18093978) RGD PMID:18093978 protein-containing complex IDA 5130945 RGD protein-containing complex ISO RGD:1315706 1624291 (PMID:23776175) RGD PMID:23776175 Molecular Function histone deacetylase binding ISO RGD:1315706 1624291 UniProtKB:Q13547 (PMID:18093978) RGD PMID:18093978 identical protein binding ISO RGD:1315706 1624291 UniProtKB:Q9Y4K3 (PMID:19465916), (PMID:21988832), (PMID:22493164), (PMID:25416956), (PMID:27107012) RGD PMID:19465916 more ... mitogen-activated protein kinase kinase kinase binding ISO RGD:1315706 1624291 UniProtKB:O43318 (PMID:10094049) RGD PMID:10094049 protein binding ISO RGD:1315707 1624291 PR:Q5DU56 more ... RGD MGI:MGI:1334074 more ... protein binding ISO RGD:1315706 1624291 UniProtKB:O00463 more ... RGD PMID:10094049 more ... protein kinase B binding ISO RGD:1315706 1624291 UniProtKB:Q9Y243 (PMID:19713527) RGD PMID:19713527 protein kinase binding ISO RGD:1315706 1624291 UniProtKB:P31749 , UniProtKB:P31751 (PMID:19713527) RGD PMID:19713527 protein N-terminus binding ISO RGD:1315706 1624291 UniProtKB:Q8IUC6 (PMID:14530355) RGD PMID:14530355 thioesterase binding ISO RGD:1315706 1624291 UniProtKB:Q93009 (PMID:11279055) RGD PMID:11279055 tumor necrosis factor receptor binding IBA PANTHER:PTN000805706 , UniProtKB:Q9Y4K3 13792537 PMID:21873635 GO_Central tumor necrosis factor receptor binding ISO RGD:1315706 1624291 UniProtKB:Q9NP84 (PMID:11728344) RGD PMID:11728344 ubiquitin conjugating enzyme binding ISO RGD:1315706 1624291 (PMID:23776175) RGD PMID:23776175 ubiquitin protein ligase activity ISO RGD:1315707 1624291 (MGI:MGI:3610521 more ... RGD MGI:MGI:3610521 more ... ubiquitin protein ligase activity ISO RGD:1315706 1624291 (PMID:15125833), (PMID:17135271), (PMID:19713527) RGD PMID:15125833 more ... ubiquitin protein ligase binding ISO RGD:1315706 1624291 UniProtKB:O94972 (PMID:11279055) RGD PMID:11279055 ubiquitin-protein transferase activity ISO RGD:1315707 1624291 (MGI:MGI:3610521, PMID:16252010) RGD MGI:MGI:3610521 , PMID:16252010 ubiquitin-protein transferase activity ISO RGD:1315706 1624291 (PMID:15361868), (PMID:17135271) RGD PMID:15361868 , PMID:17135271 ubiquitin-protein transferase activity IBA MGI:MGI:108072 more ... 13792537 PMID:21873635 GO_Central ubiquitin-protein transferase activity ISS UniProtKB:P70196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 zinc ion binding IEA InterPro:IPR001293 , InterPro:IPR012227 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Gene-Chemical Interaction Annotations
