Predicted to have several functions, including enzyme binding activity; tumor necrosis factor receptor binding activity; and ubiquitin protein ligase activity. Involved in JNK cascade; interleukin-1-mediated signaling pathway; and positive regulation of smooth muscle cell proliferation. Localizes to protein-containing complex. Orthologous to human TRAF6 (TNF receptor associated factor 6); PARTICIPATES IN interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; p38 MAPK signaling pathway; INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; bisphenol A.
[Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [AR protein binds to TRAF6 protein], [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [ESR1 protein binds to TRAF6 protein]
Glucosamine analog inhibits the reaction [TNF results in increased expression of TRAF6 mRNA], Glucosamine inhibits the reaction [TNF results in increased expression of TRAF6 mRNA]
Glucosamine analog inhibits the reaction [TNF results in increased expression of TRAF6 mRNA], Glucosamine inhibits the reaction [TNF results in increased expression of TRAF6 mRNA]
[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA, crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]
[Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA, [Atorvastatin co-treated with Telmisartan] results in decreased expression of TRAF6 mRNA
Glucosamine analog inhibits the reaction [TNF results in increased expression of TRAF6 mRNA], Glucosamine inhibits the reaction [TNF results in increased expression of TRAF6 mRNA]
[Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [AR protein binds to TRAF6 protein], [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [ESR1 protein binds to TRAF6 protein]
Erianin inhibits the reaction [Dextran Sulfate results in increased expression of TRAF6 protein], Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TRAF6 protein]
Fructose inhibits the reaction [Ethanol results in increased expression of TRAF6 protein], Fructose promotes the reaction [Ethanol results in increased expression of TRAF6 mRNA]
Fructose inhibits the reaction [Ethanol results in increased expression of TRAF6 protein], Fructose promotes the reaction [Ethanol results in increased expression of TRAF6 mRNA]
Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]]
Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]]
[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA, Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA]
[Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [AR protein binds to TRAF6 protein], [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [ESR1 protein binds to TRAF6 protein]
[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TRAF6 protein, Zinc Oxide affects the splicing of and results in increased expression of TRAF6 mRNA
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin