Enables channel activity; leucine zipper domain binding activity; and sodium ion binding activity. Involved in several processes, including cellular response to hypoxia; neuronal action potential; and sodium ion transmembrane transport. Located in axon initial segment; node of Ranvier; and plasma membrane. Is intrinsic component of plasma membrane. Part of voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy; developmental and epileptic encephalopathy 11; and episodic ataxia. Orthologous to human SCN2A (sodium voltage-gated channel alpha subunit 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl.
alternative product; NachII; Nav1.2; RII/RIIA; RIIA sodium channel protein; RNSCPIIR; SCN; Scn2a1; Scn2a2; ScpII; sodium channel protein brain II subunit alpha; sodium channel protein type 2 subunit alpha; sodium channel protein type II subunit alpha; sodium channel protein, brain II subunit alpha; Sodium channel voltage-gated type II alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type II, alpha 1; Sodium channel, voltage-gated, type II, alpha polypeptide; sodium channel, voltage-gated, type II, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.2
[BDNF protein co-treated with GDNF protein co-treated with Cyclic AMP co-treated with TGFB3 protein co-treated with Ascorbic Acid] results in increased expression of SCN2A mRNA
[[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of SCN2A mRNA, [[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of SCN2A mRNA
cypermethrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium], SCN1B protein promotes the reaction [cypermethrin binds to SCN2A protein]
[[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of SCN2A mRNA, [BDNF protein co-treated with GDNF protein co-treated with Cyclic AMP co-treated with TGFB3 protein co-treated with Ascorbic Acid] results in increased expression of SCN2A mRNA
[[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of SCN2A mRNA
[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN2A mRNA
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN2A mRNA
[[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of SCN2A mRNA, [[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of SCN2A mRNA