Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Scn2a (sodium voltage-gated channel alpha subunit 2) Rattus norvegicus
Analyze
Symbol: Scn2a
Name: sodium voltage-gated channel alpha subunit 2
Description: Exhibits channel activity; leucine zipper domain binding activity; and sodium ion binding activity. Involved in several processes, including cellular response to hypoxia; myelination; and neuronal action potential. Localizes to axon initial segment; node of Ranvier; and voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and early infantile epileptic encephalopathy 11. Orthologous to human SCN2A (sodium voltage-gated channel alpha subunit 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: alternative product; NachII; Nav1.2; RII/RIIA; RIIA sodium channel protein; RNSCPIIR; SCN; Scn2a1; Scn2a2; ScpII; sodium channel protein brain II subunit alpha; sodium channel protein type 2 subunit alpha; sodium channel protein type II subunit alpha; sodium channel protein, brain II subunit alpha; Sodium channel voltage-gated type II alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type II, alpha 1; Sodium channel, voltage-gated, type II, alpha polypeptide; sodium channel, voltage-gated, type II, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.2
Orthologs:
Homo sapiens (human) : SCN2A (sodium voltage-gated channel alpha subunit 2)  HGNC  Alliance
Mus musculus (house mouse) : Scn2a (sodium channel, voltage-gated, type II, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scn2a (sodium voltage-gated channel alpha subunit 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SCN2A (sodium voltage-gated channel alpha subunit 2)
Canis lupus familiaris (dog) : SCN2A (sodium voltage-gated channel alpha subunit 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scn2a (sodium voltage-gated channel alpha subunit 2)
Sus scrofa (pig) : LOC100515171 (sodium channel protein type 2 subunit alpha)
Chlorocebus sabaeus (African green monkey) : SCN2A (sodium voltage-gated channel alpha subunit 2)
more info ...
Allele / Splice: Scn2aem1Mcwi   Scn2aem2Mcwi  
Genetic Models: LE-Scn2aem2Mcwi LE-Scn2aem1Mcwi
Is Marker For: QTLs:   BpQTLcluster4   Tsu1   Hrtrt17  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0351,687,910 - 51,822,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl351,687,809 - 51,822,250 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0358,322,640 - 58,456,658 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4347,588,413 - 47,722,800 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1347,484,784 - 47,619,172 (+)NCBI
Celera349,896,043 - 50,030,402 (+)NCBICelera
Cytogenetic Map3q21NCBI
RH 3.4 Map3613.5RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Scn2a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3632
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.