Gene: Scn2a (sodium voltage-gated channel alpha subunit 2) Rattus norvegicus
Symbol: Scn2a
Name: sodium voltage-gated channel alpha subunit 2
Description: ENCODES a protein that exhibits leucine zipper domain binding; sodium ion binding; voltage-gated ion channel activity involved in regulation of presynaptic membrane potential; INVOLVED IN cellular response to hypoxia; myelination; neuronal action potential; ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant non-syndromic intellectual disability (ortholog); benign epilepsy with centrotemporal spikes (ortholog); FOUND IN axon initial segment; intrinsic component of plasma membrane; neuron projection; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl; 4,5,6,7-TETRABROMOBENZOTRIAZOLE
Type: protein-coding
Also known as: alternative product; NachII; Nav1.2; RII/RIIA; RIIA sodium channel protein; RNSCPIIR; SCN; Scn2a1; Scn2a2; ScpII; sodium channel protein brain II subunit alpha; sodium channel protein type 2 subunit alpha; sodium channel protein type II subunit alpha; sodium channel protein, brain II subunit alpha; Sodium channel voltage-gated type II alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type II, alpha 1; Sodium channel, voltage-gated, type II, alpha polypeptide; sodium channel, voltage-gated, type II, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.2
Is Marker For: QTLs:   BpQTLcluster4   Tsu1   Hrtrt17  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0351,687,910 - 51,822,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0358,322,640 - 58,456,658 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4347,588,413 - 47,722,800 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1347,484,784 - 47,619,172 (+)NCBI
Celera349,896,043 - 50,030,402 (+)NCBICelera
Cytogenetic Map3q21NCBI
RH 3.4 Map3613.5RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Scn2a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3632
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE