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Gene: Nr1h3 (nuclear receptor subfamily 1, group H, member 3) Rattus norvegicus
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Symbol: Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Description: Exhibits retinoid X receptor binding activity and sequence-specific DNA binding activity. Predicted to contribute to transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including bile acid signaling pathway; insulin receptor signaling pathway; and response to cholesterol. Localizes to cytoplasm and nucleus. Biomarker of non-alcoholic fatty liver disease; obesity; and premature menopause. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NR1H3 (nuclear receptor subfamily 1 group H member 3); PARTICIPATES IN bile acid signaling pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; hepatitis C pathway; INTERACTS WITH (+)-schisandrin B; (25R)-cholest-5-ene-3beta,26-diol; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: liver X receptor alpha; LXRalpha; nuclear orphan receptor LXR-alpha; nuclear receptor subfamily 1 group H member 3; oxysterols receptor LXR-alpha; RLD-1
Orthologs:
Homo sapiens (human) : NR1H3 (nuclear receptor subfamily 1 group H member 3)  HGNC  Alliance
Mus musculus (house mouse) : Nr1h3 (nuclear receptor subfamily 1, group H, member 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr1h3 (nuclear receptor subfamily 1 group H member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NR1H3 (nuclear receptor subfamily 1 group H member 3)
Canis lupus familiaris (dog) : NR1H3 (nuclear receptor subfamily 1 group H member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr1h3 (nuclear receptor subfamily 1 group H member 3)
Sus scrofa (pig) : NR1H3 (nuclear receptor subfamily 1 group H member 3)
Chlorocebus sabaeus (African green monkey) : NR1H3 (nuclear receptor subfamily 1 group H member 3)
Heterocephalus glaber (naked mole-rat) : Nr1h3 (nuclear receptor subfamily 1 group H member 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0380,004,130 - 80,014,197 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,004,130 - 80,012,750 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,712,883 - 86,722,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,542,211 - 75,550,793 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,438,551 - 75,447,172 (-)NCBI
Celera376,367,211 - 76,375,760 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nr1h3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61909
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.