Prkra (protein activator of interferon induced protein kinase EIF2AK2) - Rat Genome Database

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Gene: Prkra (protein activator of interferon induced protein kinase EIF2AK2) Rattus norvegicus
Analyze
Symbol: Prkra
Name: protein activator of interferon induced protein kinase EIF2AK2
RGD ID: 1306707
Description: Enables protein kinase binding activity. Involved in positive regulation of cell population proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RISC complex and RISC-loading complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in dystonia 16. Orthologous to human PRKRA (protein activator of interferon induced protein kinase EIF2AK2); PARTICIPATES IN ceramide signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interferon-inducible double stranded RNA-dependent protein kinase activator A; interferon-inducible double-stranded RNA-dependent protein kinase activator A; LOC311130; PKR associated protein X; protein activator of the interferon-induced protein kinase; protein kinase, interferon inducible double stranded RNA dependent activator; protein kinase, interferon-inducible double stranded RNA-dependent activator; protein kinase, interferon-inducible double-stranded RNA-dependent activator; RAX
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8381,982,669 - 82,002,028 (-)NCBIGRCr8
mRatBN7.2361,575,447 - 61,594,393 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl361,575,447 - 61,594,347 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx364,929,458 - 64,949,666 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0373,513,107 - 73,533,316 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0371,280,761 - 71,300,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0363,489,081 - 63,507,918 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl363,489,074 - 63,507,926 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0370,062,242 - 70,081,079 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4359,327,653 - 59,346,511 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1359,224,026 - 59,242,883 (-)NCBI
Celera361,061,241 - 61,080,098 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA)
perinuclear region of cytoplasm  (IEA)
RISC complex  (IBA,IEA)
RISC-loading complex  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. The double-stranded RNA-binding protein, PACT, is required for postnatal anterior pituitary proliferation. Peters GA, etal., Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10696-701. doi: 10.1073/pnas.0900735106. Epub 2009 Jun 17.
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Expression and cellular localization of microRNA-29b and RAX, an activator of the RNA-dependent protein kinase (PKR), in the retina of streptozotocin-induced diabetic rats. Silva VA, etal., Mol Vis. 2011;17:2228-40. Epub 2011 Aug 18.
11. Activation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neurons. Wang X, etal., J Neurochem. 2007 Dec;103(6):2380-90. Epub 2007 Oct 22.
12. Expression of microRNA machinery proteins in different types of chronic rhinosinusitis. Zhang YN, etal., Laryngoscope. 2012 Dec;122(12):2621-7. doi: 10.1002/lary.23517. Epub 2012 Sep 7.
Additional References at PubMed
PMID:10336432   PMID:12181197   PMID:12477932   PMID:15489334   PMID:16169070   PMID:16396499   PMID:16424907   PMID:16571658   PMID:17452327   PMID:19946888   PMID:21900206   PMID:22681889  
PMID:23661684   PMID:25416956   PMID:26234751   PMID:27987116   PMID:35421805  


Genomics

Comparative Map Data
Prkra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8381,982,669 - 82,002,028 (-)NCBIGRCr8
mRatBN7.2361,575,447 - 61,594,393 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl361,575,447 - 61,594,347 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx364,929,458 - 64,949,666 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0373,513,107 - 73,533,316 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0371,280,761 - 71,300,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0363,489,081 - 63,507,918 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl363,489,074 - 63,507,926 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0370,062,242 - 70,081,079 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4359,327,653 - 59,346,511 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1359,224,026 - 59,242,883 (-)NCBI
Celera361,061,241 - 61,080,098 (-)NCBICelera
Cytogenetic Map3q24NCBI
PRKRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382178,431,414 - 178,451,175 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2178,431,292 - 178,451,512 (-)EnsemblGRCh38hg38GRCh38
GRCh372179,296,141 - 179,315,902 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362179,004,395 - 179,024,110 (-)NCBINCBI36Build 36hg18NCBI36
Build 342179,121,656 - 179,141,371NCBI
Celera2172,899,027 - 172,918,844 (-)NCBICelera
Cytogenetic Map2q31.2NCBI
HuRef2171,166,825 - 171,186,642 (-)NCBIHuRef
CHM1_12179,302,152 - 179,321,965 (-)NCBICHM1_1
T2T-CHM13v2.02178,914,206 - 178,933,968 (-)NCBIT2T-CHM13v2.0
Prkra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39276,436,385 - 76,478,614 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl276,460,242 - 76,478,359 (-)EnsemblGRCm39 Ensembl
GRCm38276,609,215 - 76,648,220 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl276,629,898 - 76,648,015 (-)EnsemblGRCm38mm10GRCm38
MGSCv37276,467,994 - 76,486,051 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36276,430,776 - 76,448,833 (-)NCBIMGSCv36mm8
Celera278,291,609 - 78,309,670 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map245.07NCBI
Prkra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540318,373,375 - 18,410,627 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540318,394,609 - 18,410,381 (+)NCBIChiLan1.0ChiLan1.0
PRKRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21381,079,378 - 81,098,864 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B81,094,352 - 81,113,838 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B65,689,029 - 65,708,493 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B183,393,819 - 183,413,174 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B183,393,819 - 183,413,174 (-)Ensemblpanpan1.1panPan2
PRKRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13622,061,226 - 22,080,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3622,061,461 - 22,080,612 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3622,079,633 - 22,098,744 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03622,204,685 - 22,224,038 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13622,314,310 - 22,333,404 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03622,276,900 - 22,296,069 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03622,393,174 - 22,412,535 (-)NCBIUU_Cfam_GSD_1.0
Prkra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303139,099,289 - 139,115,053 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365097,653,047 - 7,668,896 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365097,653,192 - 7,668,925 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1584,133,687 - 84,156,508 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11584,134,273 - 84,156,596 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21593,668,054 - 93,690,407 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11063,982,784 - 64,003,919 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040135,571,753 - 135,592,072 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624844410,461 - 424,809 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624844410,461 - 424,833 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkra
148 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:53
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000015624
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 55 39 19 39 2 2 74 35 41 11 2
Low 2 2 2 2 6 9 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015624   ⟹   ENSRNOP00000015624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl361,575,447 - 61,594,347 (-)Ensembl
Rnor_6.0 Ensembl363,489,074 - 63,507,926 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118415   ⟹   ENSRNOP00000085624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl361,575,447 - 61,593,869 (-)Ensembl
RefSeq Acc Id: NM_001024780   ⟹   NP_001019951
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,982,669 - 82,001,525 (-)NCBI
mRatBN7.2361,575,447 - 61,594,303 (-)NCBI
Rnor_6.0363,489,081 - 63,507,918 (-)NCBI
Rnor_5.0370,062,242 - 70,081,079 (-)NCBI
RGSC_v3.4359,327,653 - 59,346,511 (-)RGD
Celera361,061,241 - 61,080,098 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104859   ⟹   XP_038960787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,982,669 - 82,001,427 (-)NCBI
mRatBN7.2361,575,447 - 61,594,393 (-)NCBI
RefSeq Acc Id: XM_063283635   ⟹   XP_063139705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8381,997,110 - 82,002,028 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001019951   ⟸   NM_001024780
- UniProtKB: Q4V8C7 (UniProtKB/Swiss-Prot),   A0A8I6A497 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015624   ⟸   ENSRNOT00000015624
RefSeq Acc Id: XP_038960787   ⟸   XM_039104859
- Peptide Label: isoform X1
- UniProtKB: A6HMH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085624   ⟸   ENSRNOT00000118415
RefSeq Acc Id: XP_063139705   ⟸   XM_063283635
- Peptide Label: isoform X2
Protein Domains
DRBM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8C7-F1-model_v2 AlphaFold Q4V8C7 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692159
Promoter ID:EPDNEW_R2684
Type:initiation region
Name:Prkra_1
Description:protein activator of interferon induced protein kinase EIF2AK2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0363,507,948 - 63,508,008EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306707 AgrOrtholog
BioCyc Gene G2FUF-49279 BioCyc
Ensembl Genes ENSRNOG00000011195 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015624 ENTREZGENE
  ENSRNOT00000015624.7 UniProtKB/TrEMBL
  ENSRNOT00000118415.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.160.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7456528 IMAGE-MGC_LOAD
InterPro dsRBD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRKRA_DSRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRKRA_DSRM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRKRA_DSRM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:311130 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114506 IMAGE-MGC_LOAD
NCBI Gene 311130 ENTREZGENE
PANTHER LOQUACIOUS, ISOFORM B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46205:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam dsrm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkra PhenoGen
PROSITE DS_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011195 RatGTEx
SMART DSRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A497 ENTREZGENE, UniProtKB/TrEMBL
  A6HMH8_RAT UniProtKB/TrEMBL
  A6HMH9 ENTREZGENE, UniProtKB/TrEMBL
  G3V7J2_RAT UniProtKB/TrEMBL
  PRKRA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Prkra  protein activator of interferon induced protein kinase EIF2AK2  Prkra  protein kinase, interferon inducible double stranded RNA dependent activator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Prkra  protein kinase, interferon inducible double stranded RNA dependent activator  Prkra_predicted  protein kinase, interferon inducible double stranded RNA dependent activator (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Prkra_predicted  protein kinase, interferon inducible double stranded RNA dependent activator (predicted)      Symbol and Name status set to approved 70820 APPROVED