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Gene: PRKRA (protein activator of interferon induced protein kinase EIF2AK2) Homo sapiens
Symbol: PRKRA
Name: protein activator of interferon induced protein kinase EIF2AK2
Description: Exhibits RNA binding activity; enzyme binding activity; and protein homodimerization activity. Involved in pre-miRNA processing; production of siRNA involved in RNA interference; and protein stabilization. Localizes to the RISC-loading complex; cytosol; and nucleoplasm. Implicated in dystonia 16.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DYT16; HSD14; interferon-inducible double stranded RNA-dependent protein kinase activator A; interferon-inducible double-stranded RNA-dependent protein kinase activator A; PACT; PKR-associated protein X; PKR-associating protein X; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double stranded RNA-dependent activator; protein kinase, interferon-inducible double-stranded RNA-dependent activator; RAX
Related Pseudogenes: PRKRAP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2178,431,414 - 178,451,512 (-)Ensembl
GRCh382178,431,414 - 178,451,175 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372179,296,141 - 179,315,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362179,004,395 - 179,024,110 (-)NCBINCBI36hg18NCBI36
Build 342179,121,656 - 179,141,371NCBI
Celera2172,899,027 - 172,918,844 (-)NCBI
Cytogenetic Map2q31.2NCBI
HuRef2171,166,825 - 171,186,642 (-)NCBIHuRef
CHM1_12179,302,152 - 179,321,974 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRKRA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315476
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.