Eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2) - Rat Genome Database

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Gene: Eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2) Rattus norvegicus
Symbol: Eif2ak2
Name: eukaryotic translation initiation factor 2-alpha kinase 2
RGD ID: 3402
Description: Predicted to enable double-stranded RNA binding activity; eukaryotic translation initiation factor 2alpha kinase activity; and identical protein binding activity. Involved in several processes, including response to exogenous dsRNA; response to lipopolysaccharide; and response to vitamin E. Located in nucleus. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; dystonia; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2); PARTICIPATES IN ceramide signaling pathway; platelet-derived growth factor signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
Previously known as: eIF-2A protein kinase 2; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible RNA-dependent protein kinase; Pkr; Prkr; protein kinase RNA-activated; Protein kinase, interferon-inducible double stranded RNA dependent; tyrosine-protein kinase EIF2AK2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2616,189,000 - 16,224,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl616,188,979 - 16,224,971 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx616,504,502 - 16,534,073 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0616,826,710 - 16,856,281 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0616,307,765 - 16,337,332 (+)NCBIRnor_WKY
Rnor_6.061,428,845 - 1,466,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl61,428,834 - 1,466,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.061,419,340 - 1,456,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera615,851,444 - 15,880,415 (+)NCBICelera
Cytogenetic Map6q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-aminopurine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diethyl maleate  (EXP)
dioxygen  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
flutamide  (EXP)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
genistein  (EXP)
glucose  (ISO)
glutathione  (EXP)
hexadecanoic acid  (EXP,ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mercury dichloride  (ISO)
metam  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
minocycline  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (ISO)
potassium atom  (EXP)
quercetin  (ISO)
quinolinic acid  (EXP)
resveratrol  (EXP,ISO)
Roridin A  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
staurosporine  (ISO)
succimer  (ISO)
sucrose  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tebuconazole  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Triptolide  (EXP)
trovafloxacin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
zebularine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid starvation  (ISO)
defense response to virus  (ISO)
endoplasmic reticulum unfolded protein response  (ISO)
innate immune response  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of osteoblast proliferation  (ISO,ISS)
negative regulation of translation  (ISO,ISS)
negative regulation of viral genome replication  (ISO,ISS)
peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of apoptotic process  (IMP)
positive regulation of chemokine production  (ISO,ISS)
positive regulation of cytokine production  (ISO,ISS)
positive regulation of MAPK cascade  (ISO,ISS)
positive regulation of NF-kappaB transcription factor activity  (ISO,ISS)
positive regulation of NIK/NF-kappaB signaling  (ISO,ISS)
positive regulation of stress-activated MAPK cascade  (ISO,ISS)
protein autophosphorylation  (ISO,ISS)
protein phosphorylation  (IEA,ISO,ISS)
regulation of hematopoietic progenitor cell differentiation  (ISO,ISS)
regulation of hematopoietic stem cell differentiation  (ISO,ISS)
regulation of hematopoietic stem cell proliferation  (ISO,ISS)
regulation of NLRP3 inflammasome complex assembly  (ISO,ISS)
regulation of translational initiation by eIF2 alpha phosphorylation  (IEA)
response to exogenous dsRNA  (IEP)
response to interferon-alpha  (ISO,ISS)
response to lipopolysaccharide  (IMP)
response to mechanical stimulus  (IEP)
response to organic substance  (IEP)
response to toxic substance  (IMP)
response to virus  (ISO,ISS)
response to vitamin E  (IPI)
translation  (ISO)

Cellular Component
cytoplasm  (ISO,ISS)
cytosol  (IBA,ISO)
nucleus  (IDA)
perinuclear region of cytoplasm  (ISO,ISS)


References - curated
# Reference Title Reference Citation
1. Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection. Al-Khatib K, etal., Exp Eye Res. 2005 Feb;80(2):167-73. doi: 10.1016/j.exer.2004.08.026.
2. Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease. Bando Y, etal., Neurochem Int. 2005 Jan;46(1):11-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice. Guidotti LG, etal., J Virol. 2002 Mar;76(6):2617-21. doi: 10.1128/jvi.76.6.2617-2621.2002.
5. Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord. Hu JH, etal., J Neurochem. 2003 Apr;85(2):432-42.
6. The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. Ingrand S, etal., FEBS Lett. 2007 Sep 18;581(23):4473-8. Epub 2007 Aug 21.
7. Satratoxin G-induced apoptosis in PC-12 neuronal cells is mediated by PKR and caspase independent. Islam Z, etal., Toxicol Sci. 2008 Sep;105(1):142-52. Epub 2008 Jun 4.
8. Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity. Jha BK, etal., J Biol Chem. 2011 Jul 29;286(30):26319-26. doi: 10.1074/jbc.M111.253443. Epub 2011 Jun 2.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells. Lee JH, etal., Glia. 2005 Apr 1;50(1):66-79.
11. TNF-alpha mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's beta-amyloid oligomers in mice and monkeys. Lourenco MV, etal., Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.
12. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
13. Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase. Mellor H, etal., Biochim Biophys Acta 1994 Nov 22;1219(3):693-6.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Neuronal phosphorylated RNA-dependent protein kinase in Creutzfeldt-Jakob disease. Paquet C, etal., J Neuropathol Exp Neurol. 2009 Feb;68(2):190-8. doi: 10.1097/NEN.0b013e318196cd7c.
16. Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue. Peel AL, etal., Hum Mol Genet. 2001 Jul 15;10(15):1531-8.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Roles of vaccinia virus genes E3L and K3L and host genes PKR and RNase L during intratracheal infection of C57BL/6 mice. Rice AD, etal., J Virol. 2011 Jan;85(1):550-67. doi: 10.1128/JVI.00254-10. Epub 2010 Oct 13.
23. Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes. Scumpia PO, etal., Glia. 2005 Nov 1;52(2):153-62.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Mechanical force activates eIF-2alpha phospho-kinases in fibroblast. Wang J, etal., Biochem Biophys Res Commun. 2005 Apr 29;330(1):123-30.
26. Activation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neurons. Wang X, etal., J Neurochem. 2007 Dec;103(6):2380-90. Epub 2007 Oct 22.
27. Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus. Xiang Y, etal., J Virol. 2002 May;76(10):5251-9. doi: 10.1128/jvi.76.10.5251-5259.2002.
Additional References at PubMed
PMID:7519779   PMID:10684936   PMID:12610133   PMID:12882984   PMID:12892903   PMID:12975376   PMID:15121867   PMID:15229216   PMID:15542627   PMID:15545996   PMID:15649892   PMID:16216244  
PMID:16373505   PMID:17652745   PMID:18080832   PMID:18835251   PMID:19046382   PMID:19189853   PMID:19840259   PMID:19946888   PMID:20038207   PMID:20213745   PMID:20357079   PMID:20600673  
PMID:21059295   PMID:21123651   PMID:21266579   PMID:21703541   PMID:22653991   PMID:22681889   PMID:22801494   PMID:23403623   PMID:24366244   PMID:25329545   PMID:25931508   PMID:26174742  
PMID:26454173   PMID:26782432   PMID:27718290   PMID:30259999   PMID:31505169   PMID:32251680   PMID:32304741  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2616,189,000 - 16,224,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl616,188,979 - 16,224,971 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx616,504,502 - 16,534,073 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0616,826,710 - 16,856,281 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0616,307,765 - 16,337,332 (+)NCBIRnor_WKY
Rnor_6.061,428,845 - 1,466,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl61,428,834 - 1,466,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.061,419,340 - 1,456,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera615,851,444 - 15,880,415 (+)NCBICelera
Cytogenetic Map6q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38237,099,210 - 37,156,980 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl237,099,210 - 37,157,522 (-)EnsemblGRCh38hg38GRCh38
GRCh37237,326,353 - 37,384,123 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36237,187,203 - 37,237,572 (-)NCBINCBI36Build 36hg18NCBI36
Build 34237,245,349 - 37,295,719NCBI
Celera237,174,728 - 37,225,214 (-)NCBICelera
Cytogenetic Map2p22.2NCBI
HuRef237,072,482 - 37,124,338 (-)NCBIHuRef
CHM1_1237,261,631 - 37,313,513 (-)NCBICHM1_1
T2T-CHM13v2.0237,106,342 - 37,164,108 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391779,157,933 - 79,190,001 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1779,159,993 - 79,190,002 (-)EnsemblGRCm39 Ensembl
GRCm381778,850,504 - 78,882,572 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1778,852,564 - 78,882,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv371779,251,890 - 79,281,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361778,757,622 - 78,787,630 (-)NCBIMGSCv36mm8
Celera1783,169,187 - 83,200,883 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1749.56NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_0049554414,908,318 - 4,944,343 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.12A37,895,805 - 37,945,465 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A37,895,814 - 37,941,686 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A37,130,386 - 37,184,587 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11729,494,641 - 29,537,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1729,496,128 - 29,537,933 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1729,310,721 - 29,351,697 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01730,145,828 - 30,187,548 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1730,143,443 - 30,180,337 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11729,373,804 - 29,415,016 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01729,436,846 - 29,477,968 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01729,654,942 - 29,696,294 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440629242,461,570 - 42,497,341 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366631,126,977 - 1,157,137 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366631,127,047 - 1,157,263 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl3103,041,221 - 103,096,738 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13103,041,029 - 103,096,741 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23109,641,276 - 109,667,770 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11470,246,081 - 70,290,851 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1470,247,168 - 70,296,463 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604541,658,265 - 41,713,053 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473818,717,092 - 18,758,457 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473818,716,623 - 18,764,243 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Eif2ak2
219 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:59
Interacting mature miRNAs:60
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2616,202,330 - 16,202,464 (-)MAPPERmRatBN7.2
Rnor_6.061,452,535 - 1,452,668NCBIRnor6.0
Rnor_5.061,442,978 - 1,443,111UniSTSRnor5.0
Celera615,857,777 - 15,857,903UniSTS
Cytogenetic Map6q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2616,204,101 - 16,204,311 (-)MAPPERmRatBN7.2
Rnor_6.061,450,688 - 1,450,897NCBIRnor6.0
Rnor_5.061,441,131 - 1,441,340UniSTSRnor5.0
Celera615,859,541 - 15,859,750UniSTS
RH 3.4 Map634.0UniSTS
Cytogenetic Map6q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 38 46 30 19 30 3 3 58 35 36 11 3
Low 5 11 11 11 5 8 16 5 5
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072810   ⟹   ENSRNOP00000067694
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl616,197,512 - 16,224,971 (+)Ensembl
Rnor_6.0 Ensembl61,430,961 - 1,454,480 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089185   ⟹   ENSRNOP00000071646
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl616,188,979 - 16,224,971 (+)Ensembl
Rnor_6.0 Ensembl61,428,834 - 1,466,201 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105846   ⟹   ENSRNOP00000094921
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl616,200,306 - 16,224,971 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111754   ⟹   ENSRNOP00000088431
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl616,188,979 - 16,224,971 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119285   ⟹   ENSRNOP00000085948
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl616,188,979 - 16,224,971 (+)Ensembl
RefSeq Acc Id: NM_019335   ⟹   NP_062208
Rat AssemblyChrPosition (strand)Source
mRatBN7.2616,189,006 - 16,224,971 (+)NCBI
Rnor_6.061,428,846 - 1,466,193 (-)NCBI
Rnor_5.061,419,340 - 1,456,636 (-)NCBI
Celera615,851,444 - 15,880,415 (+)RGD
RefSeq Acc Id: XM_008764425   ⟹   XP_008762647
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2616,189,003 - 16,224,972 (+)NCBI
Rnor_6.061,428,845 - 1,454,854 (-)NCBI
RefSeq Acc Id: XM_039112780   ⟹   XP_038968708
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2616,189,000 - 16,224,972 (+)NCBI
Protein Sequences
Protein RefSeqs NP_062208 (Get FASTA)   NCBI Sequence Viewer  
  XP_008762647 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968708 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA61926 (Get FASTA)   NCBI Sequence Viewer  
  EDM02808 (Get FASTA)   NCBI Sequence Viewer  
  Q63184 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062208   ⟸   NM_019335
- UniProtKB: A0A0G2K100 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762647   ⟸   XM_008764425
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K100 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071646   ⟸   ENSRNOT00000089185
RefSeq Acc Id: ENSRNOP00000067694   ⟸   ENSRNOT00000072810
RefSeq Acc Id: XP_038968708   ⟸   XM_039112780
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000094921   ⟸   ENSRNOT00000105846
RefSeq Acc Id: ENSRNOP00000085948   ⟸   ENSRNOT00000119285
RefSeq Acc Id: ENSRNOP00000088431   ⟸   ENSRNOT00000111754
Protein Domains
DRBM   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63184-F1-model_v2 AlphaFold Q63184 1-513 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694354
Promoter ID:EPDNEW_R4879
Type:initiation region
Description:eukaryotic translation initiation factor 2-alpha kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.061,466,198 - 1,466,258EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3402 AgrOrtholog
BioCyc Gene G2FUF-38490 BioCyc
Ensembl Genes ENSRNOG00000048315 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000067694.3 UniProtKB/TrEMBL
  ENSRNOP00000071646.1 UniProtKB/TrEMBL
  ENSRNOP00000085948.1 UniProtKB/TrEMBL
  ENSRNOP00000088431.1 UniProtKB/TrEMBL
  ENSRNOP00000094921.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072810.3 UniProtKB/TrEMBL
  ENSRNOT00000089185.2 UniProtKB/TrEMBL
  ENSRNOT00000105846.1 UniProtKB/TrEMBL
  ENSRNOT00000111754.1 UniProtKB/TrEMBL
  ENSRNOT00000119285.1 UniProtKB/TrEMBL
InterPro dsRBD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EIF2AK2_DSRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54287 UniProtKB/Swiss-Prot
Pfam dsrm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif2ak2 PhenoGen
SMART DSRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220219
  A0A8I6A187_RAT UniProtKB/TrEMBL
  E2AK2_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Eif2ak2  eukaryotic translation initiation factor 2-alpha kinase 2  Prkr  Protein kinase, interferon-inducible double stranded RNA dependent  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Prkr  Protein kinase, interferon-inducible double stranded RNA dependent      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains protein kinase and RNA binding domains 633898