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Gene: Eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2) Rattus norvegicus
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Symbol: Eif2ak2
Name: eukaryotic translation initiation factor 2-alpha kinase 2
Description: Predicted to have double-stranded RNA binding activity; eukaryotic translation initiation factor 2alpha kinase activity; and identical protein binding activity. Involved in several processes, including response to exogenous dsRNA; response to lipopolysaccharide; and response to vitamin E. Localizes to the nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and Parkinson's disease. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2); PARTICIPATES IN ceramide signaling pathway; platelet-derived growth factor signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: eIF-2A protein kinase 2; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible RNA-dependent protein kinase; Pkr; Prkr; protein kinase RNA-activated; Protein kinase, interferon-inducible double stranded RNA dependent; tyrosine-protein kinase EIF2AK2
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.061,428,845 - 1,466,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.061,419,340 - 1,456,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera615,851,444 - 15,880,415 (+)NCBICelera
Cytogenetic Map6q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Eif2ak2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3402
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.