Eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2) - Rat Genome Database
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Gene: Eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2) Rattus norvegicus
Analyze
Symbol: Eif2ak2
Name: eukaryotic translation initiation factor 2-alpha kinase 2
RGD ID: 3402
Description: Predicted to have double-stranded RNA binding activity; eukaryotic translation initiation factor 2alpha kinase activity; and identical protein binding activity. Involved in several processes, including response to exogenous dsRNA; response to lipopolysaccharide; and response to vitamin E. Localizes to nucleus. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2); PARTICIPATES IN ceramide signaling pathway; platelet-derived growth factor signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: eIF-2A protein kinase 2; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible RNA-dependent protein kinase; Pkr; Prkr; protein kinase RNA-activated; Protein kinase, interferon-inducible double stranded RNA dependent; tyrosine-protein kinase EIF2AK2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2616,189,000 - 16,224,972 (+)NCBI
Rnor_6.0 Ensembl61,428,834 - 1,466,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.061,428,845 - 1,466,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.061,419,340 - 1,456,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera615,851,444 - 15,880,415 (+)NCBICelera
Cytogenetic Map6q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-aminopurine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diethyl maleate  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
flutamide  (EXP)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
genistein  (EXP)
glucose  (ISO)
glutathione  (EXP)
hexadecanoic acid  (EXP,ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mercury dichloride  (ISO)
metam  (ISO)
methapyrilene  (ISO)
minocycline  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (ISO)
potassium atom  (EXP)
quercetin  (ISO)
quinolinic acid  (EXP)
resveratrol  (EXP)
Roridin A  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
staurosporine  (ISO)
succimer  (ISO)
sucrose  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Triptolide  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
zebularine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPKK activity  (ISO,ISS)
cellular response to amino acid starvation  (ISO)
defense response to virus  (IEA,ISO)
endoplasmic reticulum unfolded protein response  (ISO)
innate immune response  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of osteoblast proliferation  (ISO,ISS)
negative regulation of translation  (ISO,ISS)
negative regulation of viral genome replication  (ISO,ISS)
peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of apoptotic process  (IMP)
positive regulation of chemokine production  (ISO,ISS)
positive regulation of cytokine production  (ISO,ISS)
positive regulation of NF-kappaB transcription factor activity  (ISO,ISS)
positive regulation of NIK/NF-kappaB signaling  (ISO,ISS)
positive regulation of stress-activated MAPK cascade  (ISO,ISS)
protein autophosphorylation  (ISO,ISS)
protein phosphorylation  (IEA,ISO,ISS)
regulation of hematopoietic progenitor cell differentiation  (ISO,ISS)
regulation of hematopoietic stem cell differentiation  (ISO,ISS)
regulation of hematopoietic stem cell proliferation  (ISO,ISS)
regulation of NLRP3 inflammasome complex assembly  (ISO,ISS)
regulation of translational initiation by eIF2 alpha phosphorylation  (IEA)
response to exogenous dsRNA  (IEP)
response to interferon-alpha  (ISO,ISS)
response to lipopolysaccharide  (IMP)
response to mechanical stimulus  (IEP)
response to organic substance  (IEP)
response to toxic substance  (IMP)
response to virus  (ISO,ISS)
response to vitamin E  (IPI)
translation  (ISO)

Cellular Component

References

References - curated
1. Al-Khatib K, etal., Exp Eye Res. 2005 Feb;80(2):167-73. doi: 10.1016/j.exer.2004.08.026.
2. Bando Y, etal., Neurochem Int. 2005 Jan;46(1):11-8.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Guidotti LG, etal., J Virol. 2002 Mar;76(6):2617-21. doi: 10.1128/jvi.76.6.2617-2621.2002.
5. Hu JH, etal., J Neurochem. 2003 Apr;85(2):432-42.
6. Ingrand S, etal., FEBS Lett. 2007 Sep 18;581(23):4473-8. Epub 2007 Aug 21.
7. Islam Z, etal., Toxicol Sci. 2008 Sep;105(1):142-52. Epub 2008 Jun 4.
8. Jha BK, etal., J Biol Chem. 2011 Jul 29;286(30):26319-26. doi: 10.1074/jbc.M111.253443. Epub 2011 Jun 2.
9. KEGG
10. Lee JH, etal., Glia. 2005 Apr 1;50(1):66-79.
11. Lourenco MV, etal., Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.
12. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
13. Mellor H, etal., Biochim Biophys Acta 1994 Nov 22;1219(3):693-6.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Paquet C, etal., J Neuropathol Exp Neurol. 2009 Feb;68(2):190-8. doi: 10.1097/NEN.0b013e318196cd7c.
16. Peel AL, etal., Hum Mol Genet. 2001 Jul 15;10(15):1531-8.
17. Pipeline to import KEGG annotations from KEGG into RGD
18. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. RGD automated data pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Rice AD, etal., J Virol. 2011 Jan;85(1):550-67. doi: 10.1128/JVI.00254-10. Epub 2010 Oct 13.
23. Scumpia PO, etal., Glia. 2005 Nov 1;52(2):153-62.
24. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Wang J, etal., Biochem Biophys Res Commun. 2005 Apr 29;330(1):123-30.
26. Wang X, etal., J Neurochem. 2007 Dec;103(6):2380-90. Epub 2007 Oct 22.
27. Xiang Y, etal., J Virol. 2002 May;76(10):5251-9. doi: 10.1128/jvi.76.10.5251-5259.2002.
Additional References at PubMed
PMID:7519779   PMID:10684936   PMID:12610133   PMID:12882984   PMID:12892903   PMID:12975376   PMID:15121867   PMID:15229216   PMID:15542627   PMID:15545996   PMID:15649892   PMID:16216244  
PMID:16373505   PMID:17652745   PMID:18080832   PMID:18835251   PMID:19046382   PMID:19189853   PMID:19840259   PMID:19946888   PMID:20038207   PMID:20213745   PMID:20357079   PMID:20600673  
PMID:21059295   PMID:21123651   PMID:21266579   PMID:21703541   PMID:22653991   PMID:22681889   PMID:22801494   PMID:23403623   PMID:24366244   PMID:25329545   PMID:25931508   PMID:26174742  
PMID:26454173   PMID:26782432   PMID:27718290   PMID:30259999   PMID:31505169   PMID:32251680   PMID:32304741  


Genomics

Comparative Map Data
Eif2ak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2616,189,000 - 16,224,972 (+)NCBI
Rnor_6.0 Ensembl61,428,834 - 1,466,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.061,428,845 - 1,466,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.061,419,340 - 1,456,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera615,851,444 - 15,880,415 (+)NCBICelera
Cytogenetic Map6q11NCBI
EIF2AK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl237,099,210 - 37,157,522 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl237,099,210 - 37,157,065 (-)EnsemblGRCh38hg38GRCh38
GRCh38237,099,210 - 37,157,065 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37237,326,353 - 37,384,123 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36237,187,203 - 37,237,572 (-)NCBINCBI36hg18NCBI36
Build 34237,245,349 - 37,295,719NCBI
Celera237,174,728 - 37,225,214 (-)NCBI
Cytogenetic Map2p22.2NCBI
HuRef237,072,482 - 37,124,338 (-)NCBIHuRef
CHM1_1237,261,631 - 37,313,513 (-)NCBICHM1_1
Eif2ak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391779,157,933 - 79,190,001 (-)NCBIGRCm39mm39
GRCm39 Ensembl1779,159,993 - 79,190,002 (-)Ensembl
GRCm381778,850,504 - 78,882,572 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1778,852,564 - 78,882,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv371779,251,890 - 79,281,912 (-)NCBIGRCm37mm9NCBIm37
MGSCv361778,757,622 - 78,787,630 (-)NCBImm8
Celera1783,169,187 - 83,200,883 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1749.56NCBI
Eif2ak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554414,908,318 - 4,944,343 (-)NCBIChiLan1.0ChiLan1.0
EIF2AK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A37,895,805 - 37,945,465 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A37,895,814 - 37,941,686 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A37,130,386 - 37,184,587 (-)NCBIMhudiblu_PPA_v0panPan3
EIF2AK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1729,496,128 - 29,537,933 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11729,494,641 - 29,537,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Eif2ak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366631,127,047 - 1,157,263 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2AK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3103,041,224 - 103,096,738 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13103,041,029 - 103,096,741 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23109,641,276 - 109,667,770 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2AK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11470,246,081 - 70,290,851 (+)NCBI
ChlSab1.1 Ensembl1470,247,168 - 70,296,463 (+)Ensembl
Eif2ak2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473818,716,623 - 18,764,243 (-)NCBI

Position Markers
D6Wox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.061,452,535 - 1,452,668NCBIRnor6.0
Rnor_5.061,442,978 - 1,443,111UniSTSRnor5.0
Celera615,857,777 - 15,857,903UniSTS
Cytogenetic Map6q11UniSTS
BF390837  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.061,450,688 - 1,450,897NCBIRnor6.0
Rnor_5.061,441,131 - 1,441,340UniSTSRnor5.0
Celera615,859,541 - 15,859,750UniSTS
RH 3.4 Map634.0UniSTS
Cytogenetic Map6q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6123620518Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6125048718Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6135623029Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6135623029Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6135623029Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6135623029Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6135623029Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6141917988Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6142388212Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6142388212Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142388212Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6142388212Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6142388212Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6143665660Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6143665660Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6143665660Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6144015370Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6144570292Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)613505323600274Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6112039328706721Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112039346120393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:59
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000072810
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 46 30 19 30 3 3 58 35 36 11 3
Low 5 11 11 11 5 8 16 5 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072810   ⟹   ENSRNOP00000067694
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl61,430,961 - 1,454,480 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089185   ⟹   ENSRNOP00000071646
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl61,428,834 - 1,466,201 (-)Ensembl
RefSeq Acc Id: NM_019335   ⟹   NP_062208
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2616,189,006 - 16,224,971 (+)NCBI
Rnor_6.061,428,846 - 1,466,193 (-)NCBI
Rnor_5.061,419,340 - 1,456,636 (-)NCBI
Celera615,851,444 - 15,880,415 (+)RGD
Sequence:
RefSeq Acc Id: XM_008764425   ⟹   XP_008762647
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2616,189,003 - 16,224,972 (+)NCBI
Rnor_6.061,428,845 - 1,454,854 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764426   ⟹   XP_008762648
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.061,428,845 - 1,466,146 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112780   ⟹   XP_038968708
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2616,189,000 - 16,224,972 (+)NCBI
Protein Sequences
Protein RefSeqs NP_062208 (Get FASTA)   NCBI Sequence Viewer  
  XP_008762647 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968708 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA61926 (Get FASTA)   NCBI Sequence Viewer  
  EDM02808 (Get FASTA)   NCBI Sequence Viewer  
  Q63184 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062208   ⟸   NM_019335
- Sequence:
RefSeq Acc Id: XP_008762648   ⟸   XM_008764426
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008762647   ⟸   XM_008764425
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000071646   ⟸   ENSRNOT00000089185
RefSeq Acc Id: ENSRNOP00000067694   ⟸   ENSRNOT00000072810
RefSeq Acc Id: XP_038968708   ⟸   XM_039112780
- Peptide Label: isoform X2
Protein Domains
DRBM   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694354
Promoter ID:EPDNEW_R4879
Type:initiation region
Name:Eif2ak2_1
Description:eukaryotic translation initiation factor 2-alpha kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.061,466,198 - 1,466,258EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3402 AgrOrtholog
Ensembl Genes ENSRNOG00000048315 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000067694 UniProtKB/TrEMBL
  ENSRNOP00000071646 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072810 UniProtKB/TrEMBL
  ENSRNOT00000089185 ENTREZGENE, UniProtKB/TrEMBL
InterPro dsRBD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54287 UniProtKB/Swiss-Prot
NCBI Gene 54287 ENTREZGENE
Pfam dsrm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB EIF2AK2 RGD
PhenoGen Eif2ak2 PhenoGen
PROSITE DS_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220219
UniProt E2AK2_RAT UniProtKB/Swiss-Prot
  M0RDJ3_RAT UniProtKB/TrEMBL
  Q63184 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Eif2ak2  eukaryotic translation initiation factor 2-alpha kinase 2  Prkr  Protein kinase, interferon-inducible double stranded RNA dependent  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Prkr  Protein kinase, interferon-inducible double stranded RNA dependent      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains protein kinase and RNA binding domains 633898