(+)-pilocarpine multiple interactions ISO RGD:1616839 6480464 Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein], Pilocarpine results in increased phosphorylation of and results in increased activity of EIF2AK2 protein CTD PMID:16492139 (S)-nicotine increases expression ISO RGD:1345835 6480464 Nicotine results in increased expression of EIF2AK2 mRNA CTD PMID:16949557 1,2-dimethylhydrazine decreases expression ISO RGD:1616839 6480464 1, 2-Dimethylhydrazine results in decreased expression of EIF2AK2 mRNA CTD PMID:22206623 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects phosphorylation ISO RGD:1616839 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:20382208 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of EIF2AK2 mRNA CTD PMID:12655037 17beta-estradiol increases expression ISO RGD:1345835 6480464 Estradiol results in increased expression of EIF2AK2 mRNA CTD PMID:21185374 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1616839 6480464 Tetrachlorodibenzodioxin affects the expression of EIF2AK2 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of EIF2AK2 mRNA CTD PMID:21346803 2-aminopurine decreases phosphorylation ISO RGD:1345835 6480464 2-Aminopurine results in decreased phosphorylation of EIF2AK2 protein CTD PMID:16324719 2-aminopurine decreases activity ISO RGD:1345835 6480464 2-Aminopurine results in decreased activity of EIF2AK2 protein CTD PMID:12890478 2-aminopurine multiple interactions ISO RGD:1616839 6480464 2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of EIF2AK2 protein] CTD PMID:25739386 2-aminopurine multiple interactions ISO RGD:1345835 6480464 2-Aminopurine inhibits the reaction [[IFNB1 results in increased expression of EIF2AK2 protein] which results in decreased susceptibility to Mercuric Chloride] CTD PMID:16324719 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of EIF2AK2 mRNA CTD PMID:19162173 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of EIF2AK2 mRNA CTD PMID:21346803 4-hydroxynon-2-enal decreases expression ISO RGD:1616839 6480464 4-hydroxy-2-nonenal results in decreased expression of EIF2AK2 mRNA CTD PMID:19191707 5-aza-2'-deoxycytidine affects methylation ISO RGD:1345835 6480464 Decitabine affects the methylation of EIF2AK2 gene CTD PMID:17630775 acetamide affects expression EXP 6480464 acetamide affects the expression of EIF2AK2 mRNA CTD PMID:31881176 acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester multiple interactions ISO RGD:1345835 6480464 IFNA2 protein promotes the reaction [nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]] more ... CTD PMID:19664635 acrylamide affects expression EXP 6480464 Acrylamide affects the expression of EIF2AK2 mRNA CTD PMID:28959563 aflatoxin B1 increases expression ISO RGD:1616839 6480464 Aflatoxin B1 results in increased expression of EIF2AK2 mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:1345835 6480464 Aflatoxin B1 results in increased methylation of EIF2AK2 intron CTD PMID:30157460 aldehydo-D-glucose increases phosphorylation ISO RGD:1616839 6480464 Glucose results in increased phosphorylation of EIF2AK2 protein CTD PMID:18973755 aldehydo-D-glucose multiple interactions ISO RGD:1616839 6480464 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK2 protein], Glucose promotes the reaction [EIF2AK2 protein results in increased activity of MAPK14 protein] CTD PMID:18973755 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of EIF2AK2 mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein] CTD PMID:32574669 arsenous acid multiple interactions ISO RGD:1345835 6480464 Arsenic Trioxide promotes the reaction [MSI1 protein binds to EIF2AK2 protein modified form] more ... CTD PMID:29486283 arsenous acid increases phosphorylation ISO RGD:1345835 6480464 Arsenic Trioxide results in increased phosphorylation of EIF2AK2 protein CTD PMID:29486283 benzo[a]pyrene decreases expression ISO RGD:1616839 6480464 Benzoapyrene results in decreased expression of EIF2AK2 mRNA CTD PMID:19770486 benzo[a]pyrene affects methylation ISO RGD:1345835 6480464 Benzoapyrene affects the methylation of EIF2AK2 promoter CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:1616839 6480464 Benzoapyrene results in increased expression of EIF2AK2 mRNA CTD PMID:23735875 benzo[e]pyrene increases methylation ISO RGD:1345835 6480464 benzoepyrene results in increased methylation of EIF2AK2 intron CTD PMID:30157460 bisphenol A decreases expression ISO RGD:1616839 6480464 bisphenol A results in decreased expression of EIF2AK2 mRNA CTD PMID:26063408 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of EIF2AK2 mRNA CTD PMID:25181051 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of EIF2AK2 mRNA CTD PMID:25993096 cadmium dichloride increases expression ISO RGD:1345835 6480464 Cadmium Chloride results in increased expression of EIF2AK2 mRNA CTD PMID:26472689 captan increases expression ISO RGD:1616839 6480464 Captan results in increased expression of EIF2AK2 mRNA CTD PMID:31558096 carbon nanotube increases expression ISO RGD:1616839 6480464 Nanotubes more ... CTD PMID:25554681 cisplatin decreases expression ISO RGD:1345835 6480464 Cisplatin results in decreased expression of EIF2AK2 mRNA CTD PMID:25450742 cisplatin increases expression ISO RGD:1616839 6480464 Cisplatin results in increased expression of EIF2AK2 mRNA CTD PMID:21151649 , PMID:26546572 cisplatin multiple interactions ISO RGD:1616839 6480464 4-methyl-N1-3-phenylpropylbenzene-1, 2-diamine inhibits the reaction [Cisplatin results in increased expression of EIF2AK2 mRNA] CTD PMID:26546572 cobalt dichloride decreases expression ISO RGD:1345835 6480464 cobaltous chloride results in decreased expression of EIF2AK2 mRNA CTD PMID:22941251 copper atom increases activity ISO RGD:1616839 6480464 Copper results in increased activity of EIF2AK2 protein CTD PMID:25159668 copper(0) increases activity ISO RGD:1616839 6480464 Copper results in increased activity of EIF2AK2 protein CTD PMID:25159668 cyclosporin A increases expression ISO RGD:1345835 6480464 Cyclosporine results in increased expression of EIF2AK2 mRNA CTD PMID:25562108 D-glucose multiple interactions ISO RGD:1616839 6480464 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK2 protein], Glucose promotes the reaction [EIF2AK2 protein results in increased activity of MAPK14 protein] CTD PMID:18973755 D-glucose increases phosphorylation ISO RGD:1616839 6480464 Glucose results in increased phosphorylation of EIF2AK2 protein CTD PMID:18973755 deoxynivalenol affects response to substance ISO RGD:1616839 6480464 EIF2AK2 protein affects the susceptibility to deoxynivalenol CTD PMID:22491426 deoxynivalenol multiple interactions ISO RGD:1345835 6480464 EIF2AK2 protein affects the reaction [deoxynivalenol results in increased activity of RELA protein], EIF2AK2 protein affects the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA] CTD PMID:18599499 deoxynivalenol decreases expression ISO RGD:1616839 6480464 deoxynivalenol results in decreased expression of EIF2AK2 mRNA CTD PMID:17090620 dextran sulfate increases phosphorylation ISO RGD:1616839 6480464 Dextran Sulfate results in increased phosphorylation of EIF2AK2 protein CTD PMID:27920257 dextran sulfate multiple interactions ISO RGD:1616839 6480464 EIF2AK2 protein affects the reaction [Dextran Sulfate results in increased activity of CASP3 protein] more ... CTD PMID:27920257 diarsenic trioxide multiple interactions ISO RGD:1345835 6480464 Arsenic Trioxide promotes the reaction [MSI1 protein binds to EIF2AK2 protein modified form] more ... CTD PMID:29486283 diarsenic trioxide increases phosphorylation ISO RGD:1345835 6480464 Arsenic Trioxide results in increased phosphorylation of EIF2AK2 protein CTD PMID:29486283 diazinon increases methylation ISO RGD:1345835 6480464 Diazinon results in increased methylation of EIF2AK2 gene CTD PMID:22964155 dibutyl phthalate decreases expression ISO RGD:1616839 6480464 Dibutyl Phthalate results in decreased expression of EIF2AK2 mRNA CTD PMID:17361019 , PMID:21266533 dibutyl phthalate multiple interactions ISO RGD:1345835 6480464 [Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EIF2AK2 protein CTD PMID:30218697 diethyl maleate decreases expression EXP 6480464 diethyl maleate results in decreased expression of EIF2AK2 mRNA CTD PMID:21161181 doxorubicin decreases expression ISO RGD:1345835 6480464 Doxorubicin results in decreased expression of EIF2AK2 mRNA CTD PMID:29803840 doxorubicin multiple interactions ISO RGD:1345835 6480464 Doxorubicin promotes the reaction [MSI1 protein binds to EIF2AK2 protein modified form] CTD PMID:29486283 elemental selenium decreases expression ISO RGD:1345835 6480464 Selenium results in decreased expression of EIF2AK2 mRNA CTD PMID:19244175 enzyme inhibitor multiple interactions ISO RGD:1345835 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EIF2AK2 protein CTD PMID:23301498 ethanol increases expression ISO RGD:1616839 6480464 Ethanol results in increased expression of EIF2AK2 mRNA CTD PMID:30319688 ferric oxide decreases expression ISO RGD:1616839 6480464 ferric oxide analog results in decreased expression of EIF2AK2 mRNA CTD PMID:25086211 flutamide increases expression EXP 6480464 Flutamide results in increased expression of EIF2AK2 mRNA CTD PMID:24136188 folpet increases expression ISO RGD:1616839 6480464 folpet results in increased expression of EIF2AK2 mRNA CTD PMID:31558096 formaldehyde decreases expression ISO RGD:1345835 6480464 Formaldehyde results in decreased expression of EIF2AK2 mRNA CTD PMID:23649840 fructose increases expression EXP 6480464 Fructose results in increased expression of EIF2AK2 protein CTD PMID:29430716 fructose multiple interactions EXP 6480464 imoxin inhibits the reaction [Fructose results in increased expression of EIF2AK2 protein] CTD PMID:29430716 genistein increases expression EXP 6480464 Genistein results in increased expression of EIF2AK2 mRNA CTD PMID:17341692 glucose multiple interactions ISO RGD:1616839 6480464 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK2 protein], Glucose promotes the reaction [EIF2AK2 protein results in increased activity of MAPK14 protein] CTD PMID:18973755 glucose increases phosphorylation ISO RGD:1616839 6480464 Glucose results in increased phosphorylation of EIF2AK2 protein CTD PMID:18973755 glutathione decreases expression EXP 6480464 Glutathione deficiency results in decreased expression of EIF2AK2 mRNA CTD PMID:20621112 hexadecanoic acid increases expression EXP 6480464 Palmitic Acid results in increased expression of EIF2AK2 mRNA, Palmitic Acid results in increased expression of EIF2AK2 protein CTD PMID:30259999 hexadecanoic acid multiple interactions EXP 6480464 imoxin inhibits the reaction [Palmitic Acid results in increased expression of EIF2AK2 mRNA], imoxin inhibits the reaction [Palmitic Acid results in increased expression of EIF2AK2 protein] CTD PMID:30259999 hexadecanoic acid increases phosphorylation ISO RGD:1345835 6480464 Palmitic Acid results in increased phosphorylation of EIF2AK2 protein CTD PMID:30794626 lead diacetate increases expression ISO RGD:1616839 6480464 lead acetate results in increased expression of EIF2AK2 mRNA CTD PMID:20542052 lipopolysaccharide affects expression ISO RGD:1345835 6480464 Lipopolysaccharides affects the expression of EIF2AK2 mRNA CTD PMID:28070326 lipopolysaccharide increases expression ISO RGD:1345835 6480464 Lipopolysaccharides results in increased expression of EIF2AK2 mRNA, Lipopolysaccharides results in increased expression of EIF2AK2 protein CTD PMID:30501627 , PMID:30794626 lipopolysaccharide increases phosphorylation ISO RGD:1616839 6480464 Lipopolysaccharides results in increased phosphorylation of EIF2AK2 protein CTD PMID:27718290 lipopolysaccharide multiple interactions ISO RGD:1616839 6480464 EIF2AK2 protein affects the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] more ... CTD PMID:24056979 , PMID:27718290 lipopolysaccharide increases expression ISO RGD:1616839 6480464 Lipopolysaccharides results in increased expression of EIF2AK2 mRNA CTD PMID:24056979 lipopolysaccharide increases phosphorylation ISO RGD:1345835 6480464 Lipopolysaccharides results in increased phosphorylation of EIF2AK2 protein CTD PMID:30794626 lipopolysaccharide multiple interactions ISO RGD:1345835 6480464 [TNFSF11 protein results in increased susceptibility to Lipopolysaccharides] which results in increased expression of and results in increased phosphorylation of EIF2AK2 protein more ... CTD PMID:27718290 more ... manganese atom multiple interactions EXP 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein more ... CTD PMID:32574669 manganese(0) multiple interactions EXP 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein more ... CTD PMID:32574669 manganese(II) chloride multiple interactions EXP 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein more ... CTD PMID:32574669 mercury dichloride multiple interactions ISO RGD:1345835 6480464 2-Aminopurine inhibits the reaction [[IFNB1 results in increased expression of EIF2AK2 protein] which results in decreased susceptibility to Mercuric Chloride], [IFNB1 results in increased expression of EIF2AK2 protein] which results in decreased susceptibility to Mercuric Chloride CTD PMID:16324719 metam multiple interactions ISO RGD:1616839 6480464 methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of EIF2AK2 mRNA] CTD PMID:24056979 methapyrilene increases methylation ISO RGD:1345835 6480464 Methapyrilene results in increased methylation of EIF2AK2 intron CTD PMID:30157460 minocycline multiple interactions EXP 6480464 Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein] CTD PMID:17406652 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1616839 6480464 [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of EIF2AK2 mRNA CTD PMID:25566086 nicotine increases expression ISO RGD:1345835 6480464 Nicotine results in increased expression of EIF2AK2 mRNA CTD PMID:16949557 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of EIF2AK2 mRNA CTD PMID:25729387 paracetamol decreases expression ISO RGD:1345835 6480464 Acetaminophen results in decreased expression of EIF2AK2 mRNA CTD PMID:21420995 paracetamol increases expression ISO RGD:1345835 6480464 Acetaminophen results in increased expression of EIF2AK2 mRNA CTD PMID:22230336 pentachlorophenol increases expression ISO RGD:1616839 6480464 Pentachlorophenol results in increased expression of EIF2AK2 mRNA CTD PMID:23892564 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1345835 6480464 [Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EIF2AK2 protein CTD PMID:30218697 poly(I:C) increases response to substance ISO RGD:1616839 6480464 EIF2AK2 results in increased susceptibility to Poly I-C CTD PMID:10944112 poly(I:C) increases expression ISO RGD:1345835 6480464 Poly I-C results in increased expression of EIF2AK2 mRNA CTD PMID:17669408 , PMID:22558189 potassium atom increases phosphorylation EXP 6480464 Potassium deficiency results in increased phosphorylation of EIF2AK2 protein CTD PMID:19046382 quercetin increases phosphorylation ISO RGD:1345835 6480464 Quercetin results in increased phosphorylation of EIF2AK2 protein CTD PMID:16794257 quinolinic acid multiple interactions EXP 6480464 GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein], Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein CTD PMID:24211709 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of EIF2AK2 mRNA CTD PMID:25905778 Roridin A multiple interactions ISO RGD:1616839 6480464 lipopolysaccharide more ... CTD PMID:17483119 Roridin A increases expression ISO RGD:1616839 6480464 roridin A results in increased expression of EIF2AK2 mRNA CTD PMID:17483119 selenium atom decreases expression ISO RGD:1345835 6480464 Selenium results in decreased expression of EIF2AK2 mRNA CTD PMID:19244175 silver atom decreases expression ISO RGD:1616839 6480464 Silver results in decreased expression of EIF2AK2 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1616839 6480464 Silver results in decreased expression of EIF2AK2 mRNA CTD PMID:27131904 staurosporine decreases activity ISO RGD:1345835 6480464 Staurosporine results in decreased activity of EIF2AK2 protein CTD PMID:12890478 succimer multiple interactions ISO RGD:1616839 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of EIF2AK2 mRNA CTD PMID:26378955 sucrose multiple interactions ISO RGD:1616839 6480464 EIF2AK2 protein affects the reaction [Sucrose results in increased activity of and results in increased cleavage of CASP3 protein] more ... CTD PMID:27920257 sucrose increases phosphorylation ISO RGD:1616839 6480464 Sucrose results in increased phosphorylation of EIF2AK2 protein CTD PMID:27920257 sunitinib decreases expression ISO RGD:1345835 6480464 Sunitinib results in decreased expression of EIF2AK2 mRNA CTD PMID:31533062 T-2 toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of EIF2AK2 mRNA CTD PMID:26141394 tamoxifen affects expression ISO RGD:1616839 6480464 Tamoxifen affects the expression of EIF2AK2 mRNA CTD PMID:20937368 tert-butyl hydroperoxide increases expression ISO RGD:1616839 6480464 tert-Butylhydroperoxide results in increased expression of EIF2AK2 mRNA CTD PMID:14729362 , PMID:15003993 testosterone enanthate affects expression ISO RGD:1345835 6480464 testosterone enanthate affects the expression of EIF2AK2 mRNA CTD PMID:17440010 tetrachloromethane decreases expression ISO RGD:1616839 6480464 Carbon Tetrachloride results in decreased expression of EIF2AK2 mRNA CTD PMID:17484886 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of EIF2AK2 mRNA CTD PMID:15123359 thapsigargin multiple interactions ISO RGD:1616839 6480464 imoxin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK2 protein] CTD PMID:24150608 thapsigargin increases phosphorylation ISO RGD:1616839 6480464 Thapsigargin results in increased phosphorylation of EIF2AK2 protein CTD PMID:24150608 titanium dioxide increases expression ISO RGD:1616839 6480464 titanium dioxide results in increased expression of EIF2AK2 mRNA CTD PMID:23557971 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of EIF2AK2 mRNA CTD PMID:25729387 Triptolide increases expression EXP 6480464 triptolide results in increased expression of EIF2AK2 protein CTD PMID:32519852 valproic acid decreases expression ISO RGD:1345835 6480464 Valproic Acid results in decreased expression of EIF2AK2 mRNA CTD PMID:23179753 , PMID:28001369 valproic acid affects expression ISO RGD:1345835 6480464 Valproic Acid affects the expression of EIF2AK2 mRNA CTD PMID:25979313 vancomycin decreases expression ISO RGD:1616839 6480464 Vancomycin results in decreased expression of EIF2AK2 mRNA CTD PMID:18930951 vitamin E decreases expression ISO RGD:1345835 6480464 Vitamin E results in decreased expression of EIF2AK2 mRNA CTD PMID:19244175 zebularine decreases expression ISO RGD:1345835 6480464 pyrimidin-2-one beta-ribofuranoside results in decreased expression of EIF2AK2 protein modified form CTD PMID:23320119 zebularine decreases response to substance ISO RGD:1345835 6480464 EIF2AK2 protein results in decreased susceptibility to pyrimidin-2-one beta-ribofuranoside CTD PMID:23320119
