(+)-pilocarpine multiple interactions ISO RGD:1616839 6480464 Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein], Pilocarpine results in increased phosphorylation of and results in increased activity of EIF2AK2 protein CTD PMID:16492139 (S)-nicotine increases expression ISO RGD:1345835 6480464 Nicotine results in increased expression of EIF2AK2 mRNA CTD PMID:16949557 1,2-dimethylhydrazine decreases expression ISO RGD:1616839 6480464 1, 2-Dimethylhydrazine results in decreased expression of EIF2AK2 mRNA CTD PMID:22206623 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects phosphorylation ISO RGD:1616839 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:20382208 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of EIF2AK2 mRNA CTD PMID:12655037 17beta-estradiol increases expression ISO RGD:1345835 6480464 Estradiol results in increased expression of EIF2AK2 mRNA CTD PMID:21185374 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1616839 6480464 Tetrachlorodibenzodioxin affects the expression of EIF2AK2 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of EIF2AK2 mRNA CTD PMID:21346803 2-aminopurine decreases phosphorylation ISO RGD:1345835 6480464 2-Aminopurine results in decreased phosphorylation of EIF2AK2 protein CTD PMID:16324719 2-aminopurine decreases activity ISO RGD:1345835 6480464 2-Aminopurine results in decreased activity of EIF2AK2 protein CTD PMID:12890478 2-aminopurine multiple interactions ISO RGD:1616839 6480464 2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of EIF2AK2 protein] CTD PMID:25739386 2-aminopurine multiple interactions ISO RGD:1345835 6480464 2-Aminopurine inhibits the reaction [[IFNB1 results in increased expression of EIF2AK2 protein] which results in decreased susceptibility to Mercuric Chloride] CTD PMID:16324719 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of EIF2AK2 mRNA CTD PMID:19162173 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of EIF2AK2 mRNA CTD PMID:21346803 4-hydroxynon-2-enal decreases expression ISO RGD:1616839 6480464 4-hydroxy-2-nonenal results in decreased expression of EIF2AK2 mRNA CTD PMID:19191707 5-aza-2'-deoxycytidine affects methylation ISO RGD:1345835 6480464 Decitabine affects the methylation of EIF2AK2 gene CTD PMID:17630775 acetamide affects expression EXP 6480464 acetamide affects the expression of EIF2AK2 mRNA CTD PMID:31881176 acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester multiple interactions ISO RGD:1345835 6480464 IFNA2 protein promotes the reaction [nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]] more ... CTD PMID:19664635 acrylamide affects expression EXP 6480464 Acrylamide affects the expression of EIF2AK2 mRNA CTD PMID:28959563 aflatoxin B1 increases expression ISO RGD:1616839 6480464 Aflatoxin B1 results in increased expression of EIF2AK2 mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:1345835 6480464 Aflatoxin B1 results in increased methylation of EIF2AK2 intron CTD PMID:30157460 aldehydo-D-glucose increases phosphorylation ISO RGD:1616839 6480464 Glucose results in increased phosphorylation of EIF2AK2 protein CTD PMID:18973755 aldehydo-D-glucose multiple interactions ISO RGD:1616839 6480464 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK2 protein], Glucose promotes the reaction [EIF2AK2 protein results in increased activity of MAPK14 protein] CTD PMID:18973755 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of EIF2AK2 mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein] CTD PMID:32574669 arsenous acid multiple interactions ISO RGD:1345835 6480464 Arsenic Trioxide promotes the reaction [MSI1 protein binds to EIF2AK2 protein modified form] more ... CTD PMID:29486283 arsenous acid increases phosphorylation ISO RGD:1345835 6480464 Arsenic Trioxide results in increased phosphorylation of EIF2AK2 protein CTD PMID:29486283 benzo[a]pyrene decreases expression ISO RGD:1616839 6480464 Benzo(a)pyrene results in decreased expression of EIF2AK2 mRNA CTD PMID:19770486 benzo[a]pyrene affects methylation ISO RGD:1345835 6480464 Benzo(a)pyrene affects the methylation of EIF2AK2 promoter CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:1616839 6480464 Benzo(a)pyrene results in increased expression of EIF2AK2 mRNA CTD PMID:23735875 benzo[e]pyrene increases methylation ISO RGD:1345835 6480464 benzo(e)pyrene results in increased methylation of EIF2AK2 intron CTD PMID:30157460 bisphenol A decreases expression ISO RGD:1616839 6480464 bisphenol A results in decreased expression of EIF2AK2 mRNA CTD PMID:26063408 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of EIF2AK2 mRNA CTD PMID:25181051 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of EIF2AK2 mRNA CTD PMID:25993096 cadmium dichloride increases expression ISO RGD:1345835 6480464 Cadmium Chloride results in increased expression of EIF2AK2 mRNA CTD PMID:26472689 captan increases expression ISO RGD:1616839 6480464 Captan results in increased expression of EIF2AK2 mRNA CTD PMID:31558096 carbon nanotube increases expression ISO RGD:1616839 6480464 Nanotubes, Carbon analog results in increased expression of EIF2AK2 mRNA, Nanotubes, Carbon results in increased expression of EIF2AK2 mRNA CTD PMID:25554681 cisplatin decreases expression ISO RGD:1345835 6480464 Cisplatin results in decreased expression of EIF2AK2 mRNA CTD PMID:25450742 cisplatin increases expression ISO RGD:1616839 6480464 Cisplatin results in increased expression of EIF2AK2 mRNA CTD PMID:21151649 , PMID:26546572 cisplatin multiple interactions ISO RGD:1616839 6480464 4-methyl-N1-(3-phenylpropyl)benzene-1, 2-diamine inhibits the reaction [Cisplatin results in increased expression of EIF2AK2 mRNA] CTD PMID:26546572 cobalt dichloride decreases expression ISO RGD:1345835 6480464 cobaltous chloride results in decreased expression of EIF2AK2 mRNA CTD PMID:22941251 copper atom increases activity ISO RGD:1616839 6480464 Copper results in increased activity of EIF2AK2 protein CTD PMID:25159668 copper(0) increases activity ISO RGD:1616839 6480464 Copper results in increased activity of EIF2AK2 protein CTD PMID:25159668 cyclosporin A increases expression ISO RGD:1345835 6480464 Cyclosporine results in increased expression of EIF2AK2 mRNA CTD PMID:25562108 D-glucose multiple interactions ISO RGD:1616839 6480464 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK2 protein], Glucose promotes the reaction [EIF2AK2 protein results in increased activity of MAPK14 protein] CTD PMID:18973755 D-glucose increases phosphorylation ISO RGD:1616839 6480464 Glucose results in increased phosphorylation of EIF2AK2 protein CTD PMID:18973755 deoxynivalenol affects response to substance ISO RGD:1616839 6480464 EIF2AK2 protein affects the susceptibility to deoxynivalenol CTD PMID:22491426 deoxynivalenol multiple interactions ISO RGD:1345835 6480464 EIF2AK2 protein affects the reaction [deoxynivalenol results in increased activity of RELA protein], EIF2AK2 protein affects the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA] CTD PMID:18599499 deoxynivalenol decreases expression ISO RGD:1616839 6480464 deoxynivalenol results in decreased expression of EIF2AK2 mRNA CTD PMID:17090620 dextran sulfate increases phosphorylation ISO RGD:1616839 6480464 Dextran Sulfate results in increased phosphorylation of EIF2AK2 protein CTD PMID:27920257 dextran sulfate multiple interactions ISO RGD:1616839 6480464 EIF2AK2 protein affects the reaction [Dextran Sulfate results in increased activity of CASP3 protein] more ... CTD PMID:27920257 diarsenic trioxide multiple interactions ISO RGD:1345835 6480464 Arsenic Trioxide promotes the reaction [MSI1 protein binds to EIF2AK2 protein modified form] more ... CTD PMID:29486283 diarsenic trioxide increases phosphorylation ISO RGD:1345835 6480464 Arsenic Trioxide results in increased phosphorylation of EIF2AK2 protein CTD PMID:29486283 diazinon increases methylation ISO RGD:1345835 6480464 Diazinon results in increased methylation of EIF2AK2 gene CTD PMID:22964155 dibutyl phthalate decreases expression ISO RGD:1616839 6480464 Dibutyl Phthalate results in decreased expression of EIF2AK2 mRNA CTD PMID:17361019 , PMID:21266533 dibutyl phthalate multiple interactions ISO RGD:1345835 6480464 [Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EIF2AK2 protein CTD PMID:30218697 diethyl maleate decreases expression EXP 6480464 diethyl maleate results in decreased expression of EIF2AK2 mRNA CTD PMID:21161181 doxorubicin decreases expression ISO RGD:1345835 6480464 Doxorubicin results in decreased expression of EIF2AK2 mRNA CTD PMID:29803840 doxorubicin multiple interactions ISO RGD:1345835 6480464 Doxorubicin promotes the reaction [MSI1 protein binds to EIF2AK2 protein modified form] CTD PMID:29486283 elemental selenium decreases expression ISO RGD:1345835 6480464 Selenium results in decreased expression of EIF2AK2 mRNA CTD PMID:19244175 enzyme inhibitor multiple interactions ISO RGD:1345835 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EIF2AK2 protein CTD PMID:23301498 ethanol increases expression ISO RGD:1616839 6480464 Ethanol results in increased expression of EIF2AK2 mRNA CTD PMID:30319688 ferric oxide decreases expression ISO RGD:1616839 6480464 ferric oxide analog results in decreased expression of EIF2AK2 mRNA CTD PMID:25086211 flutamide increases expression EXP 6480464 Flutamide results in increased expression of EIF2AK2 mRNA CTD PMID:24136188 folpet increases expression ISO RGD:1616839 6480464 folpet results in increased expression of EIF2AK2 mRNA CTD PMID:31558096 formaldehyde decreases expression ISO RGD:1345835 6480464 Formaldehyde results in decreased expression of EIF2AK2 mRNA CTD PMID:23649840 fructose increases expression EXP 6480464 Fructose results in increased expression of EIF2AK2 protein CTD PMID:29430716 fructose multiple interactions EXP 6480464 imoxin inhibits the reaction [Fructose results in increased expression of EIF2AK2 protein] CTD PMID:29430716 genistein increases expression EXP 6480464 Genistein results in increased expression of EIF2AK2 mRNA CTD PMID:17341692 glucose multiple interactions ISO RGD:1616839 6480464 acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK2 protein], Glucose promotes the reaction [EIF2AK2 protein results in increased activity of MAPK14 protein] CTD PMID:18973755 glucose increases phosphorylation ISO RGD:1616839 6480464 Glucose results in increased phosphorylation of EIF2AK2 protein CTD PMID:18973755 glutathione decreases expression EXP 6480464 Glutathione deficiency results in decreased expression of EIF2AK2 mRNA CTD PMID:20621112 hexadecanoic acid increases expression EXP 6480464 Palmitic Acid results in increased expression of EIF2AK2 mRNA, Palmitic Acid results in increased expression of EIF2AK2 protein CTD PMID:30259999 hexadecanoic acid multiple interactions EXP 6480464 imoxin inhibits the reaction [Palmitic Acid results in increased expression of EIF2AK2 mRNA], imoxin inhibits the reaction [Palmitic Acid results in increased expression of EIF2AK2 protein] CTD PMID:30259999 hexadecanoic acid increases phosphorylation ISO RGD:1345835 6480464 Palmitic Acid results in increased phosphorylation of EIF2AK2 protein CTD PMID:30794626 lead diacetate increases expression ISO RGD:1616839 6480464 lead acetate results in increased expression of EIF2AK2 mRNA CTD PMID:20542052 lipopolysaccharide affects expression ISO RGD:1345835 6480464 Lipopolysaccharides affects the expression of EIF2AK2 mRNA CTD PMID:28070326 lipopolysaccharide increases expression ISO RGD:1345835 6480464 Lipopolysaccharides results in increased expression of EIF2AK2 mRNA, Lipopolysaccharides results in increased expression of EIF2AK2 protein CTD PMID:30501627 , PMID:30794626 lipopolysaccharide increases phosphorylation ISO RGD:1616839 6480464 Lipopolysaccharides results in increased phosphorylation of EIF2AK2 protein CTD PMID:27718290 lipopolysaccharide multiple interactions ISO RGD:1616839 6480464 EIF2AK2 protein affects the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] more ... CTD PMID:24056979 , PMID:27718290 lipopolysaccharide increases expression ISO RGD:1616839 6480464 Lipopolysaccharides results in increased expression of EIF2AK2 mRNA CTD PMID:24056979 lipopolysaccharide increases phosphorylation ISO RGD:1345835 6480464 Lipopolysaccharides results in increased phosphorylation of EIF2AK2 protein CTD PMID:30794626 lipopolysaccharide multiple interactions ISO RGD:1345835 6480464 [TNFSF11 protein results in increased susceptibility to Lipopolysaccharides] which results in increased expression of and results in increased phosphorylation of EIF2AK2 protein more ... CTD PMID:27718290 more ... manganese atom multiple interactions EXP 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein more ... CTD PMID:32574669 manganese(0) multiple interactions EXP 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein more ... CTD PMID:32574669 manganese(II) chloride multiple interactions EXP 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein more ... CTD PMID:32574669 mercury dichloride multiple interactions ISO RGD:1345835 6480464 2-Aminopurine inhibits the reaction [[IFNB1 results in increased expression of EIF2AK2 protein] which results in decreased susceptibility to Mercuric Chloride], [IFNB1 results in increased expression of EIF2AK2 protein] which results in decreased susceptibility to Mercuric Chloride CTD PMID:16324719 metam multiple interactions ISO RGD:1616839 6480464 methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of EIF2AK2 mRNA] CTD PMID:24056979 methapyrilene increases methylation ISO RGD:1345835 6480464 Methapyrilene results in increased methylation of EIF2AK2 intron CTD PMID:30157460 minocycline multiple interactions EXP 6480464 Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein] CTD PMID:17406652 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1616839 6480464 [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of EIF2AK2 mRNA CTD PMID:25566086 nicotine increases expression ISO RGD:1345835 6480464 Nicotine results in increased expression of EIF2AK2 mRNA CTD PMID:16949557 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of EIF2AK2 mRNA CTD PMID:25729387 paracetamol decreases expression ISO RGD:1345835 6480464 Acetaminophen results in decreased expression of EIF2AK2 mRNA CTD PMID:21420995 paracetamol increases expression ISO RGD:1345835 6480464 Acetaminophen results in increased expression of EIF2AK2 mRNA CTD PMID:22230336 pentachlorophenol increases expression ISO RGD:1616839 6480464 Pentachlorophenol results in increased expression of EIF2AK2 mRNA CTD PMID:23892564 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1345835 6480464 [Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EIF2AK2 protein CTD PMID:30218697 poly(I:C) increases response to substance ISO RGD:1616839 6480464 EIF2AK2 results in increased susceptibility to Poly I-C CTD PMID:10944112 poly(I:C) increases expression ISO RGD:1345835 6480464 Poly I-C results in increased expression of EIF2AK2 mRNA CTD PMID:17669408 , PMID:22558189 potassium atom increases phosphorylation EXP 6480464 Potassium deficiency results in increased phosphorylation of EIF2AK2 protein CTD PMID:19046382 quercetin increases phosphorylation ISO RGD:1345835 6480464 Quercetin results in increased phosphorylation of EIF2AK2 protein CTD PMID:16794257 quinolinic acid multiple interactions EXP 6480464 GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein], Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein CTD PMID:24211709 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of EIF2AK2 mRNA CTD PMID:25905778 Roridin A multiple interactions ISO RGD:1616839 6480464 lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [roridin A results in increased expression of EIF2AK2 mRNA], roridin A promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of EIF2AK2 mRNA] CTD PMID:17483119 Roridin A increases expression ISO RGD:1616839 6480464 roridin A results in increased expression of EIF2AK2 mRNA CTD PMID:17483119 selenium atom decreases expression ISO RGD:1345835 6480464 Selenium results in decreased expression of EIF2AK2 mRNA CTD PMID:19244175 silver atom decreases expression ISO RGD:1616839 6480464 Silver results in decreased expression of EIF2AK2 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1616839 6480464 Silver results in decreased expression of EIF2AK2 mRNA CTD PMID:27131904 staurosporine decreases activity ISO RGD:1345835 6480464 Staurosporine results in decreased activity of EIF2AK2 protein CTD PMID:12890478 succimer multiple interactions ISO RGD:1616839 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of EIF2AK2 mRNA CTD PMID:26378955 sucrose multiple interactions ISO RGD:1616839 6480464 EIF2AK2 protein affects the reaction [Sucrose results in increased activity of and results in increased cleavage of CASP3 protein] more ... CTD PMID:27920257 sucrose increases phosphorylation ISO RGD:1616839 6480464 Sucrose results in increased phosphorylation of EIF2AK2 protein CTD PMID:27920257 sunitinib decreases expression ISO RGD:1345835 6480464 Sunitinib results in decreased expression of EIF2AK2 mRNA CTD PMID:31533062 T-2 toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of EIF2AK2 mRNA CTD PMID:26141394 tamoxifen affects expression ISO RGD:1616839 6480464 Tamoxifen affects the expression of EIF2AK2 mRNA CTD PMID:20937368 tert-butyl hydroperoxide increases expression ISO RGD:1616839 6480464 tert-Butylhydroperoxide results in increased expression of EIF2AK2 mRNA CTD PMID:14729362 , PMID:15003993 testosterone enanthate affects expression ISO RGD:1345835 6480464 testosterone enanthate affects the expression of EIF2AK2 mRNA CTD PMID:17440010 tetrachloromethane decreases expression ISO RGD:1616839 6480464 Carbon Tetrachloride results in decreased expression of EIF2AK2 mRNA CTD PMID:17484886 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of EIF2AK2 mRNA CTD PMID:15123359 thapsigargin multiple interactions ISO RGD:1616839 6480464 imoxin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK2 protein] CTD PMID:24150608 thapsigargin increases phosphorylation ISO RGD:1616839 6480464 Thapsigargin results in increased phosphorylation of EIF2AK2 protein CTD PMID:24150608 titanium dioxide increases expression ISO RGD:1616839 6480464 titanium dioxide results in increased expression of EIF2AK2 mRNA CTD PMID:23557971 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of EIF2AK2 mRNA CTD PMID:25729387 Triptolide increases expression EXP 6480464 triptolide results in increased expression of EIF2AK2 protein CTD PMID:32519852 valproic acid decreases expression ISO RGD:1345835 6480464 Valproic Acid results in decreased expression of EIF2AK2 mRNA CTD PMID:23179753 , PMID:28001369 valproic acid affects expression ISO RGD:1345835 6480464 Valproic Acid affects the expression of EIF2AK2 mRNA CTD PMID:25979313 vancomycin decreases expression ISO RGD:1616839 6480464 Vancomycin results in decreased expression of EIF2AK2 mRNA CTD PMID:18930951 vitamin E decreases expression ISO RGD:1345835 6480464 Vitamin E results in decreased expression of EIF2AK2 mRNA CTD PMID:19244175 zebularine decreases expression ISO RGD:1345835 6480464 pyrimidin-2-one beta-ribofuranoside results in decreased expression of EIF2AK2 protein modified form CTD PMID:23320119 zebularine decreases response to substance ISO RGD:1345835 6480464 EIF2AK2 protein results in decreased susceptibility to pyrimidin-2-one beta-ribofuranoside CTD PMID:23320119
Biological Process activation of MAPKK activity ISO RGD:1345835 1624291 (PMID:15229216) RGD PMID:15229216 activation of MAPKK activity ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 activation of MAPKK activity IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to amino acid starvation ISO RGD:1345835 1624291 (PMID:25329545) RGD PMID:25329545 cellular response to amino acid starvation IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 defense response to virus IEA UniProtKB-KW:KW-0051 1600115 GO_REF:0000043 UniProt GO_REF:0000043 endoplasmic reticulum unfolded protein response ISO RGD:1616839 1624291 (MGI:3511630, PMID:15542627) RGD MGI:3511630 , PMID:15542627 innate immune response IEA UniProtKB-KW:KW-0399 1600115 GO_REF:0000043 UniProt GO_REF:0000043 negative regulation of apoptotic process ISO RGD:1616839 1624291 MGI:1341830 (MGI:3511630 , PMID:15542627) RGD MGI:3511630 , PMID:15542627 negative regulation of osteoblast proliferation ISO RGD:1345835 1624291 (PMID:16216244) RGD PMID:16216244 negative regulation of osteoblast proliferation ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of osteoblast proliferation IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of translation ISO RGD:1345835 1624291 (PMID:12610133), (PMID:12882984), (PMID:19189853) RGD PMID:12610133 more ... negative regulation of translation ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of translation IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of viral genome replication ISO RGD:1345835 1624291 (PMID:19189853), (PMID:19840259) RGD PMID:19189853 , PMID:19840259 negative regulation of viral genome replication ISO RGD:1616839 1624291 (MGI:5487533, PMID:20038207) RGD MGI:5487533 , PMID:20038207 negative regulation of viral genome replication ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of viral genome replication IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-tyrosine phosphorylation IEA GO:0004713 1600115 GO_REF:0000108 GOC GO_REF:0000108 peptidyl-tyrosine phosphorylation IEA GO:0004715 1600115 GO_REF:0000108 GOC GO_REF:0000108 positive regulation of apoptotic process IMP 2301730 RGD positive regulation of chemokine production ISS UniProtKB:Q03963 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of chemokine production ISO RGD:1616839 1624291 (MGI:5487533, PMID:20038207) RGD MGI:5487533 , PMID:20038207 positive regulation of cytokine production ISS UniProtKB:Q03963 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of cytokine production ISO RGD:1616839 1624291 (MGI:5487533, PMID:20038207) RGD MGI:5487533 , PMID:20038207 positive regulation of NF-kappaB transcription factor activity ISO RGD:1345835 1624291 (PMID:15121867) RGD PMID:15121867 positive regulation of NF-kappaB transcription factor activity ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of NF-kappaB transcription factor activity IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of NIK/NF-kappaB signaling ISS UniProtKB:Q03963 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of NIK/NF-kappaB signaling ISO RGD:1616839 1624291 (MGI:5487533, PMID:20038207) RGD MGI:5487533 , PMID:20038207 positive regulation of stress-activated MAPK cascade ISS UniProtKB:Q03963 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of stress-activated MAPK cascade ISO RGD:1616839 1624291 (MGI:5487533, PMID:20038207) RGD MGI:5487533 , PMID:20038207 protein autophosphorylation ISO RGD:1345835 1624291 (PMID:16216244), (PMID:22801494) RGD PMID:16216244 , PMID:22801494 protein autophosphorylation ISO RGD:1616839 1624291 (MGI:3511630 more ... RGD MGI:3511630 more ... protein autophosphorylation ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein autophosphorylation IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein phosphorylation ISO RGD:1345835 1624291 (PMID:19189853) RGD PMID:19189853 protein phosphorylation ISO RGD:1616839 1624291 (MGI:3511630 more ... RGD MGI:3511630 more ... protein phosphorylation ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of hematopoietic progenitor cell differentiation ISS UniProtKB:Q03963 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of hematopoietic progenitor cell differentiation ISO RGD:1616839 1624291 (MGI:5487705, PMID:23403623) RGD MGI:5487705 , PMID:23403623 regulation of hematopoietic stem cell differentiation ISS UniProtKB:Q03963 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of hematopoietic stem cell differentiation ISO RGD:1616839 1624291 (MGI:5487705, PMID:23403623) RGD MGI:5487705 , PMID:23403623 regulation of hematopoietic stem cell proliferation ISS UniProtKB:Q03963 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of hematopoietic stem cell proliferation ISO RGD:1616839 1624291 (MGI:5487705, PMID:23403623) RGD MGI:5487705 , PMID:23403623 regulation of NLRP3 inflammasome complex assembly ISS UniProtKB:Q03963 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of NLRP3 inflammasome complex assembly ISO RGD:1616839 1624291 (MGI:5432942, PMID:22801494) RGD MGI:5432942 , PMID:22801494 regulation of translational initiation by eIF2 alpha phosphorylation IEA GO:0004694 1600115 GO_REF:0000108 GOC GO_REF:0000108 response to exogenous dsRNA IEP 2301737 RGD response to interferon-alpha ISO RGD:1345835 1624291 (PMID:19840259) RGD PMID:19840259 response to interferon-alpha ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 response to interferon-alpha IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to lipopolysaccharide IMP 2301739 RGD response to mechanical stimulus IEP 2301738 RGD response to organic substance IEP 2301735 RGD response to toxic substance IMP 2301730 RGD response to virus ISO RGD:1345835 1624291 (PMID:19189853) RGD PMID:19189853 response to virus ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 response to virus IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to vitamin E IPI RGD:1306707 2301732 RGD translation ISO RGD:1616839 1624291 (MGI:67770, PMID:7519779) RGD MGI:67770 , PMID:7519779 Cellular Component cytoplasm ISO RGD:1345835 1624291 (PMID:15121867) RGD PMID:15121867 cytoplasm ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cytosol IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:1345835 1624291 RGD GO_REF:0000052 cytosolic ribosome IBA PANTHER:PTN000867953 , SGD:S000002691 13792537 PMID:21873635 GO_Central nucleus IDA 2301732 RGD perinuclear region of cytoplasm ISO RGD:1345835 1624291 (PMID:15121867) RGD PMID:15121867 perinuclear region of cytoplasm ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 perinuclear region of cytoplasm IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000043 UniProt GO_REF:0000043 double-stranded RNA binding ISO RGD:1345835 1624291 (PMID:21266579) RGD PMID:21266579 double-stranded RNA binding ISO RGD:1616839 1624291 (MGI:5050760, PMID:21703541) RGD MGI:5050760 , PMID:21703541 double-stranded RNA binding IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 eukaryotic translation initiation factor 2alpha kinase activity ISO RGD:1345835 1624291 (PMID:25329545) RGD PMID:25329545 eukaryotic translation initiation factor 2alpha kinase activity IBA MGI:MGI:1341830 more ... 13792537 PMID:21873635 GO_Central eukaryotic translation initiation factor 2alpha kinase activity IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 identical protein binding IEA UniProtKB:P19525 , ensembl:ENSP000002330571600115 GO_REF:0000107 Ensembl GO_REF:0000107 identical protein binding ISO RGD:1345835 1624291 UniProtKB:P19525 (PMID:16373505) RGD PMID:16373505 non-membrane spanning protein tyrosine kinase activity IEA EC:2.7.10.2 1600115 GO_REF:0000003 UniProt GO_REF:0000003 protein binding IPI RGD:1306707 2301732 RGD protein binding ISO RGD:1616839 1624291 PR:Q9R0B7 more ... RGD MGI:1345791 more ... protein binding ISO RGD:1345835 1624291 UniProtKB:O00463 more ... RGD PMID:10390359 more ... protein kinase activity ISO RGD:1345835 1624291 (PMID:12882984), (PMID:15229216), (PMID:18835251), (PMID:21123651) RGD PMID:12882984 more ... protein kinase activity ISO RGD:1616839 1624291 (MGI:3512727 more ... RGD MGI:3512727 more ... protein kinase activity IBA FB:FBgn0011737 more ... 13792537 PMID:21873635 GO_Central protein kinase activity ISS UniProtKB:P19525 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein serine kinase activity IEA EC:2.7.11.1 1600115 GO_REF:0000003 UniProt GO_REF:0000003 protein threonine kinase activity IEA EC:2.7.11.1 1600115 GO_REF:0000003 UniProt GO_REF:0000003
Gene-Chemical Interaction Annotations
