Eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2) - Rat Genome Database

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Gene: Eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2) Mus musculus
Analyze
Symbol: Eif2ak2
Name: eukaryotic translation initiation factor 2-alpha kinase 2
RGD ID: 1616839
MGI Page MGI
Description: Enables double-stranded RNA binding activity and protein kinase activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of intracellular signal transduction; and regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including endoplasmic reticulum unfolded protein response; protein phosphorylation; and translation. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; liver; mandible condylar process; skeletal musculature; and spleen. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; dystonia; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310047A08Rik; 4732414G15Rik; AI467567; AI747578; dsRNA-activated kinase; eIF-2 alpha; eIF-2A protein kinase 2; eukaryotic translation initiation factor 2 alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible RNA-dependent protein kinase; P; P1/eIF-2A protein kinase; p68 kinase; Pkr; Prkr; protein kinase RNA-activated; protein kinase, interferon inducible double stranded RNA dependent; protein kinase, interferon-inducible double stranded RNA dependent; serine/threonine-protein kinase TIK; T-cell viral integration site; Ti; Tik; tyrosine-protein kinase EIF2AK2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391779,157,933 - 79,190,001 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1779,159,993 - 79,190,002 (-)EnsemblGRCm39 Ensembl
GRCm381778,850,504 - 78,882,572 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1778,852,564 - 78,882,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv371779,251,890 - 79,281,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361778,757,622 - 78,787,630 (-)NCBIMGSCv36mm8
Celera1783,169,187 - 83,200,883 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1749.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-aminopurine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
deoxynivalenol  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl maleate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
ferric oxide  (EXP)
flutamide  (ISO)
folpet  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
genistein  (ISO)
glucose  (EXP)
glutathione  (ISO)
hexadecanoic acid  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (ISO)
metam  (EXP)
methapyrilene  (ISO)
methidathion  (EXP)
minocycline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
nicotine  (ISO)
oxaliplatin  (ISO)
paracetamol  (ISO)
pentachlorophenol  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (EXP,ISO)
potassium atom  (ISO)
quercetin  (ISO)
quinolinic acid  (ISO)
resveratrol  (ISO)
Roridin A  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
staurosporine  (ISO)
succimer  (EXP)
sucrose  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
tebuconazole  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
Triptolide  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vitamin E  (ISO)
zebularine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection. Al-Khatib K, etal., Exp Eye Res. 2005 Feb;80(2):167-73. doi: 10.1016/j.exer.2004.08.026.
2. Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease. Bando Y, etal., Neurochem Int. 2005 Jan;46(1):11-8.
3. Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice. Guidotti LG, etal., J Virol. 2002 Mar;76(6):2617-21. doi: 10.1128/jvi.76.6.2617-2621.2002.
4. Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord. Hu JH, etal., J Neurochem. 2003 Apr;85(2):432-42.
5. Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity. Jha BK, etal., J Biol Chem. 2011 Jul 29;286(30):26319-26. doi: 10.1074/jbc.M111.253443. Epub 2011 Jun 2.
6. TNF-alpha mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's beta-amyloid oligomers in mice and monkeys. Lourenco MV, etal., Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.
7. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
8. Neuronal phosphorylated RNA-dependent protein kinase in Creutzfeldt-Jakob disease. Paquet C, etal., J Neuropathol Exp Neurol. 2009 Feb;68(2):190-8. doi: 10.1097/NEN.0b013e318196cd7c.
9. Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue. Peel AL, etal., Hum Mol Genet. 2001 Jul 15;10(15):1531-8.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Roles of vaccinia virus genes E3L and K3L and host genes PKR and RNase L during intratracheal infection of C57BL/6 mice. Rice AD, etal., J Virol. 2011 Jan;85(1):550-67. doi: 10.1128/JVI.00254-10. Epub 2010 Oct 13.
16. Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus. Xiang Y, etal., J Virol. 2002 May;76(10):5251-9. doi: 10.1128/jvi.76.10.5251-5259.2002.
Additional References at PubMed
PMID:1351683   PMID:1358989   PMID:1714905   PMID:7519779   PMID:7533117   PMID:7631421   PMID:7686883   PMID:7694235   PMID:7709427   PMID:7720577   PMID:7736780   PMID:7914700  
PMID:8096514   PMID:8252616   PMID:8557029   PMID:8563181   PMID:8604343   PMID:8661153   PMID:8751373   PMID:8810318   PMID:8812437   PMID:8921913   PMID:9007065   PMID:9029159  
PMID:9151674   PMID:9434950   PMID:9823302   PMID:10026221   PMID:10349636   PMID:10366581   PMID:10488071   PMID:10657661   PMID:10767560   PMID:10801979   PMID:10933401   PMID:10944112  
PMID:11042159   PMID:11076861   PMID:11120814   PMID:11217851   PMID:11390995   PMID:11756670   PMID:11781817   PMID:11991642   PMID:12161430   PMID:12162885   PMID:12207033   PMID:12396725  
PMID:12444163   PMID:12466851   PMID:12477932   PMID:12582177   PMID:12679338   PMID:12692253   PMID:12882984   PMID:12960379   PMID:14517063   PMID:14530405   PMID:14610273   PMID:14636887  
PMID:14698665   PMID:14729979   PMID:15029200   PMID:15100308   PMID:15121867   PMID:15280454   PMID:15299031   PMID:15314157   PMID:15542627   PMID:15545996   PMID:15593126   PMID:15661870  
PMID:15711573   PMID:15851010   PMID:15994831   PMID:16002711   PMID:16033648   PMID:16051816   PMID:16141072   PMID:16141073   PMID:16176978   PMID:16216244   PMID:16339759   PMID:16431927  
PMID:16760403   PMID:16809306   PMID:16895559   PMID:17091495   PMID:17190817   PMID:17266438   PMID:17320139   PMID:17522227   PMID:17596516   PMID:17597215   PMID:17652745   PMID:17686861  
PMID:17690330   PMID:17785458   PMID:17953670   PMID:18023289   PMID:18164587   PMID:18268032   PMID:18322238   PMID:18360789   PMID:18362360   PMID:18625702   PMID:18654661   PMID:18677106  
PMID:18728014   PMID:18729737   PMID:18936160   PMID:19007793   PMID:19028691   PMID:19073740   PMID:19230833   PMID:19264662   PMID:19416861   PMID:19521506   PMID:19587046   PMID:19812373  
PMID:19846675   PMID:19889624   PMID:19901967   PMID:20029030   PMID:20038207   PMID:20074639   PMID:20144759   PMID:20181660   PMID:20219905   PMID:20353946   PMID:20457754   PMID:20478537  
PMID:20559319   PMID:20585572   PMID:20660158   PMID:20728438   PMID:20924113   PMID:20978539   PMID:21076179   PMID:21123651   PMID:21186267   PMID:21266535   PMID:21266579   PMID:21307186  
PMID:21311764   PMID:21385877   PMID:21699726   PMID:21703541   PMID:21873635   PMID:21982595   PMID:21994357   PMID:22153080   PMID:22315398   PMID:22484461   PMID:22498744   PMID:22541070  
PMID:22633459   PMID:22761388   PMID:22787234   PMID:22801494   PMID:22833567   PMID:22948222   PMID:23084476   PMID:23180319   PMID:23229543   PMID:23392680   PMID:23401008   PMID:23403623  
PMID:23418065   PMID:23903655   PMID:23990781   PMID:24382890   PMID:24463368   PMID:24554719   PMID:24642385   PMID:25131634   PMID:25456137   PMID:25587101   PMID:25590804   PMID:25687824  
PMID:25715336   PMID:25739386   PMID:25843719   PMID:25848059   PMID:25897174   PMID:26202421   PMID:26414443   PMID:26446704   PMID:26512090   PMID:26698173   PMID:26725122   PMID:26794869  
PMID:26838266   PMID:26939124   PMID:27226571   PMID:27480124   PMID:27633668   PMID:27698114   PMID:27779186   PMID:27920257   PMID:28100675   PMID:28158275   PMID:28341446   PMID:28378742  
PMID:28511573   PMID:29436711   PMID:29530722   PMID:29795582   PMID:30091670   PMID:30291236   PMID:30417125   PMID:30971430   PMID:31015330   PMID:31213553   PMID:31727829   PMID:32325033  
PMID:32554809   PMID:32800293   PMID:33017381   PMID:33333514   PMID:33361822   PMID:34343497   PMID:34602529   PMID:34643429   PMID:34706234   PMID:35148201   PMID:35979918  


Genomics

Comparative Map Data
Eif2ak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391779,157,933 - 79,190,001 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1779,159,993 - 79,190,002 (-)EnsemblGRCm39 Ensembl
GRCm381778,850,504 - 78,882,572 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1778,852,564 - 78,882,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv371779,251,890 - 79,281,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361778,757,622 - 78,787,630 (-)NCBIMGSCv36mm8
Celera1783,169,187 - 83,200,883 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1749.56NCBI
EIF2AK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38237,099,210 - 37,156,980 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl237,099,210 - 37,157,522 (-)EnsemblGRCh38hg38GRCh38
GRCh37237,326,353 - 37,384,123 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36237,187,203 - 37,237,572 (-)NCBINCBI36Build 36hg18NCBI36
Build 34237,245,349 - 37,295,719NCBI
Celera237,174,728 - 37,225,214 (-)NCBICelera
Cytogenetic Map2p22.2NCBI
HuRef237,072,482 - 37,124,338 (-)NCBIHuRef
CHM1_1237,261,631 - 37,313,513 (-)NCBICHM1_1
T2T-CHM13v2.0237,106,342 - 37,164,108 (-)NCBIT2T-CHM13v2.0
Eif2ak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2616,189,000 - 16,224,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl616,188,979 - 16,224,971 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx616,504,502 - 16,534,073 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0616,826,710 - 16,856,281 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0616,307,765 - 16,337,332 (+)NCBIRnor_WKY
Rnor_6.061,428,845 - 1,466,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl61,428,834 - 1,466,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.061,419,340 - 1,456,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera615,851,444 - 15,880,415 (+)NCBICelera
Cytogenetic Map6q11NCBI
Eif2ak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554414,908,318 - 4,944,343 (-)NCBIChiLan1.0ChiLan1.0
EIF2AK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A37,895,805 - 37,945,465 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A37,895,814 - 37,941,686 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A37,130,386 - 37,184,587 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EIF2AK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11729,494,641 - 29,537,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1729,496,128 - 29,537,933 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1729,310,721 - 29,351,697 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01730,145,828 - 30,187,548 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1730,143,443 - 30,180,337 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11729,373,804 - 29,415,016 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01729,436,846 - 29,477,968 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01729,654,942 - 29,696,294 (-)NCBIUU_Cfam_GSD_1.0
Eif2ak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629242,461,570 - 42,497,341 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366631,126,977 - 1,157,137 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366631,127,047 - 1,157,263 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2AK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3103,041,221 - 103,096,738 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13103,041,029 - 103,096,741 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23109,641,276 - 109,667,770 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2AK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11470,246,081 - 70,290,851 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1470,247,168 - 70,296,463 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604541,658,265 - 41,713,053 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2ak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473818,717,092 - 18,758,457 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473818,716,623 - 18,764,243 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1114
Count of miRNA genes:655
Interacting mature miRNAs:801
Transcripts:ENSMUST00000024884, ENSMUST00000169940, ENSMUST00000171451, ENSMUST00000171852
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined175020395784204103Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175175842585758612Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175175842585758612Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
4142201Obrq15_mobesity resistance QTL 15 (mouse)Not determined5753444780885776Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175753444793507179Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5758908991589197Mouse
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176230101095294699Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176230101095294699Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176388554895294699Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176521493895294699Mouse
14928308Manh82_mmandible shape 82 (mouse)176631524395294699Mouse
13464254Ifvrq3_minfluenza virus resistance QTL 3 (mouse)176795765583908089Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176894131995294699Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177070119895294699Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177070119895294699Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177070119895294699Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177070119895294699Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177339513295294699Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177339513295294699Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7410765193507179Mouse
1357646Axtq3_manxiety QTL 3 (mouse)Not determined177458908990395270Mouse
1357552Aaj4_manxiety in A/J 4 (mouse)Not determined177458908990395270Mouse

Markers in Region
Eif2ak2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371779,253,457 - 79,254,115UniSTSGRCm37
Celera1783,170,754 - 83,171,410UniSTS
Cytogenetic Map17E2UniSTS
cM Map1740.0UniSTS
cM Map1740.0UniSTS
AI467567  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381778,852,698 - 78,852,806UniSTSGRCm38
MGSCv371779,252,038 - 79,252,146UniSTSGRCm37
Celera1783,169,335 - 83,169,443UniSTS
Cytogenetic Map17E3UniSTS
Cytogenetic Map17E2UniSTS
cM Map1740.0UniSTS
Whitehead/MRC_RH17934.76UniSTS
AI747578  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381778,854,694 - 78,854,835UniSTSGRCm38
MGSCv371779,254,034 - 79,254,175UniSTSGRCm37
Celera1783,171,331 - 83,171,470UniSTS
Cytogenetic Map17E2UniSTS
cM Map1740.0UniSTS
Whitehead/MRC_RH17934.86UniSTS
px-60g6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10D1UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map15A1UniSTS
Cytogenetic Map3G1UniSTS
Cytogenetic Map17E2UniSTS
Cytogenetic Map10A4UniSTS
cM Map1354.0UniSTS
cM Map1740.0UniSTS
px-8b4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F1UniSTS
Cytogenetic Map10D1UniSTS
Cytogenetic Map3G1UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map17B3UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map17E2UniSTS
Cytogenetic Map3BUniSTS
cM Map1354.0UniSTS
cM Map1740.0UniSTS
STS-Z41731  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381778,881,439 - 78,881,782UniSTSGRCm38
MGSCv371779,280,779 - 79,281,122UniSTSGRCm37
Celera1783,199,235 - 83,199,578UniSTS
Cytogenetic Map17E2UniSTS
cM Map1740.0UniSTS
px-24g4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7CUniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map5A2UniSTS
Cytogenetic Map3H2UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic MapXA2UniSTS
Cytogenetic Map3F2.3UniSTS
Cytogenetic Map3G1UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map12B1UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map15A1UniSTS
Cytogenetic Map16C3.3UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic Map10D1UniSTS
Cytogenetic Map14E2.2UniSTS
Cytogenetic Map9A1UniSTS
Cytogenetic Map17E2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map17CUniSTS
cM Map91.0UniSTS
cM Map316.4UniSTS
cM Map1740.0UniSTS
cM Map1354.0UniSTS
Eif2ak2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381778,854,117 - 78,854,775UniSTSGRCm38
MGSCv371779,253,457 - 79,254,115UniSTSGRCm37
Celera1783,170,754 - 83,171,410UniSTS
Cytogenetic Map17E2UniSTS
cM Map1740.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000024884   ⟹   ENSMUSP00000024884
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1779,159,993 - 79,190,002 (-)Ensembl
GRCm38.p6 Ensembl1778,852,564 - 78,882,573 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169940
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1779,162,783 - 79,166,409 (-)Ensembl
GRCm38.p6 Ensembl1778,855,354 - 78,858,980 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171451
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1779,185,544 - 79,189,983 (-)Ensembl
GRCm38.p6 Ensembl1778,878,115 - 78,882,554 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171852
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1779,181,207 - 79,189,977 (-)Ensembl
GRCm38.p6 Ensembl1778,873,778 - 78,882,548 (-)Ensembl
RefSeq Acc Id: NM_011163   ⟹   NP_035293
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391779,159,979 - 79,190,001 (-)NCBI
GRCm381778,852,550 - 78,882,572 (-)ENTREZGENE
MGSCv371779,251,890 - 79,281,912 (-)RGD
Celera1783,169,187 - 83,200,883 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006523863   ⟹   XP_006523926
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391779,157,933 - 79,189,917 (-)NCBI
GRCm381778,850,504 - 78,882,479 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035293   ⟸   NM_011163
- UniProtKB: Q62026 (UniProtKB/Swiss-Prot),   Q03963 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006523926   ⟸   XM_006523863
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000024884   ⟸   ENSMUST00000024884
Protein Domains
DRBM   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03963-F1-model_v2 AlphaFold Q03963 1-515 view protein structure

Promoters
RGD ID:13676802
Promoter ID:EPDNEW_M22550
Type:initiation region
Name:Eif2ak2_1
Description:Mus musculus eukaryotic translation initiation factor 2-alphakinase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381778,882,543 - 78,882,603EPDNEW
RGD ID:6828038
Promoter ID:MM_KWN:24236
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_011163
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361779,281,696 - 79,282,196 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1353449 AgrOrtholog
Ensembl Genes ENSMUSG00000024079 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000024884 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000024884 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro dsRBD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EIF2AK2_DSRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EIF2AK2_DSRM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19106 UniProtKB/Swiss-Prot
MGD MGI:1353449 ENTREZGENE
NCBI Gene 19106 ENTREZGENE
Pfam dsrm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB EIF2AK2 RGD
PhenoGen Eif2ak2 PhenoGen
PROSITE DS_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E2AK2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q62026 ENTREZGENE
  Q78E06_MOUSE UniProtKB/TrEMBL
  Q91YN2_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q61742 UniProtKB/Swiss-Prot
  Q62026 UniProtKB/Swiss-Prot