EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2) - Rat Genome Database

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Gene: EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2) Canis lupus familiaris
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Symbol: EIF2AK2
Name: eukaryotic translation initiation factor 2 alpha kinase 2
RGD ID: 12185553
Description: ENCODES a protein that exhibits ATP binding (inferred); double-stranded RNA binding (inferred); eukaryotic translation initiation factor 2alpha kinase activity (inferred); INVOLVED IN endoplasmic reticulum unfolded protein response (ortholog); negative regulation of apoptotic process (ortholog); positive regulation of apoptotic process (ortholog); PARTICIPATES IN ceramide signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); Cardiovirus Infections (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; p68 kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11729,494,641 - 29,537,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1729,496,128 - 29,537,933 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1729,310,721 - 29,351,697 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01730,145,828 - 30,187,548 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1730,143,443 - 30,180,337 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11729,373,804 - 29,415,016 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01729,436,846 - 29,477,968 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01729,654,942 - 29,696,294 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16424203   PMID:16954046   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EIF2AK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11729,494,641 - 29,537,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1729,496,128 - 29,537,933 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1729,310,721 - 29,351,697 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01730,145,828 - 30,187,548 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1730,143,443 - 30,180,337 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11729,373,804 - 29,415,016 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01729,436,846 - 29,477,968 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01729,654,942 - 29,696,294 (-)NCBIUU_Cfam_GSD_1.0
EIF2AK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38237,099,210 - 37,156,980 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl237,099,210 - 37,157,522 (-)EnsemblGRCh38hg38GRCh38
GRCh37237,326,353 - 37,384,123 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36237,187,203 - 37,237,572 (-)NCBINCBI36Build 36hg18NCBI36
Build 34237,245,349 - 37,295,719NCBI
Celera237,174,728 - 37,225,214 (-)NCBICelera
Cytogenetic Map2p22.2NCBI
HuRef237,072,482 - 37,124,338 (-)NCBIHuRef
CHM1_1237,261,631 - 37,313,513 (-)NCBICHM1_1
T2T-CHM13v2.0237,106,342 - 37,164,108 (-)NCBIT2T-CHM13v2.0
Eif2ak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391779,157,933 - 79,190,001 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1779,159,993 - 79,190,002 (-)EnsemblGRCm39 Ensembl
GRCm381778,850,504 - 78,882,572 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1778,852,564 - 78,882,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv371779,251,890 - 79,281,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361778,757,622 - 78,787,630 (-)NCBIMGSCv36mm8
Celera1783,169,187 - 83,200,883 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1749.56NCBI
Eif2ak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8621,941,147 - 21,977,115 (+)NCBIGRCr8
mRatBN7.2616,189,000 - 16,224,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl616,188,979 - 16,224,971 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx616,504,502 - 16,534,073 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0616,826,710 - 16,856,281 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0616,307,765 - 16,337,332 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.061,428,845 - 1,466,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl61,428,834 - 1,466,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.061,419,340 - 1,456,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera615,851,444 - 15,880,415 (+)NCBICelera
Cytogenetic Map6q12NCBI
Eif2ak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554414,908,318 - 4,944,343 (-)NCBIChiLan1.0ChiLan1.0
EIF2AK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21289,322,413 - 89,382,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A89,326,449 - 89,386,204 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A37,130,386 - 37,184,587 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A37,895,805 - 37,945,465 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A37,895,814 - 37,941,686 (-)Ensemblpanpan1.1panPan2
Eif2ak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629242,461,570 - 42,497,341 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366631,126,977 - 1,157,137 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366631,127,047 - 1,157,263 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2AK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3103,041,221 - 103,096,738 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13103,041,029 - 103,096,741 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23109,641,276 - 109,667,770 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2AK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11470,246,081 - 70,290,851 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1470,247,168 - 70,296,463 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604541,658,265 - 41,713,053 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2ak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473818,717,092 - 18,758,457 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473818,716,623 - 18,764,243 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EIF2AK2
466 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8 3 8 1
Low 5 4 14 6 6 6 6 9 8 2 5
Below cutoff 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000009794   ⟹   ENSCAFP00000009092
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1729,496,128 - 29,537,933 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845033215   ⟹   ENSCAFP00845026003
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1730,143,443 - 30,180,337 (-)Ensembl
RefSeq Acc Id: NM_001048135   ⟹   NP_001041600
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11729,496,128 - 29,537,933 (-)NCBI
Dog10K_Boxer_Tasha1729,310,721 - 29,351,697 (-)NCBI
ROS_Cfam_1.01730,146,262 - 30,187,548 (-)NCBI
UMICH_Zoey_3.11729,373,804 - 29,415,016 (-)NCBI
UNSW_CanFamBas_1.01729,436,846 - 29,477,968 (-)NCBI
UU_Cfam_GSD_1.01729,654,942 - 29,696,294 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038690510   ⟹   XP_038546438
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01730,145,828 - 30,180,404 (-)NCBI
RefSeq Acc Id: XM_038690511   ⟹   XP_038546439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01730,145,828 - 30,180,367 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001041600   ⟸   NM_001048135
- UniProtKB: Q2KM13 (UniProtKB/TrEMBL),   A0A8C0TR41 (UniProtKB/TrEMBL),   A0A8C0LAY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000009092   ⟸   ENSCAFT00000009794
RefSeq Acc Id: XP_038546438   ⟸   XM_038690510
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TR41 (UniProtKB/TrEMBL),   Q2KM13 (UniProtKB/TrEMBL),   A0A8C0LAY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038546439   ⟸   XM_038690511
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TR41 (UniProtKB/TrEMBL),   Q2KM13 (UniProtKB/TrEMBL),   A0A8C0LAY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845026003   ⟸   ENSCAFT00845033215
Protein Domains
DRBM   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006051 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004965 UniProtKB/TrEMBL
  ENSCAFG00040024034 UniProtKB/TrEMBL
  ENSCAFG00845018782 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000009794.4 UniProtKB/TrEMBL
  ENSCAFT00030009184.1 UniProtKB/TrEMBL
  ENSCAFT00040044807.1 UniProtKB/TrEMBL
  ENSCAFT00845033215 ENTREZGENE
  ENSCAFT00845033215.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.160.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro dsRBD_dom UniProtKB/TrEMBL
  EIF2AK2_DSRM_1 UniProtKB/TrEMBL
  EIF2AK2_DSRM_2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report cfa:611397 UniProtKB/TrEMBL
NCBI Gene EIF2AK2 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED UniProtKB/TrEMBL
  INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
Pfam dsrm UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE DS_RBD UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART DSRM UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0LAY4 ENTREZGENE
  A0A8C0TR41 ENTREZGENE, UniProtKB/TrEMBL
  Q2KM13 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40257 ENTREZGENE