RGD Reference Report - Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection. - Rat Genome Database

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Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection.

Authors: Al-Khatib, Khaldun  Williams, Bryan R G  Silverman, Robert H  Halford, William  Carr, Daniel J J 
Citation: Al-Khatib K, etal., Exp Eye Res. 2005 Feb;80(2):167-73. doi: 10.1016/j.exer.2004.08.026.
RGD ID: 40902819
Pubmed: PMID:15670795   (View Abstract at PubMed)
DOI: DOI:10.1016/j.exer.2004.08.026   (Journal Full-text)

The present study investigated the role of interferon-inducible pathways in herpes simplex virus type 1-infected mice transduced with an adenoviral vector expressing murine interferon-beta (Ad:IFN-beta). Wild type mice or RNase L(-/-) mice deficient in responses to 2'-5' oligoadenylate synthetase activation, or lacking RNA-dependent protein kinase and transduced with Ad:IFN-beta showed enhanced survival following HSV-1 infection. The protective effect was associated with a reduction in viral gene expression in the cornea and trigeminal ganglion in wild type mice as well as the trigeminal ganglion of RNase L(-/-) mice. However, the efficacy of Ad:IFN-beta was lost in the corneas of RNase L(-/-) mice and significantly diminished in both the cornea and trigeminal ganglion as measured by viral gene expression in RNA-dependent protein kinase deficient mice. Collectively, the data suggest survival rates of viral-infected mice do not reflect the replication capacity as measured by herpes simplex virus type one lytic gene expression.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Eif2ak2  (eukaryotic translation initiation factor 2-alpha kinase 2)
Ifnb1  (interferon beta 1)
Rnasel  (ribonuclease L)

Genes (Mus musculus)
Eif2ak2  (eukaryotic translation initiation factor 2-alpha kinase 2)
Ifnb1  (interferon beta 1, fibroblast)
Rnasel  (ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent))

Genes (Homo sapiens)
EIF2AK2  (eukaryotic translation initiation factor 2 alpha kinase 2)
IFNB1  (interferon beta 1)
RNASEL  (ribonuclease L)


Additional Information