Cers6 (ceramide synthase 6) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cers6 (ceramide synthase 6) Rattus norvegicus
Analyze
Symbol: Cers6
Name: ceramide synthase 6
RGD ID: 1561599
Description: Predicted to enable sphingosine N-acyltransferase activity. Involved in oligodendrocyte development and positive regulation of oligodendrocyte apoptotic process. Predicted to be located in endoplasmic reticulum. Orthologous to human CERS6 (ceramide synthase 6); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LAG1 homolog, ceramide synthase 6; LAG1 longevity assurance homolog 6; Lass6; LOC366065; RGD1561599; similar to longevity assurance homolog 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,038,520 - 74,287,544 (+)NCBIGRCr8
mRatBN7.2353,630,637 - 53,879,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl353,630,959 - 53,876,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,031,533 - 57,280,360 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0365,615,110 - 65,863,927 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,377,005 - 63,625,848 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,094,240 - 55,338,370 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,094,637 - 55,338,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0361,707,597 - 61,950,319 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4350,979,559 - 51,252,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera353,194,291 - 53,442,587 (+)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
calyculin a  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fentin chloride  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glycerol  (ISO)
leflunomide  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
pravastatin  (ISO)
progesterone  (ISO)
propane-1,2-diol  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclocarban  (EXP)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis. Novgorodov SA, etal., J Biol Chem. 2011 Feb 11;286(6):4644-58. doi: 10.1074/jbc.M110.164392. Epub 2010 Dec 10.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15823095   PMID:17609214   PMID:17977534   PMID:19946888   PMID:23760501   PMID:26620563  


Genomics

Comparative Map Data
Cers6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,038,520 - 74,287,544 (+)NCBIGRCr8
mRatBN7.2353,630,637 - 53,879,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl353,630,959 - 53,876,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,031,533 - 57,280,360 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0365,615,110 - 65,863,927 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,377,005 - 63,625,848 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,094,240 - 55,338,370 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,094,637 - 55,338,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0361,707,597 - 61,950,319 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4350,979,559 - 51,252,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera353,194,291 - 53,442,587 (+)NCBICelera
Cytogenetic Map3q21NCBI
CERS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382168,456,272 - 168,775,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2168,456,249 - 168,775,134 (+)EnsemblGRCh38hg38GRCh38
GRCh372169,312,782 - 169,631,644 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,021,081 - 169,339,398 (+)NCBINCBI36Build 36hg18NCBI36
Build 342169,138,341 - 169,456,659NCBI
Celera2162,921,561 - 163,239,455 (+)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2161,192,334 - 161,510,650 (+)NCBIHuRef
CHM1_12169,318,813 - 169,637,448 (+)NCBICHM1_1
T2T-CHM13v2.02168,914,043 - 169,232,607 (+)NCBIT2T-CHM13v2.0
Cers6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39268,691,489 - 68,944,628 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl268,691,785 - 68,944,626 (+)EnsemblGRCm39 Ensembl
GRCm38268,861,145 - 69,114,284 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl268,861,441 - 69,114,282 (+)EnsemblGRCm38mm10GRCm38
MGSCv37268,699,614 - 68,949,347 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36268,662,396 - 68,912,129 (+)NCBIMGSCv36mm8
Celera270,531,557 - 70,777,053 (+)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.53NCBI
Cers6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,642,341 - 5,920,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,636,678 - 5,920,377 (-)NCBIChiLan1.0ChiLan1.0
CERS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,093,865 - 71,419,931 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,108,853 - 71,434,905 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B55,711,661 - 56,036,909 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,180,442 - 173,504,024 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,180,436 - 173,498,553 (+)Ensemblpanpan1.1panPan2
CERS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,307,461 - 13,608,123 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,308,110 - 13,602,875 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,317,100 - 13,619,138 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03613,421,960 - 13,724,119 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3613,421,381 - 13,724,116 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,508,151 - 13,809,389 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,494,552 - 13,796,285 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03613,607,070 - 13,909,590 (+)NCBIUU_Cfam_GSD_1.0
Cers6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303130,590,704 - 130,882,393 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,740,601 - 11,027,067 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,735,327 - 11,027,019 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CERS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1574,927,130 - 75,261,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11574,927,088 - 75,261,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,094,841 - 84,360,268 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CERS6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11053,972,795 - 54,299,721 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1053,972,376 - 54,294,224 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040145,236,257 - 145,554,226 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cers6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,208,478 - 6,511,708 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,208,976 - 6,511,575 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cers6
1669 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:26
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000058763
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
D3Rat75  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2353,814,841 - 53,815,045 (+)MAPPERmRatBN7.2
Rnor_6.0355,278,824 - 55,279,027NCBIRnor6.0
Rnor_5.0361,890,756 - 61,890,959UniSTSRnor5.0
RGSC_v3.4351,195,217 - 51,195,421RGDRGSC3.4
RGSC_v3.4351,195,218 - 51,195,421UniSTSRGSC3.4
RGSC_v3.1351,091,590 - 51,091,793RGD
Celera353,377,734 - 53,377,917UniSTS
RH 3.4 Map4528.12RGD
RH 3.4 Map4528.12UniSTS
SHRSP x BN Map336.0899UniSTS
SHRSP x BN Map336.0899RGD
FHH x ACI Map339.47RGD
Cytogenetic Map3q21UniSTS
D3Chm63  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2353,781,112 - 53,781,346 (+)MAPPERmRatBN7.2
Rnor_6.0355,245,276 - 55,245,509NCBIRnor6.0
Rnor_5.0361,857,234 - 61,857,467UniSTSRnor5.0
RGSC_v3.4351,161,661 - 51,161,895RGDRGSC3.4
RGSC_v3.4351,161,662 - 51,161,895UniSTSRGSC3.4
Celera353,344,358 - 53,344,591UniSTS
Cytogenetic Map3q21UniSTS
RH132016  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2353,632,717 - 53,632,908 (+)MAPPERmRatBN7.2
Rnor_6.0355,096,345 - 55,096,535NCBIRnor6.0
Rnor_5.0361,710,185 - 61,710,375UniSTSRnor5.0
RGSC_v3.4350,981,133 - 50,981,323UniSTSRGSC3.4
Celera353,196,396 - 53,196,586UniSTS
Cytogenetic Map3q21UniSTS
BE106939  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2353,855,527 - 53,855,726 (+)MAPPERmRatBN7.2
Rnor_6.0355,318,627 - 55,318,825NCBIRnor6.0
Rnor_5.0361,930,559 - 61,930,757UniSTSRnor5.0
RGSC_v3.4351,237,259 - 51,237,457UniSTSRGSC3.4
Celera353,418,422 - 53,418,620UniSTS
RH 3.4 Map4402.04UniSTS
Cytogenetic Map3q21UniSTS
AU049900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2353,814,084 - 53,814,330 (+)MAPPERmRatBN7.2
Rnor_6.0355,278,067 - 55,278,312NCBIRnor6.0
Rnor_5.0361,889,999 - 61,890,244UniSTSRnor5.0
RGSC_v3.4351,194,461 - 51,194,706UniSTSRGSC3.4
Celera353,376,977 - 53,377,222UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000058763   ⟹   ENSRNOP00000055558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl353,630,959 - 53,874,822 (+)Ensembl
Rnor_6.0 Ensembl355,094,637 - 55,338,445 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105502   ⟹   ENSRNOP00000078641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl353,630,959 - 53,874,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111194   ⟹   ENSRNOP00000088922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl353,631,007 - 53,876,848 (+)Ensembl
RefSeq Acc Id: NM_001399362   ⟹   NP_001386291
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,038,861 - 74,287,544 (+)NCBI
mRatBN7.2353,630,977 - 53,879,692 (+)NCBI
RefSeq Acc Id: NM_001399363   ⟹   NP_001386292
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,038,861 - 74,287,544 (+)NCBI
mRatBN7.2353,630,977 - 53,879,692 (+)NCBI
RefSeq Acc Id: XM_039106361   ⟹   XP_038962289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,038,520 - 74,259,005 (+)NCBI
mRatBN7.2353,630,637 - 53,836,221 (+)NCBI
RefSeq Acc Id: XM_063284272   ⟹   XP_063140342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,212,154 - 74,287,542 (+)NCBI
Ensembl Acc Id: ENSRNOP00000055558   ⟸   ENSRNOT00000058763
RefSeq Acc Id: XP_038962289   ⟸   XM_039106361
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000088922   ⟸   ENSRNOT00000111194
Ensembl Acc Id: ENSRNOP00000078641   ⟸   ENSRNOT00000105502
RefSeq Acc Id: NP_001386291   ⟸   NM_001399362
- Peptide Label: isoform 1
- UniProtKB: F1LTP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386292   ⟸   NM_001399363
- Peptide Label: isoform 2
- UniProtKB: A0A8I6A742 (UniProtKB/TrEMBL),   A6HLZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140342   ⟸   XM_063284272
- Peptide Label: isoform X2
Protein Domains
Homeobox   TLC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LTP8-F1-model_v2 AlphaFold F1LTP8 1-392 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692119
Promoter ID:EPDNEW_R2634
Type:initiation region
Name:Cers6_1
Description:ceramide synthase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0355,094,623 - 55,094,683EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561599 AgrOrtholog
BioCyc Gene G2FUF-49518 BioCyc
Ensembl Genes ENSRNOG00000024595 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058763.5 UniProtKB/TrEMBL
  ENSRNOT00000105502.1 UniProtKB/TrEMBL
  ENSRNOT00000111194.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeodomain UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  Longevity_assurance_LAG1_LAC1 UniProtKB/TrEMBL
  TLC-dom UniProtKB/TrEMBL
NCBI Gene 366065 ENTREZGENE
PANTHER CERAMIDE SYNTHASE 6 UniProtKB/TrEMBL
  PTHR12560 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
  TRAM_LAG1_CLN8 UniProtKB/TrEMBL
PhenoGen Cers6 PhenoGen
PIRSF LAG1_LAC1 UniProtKB/TrEMBL
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
  TLC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024595 RatGTEx
SMART TLC UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A8I5ZL71_RAT UniProtKB/TrEMBL
  A0A8I6A742 ENTREZGENE, UniProtKB/TrEMBL
  A6HLZ6 ENTREZGENE, UniProtKB/TrEMBL
  F1LTP8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Cers6  ceramide synthase 6  Lass6  LAG1 homolog, ceramide synthase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Lass6  LAG1 homolog, ceramide synthase 6  RGD1561599_predicted  similar to longevity assurance homolog 6 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561599_predicted  similar to longevity assurance homolog 6 (predicted)  LOC366065  similar to longevity assurance homolog 6  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC366065  similar to longevity assurance homolog 6      Symbol and Name status set to provisional 70820 PROVISIONAL