Gluco35 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Gluco35 (Glucose level QTL 35) Rattus norvegicus

Symbol: Gluco35
Name: Glucose level QTL 35
RGD ID: 2302273
Previously known as: Dmsdt1
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level   (CMO:0000046)    
LOD Score: 5.3
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83101,255,536 - 134,750,886RGD_MAPPER_PIPELINE
mRatBN7.2380,800,231 - 114,297,550RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0383,817,637 - 119,509,260RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0390,520,542 - 126,035,097RGDRnor5.0
RGSC_v3.4379,283,621 - 114,574,752RGDRGSC3.4
Cross Type: intercross
Strains Crossed: SDT/Jcl F344/NSlc 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco35Ratdiabetes mellitus  IAGP 2298688 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco35Ratincreased circulating glucose level  IAGP 2298688 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco35Ratblood glucose level  IDA 2298688 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco35Ratfasting  IDA 2298688 RGD 
Gluco35Ratglucose solution  IDA 2298688 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco35Ratoral glucose tolerance test  IDA 2298688 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco35RatF344/NSlc  IEA 2298688 RGD 
Gluco35RatSDT/Jcl  IEA 2298688 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gluco35Ratblood glucose amount  IDA 2298688 RGD 


#
Reference Title
Reference Citation
1. Identification of a major locus for islet inflammation and fibrosis in the Spontaneously Diabetic Torii rat. Fuse M, etal., Physiol Genomics. 2008 Jul 8;.

Related QTL Description Reference
Gluco39 maps to same region RGD:2298688



1 to 20 of 424 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
7539539LOC102549766uncharacterized LOC10254976638113790181152786Rat
41156540Rnu6-841RNA, U6 small nuclear 84138133842281338524Rat
1565066Rpl38l2ribosomal protein L38 like 238177463881774955Rat
1311013Lrrc4cleucine rich repeat containing 4C38230549583684039Rat
2319534Rrp8-ps1ribosomal RNA processing 8, pseudogene 138308598883099873Rat
1588505Vps26c-ps1VPS26 endosomal protein sorting factor C, pseudogene 138310296783141840Rat
2319335C1h9orf85-ps1similar to human chromosome 9 open reading frame 85, pseudogene 138433888884339352Rat
40984830LOC120101993U7 small nuclear RNA38449983684499900Rat
1590781Hsp90ab1-ps19heat shock protein 90 alpha family class B member 1, pseudogene 1938483409484836215Rat
1588504Myl12b-ps1myosin light chain 12B, pseudogene 138487283384873338Rat
1592252Necap1-ps1NECAP endocytosis associated 1, pseudogene 138544977285453693Rat
41368639LOC120101605uncharacterized LOC12010160538550759585531319Rat
41339341LOC120102127U4 spliceosomal RNA38551434785514473Rat
1592240Hsp90ab1-ps24heat shock protein 90 alpha family class B member 1, pseudogene 2438591628385918458Rat
1561224Ptbp1-ps6polypyrimidine tract binding protein 1, pseudogene 638632246986323963Rat
1560961Rfk-ps3riboflavin kinase, pseudogene 338651072986512353Rat
40977179Eno1-ps31enolase 1, pseudogene 3138676747386768066Rat
1592203Aldoa-ps9aldolase, fructose-bisphosphate A, pseudogene 938677064886804751Rat
9354787LOC103691849uncharacterized LOC10369184938769980387711037Rat
1309730Iftapintraflagellar transport associated protein38781206887906517Rat

1 to 20 of 424 rows
1 to 20 of 632 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10233D3Arb1119639621091396211109Ratregion
10234D3Mgh2813939621095996211098Ratregion
10293D3Mit716538987820789878372Ratregion
33826D3Mit69539613869996138794Ratregion
33838D3Mit181883112287552112287746Ratregion
33901D3Mit121513114297399114297550Ratregion
34228D3Mgh513139853525598535386Ratregion
34242D3Mgh131343112272331112272465Ratregion
34250D3Mgh121763112272331112272507Ratregion
34507D3Mgh111583106320129106320287Ratregion
33684D3Mit1614839299976092999908Ratregion
33774D3Mit1514039485676394856903Ratregion
36077D3Rat2816938965223689652405Ratregion
37540D3Rat862063104044341104044547Ratregion
35270D3Rat1111593108905118108905277Ratregion
35380D3Rat2717238911506889115240Ratregion
35451D3Rat211333110362260110362393Ratregion
37040D3Rat231723102019030102019204Ratregion
37156D3Rat7020039778296497783166Ratregion
37614D3Rat12713938931239989312538Ratregion
1 to 20 of 632 rows

Flank 1: (D3Arb18)
Rat AssemblyChrPosition (strand)Source
GRCr83101,255,536 - 101,255,758 (+)Marker Load Pipeline
mRatBN7.2380,800,231 - 80,800,453 (+)MAPPER
Rnor_6.0383,817,637 - 83,817,858NCBI
Rnor_5.0390,520,542 - 90,520,763UniSTS
RGSC_v3.4379,283,621 - 79,283,843RGD
RGSC_v3.4379,283,622 - 79,283,843UniSTS
RGSC_v3.1379,180,050 - 79,180,271RGD
Celera379,974,777 - 79,974,998UniSTS
RH 3.4 Map3689.3UniSTS
RH 3.4 Map3689.3RGD
FHH x ACI Map347.15UniSTS
FHH x ACI Map347.15RGD
Peak: (D3Mit12)
Rat AssemblyChrPosition (strand)Source
GRCr83134,750,735 - 134,750,886 (+)Marker Load Pipeline
mRatBN7.23114,297,399 - 114,297,550 (+)MAPPER
Rnor_6.03119,509,110 - 119,509,260NCBI
Rnor_5.03126,034,947 - 126,035,097UniSTS
RGSC_v3.43114,574,601 - 114,574,752RGD
RGSC_v3.43114,574,602 - 114,574,752UniSTS
RGSC_v3.13114,480,095 - 114,480,482RGD
Celera3113,137,443 - 113,137,593UniSTS
RH 2.0 Map3660.6RGD
SHRSP x BN Map354.0299RGD
Cytogenetic Map3q36UniSTS
Flank 2: (D3Mit12)
Rat AssemblyChrPosition (strand)Source
GRCr83134,750,735 - 134,750,886 (+)Marker Load Pipeline
mRatBN7.23114,297,399 - 114,297,550 (+)MAPPER
Rnor_6.03119,509,110 - 119,509,260NCBI
Rnor_5.03126,034,947 - 126,035,097UniSTS
RGSC_v3.43114,574,601 - 114,574,752RGD
RGSC_v3.43114,574,602 - 114,574,752UniSTS
RGSC_v3.13114,480,095 - 114,480,482RGD
Celera3113,137,443 - 113,137,593UniSTS
RH 2.0 Map3660.6RGD
SHRSP x BN Map354.0299RGD
Cytogenetic Map3q36UniSTS


1 to 10 of 56 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat

1 to 10 of 56 rows


Note Type Note Reference
qtl_cross_type intercross  
qtl_general allele responsible: SDT allele involved in the development of diabetes; affects blood glucose levels at 60 and 120 min 2298688
qtl_general software used: Map Manager QTX20b 2298688
qtl_general number of animals used: 167 F2 males 2298688
qtl_general measurement method: Glucose (2g/kg bodywt) was given orally and blood samples taken from the tail vein at 0, 15, 30, 60 and 120 min 2298688
qtl_map orthologous to human chr 2q23.3-32.1, 11q12.1-p14.2, 15q14-21.1 and 20q13-11.21 and mouse chr 2 2298688