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Gene: Actc1 (actin, alpha, cardiac muscle 1) Rattus norvegicus
Symbol: Actc1
Name: actin, alpha, cardiac muscle 1
RGD ID: 2026
Description: Predicted to have ATP binding activity; ATPase activity; and myosin binding activity. Involved in cardiac muscle contraction; response to drug; and response to ethanol. Predicted to localize to several cellular components, including I band; actin cytoskeleton; and glutamatergic synapse. Biomarker of hypertension. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: actin alpha cardiac; actin alpha cardiac 1; actin, alpha cardiac muscle 1; actin, alpha, cardiac; actin, alpha, cardiac 1; alpha-actin cardiac; alpha-cardiac actin; MGC156490
Homo sapiens (human) : ACTC1 (actin alpha cardiac muscle 1)  HGNC  Alliance
Mus musculus (house mouse) : Actc1 (actin, alpha, cardiac muscle 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Actc1 (actin alpha cardiac muscle 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100987752 (actin alpha cardiac muscle 1)
Canis lupus familiaris (dog) : ACTC1 (actin alpha cardiac muscle 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Actc1 (actin alpha cardiac muscle 1)
Sus scrofa (pig) : ACTC1 (actin alpha cardiac muscle 1)
Chlorocebus sabaeus (African green monkey) : ACTC1 (actin alpha cardiac muscle 1)
Heterocephalus glaber (naked mole-rat) : Actc1 (actin alpha cardiac muscle 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03105,507,403 - 105,512,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3105,507,403 - 105,512,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03112,080,853 - 112,086,389 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4399,901,022 - 99,906,558 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1399,797,449 - 99,798,402 (-)NCBI
Celera399,781,510 - 99,787,044 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Actc1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2026
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.