Actc1 (actin, alpha, cardiac muscle 1) - Rat Genome Database

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Gene: Actc1 (actin, alpha, cardiac muscle 1) Rattus norvegicus
Analyze
Symbol: Actc1
Name: actin, alpha, cardiac muscle 1
RGD ID: 2026
Description: Predicted to enable ATP binding activity; microfilament motor activity; and myosin binding activity. Involved in cardiac muscle contraction; response to ethanol; and response to xenobiotic stimulus. Predicted to be located in several cellular components, including I band; filopodium; and lamellipodium. Predicted to be part of dynactin complex. Predicted to be active in actin filament; glutamatergic synapse; and sarcomere. Biomarker of hypertension. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin alpha cardiac; actin alpha cardiac 1; actin, alpha cardiac muscle 1; actin, alpha, cardiac; actin, alpha, cardiac 1; alpha-actin cardiac; alpha-cardiac actin; MGC156490
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23100,811,987 - 100,817,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3100,811,987 - 100,817,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3104,444,093 - 104,449,627 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03113,043,134 - 113,048,668 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03110,726,488 - 110,732,015 (-)NCBIRnor_WKY
Rnor_6.03105,507,403 - 105,512,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3105,507,403 - 105,512,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03112,080,853 - 112,086,389 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4399,901,022 - 99,906,558 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1399,797,449 - 99,798,402 (-)NCBI
Celera399,781,510 - 99,787,044 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
choline  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diethyl malate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
estriol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
graphite  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
L-methionine  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
phenobarbital  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament  (IBA,ISO)
cell body  (ISS)
cytoplasm  (ISO,ISS)
dynactin complex  (IBA)
filopodium  (ISS)
glutamatergic synapse  (ISO)
I band  (ISO)
lamellipodium  (ISS)
sarcomere  (IBA,ISO)
synapse  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. [Analysis of written enunciations of a patient as the basis for diagnosing schizophrenia] Falicki Z, etal., Pol Tyg Lek 1978 Aug 7;33(32):1259-60.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Current estimates from the Health Interview Survey: United States--1977. Howie LJ and Drury TF, Vital Health Stat 10 1978 Sep;(126):1-98.
4. Expression of the genes coding for the skeletal muscle and cardiac actions in the heart. Mayer Y, etal., Nucleic Acids Res 1984 Jan 25;12(2):1087-100.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. alpha-cardiac actin (ACTC) binds to the band 3 (AE1) cardiac isoform. Moura Lima PR, etal., J Cell Biochem. 2003 Aug 15;89(6):1215-21.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Olson TM, etal., Science. 1998 May 1;280(5364):750-2.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Endotoxin and cytokines alter contractile protein expression in cardiac myocytes in vivo. Patten M, etal., Pflugers Arch. 2001 Sep;442(6):920-7.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Medium perfusion enables engineering of compact and contractile cardiac tissue. Radisic M, etal., Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H507-16. Epub 2003 Oct 9.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion. Simkhovich BZ, etal., Arch Biochem Biophys. 2003 Dec 15;420(2):268-78.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Long-term alcohol administration inhibits synthesis of both myofibrillar and sarcoplasmic proteins in heart. Vary TC and Deiter G, Metabolism. 2005 Feb;54(2):212-9.
20. Nifedipine represses ion channels, transporters and Ca(2+)-binding proteins in hearts of spontaneously hypertensive rats. Zwadlo C and Borlak J, Toxicol Appl Pharmacol. 2006 Jun 15;213(3):224-34. Epub 2005 Dec 15.
Additional References at PubMed
PMID:8889548   PMID:9114002   PMID:12477932   PMID:12947022   PMID:14605248   PMID:15491989   PMID:16288873   PMID:16481394   PMID:16611632   PMID:16854843   PMID:17611253   PMID:17765196  
PMID:17947298   PMID:19182904   PMID:19666135   PMID:19799913   PMID:19946888   PMID:20962418   PMID:21362503   PMID:21423176   PMID:22364878   PMID:22516433   PMID:22664934   PMID:22750946  
PMID:23533145   PMID:23580065   PMID:24413018   PMID:29476059   PMID:30361391  


Genomics

Comparative Map Data
Actc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23100,811,987 - 100,817,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3100,811,987 - 100,817,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3104,444,093 - 104,449,627 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03113,043,134 - 113,048,668 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03110,726,488 - 110,732,015 (-)NCBIRnor_WKY
Rnor_6.03105,507,403 - 105,512,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3105,507,403 - 105,512,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03112,080,853 - 112,086,389 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4399,901,022 - 99,906,558 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1399,797,449 - 99,798,402 (-)NCBI
Celera399,781,510 - 99,787,044 (-)NCBICelera
Cytogenetic Map3q35NCBI
ACTC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381534,790,230 - 34,795,549 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1534,790,230 - 34,795,549 (-)EnsemblGRCh38hg38GRCh38
GRCh371535,082,431 - 35,087,750 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361532,867,589 - 32,875,219 (-)NCBINCBI36Build 36hg18NCBI36
Build 341532,869,723 - 32,875,153NCBI
Celera1511,839,644 - 11,847,274 (-)NCBICelera
Cytogenetic Map15q14ENTREZGENE
HuRef1511,925,790 - 11,933,402 (-)NCBIHuRef
CHM1_11535,198,283 - 35,205,917 (-)NCBICHM1_1
T2T-CHM13v2.01532,595,427 - 32,600,746 (-)NCBIT2T-CHM13v2.0
Actc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392113,877,763 - 113,883,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2113,877,763 - 113,884,029 (-)EnsemblGRCm39 Ensembl
GRCm382114,047,282 - 114,052,875 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2114,047,282 - 114,053,548 (-)EnsemblGRCm38mm10GRCm38
MGSCv372113,873,025 - 113,878,547 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362113,738,730 - 113,744,252 (-)NCBIMGSCv36mm8
Celera2115,178,495 - 115,181,826 (-)NCBICelera
Cytogenetic Map2E4NCBI
cM Map257.55NCBI
Actc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554162,137,101 - 2,145,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554162,139,541 - 2,144,678 (-)NCBIChiLan1.0ChiLan1.0
LOC100987752
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11531,966,278 - 31,971,782 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1531,966,278 - 31,971,782 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01513,707,475 - 13,712,905 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACTC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1302,514,825 - 2,519,398 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl302,514,824 - 2,519,382 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha302,565,508 - 2,570,605 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0302,629,472 - 2,634,566 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl302,629,472 - 2,634,456 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1302,564,616 - 2,569,707 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0302,663,927 - 2,669,017 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0302,792,736 - 2,797,835 (-)NCBIUU_Cfam_GSD_1.0
Actc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864081,053,582 - 81,059,040 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366731,092,700 - 1,098,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1136,281,167 - 136,286,547 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11136,281,119 - 136,286,551 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21152,412,178 - 152,417,610 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12648,105,271 - 48,110,670 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2648,105,216 - 48,110,896 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604892,799,132 - 92,804,294 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248042,005,997 - 2,011,023 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248042,006,439 - 2,011,809 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
BG373920  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23100,811,733 - 100,811,903 (+)MAPPERmRatBN7.2
Rnor_6.03105,507,150 - 105,507,319NCBIRnor6.0
Rnor_5.03112,080,600 - 112,080,769UniSTSRnor5.0
RGSC_v3.4399,900,769 - 99,900,938UniSTSRGSC3.4
Celera399,781,257 - 99,781,426UniSTS
RH 3.4 Map3815.2UniSTS
Cytogenetic Map3q35UniSTS
LOC345651  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,664,470 - 11,665,066 (+)MAPPERmRatBN7.2
Rnor_6.01213,717,202 - 13,717,797NCBIRnor6.0
Rnor_5.01215,747,215 - 15,747,810UniSTSRnor5.0
RGSC_v3.41212,048,429 - 12,049,024UniSTSRGSC3.4
Celera1213,453,802 - 13,454,397UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map3q35UniSTS
STS_ADH2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23100,812,851 - 100,813,988 (+)MAPPERmRatBN7.2
mRatBN7.2437,621,193 - 37,621,465 (+)MAPPERmRatBN7.2
Rnor_6.0435,593,637 - 35,593,908NCBIRnor6.0
Rnor_6.03105,508,268 - 105,509,404NCBIRnor6.0
Rnor_5.0435,451,038 - 35,451,309UniSTSRnor5.0
Rnor_5.03112,081,718 - 112,082,854UniSTSRnor5.0
RGSC_v3.4399,901,887 - 99,903,023UniSTSRGSC3.4
RGSC_v3.4434,652,200 - 34,652,471UniSTSRGSC3.4
Celera433,105,107 - 33,105,378UniSTS
Celera399,782,375 - 99,783,511UniSTS
Cytogenetic Map3q35UniSTS
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q34UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)396127817102200699Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:95
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000011773
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 43
Medium 13 9 4 9 8 11 6 16 11 8
Low 2 27 15 14 15 27 18 18
Below cutoff 3 3 3 37 11 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011773   ⟹   ENSRNOP00000011773
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3100,811,987 - 100,817,523 (-)Ensembl
Rnor_6.0 Ensembl3105,507,403 - 105,512,939 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116592   ⟹   ENSRNOP00000082679
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3100,811,987 - 100,817,523 (-)Ensembl
RefSeq Acc Id: NM_019183   ⟹   NP_062056
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23100,811,987 - 100,817,523 (-)NCBI
Rnor_6.03105,507,403 - 105,512,939 (-)NCBI
Rnor_5.03112,080,853 - 112,086,389 (-)NCBI
RGSC_v3.4399,901,022 - 99,906,558 (-)RGD
Celera399,781,510 - 99,787,044 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062056 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI27452 (Get FASTA)   NCBI Sequence Viewer  
  EDL79827 (Get FASTA)   NCBI Sequence Viewer  
  P68035 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062056   ⟸   NM_019183
- UniProtKB: P68035 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011773   ⟸   ENSRNOT00000011773
RefSeq Acc Id: ENSRNOP00000082679   ⟸   ENSRNOT00000116592

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68035-F1-model_v2 AlphaFold P68035 1-377 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692298
Promoter ID:EPDNEW_R2822
Type:single initiation site
Name:Actc1_1
Description:actin, alpha, cardiac muscle 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03105,512,826 - 105,512,886EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2026 AgrOrtholog
BioCyc Gene G2FUF-48347 BioCyc
Ensembl Genes ENSRNOG00000008536 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011773 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000082679.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011773 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000116592.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7379877 IMAGE-MGC_LOAD
InterPro Actin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Actin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29275 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156490 IMAGE-MGC_LOAD
NCBI Gene 29275 ENTREZGENE
PANTHER PTHR11937 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Actin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Actc1 PhenoGen
PRINTS ACTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ACTINS_1 UniProtKB/Swiss-Prot
  ACTINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTINS_ACT_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ACTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204129
UniProt A0A8I5ZVP6_RAT UniProtKB/TrEMBL
  ACTC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0JPJ4 UniProtKB/Swiss-Prot
  P04270 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-15 Actc1  actin, alpha, cardiac muscle 1  Actc1  actin, alpha, cardiac 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Actc1  actin, alpha, cardiac 1  Actc1  actin alpha cardiac 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Actc1  actin alpha cardiac 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in cardiac muscle 69737
gene_homology gene has high similarity to the skeletal muscle actin Acta1 except for high divergence in the 3' untranslated sequence 69737
gene_homology has high similarity over 3'untranslated sequence with human cardiac muscle actin 69737
gene_product member of the actin family 69737