Actc1 (actin alpha cardiac muscle 1) - Rat Genome Database

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Gene: Actc1 (actin alpha cardiac muscle 1) Heterocephalus glaber
Analyze
Symbol: Actc1
Name: actin alpha cardiac muscle 1
RGD ID: 18908468
Description: ENCODES a protein that exhibits ATP binding (ortholog); microfilament motor activity (ortholog); myosin binding (ortholog); INVOLVED IN actin filament-based movement (ortholog); actin-mediated cell contraction (ortholog); actin-myosin filament sliding (ortholog); ASSOCIATED WITH arthrogryposis multiplex congenita (ortholog); atrial heart septal defect (ortholog); atrial heart septal defect 5 (ortholog); FOUND IN actin filament (ortholog); cytoplasm (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: actin, alpha cardiac muscle 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248042,005,997 - 2,011,023 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248042,006,439 - 2,011,809 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actc1Naked Mole-Ratdilated cardiomyopathy susceptibilityISOACTC1 (Homo sapiens)9068941DNA:point mutations: :p.Arg312His and p.Glu361Gly (human)RGDPMID:9563954 and REF_RGD_ID:1559158
Actc1Naked Mole-RatEndotoxemia  ISOActc1 (Rattus norvegicus)9068941 RGDPMID:11680626 and REF_RGD_ID:1598729
Actc1Naked Mole-Rathypertension  ISOActc1 (Rattus norvegicus)9068941 RGDPMID:16343576 and REF_RGD_ID:1598724
1 to 20 of 24 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actc1Naked Mole-Ratarthrogryposis multiplex congenita  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: ArthrogryposisClinVarPMID:25741868 and PMID:36945405
Actc1Naked Mole-Ratatrial heart septal defect  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrial septal defectClinVarPMID:28492532
Actc1Naked Mole-Ratatrial heart septal defect 5  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrial septal defect 5ClinVarPMID:10494087 more ...
Actc1Naked Mole-RatBloom syndrome  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
Actc1Naked Mole-Ratcardiomyopathy  ISOACTC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10494087 more ...
Actc1Naked Mole-Ratcolorectal cancer  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial colorectal cancerClinVarPMID:28492532
Actc1Naked Mole-Ratdilated cardiomyopathy  ISOACTC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10966831 more ...
Actc1Naked Mole-Ratdilated cardiomyopathy  ISOACTC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10966831 more ...
Actc1Naked Mole-Ratdilated cardiomyopathy  ISOACTC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10966831 more ...
Actc1Naked Mole-Ratdilated cardiomyopathy  ISOACTC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10966831 more ...
Actc1Naked Mole-Ratdilated cardiomyopathy  ISOACTC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10966831 more ...
Actc1Naked Mole-Ratdilated cardiomyopathy  ISOACTC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10966831 more ...
Actc1Naked Mole-Ratdilated cardiomyopathy 1A  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated cardiomyopathy 1AClinVarPMID:25741868 and PMID:28492532
Actc1Naked Mole-Ratdilated cardiomyopathy 1R  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated cardiomyopathy 1RClinVarPMID:10494087 more ...
Actc1Naked Mole-RatDilated Cardiomyopathy with Left Ventricular Noncompaction  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Left ventricular noncompaction cardiomyopathyClinVarPMID:28492532
Actc1Naked Mole-Ratfamilial hypertrophic cardiomyopathy  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary familial hypertrophic cardiomyopathyClinVarPMID:10966831 more ...
Actc1Naked Mole-Ratfamilial hypertrophic cardiomyopathy  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary familial hypertrophic cardiomyopathyClinVarPMID:10966831 more ...
Actc1Naked Mole-Ratgenetic disease  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:24033266
Actc1Naked Mole-Rathypertrophic cardiomyopathy  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathyClinVarPMID:10494087 more ...
Actc1Naked Mole-Rathypertrophic cardiomyopathy 1  ISOACTC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Idiopathic hypertrophic subaortic stenosisClinVarPMID:10966831 more ...
1 to 20 of 24 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actc1Naked Mole-Ratpre-malignant neoplasm  ISOACTC1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21472284
Actc1Naked Mole-Ratrefractive error  ISOACTC1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20835239
Actc1Naked Mole-RatStomach Neoplasms  ISOACTC1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19424620
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actc1Naked Mole-Ratatrial heart septal defect 5  ISOACTC1 (Homo sapiens)7240710 OMIM 
Actc1Naked Mole-Ratdilated cardiomyopathy 1R  ISOACTC1 (Homo sapiens)7240710 OMIM 
Actc1Naked Mole-Rathypertrophic cardiomyopathy 11  ISOACTC1 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actc1Naked Mole-Ratactin filament-based movement involved_inISOACTC1 (Homo sapiens)9068941 PMID:16611632UniProtPMID:16611632
Actc1Naked Mole-Ratactin-mediated cell contraction acts_upstream_of_or_withinISOActc1 (Mus musculus)9068941 PMID:22750946MGIPMID:22750946
Actc1Naked Mole-Ratactin-myosin filament sliding involved_inISOACTC1 (Homo sapiens)9068941 PMID:19799913BHF-UCLPMID:19799913
Actc1Naked Mole-Ratactomyosin structure organization acts_upstream_of_or_withinISOMGI:21800729068941 PMID:14605248MGIPMID:14605248
Actc1Naked Mole-Ratcardiac muscle contraction  ISOActc1 (Rattus norvegicus)9068941 RGDPMID:14551059 and REF_RGD_ID:1600569
Actc1Naked Mole-Ratcardiac muscle tissue morphogenesis acts_upstream_of_or_withinISOMGI:21800729068941 PMID:14605248MGIPMID:14605248
Actc1Naked Mole-Ratcardiac myofibril assembly acts_upstream_of_or_withinISOMGI:21800729068941 PMID:9114002MGIPMID:9114002
Actc1Naked Mole-Ratheart contraction involved_inISOACTC1 (Homo sapiens)9068941 PMID:17611253 more ...UniProtPMID:17611253 more ...
Actc1Naked Mole-Ratnegative regulation of apoptotic process acts_upstream_of_or_withinISOMGI:21800729068941 PMID:14605248MGIPMID:14605248
Actc1Naked Mole-Ratresponse to ethanol  ISOActc1 (Rattus norvegicus)9068941 RGDPMID:15690316 and REF_RGD_ID:1598722
Actc1Naked Mole-Ratresponse to xenobiotic stimulus  ISOActc1 (Rattus norvegicus)9068941 RGDPMID:16343576 and REF_RGD_ID:1598724
Actc1Naked Mole-Ratskeletal muscle thin filament assembly acts_upstream_of_or_withinISOMGI:21800729068941 PMID:9114002MGIPMID:9114002
1 to 12 of 12 rows

Cellular Component

  

Molecular Function

  

PMID:30032202  



Actc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248042,005,997 - 2,011,023 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248042,006,439 - 2,011,809 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ACTC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381534,790,230 - 34,795,549 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1534,790,107 - 34,795,589 (-)EnsemblGRCh38hg38GRCh38
GRCh371535,082,431 - 35,087,750 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361532,867,589 - 32,875,219 (-)NCBINCBI36Build 36hg18NCBI36
Build 341532,869,723 - 32,875,153NCBI
Celera1511,839,644 - 11,847,274 (-)NCBICelera
Cytogenetic Map15q14ENTREZGENE
HuRef1511,925,790 - 11,933,402 (-)NCBIHuRef
CHM1_11535,198,283 - 35,205,917 (-)NCBICHM1_1
T2T-CHM13v2.01532,595,427 - 32,600,746 (-)NCBIT2T-CHM13v2.0
Actc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392113,877,763 - 113,883,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2113,877,763 - 113,884,029 (-)EnsemblGRCm39 Ensembl
GRCm382114,047,282 - 114,052,875 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2114,047,282 - 114,053,548 (-)EnsemblGRCm38mm10GRCm38
MGSCv372113,873,025 - 113,878,547 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362113,738,730 - 113,744,252 (-)NCBIMGSCv36mm8
Celera2115,178,495 - 115,181,826 (-)NCBICelera
Cytogenetic Map2E4NCBI
cM Map257.55NCBI
Actc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83121,266,291 - 121,271,827 (-)NCBIGRCr8
mRatBN7.23100,811,987 - 100,817,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3100,811,987 - 100,817,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3104,444,093 - 104,449,627 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03113,043,134 - 113,048,668 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03110,726,488 - 110,732,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03105,507,403 - 105,512,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3105,507,403 - 105,512,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03112,080,853 - 112,086,389 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4399,901,022 - 99,906,558 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1399,797,449 - 99,798,402 (-)NCBI
Celera399,781,510 - 99,787,044 (-)NCBICelera
Cytogenetic Map3q35NCBI
Actc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554162,137,101 - 2,145,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554162,139,541 - 2,144,678 (-)NCBIChiLan1.0ChiLan1.0
LOC100987752
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21624,005,887 - 24,013,787 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11528,151,250 - 28,162,184 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01513,707,475 - 13,712,905 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11531,966,278 - 31,971,782 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1531,966,278 - 31,971,782 (-)Ensemblpanpan1.1panPan2
ACTC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1302,514,825 - 2,519,398 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl302,514,824 - 2,519,382 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha302,565,508 - 2,570,605 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0302,629,472 - 2,634,566 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl302,629,472 - 2,634,456 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1302,564,616 - 2,569,707 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0302,663,927 - 2,669,017 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0302,792,736 - 2,797,835 (-)NCBIUU_Cfam_GSD_1.0
Actc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864081,053,582 - 81,059,040 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366731,092,717 - 1,100,331 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366731,092,700 - 1,098,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1136,281,167 - 136,286,547 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11136,281,119 - 136,286,551 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21152,412,178 - 152,417,610 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12648,105,271 - 48,110,670 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2648,105,216 - 48,110,896 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604892,799,132 - 92,804,294 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.
RefSeq Transcripts XM_004861507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01072485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01072486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000025908   ⟹   ENSHGLP00000025680
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248042,005,997 - 2,011,023 (-)Ensembl
RefSeq Acc Id: XM_004861507   ⟹   XP_004861564
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248042,006,439 - 2,011,809 (-)NCBI
Protein RefSeqs XP_004861564 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000025680
RefSeq Acc Id: XP_004861564   ⟸   XM_004861507
- UniProtKB: A0A0N8ET52 (UniProtKB/TrEMBL),   A0AAX6PYU0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000025680   ⟸   ENSHGLT00000025908



1 to 19 of 19 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000018281 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000025908 ENTREZGENE
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
  Actin, Chain A, domain 4 UniProtKB/TrEMBL
InterPro Actin UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/TrEMBL
  Actin_CS UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/TrEMBL
NCBI Gene Actc1 ENTREZGENE
PANTHER ACTIN UniProtKB/TrEMBL
Pfam Actin UniProtKB/TrEMBL
PRINTS ACTIN UniProtKB/TrEMBL
PROSITE ACTINS_1 UniProtKB/TrEMBL
  ACTINS_2 UniProtKB/TrEMBL
  ACTINS_ACT_LIKE UniProtKB/TrEMBL
SMART ACTIN UniProtKB/TrEMBL
Superfamily-SCOP Actin-like ATPase domain UniProtKB/TrEMBL
UniProt A0A0N8ET52 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6PYU0 ENTREZGENE, UniProtKB/TrEMBL
1 to 19 of 19 rows