Thbs1 (thrombospondin 1) - Rat Genome Database

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Gene: Thbs1 (thrombospondin 1) Rattus norvegicus
Analyze
Symbol: Thbs1
Name: thrombospondin 1
RGD ID: 1588455
Description: Enables transforming growth factor beta binding activity. Involved in several processes, including cellular response to tumor necrosis factor; positive regulation of transforming growth factor beta production; and response to testosterone. Located in extracellular space. Biomarker of diabetic retinopathy; heart disease; myocardial infarction; and prostate cancer. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; pancreatic ductal carcinoma; and primary open angle glaucoma. Orthologous to human THBS1 (thrombospondin 1); PARTICIPATES IN syndecan signaling pathway; cell-extracellular matrix signaling pathway; malaria pathway; INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: thrombospondin-1; TSP-1; Tsp1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83125,510,250 - 125,525,402 (+)NCBIGRCr8
mRatBN7.23105,056,293 - 105,071,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,056,292 - 105,071,440 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3108,721,861 - 108,736,913 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,317,382 - 117,332,433 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03114,977,769 - 114,992,820 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03109,862,120 - 109,873,466 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3109,862,117 - 109,873,466 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,411,045 - 116,422,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3103,978,436 - 103,990,486 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
amphetamine  (EXP)
andrographolide  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
aspartame  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
axitinib  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boron nitride  (ISO)
busulfan  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clopidogrel  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl malate  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
diiodine  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
equol  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenoldopam  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
magnesium atom  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
NORCANTHARIDIN  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
perfluorononanoic acid  (ISO)
phenformin  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phthalaldehyde  (ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
ticlopidine  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to pain  (ISO)
blood vessel morphogenesis  (ISO)
cell migration  (ISO)
cellular response to growth factor stimulus  (IEP)
cellular response to nitric oxide  (ISO)
cellular response to tumor necrosis factor  (IEP)
chronic inflammatory response  (ISO)
endocardial cushion development  (ISO)
engulfment of apoptotic cell  (ISO)
growth plate cartilage development  (ISO)
immune response  (ISO)
inflammatory response  (ISO)
monocyte aggregation  (ISO)
negative regulation of angiogenesis  (IBA,IDA,ISO)
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell-matrix adhesion  (ISO)
negative regulation of cGMP-mediated signaling  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
negative regulation of dendritic cell antigen processing and presentation  (ISO)
negative regulation of endothelial cell chemotaxis  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of fibrinolysis  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of interleukin-10 production  (IEA,ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of long-chain fatty acid import across plasma membrane  (ISO)
negative regulation of nitric oxide mediated signal transduction  (ISO)
negative regulation of plasminogen activation  (ISO)
negative regulation of sprouting angiogenesis  (ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
nitric oxide-cGMP-mediated signaling  (ISO)
outflow tract morphogenesis  (ISO)
peptide cross-linking  (IEA,ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood coagulation  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of MAP kinase activity  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transforming growth factor beta production  (IMP)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of translation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
response to calcium ion  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to glucose  (ISO)
response to magnesium ion  (ISO)
response to mechanical stimulus  (IMP)
response to testosterone  (IEP)
response to xenobiotic stimulus  (ISO)
sprouting angiogenesis  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity. Abu-Farha M, etal., PLoS One. 2013 Sep 24;8(9):e75342. doi: 10.1371/journal.pone.0075342. eCollection 2013.
2. The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma. Aishima S, etal., Int J Surg Pathol. 2002 Jan;10(1):47-56.
3. Capillary sprout endothelial cells exhibit a CD36 low phenotype: regulation by shear stress and vascular endothelial growth factor-induced mechanism for attenuating anti-proliferative thrombospondin-1 signaling. Anderson CR, etal., Am J Pathol. 2008 Oct;173(4):1220-8. Epub 2008 Sep 4.
4. A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. Belmadani S, etal., Am J Pathol. 2007 Sep;171(3):777-89. Epub 2007 Jul 19.
5. Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cells. Breitkopf K, etal., Gut. 2005 May;54(5):673-81.
6. Androgens repress the expression of the angiogenesis inhibitor thrombospondin-1 in normal and neoplastic prostate. Colombel M, etal., Cancer Res. 2005 Jan 1;65(1):300-8.
7. Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo. Daniel C, etal., Diabetes. 2007 Dec;56(12):2982-9. Epub 2007 Sep 18.
8. Protection of erythropoietin on experimental spinal cord injury by reducing the expression of thrombospondin-1 and transforming growth factor-beta. Fang XQ, etal., Chin Med J (Engl). 2009 Jul 20;122(14):1631-5.
9. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. Lee S, etal., Am J Pathol. 2002 Sep;161(3):1015-22.
12. Identification and Validation of Stage-Associated Serum Biomarkers in Colorectal Cancer Using MS-Based Procedures. Marín-Vicente C, etal., Proteomics Clin Appl. 2020 Jan;14(1):e1900052. doi: 10.1002/prca.201900052. Epub 2019 Sep 18.
13. Methylation profile of circulating plasma DNA in patients with pancreatic cancer. Melnikov AA, etal., J Surg Oncol. 2009 Feb 1;99(2):119-22.
14. Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma. Ohtani Y, etal., Int J Oncol. 1999 Sep;15(3):453-7.
15. Stromal thrombospondin-1 expression is a prognostic indicator and a new marker of invasiveness in intraductal papillary-mucinous neoplasm of the pancreas. Okada K, etal., Biomed Res. 2010;31(1):13-9.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Thrombospondin-1 is induced in rat myocardial infarction and its induction is accelerated by ischemia/reperfusion. Sezaki S, etal., Exp Biol Med (Maywood). 2005 Oct;230(9):621-30.
22. Association of angiogenesis related markers with bladder cancer outcomes and other molecular markers. Shariat SF, etal., J Urol. 2010 May;183(5):1744-50. doi: 10.1016/j.juro.2010.01.018. Epub 2010 Mar 17.
23. Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance. Tang D, etal., Oncol Rep. 2006 Mar;15(3):525-32.
24. Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. Tobita K, etal., Int J Oncol. 2002 Dec;21(6):1189-95.
25. Purinergic signaling induces thrombospondin-1 expression in astrocytes. Tran MD and Neary JT, Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9321-6. Epub 2006 Jun 5.
26. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Ueki T, etal., Cancer Res. 2000 Apr 1;60(7):1835-9.
27. Thrombospondins, metallo proteases and thrombospondin receptors messenger RNA and protein expression in different tumour sublines of the Dunning prostate cancer model. Vallbo C and Damber JE, Acta Oncol. 2005;44(3):293-8.
28. [The study of thrombospondin-I (TSP1) expression in the early stages of diabetic retinopathy induced by streptozotocin] Wang JY, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2006 Oct;39(5):431-7.
29. Identification of Missense Extracellular Matrix Gene Variants in a Large Glaucoma Pedigree and Investigation of the N700S Thrombospondin-1 Variant in Normal and Glaucomatous Trabecular Meshwork Cells. Wirtz MK, etal., Curr Eye Res. 2022 Jan;47(1):79-90. doi: 10.1080/02713683.2021.1945109. Epub 2021 Jul 6.
30. Expression of angiogenic factors is upregulated in DMBA-induced rat mammary pathologies. Yan M, etal., Pathobiology. 2004;71(5):253-60.
31. Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36. Yehualaeshet T, etal., Am J Pathol. 1999 Sep;155(3):841-51.
32. Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model. Zhang X, etal., Cancer Lett. 2007 Mar 8;247(1):143-9. Epub 2006 Jun 6.
33. [The role of glucose/TSP-1/TGFbeta1 signal pathways in diabetic cardiomyopathy] Zhong M, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Mar;34(3):217-21.
34. Alteration of thrombospondin-1 and -2 in rat brains following experimental intracerebral hemorrhage. Zhou HJ, etal., J Neurosurg. 2010 Feb 5.
Additional References at PubMed
PMID:101549   PMID:2435757   PMID:3084490   PMID:3997886   PMID:6341993   PMID:6438154   PMID:6693501   PMID:6777381   PMID:8288588   PMID:9006956   PMID:9657149   PMID:11961406  
PMID:12498716   PMID:12511771   PMID:12882934   PMID:12937160   PMID:14717916   PMID:15184388   PMID:15700281   PMID:15963261   PMID:16019429   PMID:16150726   PMID:16294224   PMID:16310163  
PMID:16502470   PMID:16882710   PMID:17381066   PMID:17413041   PMID:17416590   PMID:17596205   PMID:17879962   PMID:17996481   PMID:18045834   PMID:18096704   PMID:18407596   PMID:18467703  
PMID:18555217   PMID:18575624   PMID:18653767   PMID:18674744   PMID:18722097   PMID:18726995   PMID:18757424   PMID:18757743   PMID:18940719   PMID:19056867   PMID:19127780   PMID:19189070  
PMID:19199708   PMID:19278574   PMID:19342245   PMID:19571575   PMID:19734591   PMID:19738618   PMID:19818485   PMID:19821086   PMID:20016205   PMID:20026598   PMID:20080874   PMID:20215829  
PMID:20524210   PMID:20551380   PMID:20878350   PMID:20889977   PMID:21152035   PMID:21362503   PMID:21394550   PMID:21422735   PMID:22206666   PMID:22418977   PMID:22455124   PMID:22682248  
PMID:22745497   PMID:22776902   PMID:23009856   PMID:23043906   PMID:23087362   PMID:23144964   PMID:23376485   PMID:23533145   PMID:23541831   PMID:23658023   PMID:23843515   PMID:23979707  
PMID:24006456   PMID:24121060   PMID:24177325   PMID:24615654   PMID:25387836   PMID:25660232   PMID:25884585   PMID:25958163   PMID:26092525   PMID:26395742   PMID:27068509   PMID:27588705  
PMID:27735996   PMID:28124060   PMID:28228282   PMID:29408825   PMID:29683384   PMID:30360646   PMID:30537736   PMID:30720765   PMID:34015597   PMID:34957570   PMID:36528876   PMID:36920202  
PMID:37573658   PMID:38108523   PMID:38237742   PMID:38439091  


Genomics

Comparative Map Data
Thbs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83125,510,250 - 125,525,402 (+)NCBIGRCr8
mRatBN7.23105,056,293 - 105,071,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,056,292 - 105,071,440 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3108,721,861 - 108,736,913 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,317,382 - 117,332,433 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03114,977,769 - 114,992,820 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03109,862,120 - 109,873,466 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3109,862,117 - 109,873,466 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,411,045 - 116,422,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3103,978,436 - 103,990,486 (+)NCBICelera
Cytogenetic Map3q35NCBI
THBS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381539,581,079 - 39,599,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1539,581,079 - 39,599,466 (+)EnsemblGRCh38hg38GRCh38
GRCh371539,873,280 - 39,891,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361537,660,572 - 37,676,960 (+)NCBINCBI36Build 36hg18NCBI36
Build 341537,660,571 - 37,676,959NCBI
Celera1516,636,119 - 16,652,508 (+)NCBICelera
Cytogenetic Map15q14NCBI
HuRef1516,716,691 - 16,733,080 (+)NCBIHuRef
CHM1_11539,992,660 - 40,009,050 (+)NCBICHM1_1
T2T-CHM13v2.01537,385,886 - 37,404,273 (+)NCBIT2T-CHM13v2.0
Thbs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392117,942,357 - 117,957,614 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2117,942,357 - 117,957,614 (+)EnsemblGRCm39 Ensembl
GRCm382118,111,876 - 118,127,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,111,876 - 118,127,133 (+)EnsemblGRCm38mm10GRCm38
MGSCv372117,937,658 - 117,952,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362119,046,897 - 119,061,990 (+)NCBIMGSCv36mm8
MGSCv362117,803,363 - 117,818,574 (+)NCBIMGSCv36mm8
Celera2119,257,347 - 119,271,479 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.34NCBI
Thbs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554166,489,451 - 6,506,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554166,490,034 - 6,506,419 (+)NCBIChiLan1.0ChiLan1.0
THBS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21628,821,736 - 28,838,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11532,972,998 - 32,987,997 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01518,521,802 - 18,538,172 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11536,776,756 - 36,793,469 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1536,776,756 - 36,793,170 (+)Ensemblpanpan1.1panPan2
THBS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1306,770,212 - 6,786,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl306,769,470 - 6,784,915 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha306,824,809 - 6,841,468 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0306,896,290 - 6,912,963 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl306,895,539 - 6,911,152 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1306,820,232 - 6,836,894 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0306,926,083 - 6,942,777 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,055,241 - 7,071,904 (+)NCBIUU_Cfam_GSD_1.0
Thbs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,216,385 - 85,233,062 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,064,422 - 3,081,949 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,064,466 - 3,081,125 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THBS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,728,784 - 131,746,115 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,728,781 - 131,746,098 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,905,998 - 146,923,315 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THBS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12643,410,693 - 43,427,816 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2643,410,580 - 43,427,812 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604897,515,387 - 97,532,504 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thbs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248046,849,670 - 6,867,684 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248046,849,660 - 6,866,164 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Thbs1
87 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:48
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000070912
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
M87276  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,069,602 - 105,069,776 (+)MAPPERmRatBN7.2
Rnor_6.03109,873,417 - 109,873,590NCBIRnor6.0
Rnor_5.03116,422,052 - 116,422,225UniSTSRnor5.0
Celera3103,990,437 - 103,990,610UniSTS
PMC152639P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,068,151 - 105,068,227 (+)MAPPERmRatBN7.2
Rnor_6.03109,871,965 - 109,872,040NCBIRnor6.0
Rnor_5.03116,420,600 - 116,420,675UniSTSRnor5.0
Celera3103,988,986 - 103,989,061UniSTS
Thbs1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03109,867,214 - 109,867,537NCBIRnor6.0
Rnor_5.03116,415,849 - 116,416,172UniSTSRnor5.0
Celera3103,984,219 - 103,984,549UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000070912   ⟹   ENSRNOP00000066041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3109,862,120 - 109,873,466 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083351   ⟹   ENSRNOP00000069322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3105,056,292 - 105,071,440 (+)Ensembl
Rnor_6.0 Ensembl3109,862,117 - 109,872,871 (+)Ensembl
RefSeq Acc Id: NM_001013062   ⟹   NP_001013080
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,510,250 - 125,525,402 (+)NCBI
mRatBN7.23105,056,293 - 105,071,445 (+)NCBI
Rnor_6.03109,862,120 - 109,873,466 (+)NCBI
Rnor_5.03116,411,045 - 116,422,101 (+)NCBI
Celera3103,978,436 - 103,990,486 (+)RGD
Sequence:
RefSeq Acc Id: NM_001398940   ⟹   NP_001385869
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,510,250 - 125,525,402 (+)NCBI
mRatBN7.23105,056,293 - 105,071,445 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001013080 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385869 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ14549 (Get FASTA)   NCBI Sequence Viewer  
  EDL79850 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069322.2
RefSeq Acc Id: NP_001013080   ⟸   NM_001013062
- Peptide Label: isoform 1 precursor
- UniProtKB: Q71SA3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066041   ⟸   ENSRNOT00000070912
Ensembl Acc Id: ENSRNOP00000069322   ⟸   ENSRNOT00000083351
RefSeq Acc Id: NP_001385869   ⟸   NM_001398940
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A0G2JV24 (UniProtKB/TrEMBL),   Q71SA3 (UniProtKB/TrEMBL)
Protein Domains
EGF-like   TSP C-terminal   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JV24-F1-model_v2 AlphaFold A0A0G2JV24 1-1152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588455 AgrOrtholog
BioCyc Gene G2FUF-48263 BioCyc
Ensembl Genes ENSRNOG00000045829 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083351.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.200 UniProtKB/TrEMBL
  4.10.1080.10 UniProtKB/TrEMBL
  6.20.200.20 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF_dom UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  Thrombospondin_3-like_rpt UniProtKB/TrEMBL
  Thrombospondin_3_rpt UniProtKB/TrEMBL
  Thrombospondin_C UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
  TSP_type-3_rpt UniProtKB/TrEMBL
  TSPN-like_N UniProtKB/TrEMBL
  VWF_C UniProtKB/TrEMBL
KEGG Report rno:445442 UniProtKB/TrEMBL
NCBI Gene 445442 ENTREZGENE
PANTHER PTHR10199:SF78 UniProtKB/TrEMBL
  THROMBOSPONDIN UniProtKB/TrEMBL
Pfam EGF_3 UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
  TSP_3 UniProtKB/TrEMBL
  TSP_C UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
PhenoGen Thbs1 PhenoGen
PRINTS TSP1REPEAT UniProtKB/TrEMBL
PROSITE EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  TSP3 UniProtKB/TrEMBL
  TSP_CTER UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045829 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  TSPN UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  FnI-like domain UniProtKB/TrEMBL
  SSF103647 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
UniProt A0A0G2JV24 ENTREZGENE, UniProtKB/TrEMBL
  A6HP99_RAT UniProtKB/TrEMBL
  Q71SA3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-11-19 Thbs1  thrombospondin 1      Symbol and Name status set to provisional 70820 PROVISIONAL