Chp1 (calcineurin-like EF-hand protein 1) - Rat Genome Database

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Gene: Chp1 (calcineurin-like EF-hand protein 1) Rattus norvegicus
Analyze
Symbol: Chp1
Name: calcineurin-like EF-hand protein 1
RGD ID: 620447
Description: Enables calcium ion binding activity; kinase binding activity; and microtubule binding activity. Involved in several processes, including microtubule cytoskeleton organization; protein stabilization; and regulation of protein modification process. Located in several cellular components, including Golgi membrane; endoplasmic reticulum; and transport vesicle. Human ortholog(s) of this gene implicated in spastic ataxia. Orthologous to human CHP1 (calcineurin like EF-hand protein 1); PARTICIPATES IN Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; apoptotic cell death pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcineurin B homologous protein 1; calcineurin B-like protein; calcineurin homologous protein; calcium binding protein p22; calcium-binding protein CHP; calcium-binding protein p22; Chp; EF-hand Ca2+-binding protein p22; EF-hand calcium-binding domain-containing protein p22; Wrch2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,989,800 - 127,025,071 (+)NCBIGRCr8
mRatBN7.23106,536,009 - 106,571,255 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,536,004 - 106,571,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3110,213,376 - 110,248,697 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,808,913 - 118,844,244 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,469,312 - 116,504,631 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,354,506 - 111,389,998 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,354,506 - 111,389,989 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,902,988 - 117,938,480 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,066,389 - 106,101,635 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13105,962,816 - 105,998,059 (+)NCBI
Celera3105,447,792 - 105,483,065 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules. Andrade J, etal., Biochem J. 2004 Dec 1;384(Pt 2):327-36.
2. The EF-hand Ca2+-binding protein p22 plays a role in microtubule and endoplasmic reticulum organization and dynamics with distinct Ca2+-binding requirements. Andrade J, etal., Mol Biol Cell. 2004 Feb;15(2):481-96. Epub 2003 Dec 2.
3. A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic. Barroso MR, etal., J Biol Chem 1996 Apr 26;271(17):10183-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Prevalence of left and balanced coronary arterial dominance decreases with increasing age of patients at autopsy. A postmortem coronary angiograms study. Knaapen M, etal., Cardiovasc Pathol. 2013 Jan-Feb;22(1):49-53. doi: 10.1016/j.carpath.2012.02.012. Epub 2012 Mar 30.
6. The apoptosis-inducing protein kinase DRAK2 is inhibited in a calcium-dependent manner by the calcium-binding protein CHP. Kuwahara H, etal., J Biochem. 2003 Aug;134(2):245-50.
7. A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger. Matsumoto M, etal., J Biochem (Tokyo) 2001 Aug;130(2):217-25.
8. Dual functional significance of calcineurin homologous protein 1 binding to Na(+)/H(+) exchanger isoform 1. Matsushita M, etal., Am J Physiol Cell Physiol. 2011 Aug;301(2):C280-8. doi: 10.1152/ajpcell.00404.2010. Epub 2011 May 4.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Two nuclear export signals specify the cytoplasmic localization of calcineurin B homologous protein 1. Nagita M, etal., J Biochem. 2003 Dec;134(6):919-25.
11. KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles. Nakamura N, etal., J Biochem. 2002 Sep;132(3):483-91.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. CFU-C in Agar. Praloran V and Bartocci A, Methods Mol Biol. 1990;5:323-30. doi: 10.1385/0-89603-150-0:323.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. The EF-hand Ca(2+)-binding protein p22 associates with microtubules in an N-myristoylation-dependent manner. Timm S, etal., Mol Biol Cell. 1999 Oct;10(10):3473-88.
19. SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder. Zhang-James Y, etal., Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(7):835-43. doi: 10.1002/ajmg.b.31229. Epub 2011 Aug 19.
Additional References at PubMed
PMID:8901634   PMID:10593895   PMID:11350981   PMID:15035633   PMID:15489334   PMID:15987692   PMID:19056867   PMID:21085126   PMID:21423176   PMID:23376485   PMID:23904602   PMID:29379881  


Genomics

Comparative Map Data
Chp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,989,800 - 127,025,071 (+)NCBIGRCr8
mRatBN7.23106,536,009 - 106,571,255 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,536,004 - 106,571,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3110,213,376 - 110,248,697 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,808,913 - 118,844,244 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,469,312 - 116,504,631 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,354,506 - 111,389,998 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,354,506 - 111,389,989 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,902,988 - 117,938,480 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,066,389 - 106,101,635 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13105,962,816 - 105,998,059 (+)NCBI
Celera3105,447,792 - 105,483,065 (+)NCBICelera
Cytogenetic Map3q35NCBI
CHP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381541,231,268 - 41,281,887 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1541,230,839 - 41,281,887 (+)EnsemblGRCh38hg38GRCh38
GRCh371541,523,466 - 41,574,085 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361539,310,729 - 39,361,377 (+)NCBINCBI36Build 36hg18NCBI36
Build 341539,310,728 - 39,361,373NCBI
Celera1518,291,415 - 18,342,063 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1518,371,799 - 18,422,604 (+)NCBIHuRef
CHM1_11541,641,426 - 41,692,297 (+)NCBICHM1_1
T2T-CHM13v2.01539,037,454 - 39,088,066 (+)NCBIT2T-CHM13v2.0
Chp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,378,172 - 119,417,505 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2119,378,178 - 119,417,508 (+)EnsemblGRCm39 Ensembl
GRCm382119,547,707 - 119,587,024 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,547,697 - 119,587,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv372119,373,443 - 119,412,760 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362119,239,155 - 119,278,461 (+)NCBIMGSCv36mm8
Celera2120,700,969 - 120,740,985 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.97NCBI
Chp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554168,090,034 - 8,132,870 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554168,090,034 - 8,131,605 (+)NCBIChiLan1.0ChiLan1.0
CHP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21630,472,900 - 30,523,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11534,624,238 - 34,674,873 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01520,172,874 - 20,223,382 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11538,418,815 - 38,466,925 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1538,418,815 - 38,467,681 (+)Ensemblpanpan1.1panPan2
CHP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1308,304,939 - 8,352,833 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl308,305,007 - 8,350,904 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha308,363,447 - 8,409,616 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0308,438,344 - 8,484,537 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl308,438,397 - 8,486,280 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1308,359,874 - 8,408,027 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0308,467,375 - 8,515,299 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,598,734 - 8,645,069 (+)NCBIUU_Cfam_GSD_1.0
Chp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,763,916 - 86,812,248 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,611,252 - 4,660,359 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364714,611,980 - 4,660,320 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1130,073,928 - 130,112,751 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11130,073,919 - 130,112,461 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21145,221,139 - 145,259,701 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12641,734,698 - 41,785,273 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2641,733,063 - 41,785,586 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604899,207,184 - 99,258,544 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248048,431,996 - 8,474,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248048,431,999 - 8,474,458 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chp1
161 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:369
Count of miRNA genes:199
Interacting mature miRNAs:263
Transcripts:ENSRNOT00000056405
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat

Markers in Region
RH134406  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3q35UniSTS
RH143965  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q24UniSTS
Cytogenetic Map3q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000056405   ⟹   ENSRNOP00000053243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3106,536,004 - 106,571,251 (+)Ensembl
Rnor_6.0 Ensembl3111,354,506 - 111,389,989 (+)Ensembl
RefSeq Acc Id: NM_024139   ⟹   NP_077053
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,989,825 - 127,025,071 (+)NCBI
mRatBN7.23106,536,009 - 106,571,255 (+)NCBI
Rnor_6.03111,354,506 - 111,389,998 (+)NCBI
Rnor_5.03117,902,988 - 117,938,480 (+)NCBI
RGSC_v3.43106,066,389 - 106,101,635 (+)RGD
Celera3105,447,792 - 105,483,065 (+)RGD
Sequence:
RefSeq Acc Id: XM_063284499   ⟹   XP_063140569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,989,800 - 127,022,784 (+)NCBI
RefSeq Acc Id: NP_077053   ⟸   NM_024139
- UniProtKB: P61023 (UniProtKB/Swiss-Prot),   A6HPF8 (UniProtKB/TrEMBL),   A6HPG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000053243   ⟸   ENSRNOT00000056405
RefSeq Acc Id: XP_063140569   ⟸   XM_063284499
- Peptide Label: isoform X1
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61023-F1-model_v2 AlphaFold P61023 1-195 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692328
Promoter ID:EPDNEW_R2852
Type:initiation region
Name:Chp1_1
Description:calcineurin-like EF-hand protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03111,354,583 - 111,354,643EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620447 AgrOrtholog
BioCyc Gene G2FUF-48200 BioCyc
Ensembl Genes ENSRNOG00000004742 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055003343 UniProtKB/Swiss-Prot
  ENSRNOG00055023007 UniProtKB/Swiss-Prot
  ENSRNOG00060026528 UniProtKB/Swiss-Prot
  ENSRNOG00060028723 UniProtKB/Swiss-Prot
  ENSRNOG00065004699 UniProtKB/Swiss-Prot
  ENSRNOG00065023898 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000056405 ENTREZGENE
  ENSRNOT00000056405.3 UniProtKB/Swiss-Prot
  ENSRNOT00055005196 UniProtKB/Swiss-Prot
  ENSRNOT00055039535 UniProtKB/Swiss-Prot
  ENSRNOT00060045953 UniProtKB/Swiss-Prot
  ENSRNOT00060049915 UniProtKB/Swiss-Prot
  ENSRNOT00065006805 UniProtKB/Swiss-Prot
  ENSRNOT00065040996 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623922 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64152 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72429 IMAGE-MGC_LOAD
NCBI Gene 64152 ENTREZGENE
PANTHER CALCINEURIN B HOMOLOGOUS PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EG:114D9.1 PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Chp1 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004742 RatGTEx
  ENSRNOG00055003343 RatGTEx
  ENSRNOG00055023007 RatGTEx
  ENSRNOG00060026528 RatGTEx
  ENSRNOG00060028723 RatGTEx
  ENSRNOG00065004699 RatGTEx
  ENSRNOG00065023898 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EF-hand UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HPF8 ENTREZGENE, UniProtKB/TrEMBL
  A6HPG0 ENTREZGENE, UniProtKB/TrEMBL
  CHP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q62877 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-16 Chp1  calcineurin-like EF-hand protein 1  Chp  calcium binding protein p22  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Chp  calcium binding protein p22      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Chp  Chp      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the EF-hand family of Ca2+ binding proteins 724726