Ltk (leukocyte receptor tyrosine kinase)

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Gene: Ltk (leukocyte receptor tyrosine kinase) Rattus norvegicus

Analyze

Symbol:

Ltk

Name:

leukocyte receptor tyrosine kinase

RGD ID:

1309323

Description:

Predicted to enable receptor signaling protein tyrosine kinase activator activity and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including cellular response to retinoic acid; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of apoptotic process. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human LTK (leukocyte receptor tyrosine kinase); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

leukocyte tyrosine kinase; leukocyte tyrosine kinase receptor; LOC311337

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LTK (leukocyte receptor tyrosine kinase)	HGNC	Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Ltk (leukocyte tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ltk (leukocyte receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LTK (leukocyte receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LTK (leukocyte receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ltk (leukocyte receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LTK (leukocyte receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LTK (leukocyte receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ltk (leukocyte receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CCDC112 (coiled-coil domain containing 112)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	LTK (leukocyte receptor tyrosine kinase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ltk (leukocyte tyrosine kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ltk (leukocyte receptor tyrosine kinase)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Alk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	scd-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ltk	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

NCBI Annotation Information:

Annotation category: suggests misassembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	106,734,675 - 106,741,552 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	106,734,676 - 106,743,369 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	110,409,972 - 110,416,829 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	119,005,519 - 119,012,376 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	116,665,912 - 116,672,769 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	111,553,679 - 111,560,556 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	111,553,680 - 111,560,556 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	118,102,134 - 118,109,011 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	106,266,245 - 106,273,122 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	106,162,954 - 106,174,551 (-)	NCBI
Celera	3	105,645,555 - 105,652,432 (-)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

polycystic ovary syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

all-trans-retinoic acid (ISO)

amosite asbestos (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

CGP 52608 (ISO)

chlorpyrifos (ISO)

crocidolite asbestos (ISO)

diazinon (ISO)

diethylstilbestrol (EXP)

fulvestrant (ISO)

methamphetamine (EXP)

N-methyl-4-phenylpyridinium (EXP)

oxaliplatin (EXP)

paracetamol (EXP)

perfluorooctanoic acid (ISO)

potassium dichromate (ISO)

rifampicin (ISO)

SCH 23390 (EXP)

serpentine asbestos (ISO)

Soman (EXP)

testosterone (EXP)

thioacetamide (EXP)

topotecan (EXP)

trichloroethene (EXP)

triclosan (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell population proliferation (ISO)

cellular response to retinoic acid (ISO)

negative regulation of apoptotic process (ISO)

positive regulation of cardiac muscle cell apoptotic process (ISO)

positive regulation of neuron projection development (ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

regulation of cell population proliferation (IBA)

regulation of neuron differentiation (IBA)

transmembrane receptor protein tyrosine kinase signaling pathway (IBA,ISO)

Cellular Component

membrane (ISO)

plasma membrane (ISO)

receptor complex (IBA)

Molecular Function

ATP binding (IEA)

protein binding (ISO)

protein kinase activity (ISO)

receptor signaling protein tyrosine kinase activator activity (ISO)

transmembrane receptor protein tyrosine kinase activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2836739	PMID:8889548	PMID:9223670	PMID:10445845	PMID:17910947

Genomics

Comparative Map Data

Ltk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	106,734,675 - 106,741,552 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	106,734,676 - 106,743,369 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	110,409,972 - 110,416,829 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	119,005,519 - 119,012,376 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	116,665,912 - 116,672,769 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	111,553,679 - 111,560,556 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	111,553,680 - 111,560,556 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	118,102,134 - 118,109,011 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	106,266,245 - 106,273,122 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	106,162,954 - 106,174,551 (-)	NCBI
Celera	3	105,645,555 - 105,652,432 (-)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

LTK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	41,503,637 - 41,513,827 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	41,503,637 - 41,513,887 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	41,795,835 - 41,806,025 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	39,583,132 - 39,593,369 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	39,583,131 - 39,593,369	NCBI
Celera	15	18,563,799 - 18,574,044 (-)	NCBI		Celera
Cytogenetic Map	15	q15.1	NCBI
HuRef	15	18,644,053 - 18,654,294 (-)	NCBI		HuRef
CHM1_1	15	41,914,406 - 41,924,652 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	39,309,799 - 39,319,984 (-)	NCBI		T2T-CHM13v2.0

Ltk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	119,581,807 - 119,590,912 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	119,581,801 - 119,590,912 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	119,751,326 - 119,760,431 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	119,751,320 - 119,760,431 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	119,577,062 - 119,586,167 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	119,442,767 - 119,451,872 (-)	NCBI		MGSCv36	mm8
Celera	2	120,907,813 - 120,917,057 (-)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	59.97	NCBI

Ltk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955416	8,310,304 - 8,319,463 (-)	NCBI	ChiLan1.0	ChiLan1.0

LTK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	15	34,896,284 - 34,904,600 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	20,444,471 - 20,455,586 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	38,685,255 - 38,695,381 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	38,685,255 - 38,695,381 (-)	Ensembl	panpan1.1		panPan2

LTK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	8,541,328 - 8,550,108 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	8,600,243 - 8,608,930 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	8,675,659 - 8,684,364 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	30	8,596,963 - 8,605,660 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	8,704,371 - 8,709,292 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	8,836,123 - 8,844,819 (-)	NCBI		UU_Cfam_GSD_1.0

Ltk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	87,000,904 - 87,010,026 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	4,849,219 - 4,855,678 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936471	4,849,261 - 4,857,892 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LTK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	1	129,863,837 - 129,867,254 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	144,931,290 - 144,938,987 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LTK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	41,489,867 - 41,502,314 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	41,490,902 - 41,501,956 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	99,479,378 - 99,489,494 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ltk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	8,665,097 - 8,672,346 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	8,664,682 - 8,673,686 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ltk
14 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	48
Count of miRNA genes:	42
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000030532
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	80800231	114297550	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	96127817	115665732	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	102200529	115665732	Rat

Markers in Region

RH130923

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	106,734,384 - 106,734,572 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	111,553,389 - 111,553,576	NCBI	Rnor6.0
Rnor_5.0	3	118,101,844 - 118,102,031	UniSTS	Rnor5.0
RGSC_v3.4	3	106,265,955 - 106,266,142	UniSTS	RGSC3.4
Celera	3	105,645,265 - 105,645,452	UniSTS
RH 3.4 Map	3	917.7	UniSTS
Cytogenetic Map	3	q35	UniSTS

BE106366

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	106,734,718 - 106,734,882 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	111,553,723 - 111,553,886	NCBI	Rnor6.0
Rnor_5.0	3	118,102,178 - 118,102,341	UniSTS	Rnor5.0
RGSC_v3.4	3	106,266,289 - 106,266,452	UniSTS	RGSC3.4
Celera	3	105,645,599 - 105,645,762	UniSTS
RH 3.4 Map	3	921.1	UniSTS
Cytogenetic Map	3	q35	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									15			2
Low	3	25	34	20	19	20			59	20	26	9
Below cutoff		18	22	20		20	6	7		15	13		6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC107565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE106366	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000030532 ⟹ ENSRNOP00000030962

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	106,734,676 - 106,743,369 (-)	Ensembl
Rnor_6.0 Ensembl	3	111,553,680 - 111,560,556 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099587 ⟹ ENSRNOP00000085416

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	106,734,676 - 106,743,369 (-)	Ensembl

RefSeq Acc Id:

NM_001107763 ⟹ NP_001101233

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	106,734,675 - 106,741,552 (-)	NCBI
Rnor_6.0	3	111,553,679 - 111,560,556 (-)	NCBI
Rnor_5.0	3	118,102,134 - 118,109,011 (-)	NCBI
RGSC_v3.4	3	106,266,245 - 106,273,122 (-)	RGD
Celera	3	105,645,555 - 105,652,432 (-)	RGD

Sequence:

show sequence

CTGGGTGCTGTCGCCTCGACCCCCAGTTGAGTGTCCCAGGCCCTTCTTTCTCTCTCGCTGGGTT
CCCGGGGCTCAGGACCCAGGCGCGGTCCCTGACCGGCCACTGGCCCCATAGCTGCGCACAGGGA
AGCCAGAGCCGCTGCTGGTGGCGGCGGGAGGTGGCGGGAGGTCCTACAGGAGGCGACCTGAGCG
CGGCTGGACTCAGGCGGCCCCCGAGAGGCTGGAGACCCGCGCGGCGGCGCAGGGCAGCGGCAGG
AGAGGAGGCGCGGCCGGCGGTGATACTTCTGAGTCTGACCTCCTCTGGGCTGATGGGGAAGATG
GCATATCCTTCGTCCACCCTAGTGGCGAGCTTTACCTACAACCTCTGGCAGTCACAGAGGGCGA
TGTTGAGGTGGAGATCCGAAGGCACCCCAATTGCAGTCACTGCTCTTTCAAAGACTGCCAGTGG
CAGGCAGAGCTCTGGAGGGCTGAATGCATATGCCCAGAGGGCATGGAGCTAGCTGTGGATAATA
TCACATGCACGGGCCTGCCAACCACCACAAGCCCTCTGATAATGATGGGAGCTGTTGTGACAGC
CTTGACGCTGAGTCTCCTTATGATGTGTGGAGTCCTAATTCTAGTGAACCAGAAGAAATGTCAG
AGCCTGCGGGGAACCAGGCTGCCAGGCCCTGAGCTTGAGCTGAGTAAGCTGAGAACCTCTGCCA
TCAGGACAGCACCCAACCCATATTACTGTCAGGTGGGGCTCAGCCCTGCCCAGGCCTGGCCTCT
GCCCCAAGGGCTCACTGAGGTTTCCCCAGCCAATGTCACTCTACTCAGAGCCCTTGGCCATGGT
GCCTTTGGGGAAGTGTATGAGGGACTAGTGATTGGTCTTCCTGGGGATTCCAGCCCTCTTCCGG
TGGCTATCAAGACTCTGCCGGAGCTCTGCTCCCCTCAGGATGAGCTGGACTTTCTCATGGAGGC
TCTCATCATCAGCAAGTTCAGCCATCAGAATATTGTACGCTGTGTGGGGCTCAGCTTCCAGGCT
GCCCCTCGCCTCATTCTGCTGGAGCTGATGTCTGGTGGGGACATGAAGAGCTTTCTGAGGCATA
GCAGACCACACCCGGGACAACTGTCACCTCTGACCATGCAGGACCTATTACAGTTGGCCCAGGA
TATAGCTCAGGGCTGCCACTACTTGGAGGAAAATCACTTTATCCACAGAGACATTGCCGCCCGA
AACTGTCTGCTTAGCTGCAGTGGAGACAGCCGAGTGGCCAAGATTGGAGACTTTGGAATGGCAA
GAGATATCTACCAGGCCAGTTATTATCGCAAAGGGGGCCGGACCTTGCTCCCAGTGAAGTGGAT
GCCCCCAGAAGCTCTCCTGGAGGGCCTTTTCACATCCAAGACGGACTCCTGGTCTTTTGGGGTC
CTGCTCTGGGAGATCTTCTCACTAGGTTATATGCCCTACCCTGGACACACCAACCAGGAGGTTC
TAGACTTCATTGCCACAGGGAACAGGATGGACCCTCCTAGGAACTGTCCTGGGCCAGTGTACCG
AATCATGACCCAGTGCTGGCAGCTTCAACCTGAGCTCCGCCCTGACTTTGCCAGCATCTTGGAG
CGCATTCAATACTGCATTCAGGACCCTGATGTGCTGAACTCGCCCTTGCCCATGGAACCAGGGC
CCATTGTGGAGGAGGAAGGGGCCTCTGGGCCGGGGAACAGGTCACTGGAAGGTCTTAGATCCCC
AAAGACCCTGGAACTGAGTTCCCAGAACTTGAAAAGCCGGGGAGGAGACCTTCTTGGCTCTCAG
CTGCCCTCTGGCCTCAAGACCCTCACATCCAGATGCCTTCAACCTCAGAACATTTGGAACCCCA
CCTATGGCTCCTGGACCCCAAGGAGCCCCCAGGGTGAAGATTCAGACATTGACCTTAGCAATGG
CCCCTCCTCGGATTCCTTTCCAGGCGAGCAGTAGCCTCTGCCCCCTGCAGTCTCTGCTGCATGT
TCAGGCATGTTTCAGGGATGTCCAAGCGGCCTGCCTGGCCTTTTTACACTGGAAACCATCCTCG
ACCCTCTTGGGGAAGGCCTGGGCTACTCTCAGTCTTTGGAGTCAGTTGGGAATCCTGGATTGTC
CACTCCCTATAAGTATCTTTCCTCTGACCCATGCCAGTGCTACAAATGTTTTTAGTAATGGTGA
TGGTGATGATGATGATGGTGATGATGATGATGATGATAATAAAACCCTTCTAATTCTTCAAAAA
AAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101233	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL79925	(Get FASTA)	NCBI Sequence Viewer
	EDL79926	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001101233 ⟸ NM_001107763

- UniProtKB:

A6HPH5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

METRAAAQGSGRRGGAAGGDTSESDLLWADGEDGISFVHPSGELYLQPLAVTEGDVEVEIRRHP
NCSHCSFKDCQWQAELWRAECICPEGMELAVDNITCTGLPTTTSPLIMMGAVVTALTLSLLMMC
GVLILVNQKKCQSLRGTRLPGPELELSKLRTSAIRTAPNPYYCQVGLSPAQAWPLPQGLTEVSP
ANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLPVAIKTLPELCSPQDELDFLMEALIISKFSHQ
NIVRCVGLSFQAAPRLILLELMSGGDMKSFLRHSRPHPGQLSPLTMQDLLQLAQDIAQGCHYLE
ENHFIHRDIAARNCLLSCSGDSRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGL
FTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQLQ
PELRPDFASILERIQYCIQDPDVLNSPLPMEPGPIVEEEGASGPGNRSLEGLRSPKTLELSSQN
LKSRGGDLLGSQLPSGLKTLTSRCLQPQNIWNPTYGSWTPRSPQGEDSDIDLSNGPSSDSFPGE
Q

hide sequence

RefSeq Acc Id:

ENSRNOP00000030962 ⟸ ENSRNOT00000030532

RefSeq Acc Id:

ENSRNOP00000085416 ⟸ ENSRNOT00000099587

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M0B3-F1-model_v2	AlphaFold	F1M0B3	1-577	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309323	AgrOrtholog
BioCyc Gene	G2FUF-48191	BioCyc
Ensembl Genes	ENSRNOG00000025130	Ensembl, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000030962.4	UniProtKB/TrEMBL
	ENSRNOP00000085416.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000030532.4	UniProtKB/TrEMBL
	ENSRNOT00000099587.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Tyr_kinase_rcpt_2_CS	UniProtKB/TrEMBL
NCBI Gene	311337	ENTREZGENE
PANTHER	PTHR24416:SF294	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE RECEPTOR	UniProtKB/TrEMBL
Pfam	Gly_rich	UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/TrEMBL
PhenoGen	Ltk	PhenoGen
PRINTS	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	RECEPTOR_TYR_KIN_II	UniProtKB/TrEMBL
SMART	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A8I6GCV6_RAT	UniProtKB/TrEMBL
	A6HPH5	ENTREZGENE, UniProtKB/TrEMBL
	F1M0B3_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-18	Ltk	leukocyte receptor tyrosine kinase	Ltk	leukocyte tyrosine kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Ltk	leukocyte tyrosine kinase	Ltk_predicted	leukocyte tyrosine kinase (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ltk_predicted	leukocyte tyrosine kinase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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