Tyro3 (TYRO3 protein tyrosine kinase)

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Gene: Tyro3 (TYRO3 protein tyrosine kinase) Rattus norvegicus

Analyze

Symbol:

Tyro3

Name:

TYRO3 protein tyrosine kinase

RGD ID:

3923

Description:

Exhibits phosphatidylinositol 3-kinase binding activity. Involved in protein phosphorylation. Localizes to endoplasmic reticulum membrane and nuclear envelope. Orthologous to human TYRO3 (TYRO3 protein tyrosine kinase); INTERACTS WITH 1,2,4-trimethylbenzene; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Brt; Bruton agammaglobulinemia tyrosine kinase; TYRO3 protein tyrosine kinase 3; tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase SKY

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TYRO3 (TYRO3 protein tyrosine kinase)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Tyro3 (TYRO3 protein tyrosine kinase 3)	HGNC	NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Tyro3 (TYRO3 protein tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TYRO3 (TYRO3 protein tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TYRO3 (TYRO3 protein tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tyro3 (TYRO3 protein tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TYRO3 (TYRO3 protein tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	TYRO3 (TYRO3 protein tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tyro3 (TYRO3 protein tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tyro3 (TYRO3 protein tyrosine kinase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Homo sapiens (human):	TYRO3 (TYRO3 protein tyrosine kinase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	tyro3 (TYRO3 protein tyrosine kinase)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	svh-2	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	106,777,686 - 106,797,154 (+)	NCBI
Rnor_6.0 Ensembl	3	111,597,102 - 111,616,142 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	3	111,597,102 - 111,616,142 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	118,145,366 - 118,165,796 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	106,309,671 - 106,328,607 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	106,206,098 - 106,225,035 (+)	NCBI
Celera	3	105,690,533 - 105,707,759 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2,4-trimethylbenzene (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (ISO)

6-propyl-2-thiouracil (EXP)

ADP (ISO)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

all-trans-retinoic acid (EXP,ISO)

ammonium chloride (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

fenvalerate (EXP)

gamma-hexachlorocyclohexane (EXP)

genistein (EXP)

hydrogen peroxide (ISO)

methotrexate (ISO)

methoxychlor (EXP)

N-nitrosodiethylamine (EXP)

naphthalenes (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

O-methyleugenol (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

paraquat (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (EXP)

pirinixic acid (EXP)

progesterone (EXP)

rac-lactic acid (ISO)

retinyl acetate (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tamibarotene (ISO)

Tesaglitazar (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

undecane (EXP)

valproic acid (ISO)

vorinostat (ISO)

warfarin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic cell clearance (IEA,ISO,ISS)

cell migration (IBA)

forebrain cell migration (IEA,ISO,ISS)

multicellular organism development (IBA)

natural killer cell differentiation (IEA,ISO)

negative regulation of inflammatory response (IEA,ISO,ISS)

negative regulation of innate immune response (IEA,ISO,ISS)

negative regulation of lymphocyte activation (IEA,ISO)

negative regulation of neuron apoptotic process (IEA,ISO,ISS)

negative regulation of toll-like receptor signaling pathway (IEA,ISO,ISS)

nervous system development (IBA)

neuron cellular homeostasis (IEA,ISO,ISS)

neuropeptide signaling pathway (IEA,ISO)

ovulation cycle (IEA,ISO,ISS)

peptidyl-tyrosine phosphorylation (IEA)

phagocytosis (IBA)

platelet activation (ISO,ISS)

platelet aggregation (IBA,IEA,ISO,ISS)

positive regulation of kinase activity (IBA)

positive regulation of viral life cycle (IEA,ISO)

protein autophosphorylation (IEA,ISO,ISS)

protein kinase B signaling (IEA,ISO,ISS)

protein phosphorylation (IDA)

secretion by cell (IEA,ISO,ISS)

spermatogenesis (IEA,ISO,ISS)

substrate adhesion-dependent cell spreading (IEA,ISO,ISS)

transmembrane receptor protein tyrosine kinase signaling pathway (IBA)

vagina development (IEA,ISO)

viral entry into host cell (IEA)

Cellular Component

cell surface (IEA,ISO)

endoplasmic reticulum membrane (IDA)

integral component of membrane (IEA)

integral component of plasma membrane (IBA)

nuclear envelope (IDA)

nucleus (IDA)

plasma membrane (IEA)

receptor complex (IBA)

Molecular Function

ATP binding (IEA)

phosphatidylinositol 3-kinase binding (IEA,IPI,ISO)

protein binding (ISO)

protein tyrosine kinase activity (ISO,ISS)

transmembrane receptor protein tyrosine kinase activity (IBA,IEA)

virus receptor activity (IEA,ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA data from the GO Consortium
3.	Gould WR, etal., J Thromb Haemost. 2005 Apr;3(4):733-41. Epub 2005 Feb 23.
4.	Kajii Y, etal., Biol Cell. 1996;88(1-2):45-54.
5.	Lan Z, etal., Blood. 2000 Jan 15;95(2):633-8.
6.	MGD data from the GO Consortium
7.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Ohashi K, etal., J Biochem (Tokyo) 1995 Jun;117(6):1267-75.
9.	RGD automated data pipeline
10.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	RGD automated import pipeline for gene-chemical interactions
12.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:7511603	PMID:7537495	PMID:9331176	PMID:10227296	PMID:11452127	PMID:15650770	PMID:16751775	PMID:17442946	PMID:17980494	PMID:18083102	PMID:18159085	PMID:18393392
PMID:18787040	PMID:19027714	PMID:20546121	PMID:21084607	PMID:21270900	PMID:22119469	PMID:22606290

Genomics

Comparative Map Data

Tyro3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	106,777,686 - 106,797,154 (+)	NCBI
Rnor_6.0 Ensembl	3	111,597,102 - 111,616,142 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	3	111,597,102 - 111,616,142 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	118,145,366 - 118,165,796 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	106,309,671 - 106,328,607 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	106,206,098 - 106,225,035 (+)	NCBI
Celera	3	105,690,533 - 105,707,759 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

TYRO3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	15	41,557,675 - 41,583,589 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	15	41,559,212 - 41,583,589 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	15	41,851,410 - 41,875,787 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	15	41,851,220 - 41,871,536 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	39,638,524 - 39,658,818 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	15	39,638,523 - 39,658,818	NCBI
Celera	15	18,619,191 - 18,639,503 (+)	NCBI
Cytogenetic Map	15	q15.1	NCBI
HuRef	15	18,699,536 - 18,719,735 (+)	NCBI		HuRef
CHM1_1	15	41,969,757 - 41,990,068 (+)	NCBI		CHM1_1

Tyro3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	119,628,221 - 119,648,585 (+)	NCBI	GRCm39		mm39
GRCm38	2	119,797,740 - 119,818,104 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	119,797,733 - 119,818,104 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	119,625,250 - 119,643,840 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	119,490,955 - 119,509,545 (+)	NCBI			mm8
Celera	2	120,956,991 - 120,973,578 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	59.97	NCBI

Tyro3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	8,359,207 - 8,377,692 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	8,361,722 - 8,377,629 (+)	NCBI	ChiLan1.0	ChiLan1.0

TYRO3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	15	38,739,509 - 38,760,288 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	38,739,509 - 38,760,288 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	15	20,499,789 - 20,520,152 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

TYRO3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	30	8,571,475 - 8,598,721 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	30	8,571,230 - 8,602,655 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Tyro3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936471	4,893,185 - 4,910,779 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TYRO3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	129,811,539 - 129,828,991 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	129,811,540 - 129,829,395 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	144,883,363 - 144,900,853 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TYRO3
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	41,429,667 - 41,449,130 (-)	NCBI
ChlSab1.1 Ensembl	26	41,429,556 - 41,449,175 (-)	Ensembl

Tyro3
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624804	8,711,487 - 8,729,025 (+)	NCBI

Position Markers

Tyro3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RGSC_v3.4	3	106,327,758 - 106,327,964	UniSTS	RGSC3.4
Celera	3	105,706,911 - 105,707,117	UniSTS
Celera	3	105,707,001 - 105,707,156	UniSTS

D15S1348

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	111,615,194 - 111,615,430	NCBI	Rnor6.0
Rnor_5.0	3	118,164,839 - 118,165,075	UniSTS	Rnor5.0
RGSC_v3.4	3	106,327,658 - 106,327,894	UniSTS	RGSC3.4
Celera	3	105,706,811 - 105,707,047	UniSTS
Cytogenetic Map	3	q36.1	UniSTS

Tyro3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	3	118,165,029 - 118,165,184	UniSTS	Rnor5.0
Celera	3	105,707,001 - 105,707,156	UniSTS
Cytogenetic Map	3	q36.1	UniSTS

Tyro3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	3	118,164,939 - 118,165,145	UniSTS	Rnor5.0
RGSC_v3.4	3	106,327,758 - 106,327,964	UniSTS	RGSC3.4
Celera	3	105,706,911 - 105,707,117	UniSTS
Cytogenetic Map	3	q36.1	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	30114912	123700444	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	30846101	172879276	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	39248391	140271184	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	43295930	163640485	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	43295930	163640485	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	45406058	127023997	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	45406058	177699992	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	48561928	155263151	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	48562146	115249962	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	48562146	115249962	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	51821836	124513579	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	51822008	120917851	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	54630948	119830094	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	54630948	119830094	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	54630948	119830094	Rat
1581568	Rf53	Renal function QTL 53			total urine protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	58204463	170534769	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	61241033	165369047	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	62922868	127023997	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	66711607	119830094	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	66711607	119830094	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	72672290	127023997	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	72973445	127023997	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	78700444	123700444	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	total urine protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	81136227	154416635	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	83817637	119509260	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	88910015	133910015	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	94788365	139788365	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	97009185	142009185	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	99465522	168732722	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	100730984	119830094	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	101058963	146058963	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	102152812	155263151	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	102466149	147466149	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	103141814	176418101	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	103141814	176418101	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	103141814	176418101	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	103141944	170934860	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	106900427	119830094	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	362
Count of miRNA genes:	222
Interacting mature miRNAs:	252
Transcripts:	ENSRNOT00000007656
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	16	6	6		6			74	28	35
Low	2	27	51	35	19	35	5	6		7	6	11	5
Below cutoff							3	5					3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC107565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D37880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000081462 ⟹ ENSRNOP00000069466

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	111,597,102 - 111,616,142 (+)	Ensembl

RefSeq Acc Id:

NM_017092 ⟹ NP_058788

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	106,778,102 - 106,797,142 (+)	NCBI
Rnor_6.0	3	111,597,102 - 111,616,142 (+)	NCBI
Rnor_5.0	3	118,145,366 - 118,165,796 (+)	NCBI
RGSC_v3.4	3	106,309,671 - 106,328,607 (+)	RGD
Celera	3	105,690,533 - 105,707,759 (+)	RGD

Sequence:

show sequence

CCGGCATGGTGCGGCGTCGCCGCCGATGGCGCTGAGGCGGAGCATGGGGCGGCCGGGGCTCCGG
CCGCTGCTGCTGGCGGGGCTGGCCTCTCTGCTGCTCCCAGGGTCCGCGGCCGCAGGCCTGAAGC
TCATGGGAGCCCCAGTGAAGATGACAGTGTCTCAGGGGCAGCCAGTGAAGCTTAACTGCAGTGT
GGAAGGGATGGATGACCCTGACATACACTGGATGAAGGATGGCGCTGTGGTCCAGAATGCAAGC
CAGGTGTCCATCTCAATAAGCGAACAGAACTGGATTGGCTTACTCAGCCTAAAGTCAGCGGAGC
GGTCTGATGCCGGCCTGTACTGGTGCCAGGTGAAGGATGGGGAGGAAACCAAGATCTCTCAGTC
AGTATGGCTCACTGTTGAAGGTGTGCCATTCTTCACGGTGGAACCAAAAGATCTGGCGGTGCCA
CCCAATGTCCCTTTTCAACTGTCTTGTGAGGCTGTGGGTCCACCAGAACCCGTAACCATTTTCT
GGTGGAGAGGACCCACTAAGGTTGGGGGACCTGCTTCCTCTCCCTCTGTTTTAAATGTAACAGG
AGTGACCCAGCGCACAGAGTTTTCTTGTGAAGCTCATAACATAAAAGGCCTGGCCACTTCCCGA
CCAGCCATTATTCGCCTTCAAGCACCGCCTGCAGCTCCTTTCAACATCACAGTAACAACGATCT
CCAGCAGCAACGCTAGTGTGGCCTGGGTGCCGGGTGCTGATGGCTTAGCTCTGCTGCACTCCTG
TACTGTACAGGTGGCACATGCCCCAGGAGAATGGGAGGCCCTTGCTGTCGTGGTTCCCGTGCCA
CCCTTTACTTGCTTGCTTCGGAACTTGGCCCCTGCCACCAACTACAGCCTTAGGGTTCGCTGTG
CCAACGCCTTGGGCCCTTCTCCCTATGGCGACTGGGTGCCCTTTCAGACAAAGGGCCTAGCGCC
AGCCAGAGCCCCTCAGAATTTCCACGCCATTCGTACTGACTCAGGCCTTATCCTGGAATGGGAA
GAAGTGATTCCTGAGGACCCTGGGGAAGGCCCCCTGGGACCTTATAAGCTGTCCTGGGTCCAAG
AAAATGGAACCCAGGATGAGCTGATGGTGGAAGGAACTACGGCCAATCTGACTGACTGGGATCC
CCAGAAGGACCTGGTTTTGCGTGTGTGTGCCTCCAATGCAATTGGTGATGGGCCCTGGAGTCAA
CCACTGGTGGTGTCTTCTCATGACCATGCAGGGAGGCAGGGCCCTCCTCACAGCCGTACATCCT
GGGTGCCTGTGGTCCTGGGTGTGCTCACCGCCCTGATCACAGCTGCTGCCTTGGCCCTCATCCT
GCTTCGGAAGAGACGCAAGGAGACGCGGTTCGGGCAAGCCTTTGACAGTGTCATGGCCCGAGGG
GAGCCAGCTGTACACTTCCGGGCAGCCCGGTCTTTCAATCGAGAAAGGCCTGAACGCATTGAAG
CTACATTGGATAGCCTGGGCATCAGCGATGAATTGAAGGAGAAGCTGGAGGACGTCCTCATCCC
AGAGCAGCAGTTCACCCTCGGCCGGATGTTGGGCAAAGGAGAGTTTGGATCAGTGCGGGAAGCC
CAGCTGAAGCAGGAAGATGGCTCCTTTGTGAAAGTGGCAGTGAAGATGCTGAAAGCTGACATCA
TTGCCTCAAGCGACATAGAAGAGTTCCTGAGAGAAGCAGCTTGCATGAAGGAGTTTGACCATCC
ACACGTGGCCAAGCTTGTTGGAGTGAGCCTCCGGAGCAGGGCTAAAGGTCGTCTCCCCATTCCC
ATGGTCATCCTGCCCTTCATGAAGCACGGAGACTTGCATGCCTTTCTGCTCGCCTCCCGAATTG
GGGAGAACCCTTTTAACCTGCCCCTCCAGACCCTCGTCCGGTTCATGGTGGACATTGCCTGTGG
CATGGAGTACCTGAGCTCCCGGAACTTCATCCACCGAGACCTAGCAGCTCGGAATTGCATGCTG
GCAGAGGACATGACAGTGTGTGTGGCTGACTTTGGACTCTCCCGGAAAATTTATAGCGGGGACT
ATTATCGTCAGGGCTGTGCCTCCAAACTGCCTGTCAAGTGGCTGGCCCTGGAGAGCTTGGCTGA
CAACTTGTATACTGTACACAGCGATGTGTGGGCCTTCGGGGTGACCATGTGGGAGATCATGACT
CGTGGGCAGACGCCATATGCTGGCATCGAAAATGCTGAGATTTACAACTACCTCATCAGCGGGA
ACCGCCTGAAGCAGCCTCCGGAGTGCATGGAGGAAGTGTATGATCTCATGTACCAGTGCTGGAG
TGCCGACCCAAAGCAGCGCCCAAGCTTCACATGCCTGCGAATGGAACTGGAGAACATTCTGGGC
CACCTATCTGTTCTGTCCACCAGCCAGGACCCCTTGTACATCAACATTGAGAGAGCTGGGCAGC
CTGCTGAGAATGGCAGTCCCGAGCTGCCCTGTGGAGAGCAGTCTAGCAGCGAGGCGGGGGATGG
CAGTGGCATGGGGGCAATAGGTGGCATCCCCAGTGACTGTCGGTACATCTTCAGCCCTGGAGGG
TTGGCCGAGTCACCAGGGCAGCTGGAGCAGCAGCCAGAAAGCCCCCTCAACGAGAACCAGAGGC
TTTTGTTGTTGCAGCAAGGGCTACTGCCTCACAGTAGCTGTTAACCTGCAGGCAGAGGACAGCT
GGGGCCCCCTGGCTCTGCCGGCCATTGCGCTGGCTTACTAGGCCCCGTCTGATCACAGCCCAGG
CAGCAAGGTATGGAGGCTCCTGTGGTAGTCCTCCCAAGCTGTGCTGGGACCTGGACTGACCAAA
TTGCCCAATCCCAGTTCTTCCTGCAGCCGCTCTGGCCAGCCTGGCATCAGTTCAGGCCTTGGCT
TAGAGGAGGTGAGCCAGATCTGGTTGCCTGAATGCAGGCAGCTGGCAGGAGGGGAGGGTGGCTG
TGTTTCCATGGGTACCATGGGTGTGGATGGCAGTAAGGGAGGGTAGCAGCAGCCCTGTGGGCCC
CTACCCTCCTGGCTGAGCTGCTCCTACTTTAGTGCATGCTTGGAGCCGCCTGCAGCCTGGAGCT
CAGCACTGCCCACCACACCTGAGTTTAAATGCCAGGTTTGCCCCTCTACGTCACAAAGAGATGT
CCTTGTATTGTTCCCTTTTAGGTGACGATTAGGAAGGGATTGGCACACTTAGGTCCTTAAGCCC
CATGACAGGAAATGGTGGGATATTCTCAGGTCCGAATCCTCATCACCTTCCTGATTCCCCACCC
TGCCATGGCCTGGAACTGACTGGGTGGCTGAGGGATGCACGAGGACAAAGACTACCGAGATCCG
ACTCCTAAAGGCAGGGTCTGAGTCTGCCAGATGGAGGGGGTGCTAAGAGGTTGGCCCAGGAGTC
AGGCATTTCAGGACCCCTCTAAGCTTCTACAGTCTGTCTGAGCATGCTACCAAGCCCCCAAACA
TCCCAGAACTAACAGGCAGTTTTGTCTGAGCCCAGCCCTTCCACATGGTGACCCTTAGGTCTAC
CATCCTCTCTGAATGGATATCACTTGTCCCAAGTCTTAAGAGAGAGATACACCTGATGGCTGAT
GTGGGTAAGAAAAGTTCCTGGAACCAGGGCTGGGGTCTAGGCACCGCACTGCAAACCTCCTGGA
ATGCAGAGGCAGGCTCTTGGGCTGTTAGGAACATTTCCAAGCTATTAAGTTGCTGTTTCAAAAC
AATAAAATTGAAAC

hide sequence

RefSeq Acc Id:

XM_039104341 ⟹ XP_038960269

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	106,777,686 - 106,797,154 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_058788	(Get FASTA)	NCBI Sequence Viewer
	XP_038960269	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA07119	(Get FASTA)	NCBI Sequence Viewer
	EDL79928	(Get FASTA)	NCBI Sequence Viewer
	P55146	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_058788 ⟸ NM_017092
- Peptide Label:	precursor
- UniProtKB:	P55146 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MALRRSMGRPGLRPLLLAGLASLLLPGSAAAGLKLMGAPVKMTVSQGQPVKLNCSVEGMDDPDI HWMKDGAVVQNASQVSISISEQNWIGLLSLKSAERSDAGLYWCQVKDGEETKISQSVWLTVEGV PFFTVEPKDLAVPPNVPFQLSCEAVGPPEPVTIFWWRGPTKVGGPASSPSVLNVTGVTQRTEFS CEAHNIKGLATSRPAIIRLQAPPAAPFNITVTTISSSNASVAWVPGADGLALLHSCTVQVAHAP GEWEALAVVVPVPPFTCLLRNLAPATNYSLRVRCANALGPSPYGDWVPFQTKGLAPARAPQNFH AIRTDSGLILEWEEVIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTTANLTDWDPQKDLVLRV CASNAIGDGPWSQPLVVSSHDHAGRQGPPHSRTSWVPVVLGVLTALITAAALALILLRKRRKET RFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGR MLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGV SLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRN FIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSD VWAFGVTMWEIMTRGQTPYAGIENAEIYNYLISGNRLKQPPECMEEVYDLMYQCWSADPKQRPS FTCLRMELENILGHLSVLSTSQDPLYINIERAGQPAENGSPELPCGEQSSSEAGDGSGMGAIGG IPSDCRYIFSPGGLAESPGQLEQQPESPLNENQRLLLLQQGLLPHSSC hide sequence

RefSeq Acc Id:

ENSRNOP00000069466 ⟸ ENSRNOT00000081462

RefSeq Acc Id:	XP_038960269 ⟸ XM_039104341
- Peptide Label:	isoform X1

Protein Domains

Fibronectin type-III Ig-like Ig-like C2-type Protein kinase

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692337

Promoter ID:

EPDNEW_R2860

Type:

initiation region

Name:

Tyro3_1

Description:

TYRO3 protein tyrosine kinase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	111,597,080 - 111,597,140	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

Visual

CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3923	AgrOrtholog
Ensembl Genes	ENSRNOG00000058586	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000069466	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000081462	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	FN3_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN3_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_I-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25232	UniProtKB/Swiss-Prot
NCBI Gene	25232	ENTREZGENE
Pfam	fn3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	I-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tyro3	PhenoGen
PRINTS	TYRKINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	FN3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IG_LIKE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	FN3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IGc2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00409	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TyrKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49265	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC205180
UniProt	F1M7U7_RAT	UniProtKB/TrEMBL
	P55146	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-23	Tyro3	TYRO3 protein tyrosine kinase	Tyro3	TYRO3 protein tyrosine kinase 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	Tyro3	TYRO3 protein tyrosine kinase 3		Bruton agammaglobulinemia tyrosine kinase	Name updated	629478	APPROVED
2002-06-10	Tyro3	Bruton agammaglobulinemia tyrosine kinase			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	extracellular domain consists of two immunoglobulin (Ig)-like and two fibronectin type III (FN III) motifs	729988

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD