Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2) Homo sapiens
Symbol: PIK3R2
Name: phosphoinositide-3-kinase regulatory subunit 2
Description: Exhibits phosphotyrosine residue binding activity; protein phosphatase binding activity; and receptor tyrosine kinase binding activity. Involved in negative regulation of MAPK cascade; phosphatidylinositol 3-kinase signaling; and regulation of autophagy. Predicted to localize to the nucleus and phosphatidylinositol 3-kinase complex. Implicated in pancreatic ductal adenocarcinoma. Biomarker of colon cancer and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MPPH; MPPH1; p85; p85-BETA; P85B; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphoinositide-3-kinase regulatory subunit beta; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta); PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta
Mus musculus (house mouse) : Pik3r2 (phosphoinositide-3-kinase regulatory subunit 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pik3r2 (phosphoinositide-3-kinase regulatory subunit 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pik3r2 (phosphoinositide-3-kinase regulatory subunit 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)
Canis lupus familiaris (dog) : PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pik3r2 (phosphoinositide-3-kinase regulatory subunit 2)
Sus scrofa (pig) : PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)
Chlorocebus sabaeus (green monkey) : PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)
Heterocephalus glaber (naked mole-rat) : Pik3r2 (phosphoinositide-3-kinase regulatory subunit 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1918,153,163 - 18,170,532 (+)Ensembl
GRCh381918,153,163 - 18,170,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,263,988 - 18,281,343 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,125,016 - 18,142,343 (+)NCBINCBI36hg18NCBI36
Build 341918,125,015 - 18,142,343NCBI
Celera1918,165,735 - 18,183,085 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,827,466 - 17,844,856 (+)NCBIHuRef
CHM1_11918,263,528 - 18,280,901 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PIK3R2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68478
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.