Slc27a2 (solute carrier family 27 member 2) - Rat Genome Database

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Gene: Slc27a2 (solute carrier family 27 member 2) Rattus norvegicus
Analyze
Symbol: Slc27a2
Name: solute carrier family 27 member 2
RGD ID: 71103
Description: Enables long-chain fatty acid-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid metabolic process. Located in endoplasmic reticulum and peroxisomal membrane. Orthologous to human SLC27A2 (solute carrier family 27 member 2); PARTICIPATES IN phytanic acid degradation pathway; Refsum disease pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arachidonate--CoA ligase; FATP-2; fatty acid transport protein 2; fatty-acid-coenzyme A ligase, very long-chain 1; long-chain fatty acid transport protein 2; long-chain-fatty-acid--CoA ligase; MGC93337; phytanate--CoA ligase; solute carrier family 27 (fatty acid transporter) member 2; solute carrier family 27 (fatty acid transporter), member 2; solute carrier family 27 (fatty acid transporter), member 32; THCA-CoA ligase; very long-chain acyl-CoA synthetase; very long-chain-fatty-acid-CoA ligase; VLACS; VLCS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,258,101 - 134,295,581 (+)NCBIGRCr8
mRatBN7.23113,804,728 - 113,842,208 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,804,728 - 113,842,208 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,687,726 - 117,725,657 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,283,254 - 126,321,189 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,943,634 - 123,981,567 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,014,620 - 119,052,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,014,620 - 119,052,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03125,542,772 - 125,580,197 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,072,570 - 114,114,269 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13113,978,142 - 114,019,842 (+)NCBI
Celera3112,647,886 - 112,684,776 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzylpenicillin  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gemfibrozil  (EXP)
genistein  (ISO)
glucose  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
isotretinoin  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nicotinic acid  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
olanzapine  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
procymidone  (ISO)
progesterone  (ISO)
propamocarb  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
4. Cellular cholesterol stimulates acute uptake of palmitate by redistribution of fatty acid translocase in type II pneumocytes. Kolleck I, etal., Biochemistry 2002 May 21;41(20):6369-75.
5. Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix. Makkar RS, etal., Arch Biochem Biophys. 2006 Jul 15;451(2):128-40. Epub 2006 May 24.
6. Gene Data Set MGD Curation, June 12, 2002
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway. Ohkuni A, etal., Biochem Biophys Res Commun. 2013 Dec 13;442(3-4):195-201. doi: 10.1016/j.bbrc.2013.11.036. Epub 2013 Nov 19.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Intraperoxisomal localization of very-long-chain fatty acyl-CoA synthetase: implication in X-adrenoleukodystrophy. Smith BT, etal., Exp Cell Res. 2000 Feb 1;254(2):309-20.
16. Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. Steinberg SJ, etal., Biochem Biophys Res Commun. 1999 Apr 13;257(2):615-21.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Molecular cloning of cDNA encoding rat very long-chain acyl-CoA synthetase. Uchiyama A, etal., J Biol Chem 1996 Nov 29;271(48):30360-5.
Additional References at PubMed
PMID:9271215   PMID:9671728   PMID:10749848   PMID:11980911   PMID:12048192   PMID:12719378   PMID:14651853   PMID:15699031   PMID:19056867   PMID:20142826   PMID:20178365   PMID:20530735  
PMID:21768100   PMID:22022213   PMID:23376485   PMID:28993506  


Genomics

Comparative Map Data
Slc27a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,258,101 - 134,295,581 (+)NCBIGRCr8
mRatBN7.23113,804,728 - 113,842,208 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,804,728 - 113,842,208 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,687,726 - 117,725,657 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,283,254 - 126,321,189 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,943,634 - 123,981,567 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,014,620 - 119,052,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,014,620 - 119,052,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03125,542,772 - 125,580,197 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,072,570 - 114,114,269 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13113,978,142 - 114,019,842 (+)NCBI
Celera3112,647,886 - 112,684,776 (+)NCBICelera
Cytogenetic Map3q36NCBI
SLC27A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381550,182,196 - 50,236,385 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1550,182,196 - 50,236,385 (+)EnsemblGRCh38hg38GRCh38
GRCh371550,474,393 - 50,528,582 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361548,261,714 - 48,315,862 (+)NCBINCBI36Build 36hg18NCBI36
Build 341548,261,713 - 48,315,862NCBI
Celera1527,367,005 - 27,421,191 (+)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1527,305,393 - 27,359,548 (+)NCBIHuRef
CHM1_11550,592,321 - 50,646,529 (+)NCBICHM1_1
T2T-CHM13v2.01547,990,417 - 48,044,633 (+)NCBIT2T-CHM13v2.0
Slc27a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,394,944 - 126,430,163 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2126,394,327 - 126,430,163 (+)EnsemblGRCm39 Ensembl
GRCm382126,553,024 - 126,588,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,552,407 - 126,588,243 (+)EnsemblGRCm38mm10GRCm38
MGSCv372126,378,760 - 126,413,979 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362126,244,596 - 126,279,377 (+)NCBIMGSCv36mm8
Celera2127,790,803 - 127,826,187 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Slc27a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554094,077,149 - 4,112,828 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554094,077,685 - 4,112,828 (-)NCBIChiLan1.0ChiLan1.0
SLC27A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21639,422,327 - 39,474,538 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11543,606,084 - 43,658,662 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01529,130,262 - 29,182,752 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11547,452,227 - 47,505,066 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1547,452,227 - 47,505,066 (+)Ensemblpanpan1.1panPan2
SLC27A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13016,155,932 - 16,196,919 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,156,063 - 16,196,829 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,082,144 - 16,122,978 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03016,299,840 - 16,340,742 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3016,299,931 - 16,340,726 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13016,222,402 - 16,263,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03016,339,970 - 16,380,747 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03016,446,344 - 16,487,168 (+)NCBIUU_Cfam_GSD_1.0
Slc27a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864094,411,670 - 94,450,694 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647112,259,734 - 12,298,760 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647112,259,779 - 12,298,760 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC27A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,526,295 - 121,579,120 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11121,530,449 - 121,578,994 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21135,172,705 - 135,221,753 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC27A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12633,080,844 - 33,134,467 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2633,083,317 - 33,134,433 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048108,014,439 - 108,068,707 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc27a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247319,862,731 - 9,896,661 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247319,862,948 - 9,896,064 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc27a2
330 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:125
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000013605, ENSRNOT00000067700
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
D3Got230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23113,804,232 - 113,804,401 (+)MAPPERmRatBN7.2
Rnor_6.03119,014,125 - 119,014,293NCBIRnor6.0
Rnor_5.03125,542,277 - 125,542,445UniSTSRnor5.0
RGSC_v3.43114,072,075 - 114,072,243UniSTSRGSC3.4
Celera3112,647,391 - 112,647,559UniSTS
Cytogenetic Map3q36UniSTS
RH128972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23113,841,956 - 113,842,152 (+)MAPPERmRatBN7.2
Rnor_6.03119,052,280 - 119,052,475NCBIRnor6.0
Rnor_5.03125,579,946 - 125,580,141UniSTSRnor5.0
RGSC_v3.43114,114,018 - 114,114,213UniSTSRGSC3.4
Celera3112,684,525 - 112,684,720UniSTS
RH 3.4 Map3988.0UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 40 113 91 90 59 25 59 6 207 86 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000013605   ⟹   ENSRNOP00000013607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3119,015,412 - 119,052,222 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000067700   ⟹   ENSRNOP00000059771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3113,804,728 - 113,842,208 (+)Ensembl
Rnor_6.0 Ensembl3119,014,620 - 119,052,531 (+)Ensembl
RefSeq Acc Id: NM_031736   ⟹   NP_113924
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,258,101 - 134,295,581 (+)NCBI
mRatBN7.23113,804,728 - 113,842,208 (+)NCBI
Rnor_6.03119,014,620 - 119,052,531 (+)NCBI
Rnor_5.03125,542,772 - 125,580,197 (+)NCBI
RGSC_v3.43114,072,570 - 114,114,269 (+)RGD
Celera3112,647,886 - 112,684,776 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113924 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81766 (Get FASTA)   NCBI Sequence Viewer  
  BAA12722 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059771
GenBank Protein P97524 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113924   ⟸   NM_031736
- UniProtKB: P97524 (UniProtKB/Swiss-Prot),   D3ZSL9 (UniProtKB/TrEMBL),   Q66HN6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059771   ⟸   ENSRNOT00000067700
Ensembl Acc Id: ENSRNOP00000013607   ⟸   ENSRNOT00000013605
Protein Domains
AMP-binding enzyme C-terminal   AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97524-F1-model_v2 AlphaFold P97524 1-620 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692388
Promoter ID:EPDNEW_R2913
Type:initiation region
Name:Slc27a2_1
Description:solute carrier family 27 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03119,015,273 - 119,015,333EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71103 AgrOrtholog
BioCyc Gene G2FUF-48024 BioCyc
BioCyc Pathway PWY-5143 [long-chain fatty acid activation] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-6000 [gamma-linolenate biosynthesis II (animals)] BioCyc
  PWY-6061 [bile acid biosynthesis, neutral pathway] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
BioCyc Pathway Image PWY-5143 BioCyc
  PWY-5972 BioCyc
  PWY-6000 BioCyc
  PWY-6061 BioCyc
  PWY3DJ-11470 BioCyc
Ensembl Genes ENSRNOG00000010128 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000067700 ENTREZGENE
Gene3D-CATH 3.30.300.30 UniProtKB/Swiss-Prot
  3.40.50.12780 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106977 IMAGE-MGC_LOAD
InterPro AMP-bd_C UniProtKB/Swiss-Prot
  AMP-bd_C_sf UniProtKB/Swiss-Prot
  AMP-binding_CS UniProtKB/Swiss-Prot
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot
  AMP-dep_Synthh-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:65192 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93337 IMAGE-MGC_LOAD
NCBI Gene 65192 ENTREZGENE
PANTHER LONG-CHAIN FATTY ACID TRANSPORT PROTEIN UniProtKB/Swiss-Prot
  LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 2 UniProtKB/Swiss-Prot
Pfam AMP-binding UniProtKB/Swiss-Prot
  AMP-binding_C UniProtKB/Swiss-Prot
PhenoGen Slc27a2 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010128 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot
UniProt D3ZSL9 ENTREZGENE
  P97524 ENTREZGENE
  Q66HN6 ENTREZGENE, UniProtKB/TrEMBL
  S27A2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc27a2  solute carrier family 27 member 2  Slc27a2  solute carrier family 27 (fatty acid transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc27a2  solute carrier family 27 (fatty acid transporter), member 2    solute carrier family 27 (fatty acid transporter), member 32  Name updated 1299863 APPROVED
2002-07-09 Slc27a2  solute carrier family 27 (fatty acid transporter), member 32      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference