Abcd1 (ATP binding cassette subfamily D member 1)

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Gene: Abcd1 (ATP binding cassette subfamily D member 1) Rattus norvegicus

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Symbol:

Abcd1

Name:

ATP binding cassette subfamily D member 1

RGD ID:

1562128

Description:

Enables ATP binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in very long-chain fatty acid catabolic process. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ABCD1 (ATP binding cassette subfamily D member 1); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ALDP; ATP-binding cassette sub-family D member 1; ATP-binding cassette, sub-family D (ALD), member 1; ATP-binding cassette, subfamily D (ALD), member 1; LOC363516; RGD1562128; similar to mALDP

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ABCD1 (ATP binding cassette subfamily D member 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Abcd1 (ATP-binding cassette, sub-family D member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Abcd1 (ATP binding cassette subfamily D member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ABCD1 (ATP binding cassette subfamily D member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ABCD1 (ATP binding cassette subfamily D member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Abcd1 (ATP binding cassette subfamily D member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ABCD1 (ATP binding cassette subfamily D member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ABCD1 (ATP binding cassette subfamily D member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Abcd1 (ATP binding cassette subfamily D member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GLO1 (glyoxalase I)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ABCD1 (ATP binding cassette subfamily D member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Abcd1 (ATP-binding cassette, sub-family D member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	abcd1 (ATP-binding cassette, sub-family D (ALD), member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG2316	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PXA2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	pmp-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	abcd1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Abcd1^em2Mcwi Abcd1^em4Mcwi

Genetic Models:

DA-Abcd1^em4Mcwi DA-Abcd1^em2Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	156,579,669 - 156,601,448 (+)	NCBI		GRCr8
mRatBN7.2	X	151,428,334 - 151,450,115 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	151,428,578 - 151,450,115 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	153,569,626 - 153,591,020 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,132,856 - 157,154,250 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	154,804,685 - 154,826,079 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	157,073,860 - 157,095,652 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	157,072,736 - 157,095,274 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,823,436 - 152,844,829 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	159,614,569 - 159,635,963 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	136,439,697 - 136,461,090 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Addison's disease (ISO)

adrenoleukodystrophy (ISO,ISS)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

Barth syndrome (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

Chromosome Xq28 Duplication Syndrome (ISO)

COVID-19 (ISO)

deafness, dystonia, and cerebral hypomyelination (ISO)

dyskeratosis congenita (ISO)

Ehlers-Danlos syndrome kyphoscoliotic type 1 (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

encephalitis (ISO)

factor VIII deficiency (ISO)

favism (ISO)

genetic disease (ISO)

immunodeficiency 33 (ISO)

intellectual disability (ISO)

Nervous System Malformations (ISO)

Neurologic Gait Disorders (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

peroxisome biogenesis disorder 2B (ISO)

severe congenital encephalopathy due to MECP2 mutation (ISO)

Splenomegaly (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked spondyloepimetaphyseal dysplasia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

(R,R,R)-alpha-tocopherol (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

7-ketocholesterol (ISO)

acrylamide (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

aspartame (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

chlormequat chloride (EXP)

cisplatin (ISO)

clofibric acid (EXP)

dicrotophos (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

fenthion (ISO)

fluoranthene (ISO)

hypochlorous acid (ISO)

kojic acid (ISO)

methotrexate (ISO)

monosodium L-glutamate (ISO)

N-ethyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP,ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

progesterone (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid beta-oxidation (IBA,ISO,ISS)

fatty acid elongation (ISO,ISS)

fatty acid homeostasis (ISO)

fatty-acyl-CoA transport (IEA)

long-chain fatty acid catabolic process (ISO,ISS)

long-chain fatty acid import into peroxisome (IBA,ISO,ISS)

myelin maintenance (ISO)

negative regulation of cytokine production involved in inflammatory response (ISO,ISS)

negative regulation of reactive oxygen species biosynthetic process (ISO,ISS)

neuron projection maintenance (ISO)

peroxisome organization (IBA,ISO)

positive regulation of fatty acid beta-oxidation (ISO,ISS)

positive regulation of unsaturated fatty acid biosynthetic process (ISO)

regulation of cellular response to oxidative stress (ISO)

regulation of fatty acid beta-oxidation (ISO)

regulation of mitochondrial depolarization (ISO)

regulation of oxidative phosphorylation (ISO)

sterol homeostasis (ISO)

transmembrane transport (IEA)

very long-chain fatty acid catabolic process (IBA,IMP,ISO,ISS)

very long-chain fatty acid metabolic process (ISO,ISS)

very long-chain fatty-acyl-CoA catabolic process (ISO,ISS)

Cellular Component

cytoplasm (ISO)

endoplasmic reticulum membrane (ISO)

lysosomal membrane (ISO)

membrane (IEA)

mitochondrial membrane (ISO)

perinuclear region of cytoplasm (ISO)

peroxisomal membrane (IBA,IDA,ISO)

peroxisome (IDA,ISO)

Molecular Function

ABC-type fatty-acyl-CoA transporter activity (ISO,ISS)

ABC-type transporter activity (IEA)

ADP binding (ISO)

ATP binding (IBA,IDA,IEA,ISO)

ATP hydrolysis activity (IEA,ISO,ISS)

ATPase-coupled transmembrane transporter activity (IBA,ISO,ISS)

enzyme binding (ISO)

fatty acyl-CoA hydrolase activity (ISO,ISS)

identical protein binding (ISO)

long-chain fatty acid transmembrane transporter activity (IBA,ISO,ISS)

protein binding (IPI,ISO)

protein heterodimerization activity (IDA)

protein homodimerization activity (IDA,ISO)

very long-chain fatty acyl-CoA hydrolase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

adrenoleukodystrophy pathway (ISO)

carnitine-acylcarnitine translocase deficiency (ISO)

fatty acid beta degradation pathway (ISO)

phytanic acid degradation pathway (ISO)

Refsum disease pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Topology of ATP-binding domain of adrenoleukodystrophy gene product in peroxisomes.	Contreras M, etal., Arch Biochem Biophys. 1996 Oct 15;334(2):369-79.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers.	Geillon F, etal., J Biol Chem. 2014 Aug 29;289(35):24511-20. doi: 10.1074/jbc.M114.575506. Epub 2014 Jul 20.
4.	Peroxisomal ATP-binding cassette transporters form mainly tetramers.	Geillon F, etal., J Biol Chem. 2017 Apr 28;292(17):6965-6977. doi: 10.1074/jbc.M116.772806. Epub 2017 Mar 3.
5.	Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2).	Genin EC, etal., J Biol Chem. 2011 Mar 11;286(10):8075-8084. doi: 10.1074/jbc.M110.211912. Epub 2011 Jan 5.
6.	Identification of a two base pair deletion in five unrelated families with adrenoleukodystrophy: a possible hot spot for mutations.	Kemp S, etal., Biochem Biophys Res Commun. 1994 Jul 29;202(2):647-53.
7.	Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix.	Makkar RS, etal., Arch Biochem Biophys. 2006 Jul 15;451(2):128-40. Epub 2006 May 24.
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Intraperoxisomal localization of very-long-chain fatty acyl-CoA synthetase: implication in X-adrenoleukodystrophy.	Smith BT, etal., Exp Cell Res. 2000 Feb 1;254(2):309-20.
13.	ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1).	Tanaka AR, etal., J Biol Chem. 2002 Oct 18;277(42):40142-7. Epub 2002 Aug 9.

Additional References at PubMed

PMID:9126326	PMID:9256488	PMID:9418970	PMID:9425230	PMID:10196381	PMID:10551832	PMID:10777694	PMID:11248239	PMID:11500517	PMID:11875044	PMID:14533738	PMID:14561759
PMID:15489218	PMID:15682271	PMID:16213491	PMID:16946495	PMID:17542813	PMID:17609205	PMID:17761426	PMID:18344354	PMID:18614015	PMID:18723473	PMID:18757502	PMID:18854420
PMID:19946888	PMID:20810565	PMID:21145416	PMID:22521832	PMID:23123468	PMID:23604518	PMID:23671276	PMID:25255441	PMID:25583114	PMID:26108493

Genomics

Comparative Map Data

Abcd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	156,579,669 - 156,601,448 (+)	NCBI		GRCr8
mRatBN7.2	X	151,428,334 - 151,450,115 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	151,428,578 - 151,450,115 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	153,569,626 - 153,591,020 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,132,856 - 157,154,250 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	154,804,685 - 154,826,079 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	157,073,860 - 157,095,652 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	157,072,736 - 157,095,274 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,823,436 - 152,844,829 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	159,614,569 - 159,635,963 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	136,439,697 - 136,461,090 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

ABCD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	153,724,856 - 153,744,755 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	153,724,856 - 153,744,755 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	152,990,311 - 153,010,209 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	152,643,530 - 152,663,375 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	152,511,182 - 152,531,028	NCBI
Celera	X	153,224,004 - 153,243,898 (+)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	141,647,579 - 141,667,479 (+)	NCBI		HuRef
CHM1_1	X	152,864,732 - 152,884,627 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	151,998,519 - 152,018,419 (+)	NCBI		T2T-CHM13v2.0

Abcd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	72,760,203 - 72,782,140 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	72,760,203 - 72,782,140 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	73,716,597 - 73,738,534 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	73,716,597 - 73,738,534 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	70,961,936 - 70,983,626 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	69,969,317 - 69,991,007 (+)	NCBI		MGSCv36	mm8
Celera	X	64,970,295 - 64,991,971 (+)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.39	NCBI

Abcd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	459,715 - 475,774 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	459,715 - 475,363 (+)	NCBI	ChiLan1.0	ChiLan1.0

ABCD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	153,764,997 - 153,785,252 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	153,768,686 - 153,788,864 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	143,275,165 - 143,295,283 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	153,162,412 - 153,182,424 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	153,162,412 - 153,182,424 (+)	Ensembl	panpan1.1		panPan2

ABCD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	121,545,690 - 121,564,117 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	121,545,586 - 121,563,186 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	106,875,063 - 106,895,708 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	124,687,215 - 124,707,872 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	124,687,201 - 124,705,644 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	120,456,646 - 120,477,290 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	122,971,670 - 122,992,305 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	122,733,767 - 122,754,413 (+)	NCBI		UU_Cfam_GSD_1.0

Abcd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	118,877,295 - 118,896,851 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	615,139 - 635,990 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	615,133 - 634,618 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ABCD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	124,485,076 - 124,501,741 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	124,485,076 - 124,501,742 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	142,049,646 - 142,066,321 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ABCD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	128,152,697 - 128,171,007 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666065	66,018,682 - 66,038,332 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Abcd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624946	421,132 - 440,075 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624946	421,113 - 439,961 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Abcd1
15 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	381
Count of miRNA genes:	192
Interacting mature miRNAs:	226
Transcripts:	ENSRNOT00000025863
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634346	Insul4	Insulin level QTL 4	0		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	X	126975089	152453651	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	113937816	152453651	Rat

Markers in Region

GDB:376683

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	151,442,695 - 151,442,776 (-)	MAPPER	mRatBN7.2
Rnor_6.0	X	157,081,197 - 157,081,277	NCBI	Rnor6.0
Rnor_5.0	1	152,830,516 - 152,830,596	UniSTS	Rnor5.0
RGSC_v3.4	X	159,628,803 - 159,628,883	UniSTS	RGSC3.4
Celera	1	136,446,781 - 136,446,861	UniSTS
Cytogenetic Map	X	q37	UniSTS

UniSTS:238038

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	151,449,689 - 151,449,871 (-)	MAPPER	mRatBN7.2
Rnor_6.0	X	157,074,104 - 157,074,285	NCBI	Rnor6.0
Rnor_5.0	1	152,823,423 - 152,823,604	UniSTS	Rnor5.0
RGSC_v3.4	X	159,635,795 - 159,635,976	UniSTS	RGSC3.4
Celera	1	136,439,684 - 136,439,865	UniSTS
Cytogenetic Map	X	q37	UniSTS

Genetic Models

This gene Abcd1 is modified in the following models/strains:

DA-Abcd1^em4Mcwi DA-Abcd1^em2Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005498011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000084088 ⟹ ENSRNOP00000070359

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	151,428,578 - 151,450,115 (+)	Ensembl
Rnor_6.0 Ensembl	X	157,072,736 - 157,095,274 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107613 ⟹ ENSRNOP00000083864

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	151,428,578 - 151,450,115 (+)	Ensembl

RefSeq Acc Id:

NM_001108821 ⟹ NP_001102291

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	156,579,797 - 156,601,191 (+)	NCBI
mRatBN7.2	X	151,428,461 - 151,449,858 (+)	NCBI
Rnor_6.0	X	157,074,117 - 157,095,511 (-)	NCBI
Rnor_5.0	1	152,823,436 - 152,844,829 (-)	NCBI
RGSC_v3.4	X	159,614,569 - 159,635,963 (+)	RGD
Celera	1	136,439,697 - 136,461,090 (-)	NCBI

Sequence:

show sequence

CTTGGTGTAGACGCTGTGGTTACTGCCCGGCTGCAGAGCGGACAAACACGCCTAGTGCCCCGGG
GAGGGGCGTCACGGGGGGGGGGGAGGAGCAGTAAAGAAGAGGGAGGTGGAAGGGAAGAGACAAC
CTCTCTGTTTAAGACCTCTCGAGGCTCTGACCTCAGGGGCTAAGGGACAATCTGTGGAGGGAAG
CCAGTTTCCTCCACCCGGGCTGCCTGAAGAGGCCACGACCCTGGAGGATTCTAACCCAACCGAT
CCAGGGGCCCCAGCACCACCCCGAGGGCCTAAAGCAACAGTCTCAGGGACCACTTCAAGGTTTC
CAGTTGCCTAGACAACGAGCCCTGGGTCAGAGAAACAGCCCTTCCAGGATCTGCCCGCAACTGT
AGCCTCGGGCAGCAGTTCCAGCCCTCAGCCTGCTCACCAGTCCAGGTGACATGCCGGTACTCTC
CACTCCCTCCCGGCCCTCGCGGGTGACCACGCTTAAGCGCACAGCTGTGGTCCTGGCCCTCACA
GCCTATGGAGTCCACAAAATCTACCCTCTAGTACGGCAGTGTCTGACTCCTGCCAGAGGTCCTC
AGGTGCCAGCTGGGGAGTCCACGCAAGAGGCCTCTGGGGCCACCACAGCCAAGGCTGGCATGAA
CCGGGTATTCCTGCAGCGGCTCCTGGTGCTCCTGAGGCTGCTGTTCCCCGGAGTCTTGTGCCGG
GAAACAGGGCTACTGGCCCTGCATTCTGCTGCCCTGGTAAGCCGAACTTTCCTGTCTGTGTATG
TTGCCCGCCTGGACGGCAGACTGGCCCGCTGCATTGTACGTAAGGACCCAAGGGCCTTTAGCTG
GCAACTGCTGCAGTGGCTCCTCATCGCCCTTCCTGCCACTTTCATCAACAGTGCCATCCGCTAC
CTAGAGGGCCAGCTGGCTCTTTCTTTCCGAAGCCGTCTAGTAGCTCATGCCTATGGCCTCTACT
TCTCCCAGCAGACTTACTACCGAGTAAGCAACATGGATGGACGGCTTCGAAACCCTGACCAGTC
TCTGACAGAGGATATGGTAGCCTTTGCTGCTTCTGTAGCCCACCTTTATTCCAACCTGACCAAG
CCACTCCTGGATGTGGCTGTGACCTCCTACACTCTTCTTCGAGCTGCCCGATCCCGAGGAGCTG
GTACAGCCTGGCCCTCAGCCATCGCTGGCCTGGTGGTGTTCCTCACAGCCAACGTGCTTCGAGC
CTTCTCTCCCAAGTTTGGGGAGCTAGTGGCAGAGGAGGCACGGCGAAAGGGGGAACTGCGCTAC
ATGCACTCTCGAGTGGTGGCCAACTCAGAGGAAATTGCCTTCTACGGGGGCCATGAGGTAGAGC
TGGCACTACTACAACACTCCTATCAAGACCTGGCTTCACAGATCAACCTCATCCTCCTAGAACG
CCTGTGGTATGTCATGCTAGAACAGTTCCTCATGAAATATGTGTGGAGTGCATCTGGCCTGCTC
ATGGTAGCTGTCCCCATCATCACAGCCACTGGCTATGCAGAGTCAGACTCAGAAGCCATGAAAA
AGGCAGCCTTAGAAATGAAGGAAGAGGAGCTGGTTAGTGAACGTACAGAAGCCTTCACCATTGC
CCGAAACCTCCTCACAGCTGCTGCAGATGCCACTGAGAGGATCATGTCATCCTACAAGGAGGTG
ACAGAGCTGGCTGGCTACACAGCCAGGGTGTACGAGATGTTCCAGGTATTTGAAGATGTCCAAC
ACTGTCGTTTTAAGAGGACAGGAGATCTAGAGGAGGCTCAGGCTGGGCCTGGGTCCATGGTGCA
TTCTGGTGTTCATATAGAAGGGCCCCTGAAGATCCAAGGCCAGGTGGTGGATGTGGAGCAGGGG
ATCATCTGTGAGAACATCCCTATCATCACACCCACTGGAGAGGTGGTGGTGGCCAGCCTCAACA
TCAGGGTGGAGGAAGGCATGCACCTGCTCATCACAGGCCCCAATGGCTGCGGCAAGAGTTCTCT
GTTCCGAATCCTAGGTGGACTCTGGCCAACATACAGTGGGGTACTCTATAAGCCCCCACCCCAG
CGCATGTTCTATATCCCTCAGAGGCCCTACATGTCCGTGGGCTCCTTGCGTGACCAAGTGATCT
ATCCTGACTCTGCGGAAGACATGCGGAGGAAGGGCTGCTCGGAGCAGCAGCTGGAAGCCATCCT
GGGCATCGTGCATCTCCGACACATCCTGCAACGGGAGGGAGGTTGGGAGGCTGTGTGTGACTGG
AAGGACGTCCTTTCTGGTGGTGAGAAGCAGAGGATTGGTATGGCGCGCATGTTCTATCACAGGC
CCAAGTACGCCCTCCTGGATGAGTGCACTAGTGCCGTGAGCATTGATGTGGAAGGCAAGATCTT
CCAAGCAGCCAAAGATGCTGGTATCTCACTGCTGTCCATCACCCATCGACCCTCCCTATGGAAG
TACCACACACACTTGCTGCAGTTTGATGGGGAGGGAGGCTGGAAGTTTGAGAAGCTGGATTCTG
CTGCCCGCCTGAGCCTGACTGAAGAGAAGCAGCGCCTGGAGCAGCAACTGGCAGGCATCCCTAA
GATGCAGGGGCGCCTTCAGGAGCTCCGCCAGATCCTTGGCGAAGCTGCAGCCCCAGTTCAACCT
CTGGTCCCAGGCATCCCCACTTGACTGGGGACCTTATCCCTAGCTCCCACCCTTCTCCAAGCTC
TCGGATCACATGAAGGAAGCTGCAGCTCCTATCCTCCCCTTACTGCCCTGCATGCCTTCCCCTC
CCAAGCCTCCTAGCCAATTACCTGCTTTCCCTGAAGACCCCACTCTGGAGCAAGTAGATATGAA
TGGGGACACTCTGCATTCCACCTTCACTCTGGGGTCTGCTCCAGAAACTGTGCCCTGTTCGGGA
CAATGTGTCCTTTACTTTTCTCTGAGGAGGGATGGAGGGTTTGGAAGGCCCCAGTCCTGACTCT
ATACCAGTATGGCTGAGTCATAGGAAGTAAGCAGGAGCTGCCCTCTTACTGCCAGCAGCCAGAA
TGTGTGAAGCCTGGTGGTTGTGGATCACATCCCTCTTAAAACCCAAACCCTCGTCATTGCTTTG
ATCCATCCCTTTGTTGCCATCCCCTAGGGTGGCCAACCAATGCCCCTGTCCTATAGGACACTCC
TGCCATGAAAACAGCCTAATGGAGCCCAGGATTAGATGGGGCCCAAAGCGTGCCCTTCCCCATG
GTTACCCCCAGAATGGCATGGTTACCTCCTGAGCCATGAGAAGAATGTAGCCCTGGCCCTCCCA
CTCCTCCACCTCTACAACCTAATTTATTGGACTCCCAGTTTATAGGTGTCTAAATTGCCAACAT
GAGTACCCTGCCAGCACAGGAGGTGACTGGGTGGTCCCTTTAATCTACCTAGTCTCTGGTGCCA
AACCTGGCCCCTCACTAGC

hide sequence

RefSeq Acc Id:

XM_039099912 ⟹ XP_038955840

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	156,579,694 - 156,601,448 (+)	NCBI
mRatBN7.2	X	151,428,346 - 151,450,115 (+)	NCBI

RefSeq Acc Id:

XR_005498011

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	156,579,669 - 156,600,124 (+)	NCBI
mRatBN7.2	X	151,428,334 - 151,448,791 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102291	(Get FASTA)	NCBI Sequence Viewer
	XP_038955840	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZHR2	(Get FASTA)	NCBI Sequence Viewer
	EDL85026	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070359.1
	ENSRNOP00000083864.1
	ENSRNOP00055034141
	ENSRNOP00060007640
	ENSRNOP00065018852

RefSeq Acc Id:

NP_001102291 ⟸ NM_001108821

- UniProtKB:

D3ZHR2 (UniProtKB/TrEMBL), A0A8I5ZWT6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPVLSTPSRPSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPARGPQVPAGESTQEASGATTA
KAGMNRVFLQRLLVLLRLLFPGVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDP
RAFSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVSNMDGRLR
NPDQSLTEDMVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTA
NVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLASQINL
ILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVSERTE
AFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVQHCRFKRTGDLEEAQAGP
GSMVHSGVHIEGPLKIQGQVVDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGC
GKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAEDMRRKGCSEQQ
LEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDV
EGKIFQAAKDAGISLLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQL
AGIPKMQGRLQELRQILGEAAAPVQPLVPGIPT

hide sequence

Ensembl Acc Id:

ENSRNOP00000070359 ⟸ ENSRNOT00000084088

RefSeq Acc Id:	XP_038955840 ⟸ XM_039099912
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000083864 ⟸ ENSRNOT00000107613

Protein Domains

ABC transmembrane type-1 ABC transporter

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZHR2-F1-model_v2	AlphaFold	D3ZHR2	1-737	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562128	AgrOrtholog
BioCyc Gene	G2FUF-666	BioCyc
Ensembl Genes	ENSRNOG00000056524	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055024378	UniProtKB/Swiss-Prot
	ENSRNOG00060006225	UniProtKB/Swiss-Prot
	ENSRNOG00065014619	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000084088.2	UniProtKB/Swiss-Prot
	ENSRNOT00000107613.1	UniProtKB/TrEMBL
	ENSRNOT00055041904	UniProtKB/Swiss-Prot
	ENSRNOT00060010244	UniProtKB/Swiss-Prot
	ENSRNOT00065024160	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	AAA+_ATPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ABC1_TM_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ABC_transporter-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ABC_transporter_CS	UniProtKB/Swiss-Prot
	ABC_transporter_sub-D	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FA_transporter	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:363516	UniProtKB/Swiss-Prot
NCBI Gene	363516	ENTREZGENE
PANTHER	ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11384:SF21	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ABC_membrane_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ABC_tran	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Abcd1	PhenoGen
PROSITE	ABC_TM1F	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ABC_TRANSPORTER_1	UniProtKB/Swiss-Prot
	ABC_TRANSPORTER_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000056524	RatGTEx
	ENSRNOG00055024378	RatGTEx
	ENSRNOG00060006225	RatGTEx
	ENSRNOG00065014619	RatGTEx
SMART	AAA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZWT6	ENTREZGENE, UniProtKB/TrEMBL
	ABCD1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-09	Abcd1	ATP binding cassette subfamily D member 1	Abcd1	ATP-binding cassette, subfamily D (ALD), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-11-16	Abcd1	ATP-binding cassette, subfamily D (ALD), member 1	Abcd1	ATP-binding cassette, sub-family D (ALD), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Abcd1	ATP-binding cassette, sub-family D (ALD), member 1	Abcd1_predicted	ATP-binding cassette, sub-family D (ALD), member 1 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Abcd1_predicted	ATP-binding cassette, sub-family D (ALD), member 1 (predicted)	RGD1562128_predicted	similar to mALDP (predicted)	Symbol and Name updated	1299863	APPROVED
2006-03-07	RGD1562128_predicted	similar to mALDP (predicted)	LOC363516	similar to mALDP	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC363516	similar to mALDP			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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