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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71103
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc27a2
Name: solute carrier family 27 member 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc27a2affects methylationISOSLC27A2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SLC27A2 intron; Benzo(a)pyrene affects the methylation of SLC27A2 promoterPMID:27901495 PMID:30157460
Slc27a2decreases expressionISOSLC27A2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of SLC27A2 mRNAPMID:32234424
Slc27a2multiple interactionsISOSlc27a2 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to SLC27A2 promoter]PMID:19654925
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