Pdia3 (protein disulfide isomerase family A, member 3) - Rat Genome Database

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Gene: Pdia3 (protein disulfide isomerase family A, member 3) Rattus norvegicus
Symbol: Pdia3
Name: protein disulfide isomerase family A, member 3
RGD ID: 68430
Description: Enables MHC class I protein binding activity; peptidase activity; and protein-disulfide reductase (glutathione) activity. Involved in several processes, including cellular response to nonylphenol; response to benzene; and response to ischemia. Located in several cellular components, including acrosomal vesicle; apical plasma membrane; and smooth endoplasmic reticulum. Part of TAP complex. Used to study autoimmune hepatitis and irritable bowel syndrome. Biomarker of asphyxia neonatorum; irritable bowel syndrome; liver cirrhosis; post-traumatic stress disorder; and pulmonary hypertension. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3); PARTICIPATES IN antigen processing and presentation pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; ER protein 57; ER protein 60; ER-60 protease; ER60; ERp57; ERp60; glucose regulated protein, 58 kDa; Grp58; HIP-70; oxidoreductase ERp57; p58; protein disulfide isomerase associated 3; protein disulfide-isomerase A3; Q-2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83128,841,781 - 128,865,733 (+)NCBIGRCr8
mRatBN7.23108,388,189 - 108,412,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3108,388,245 - 108,413,236 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3112,062,478 - 112,086,451 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03120,657,999 - 120,681,970 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03118,318,399 - 118,342,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03113,376,983 - 113,400,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,376,983 - 113,400,707 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03119,916,772 - 119,940,826 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,216,414 - 108,240,138 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13108,117,203 - 108,140,928 (+)NCBI
Celera3107,289,603 - 107,313,229 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
benzatropine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
Brodifacoum  (EXP)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (EXP)
carbon nanotube  (ISO)
choline  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
clozapine  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
dopamine  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
etoposide  (EXP)
flavonoids  (EXP)
folic acid  (EXP)
furan  (EXP)
genistein  (EXP)
glucose  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
iodide salt  (EXP)
isoflavones  (EXP)
ivermectin  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
L-methionine  (EXP)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
limonene  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lovastatin  (ISO)
methamphetamine  (EXP)
microcystin RR  (ISO)
microcystin-LR  (EXP)
Monobutylphthalate  (ISO)
N-hydroxy-PhIP  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
procymidone  (EXP)
progesterone  (ISO)
Propiverine  (EXP)
pyrogallol  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sarin  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
T-2 toxin  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
warfarin  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. The oxidoreductase ERp57 efficiently reduces partially folded in preference to fully folded MHC class I molecules. Antoniou AN, etal., EMBO J. 2002 Jun 3;21(11):2655-63.
2. A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats. Aroor AR, etal., Proteome Sci. 2012 Apr 30;10(1):29. doi: 10.1186/1477-5956-10-29.
3. Molecular cloning and complete amino-acid sequence of form-I phosphoinositide-specific phospholipase C. Bennett CF, etal., Nature 1988 Jul 21;334(6179):268-70.
4. PDIA3 mRNA expression and IL-2, IL-4, IL-6, and CRP levels of acute kidney allograft rejection in rat. Chen G, etal., Mol Biol Rep. 2012 May;39(5):5233-8. doi: 10.1007/s11033-011-1321-1. Epub 2011 Dec 27.
5. [Proteomic expression analysis of colonic mucosa in a rat model of irritable bowel syndrome]. Ding Y, etal., Zhonghua Yi Xue Za Zhi. 2010 Mar 2;90(8):564-9.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Dehydration-induced proteome changes in the rat hypothalamo-neurohypophyseal system. Gouraud SS, etal., Endocrinology. 2007 Jul;148(7):3041-52. Epub 2007 Apr 5.
8. The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity. Hetz C, etal., J Neurosci. 2005 Mar 16;25(11):2793-802.
9. An interaction map of endoplasmic reticulum chaperones and foldases. Jansen G, etal., Mol Cell Proteomics. 2012 Sep;11(9):710-23. doi: 10.1074/mcp.M111.016550. Epub 2012 Jun 4.
10. Evidence for phosphorylation of rat liver glucose-regulated protein 58, GRP58/ERp57/ER-60, induced by fasting and leptin. Kita K, etal., FEBS Lett. 2006 Jan 9;580(1):199-205. Epub 2005 Dec 9.
11. Life-long effects of perinatal asphyxia on stress-induced proteins and dynamin 1 in rat brain. Kitzmueller E, etal., Neurochem Res. 2004 Sep;29(9):1767-77.
12. Identification of seven proteins in the endoplasmic reticulum as targets for reactive metabolites of bromobenzene. Koen YM and Hanzlik RP, Chem Res Toxicol. 2002 May;15(5):699-706.
13. LKM-1 sera from autoimmune hepatitis patients that recognize ERp57, carboxylesterase 1 and CYP2D6. Komurasaki R, etal., Drug Metab Pharmacokinet. 2010;25(1):84-92.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules. Morrice NA and Powis SJ, Curr Biol. 1998 Jun 4;8(12):713-6.
16. Proteomic analysis of the lung in rats with hypobaric hypoxia-induced pulmonary hypertension. Ohata Y, etal., Histol Histopathol. 2013 Jul;28(7):893-902. Epub 2013 Jan 10.
17. ERp57-associated mitochondrial micro-calpain truncates apoptosis-inducing factor. Ozaki T, etal., Biochim Biophys Acta. 2008 Oct;1783(10):1955-63. doi: 10.1016/j.bbamcr.2008.05.011. Epub 2008 May 24.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS)-binding protein in rat IEC-6 cells. Rohe B, etal., Steroids. 2005 May-Jun;70(5-7):458-63. Epub 2005 Apr 1.
23. Molecular architecture of the TAP-associated MHC class I peptide-loading complex. Rufer E, etal., J Immunol. 2007 Nov 1;179(9):5717-27.
24. Proteomic analysis of rat heart in ischemia and ischemia-reperfusion using fluorescence two-dimensional difference gel electrophoresis. Sakai J, etal., Proteomics. 2003 Jul;3(7):1318-24.
25. Differential cooperative enzymatic activities of protein disulfide isomerase family in protein folding. Satoh M, etal., Cell Stress Chaperones. 2005 Autumn;10(3):211-20.
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
28. Inhibition by acidic phospholipids of protein degradation by ER-60 protease, a novel cysteine protease, of endoplasmic reticulum. Urade R and Kito M, FEBS Lett. 1992 Nov 2;312(1):83-6.
29. Proteomic discovery of genistein action in the rat mammary gland. Wang J, etal., J Proteome Res. 2011 Apr 1;10(4):1621-31. Epub 2011 Feb 22.
30. Proteomic analysis of changes induced by nonylphenol in Sprague-Dawley rat Sertoli cells. Wu J, etal., Chem Res Toxicol. 2009 Apr;22(4):668-75. doi: 10.1021/tx800406z.
31. Interaction with grp58 increases activity of the thiazide-sensitive Na-Cl cotransporter. Wyse B, etal., Am J Physiol Renal Physiol 2002 Mar;282(3):F424-30.
32. Knockdown of ERp57 increases BiP/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis. Xu D, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L44-51. doi: 10.1152/ajplung.90626.2008. Epub 2009 May 1.
33. Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons. Yu B, etal., BMC Neurosci. 2014 Oct 21;15:115. doi: 10.1186/s12868-014-0115-5.
34. Proteome analysis of hepatic non-parenchymal cells of immune liver fibrosis rats. Zhao Q, etal., Sci China Life Sci. 2014 Mar;57(3):303-14. doi: 10.1007/s11427-014-4619-0. Epub 2014 Feb 21.
35. Distribution of PDIA3 transcript and protein in rat testis and sperm cells. Zhao XJ, etal., Reprod Domest Anim. 2013 Feb;48(1):59-63. doi: 10.1111/j.1439-0531.2012.02024.x. Epub 2012 Apr 2.
36. The effect of PDIA3 gene knockout on the mucosal immune function in IBS rats. Zhuang ZM, etal., Int J Clin Exp Med. 2015 May 15;8(5):6866-77. eCollection 2015.
Additional References at PubMed
PMID:1321829   PMID:1650195   PMID:1657921   PMID:2181662   PMID:9399589   PMID:9493907   PMID:10464281   PMID:13678524   PMID:15489334   PMID:15858817   PMID:15862830   PMID:16260597  
PMID:16516209   PMID:16677074   PMID:16905107   PMID:17154719   PMID:17634366   PMID:18765931   PMID:19199708   PMID:19995400   PMID:20109102   PMID:20130111   PMID:20387083   PMID:21263072  
PMID:21423176   PMID:21630459   PMID:21734266   PMID:21976707   PMID:22658674   PMID:23106098   PMID:23226417   PMID:23376485   PMID:23826168   PMID:24415168   PMID:25241190   PMID:26724776  
PMID:28707894   PMID:29104478   PMID:29581031   PMID:31176989   PMID:34338991   PMID:35352799  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83128,841,781 - 128,865,733 (+)NCBIGRCr8
mRatBN7.23108,388,189 - 108,412,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3108,388,245 - 108,413,236 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3112,062,478 - 112,086,451 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03120,657,999 - 120,681,970 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03118,318,399 - 118,342,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03113,376,983 - 113,400,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,376,983 - 113,400,707 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03119,916,772 - 119,940,826 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,216,414 - 108,240,138 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13108,117,203 - 108,140,928 (+)NCBI
Celera3107,289,603 - 107,313,229 (+)NCBICelera
Cytogenetic Map3q35NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381543,746,438 - 43,773,278 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1543,746,394 - 43,773,279 (+)EnsemblGRCh38hg38GRCh38
GRCh371544,038,636 - 44,065,476 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361541,825,882 - 41,852,096 (+)NCBINCBI36Build 36hg18NCBI36
Celera1520,928,053 - 20,954,266 (+)NCBICelera
Cytogenetic Map15q15.3NCBI
HuRef1520,861,356 - 20,887,666 (+)NCBIHuRef
CHM1_11544,156,851 - 44,183,060 (+)NCBICHM1_1
T2T-CHM13v2.01541,553,795 - 41,580,638 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392121,244,383 - 121,269,168 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2121,244,256 - 121,269,168 (+)EnsemblGRCm39 Ensembl
GRCm382121,413,902 - 121,438,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2121,413,775 - 121,438,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv372121,239,638 - 121,264,423 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362121,105,401 - 121,129,421 (+)NCBIMGSCv36mm8
Celera2122,564,601 - 122,589,381 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.38NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541610,198,099 - 10,220,792 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541610,197,957 - 10,221,104 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21632,997,271 - 33,023,322 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11537,158,999 - 37,185,059 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01522,706,520 - 22,731,672 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11540,794,144 - 40,821,615 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1540,794,144 - 40,821,763 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13010,487,926 - 10,513,437 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3010,487,921 - 10,513,397 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3010,546,317 - 10,571,800 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03010,624,436 - 10,649,938 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3010,624,468 - 10,651,817 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13010,533,603 - 10,559,083 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03010,655,339 - 10,680,999 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03010,775,223 - 10,800,728 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440864088,961,177 - 88,986,202 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364716,809,195 - 6,836,169 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364716,809,181 - 6,834,189 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1127,785,772 - 127,814,196 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11127,786,174 - 127,814,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21142,615,686 - 142,643,747 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12639,273,982 - 39,300,170 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2639,272,997 - 39,349,966 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048101,691,336 - 101,717,748 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462480410,755,103 - 10,784,337 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480410,754,978 - 10,784,641 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Pdia3
164 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:404
Count of miRNA genes:229
Interacting mature miRNAs:270
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,412,652 - 108,412,850 (+)MAPPERmRatBN7.2
Rnor_6.03113,401,350 - 113,401,547NCBIRnor6.0
Rnor_5.03119,941,469 - 119,941,666UniSTSRnor5.0
RGSC_v3.43108,240,781 - 108,240,978UniSTSRGSC3.4
Celera3107,313,872 - 107,314,069UniSTS
RH 3.4 Map3953.6UniSTS
Cytogenetic Map3q35UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,407,474 - 108,407,641 (+)MAPPERmRatBN7.2
Rnor_6.03113,396,172 - 113,396,338NCBIRnor6.0
Rnor_5.03119,936,291 - 119,936,457UniSTSRnor5.0
RGSC_v3.43108,235,603 - 108,235,769UniSTSRGSC3.4
Celera3107,308,692 - 107,308,858UniSTS
RH 3.4 Map3954.5UniSTS
Cytogenetic Map3q35UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,390,715 - 108,390,871 (+)MAPPERmRatBN7.2
mRatBN7.2456,924,637 - 56,924,731 (+)MAPPERmRatBN7.2
Rnor_6.03113,379,415 - 113,379,570NCBIRnor6.0
Rnor_5.03119,919,204 - 119,919,648UniSTSRnor5.0
Rnor_5.03119,919,204 - 119,919,359UniSTSRnor5.0
RGSC_v3.43108,218,846 - 108,219,001UniSTSRGSC3.4
Celera3107,292,035 - 107,292,190UniSTS
RH 3.4 Map3947.6UniSTS
Cytogenetic Map3q35UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,411,882 - 108,412,007 (+)MAPPERmRatBN7.2
Rnor_6.03113,400,580 - 113,400,704NCBIRnor6.0
Rnor_5.03119,940,699 - 119,940,823UniSTSRnor5.0
RGSC_v3.43108,240,011 - 108,240,135UniSTSRGSC3.4
Celera3107,313,102 - 107,313,226UniSTS
Cytogenetic Map3q35UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6 6 6 2 1
Medium 3 43 51 35 19 35 8 11 74 33 40 11 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000020478   ⟹   ENSRNOP00000020478
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3108,388,249 - 108,411,982 (+)Ensembl
Rnor_6.0 Ensembl3113,376,983 - 113,400,707 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113825   ⟹   ENSRNOP00000083210
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3108,388,245 - 108,413,236 (+)Ensembl
RefSeq Acc Id: NM_017319   ⟹   NP_059015
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr83128,841,914 - 128,865,733 (+)NCBI
mRatBN7.23108,388,189 - 108,412,013 (+)NCBI
Rnor_6.03113,376,983 - 113,400,707 (+)NCBI
Rnor_5.03119,916,772 - 119,940,826 (+)NCBI
RGSC_v3.43108,216,414 - 108,240,138 (+)RGD
Celera3107,289,603 - 107,313,229 (+)RGD
RefSeq Acc Id: XM_063283216   ⟹   XP_063139286
Rat AssemblyChrPosition (strand)Source
GRCr83128,841,781 - 128,865,731 (+)NCBI
RefSeq Acc Id: NP_059015   ⟸   NM_017319
- Peptide Label: precursor
- UniProtKB: P11598 (UniProtKB/Swiss-Prot),   A0A8I6GAH4 (UniProtKB/TrEMBL),   A6HPP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020478   ⟸   ENSRNOT00000020478
RefSeq Acc Id: ENSRNOP00000083210   ⟸   ENSRNOT00000113825
RefSeq Acc Id: XP_063139286   ⟸   XM_063283216
- Peptide Label: isoform X1
- UniProtKB: P11598 (UniProtKB/Swiss-Prot)
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11598-F1-model_v2 AlphaFold P11598 1-505 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692356
Promoter ID:EPDNEW_R2881
Type:multiple initiation site
Description:protein disulfide isomerase family A, member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.03113,376,951 - 113,377,011EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68430 AgrOrtholog
BioCyc Gene G2FUF-48134 BioCyc
Ensembl Genes ENSRNOG00000015018 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055002778 UniProtKB/Swiss-Prot
  ENSRNOG00060015056 UniProtKB/Swiss-Prot
  ENSRNOG00065027072 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020478.8 UniProtKB/TrEMBL
  ENSRNOT00000113825.1 UniProtKB/TrEMBL
  ENSRNOT00055004360 UniProtKB/Swiss-Prot
  ENSRNOT00060025815 UniProtKB/Swiss-Prot
  ENSRNOT00065046688 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Disulphide_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDIA3_PDI_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_disulphide_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29468 UniProtKB/Swiss-Prot
Pfam Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdia3 PhenoGen
  THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015018 RatGTEx
  ENSRNOG00055002778 RatGTEx
  ENSRNOG00060015056 RatGTEx
  ENSRNOG00065027072 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217371
  P11598 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-10 Pdia3  protein disulfide isomerase family A, member 3  Pdia3  protein disulfide isomerase associated 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Pdia3  protein disulfide isomerase associated 3      Symbol and Name updated 1299863 APPROVED
2002-06-10 Grp58  glucose regulated protein, 58 kDa      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process increases activity of the thiazide-sensitive Na-Cl cotransporter 632898