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Gene: Pdia3 (protein disulfide isomerase family A, member 3) Rattus norvegicus
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Symbol: Pdia3
Name: protein disulfide isomerase family A, member 3
Description: Exhibits MHC class I protein binding activity; peptidase activity; and protein-disulfide reductase (glutathione) activity. Involved in several processes, including cellular response to nonylphenol; response to benzene; and response to ischemia. Localizes to several cellular components, including the apical plasma membrane; cytoplasm; and extracellular space. Used to study autoimmune hepatitis. Biomarker of asphyxia neonatorum; irritable bowel syndrome; liver cirrhosis; post-traumatic stress disorder; and pulmonary hypertension. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3); PARTICIPATES IN antigen processing and presentation pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; ER protein 57; ER protein 60; ER-60 protease; ER60; ERp57; ERp60; glucose regulated protein, 58 kDa; Grp58; HIP-70; oxidoreductase ERp57; p58; protein disulfide isomerase associated 3; protein disulfide-isomerase A3; Q-2
Orthologs:
Homo sapiens (human) : PDIA3 (protein disulfide isomerase family A member 3)  HGNC  Alliance
Mus musculus (house mouse) : Pdia3 (protein disulfide isomerase associated 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdia3 (protein disulfide isomerase family A member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PDIA3 (protein disulfide isomerase family A member 3)
Canis lupus familiaris (dog) : PDIA3 (protein disulfide isomerase family A member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdia3 (protein disulfide isomerase family A member 3)
Sus scrofa (pig) : PDIA3 (protein disulfide isomerase family A member 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03113,376,983 - 113,400,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03119,916,772 - 119,940,826 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,216,414 - 108,240,138 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13108,117,203 - 108,140,928 (+)NCBI
Celera3107,289,603 - 107,313,229 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pdia3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68430
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.