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Gene: Pdia3 (protein disulfide isomerase associated 3) Mus musculus
Symbol: Pdia3
Name: protein disulfide isomerase associated 3
Description: Predicted to have several functions, including identical protein binding activity; oxidoreductase activity, acting on a sulfur group of donors; and protein disulfide isomerase activity. Involved in cellular response to interleukin-7 and positive regulation of extrinsic apoptotic signaling pathway. Localizes to the cell surface and endoplasmic reticulum. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb segment. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3); PARTICIPATES IN antigen processing and presentation pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; 58kDa; disulfide isomerase ER-60; endoplasmic reticulum protein; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; ER protein 57; ER protein 60; Erp; ERp57; ERp60; ERp61; glucose regulated protein, 58 kDa; Grp58; p58; PDI; PDI-Q2; phospholipase C, alpha; PI-PLC; PLC[a]; Plca; protein disulfide-isomerase A3
Homo sapiens (human) : PDIA3 (protein disulfide isomerase family A member 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pdia3 (protein disulfide isomerase family A, member 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdia3 (protein disulfide isomerase family A member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PDIA3 (protein disulfide isomerase family A member 3)
Canis lupus familiaris (dog) : PDIA3 (protein disulfide isomerase family A member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdia3 (protein disulfide isomerase family A member 3)
Sus scrofa (pig) : PDIA3 (protein disulfide isomerase family A member 3)
Chlorocebus sabaeus (green monkey) : PDIA3 (protein disulfide isomerase family A member 3)
Heterocephalus glaber (naked mole-rat) : Pdia3 (protein disulfide isomerase family A member 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl2121,413,775 - 121,438,687 (+)Ensembl
GRCm382121,413,902 - 121,438,687 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372121,239,638 - 121,264,423 (+)NCBIGRCm37mm9NCBIm37
MGSCv362121,105,401 - 121,129,421 (+)NCBImm8
Celera2122,564,601 - 122,589,381 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pdia3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1553192
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.