Capn1 (calpain 1) - Rat Genome Database

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Gene: Capn1 (calpain 1) Rattus norvegicus
Analyze
Symbol: Capn1
Name: calpain 1
RGD ID: 2267
Description: Enables several functions, including calcium ion binding activity; calcium-dependent cysteine-type endopeptidase activity; and cytoskeletal protein binding activity. Involved in several processes, including negative regulation of non-canonical NF-kappaB signal transduction; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of leukocyte tethering or rolling. Is active in glutamatergic synapse; postsynaptic density; and presynapse. Biomarker of acute kidney failure; aortic atherosclerosis; epilepsy; sciatic neuropathy; and traumatic brain injury. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1); PARTICIPATES IN the proteolytic pathway involving calcium-dependent proteases; Alzheimer's disease pathway; apoptotic cell death pathway; INTERACTS WITH (S)-colchicine; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium-activated neutral proteinase 1; calpain 1, (mu/I) large subunit; calpain mu-type; calpain-1 catalytic subunit; calpain-1 large subunit; CANP 1; micromolar-calpain; muCANP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,705,219 - 212,736,134 (-)NCBIGRCr8
mRatBN7.21203,275,912 - 203,300,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,277,344 - 203,300,177 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,629,235 - 211,653,778 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,721,298 - 218,745,531 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,412,355 - 211,436,597 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,346,081 - 221,370,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,346,066 - 221,370,322 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01228,280,716 - 228,306,187 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,620,286 - 208,645,007 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,773,739 - 208,798,460 (-)NCBI
Celera1200,809,826 - 200,833,901 (-)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aloxistatin  (ISO)
alprazolam  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
caffeine  (ISO)
calcium atom  (EXP,ISO)
calcium carbonate  (ISO)
calcium(0)  (EXP,ISO)
Calpeptin  (EXP,ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon disulfide  (EXP)
casticin  (ISO)
chloroacetic acid  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
dantrolene  (EXP)
DDE  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP)
diuron  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
excitatory amino acid agonist  (ISO)
fisetin  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furans  (ISO)
gallic acid  (ISO)
genistein  (ISO)
glimepiride  (ISO)
glucose  (EXP,ISO)
glyphosate  (EXP,ISO)
heparin  (ISO)
hydrogen cyanide  (ISO)
indometacin  (EXP,ISO)
isoflurane  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (EXP,ISO)
lumacaftor  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
melatonin  (EXP,ISO)
memantine  (ISO)
Mesaconitine  (EXP)
methimazole  (EXP)
methoxychlor  (ISO)
methylcobalamin  (EXP)
N-acetyl-L-cysteine  (ISO)
N-Acetylleucyl-leucyl-methioninal  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
NS-398  (EXP)
Nutlin-3  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
procaine  (ISO)
quercetin  (EXP,ISO)
sarin  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfur dioxide  (EXP)
surfactin  (ISO)
surfactin C  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
trichloroethene  (EXP)
trichostatin A  (EXP)
Triptolide  (ISO)
undecane  (EXP)
valproic acid  (ISO)
Z-Val-Phe-H  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cornified envelope  (IEA,ISO)
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO,ISS)
glutamatergic synapse  (IDA,IMP)
lysosome  (IEA,ISO)
membrane  (ISO)
mitochondrion  (IEA,ISO)
plasma membrane  (ISO,ISS)
postsynapse  (IDA,IMP)
postsynaptic density  (IDA)
presynapse  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. Briz V, etal., J Neurosci. 2015 Feb 4;35(5):2269-82. doi: 10.1523/JNEUROSCI.2302-14.2015.
2. Proteomic study of calpain interacting proteins during skeletal muscle aging. Brulé C, etal., Biochimie. 2010 Dec;92(12):1923-33. doi: 10.1016/j.biochi.2010.09.003. Epub 2010 Sep 17.
3. Calpain/calpastatin activities and substrate depletion patterns during hindlimb unweighting and reweighting in skeletal muscle. Enns DL, etal., Eur J Appl Physiol. 2007 Jul;100(4):445-55. Epub 2007 Apr 12.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis. Jiang L, etal., Hypertension. 2012 Nov;60(5):1192-9. doi: 10.1161/HYPERTENSIONAHA.112.196840. Epub 2012 Sep 24.
7. Increased proteolytic activity in lymphocytes from patients with early onset Alzheimer's disease. Karlsson JO, etal., Neurobiol Aging. 1995 Nov-Dec;16(6):901-6.
8. High glucose-induced Ca2+ overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways. Kumar S, etal., Biochim Biophys Acta. 2012 Jul;1820(7):907-20. doi: 10.1016/j.bbagen.2012.02.010. Epub 2012 Feb 28.
9. [Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models]. Li MQ, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Mar;46(2):201-4.
10. [Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25]. Li X, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Mar;32(3):202-6.
11. Calpain 1 and Calpastatin expression is developmentally regulated in rat brain. Li Y, etal., Exp Neurol. 2009 Dec;220(2):316-9. Epub 2009 Sep 12.
12. Calpain-mediated degradation of PSD-95 in developing and adult rat brain. Lu X, etal., Neurosci Lett. 2000 Jun 2;286(2):149-53. doi: 10.1016/s0304-3940(00)01101-0.
13. Influence of electrical stimulation on calpain and ubiquitin-proteasome systems in the denervated and unloaded rat tibialis anterior muscles. Matsumoto A, etal., Acta Histochem. 2014 Jun;116(5):936-42. doi: 10.1016/j.acthis.2014.03.006. Epub 2014 Apr 16.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. A Ca(2+) switch aligns the active site of calpain. Moldoveanu T, etal., Cell 2002 Mar 8;108(5):649-60.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. ERp57-associated mitochondrial micro-calpain truncates apoptosis-inducing factor. Ozaki T, etal., Biochim Biophys Acta. 2008 Oct;1783(10):1955-63. doi: 10.1016/j.bbamcr.2008.05.011. Epub 2008 May 24.
18. Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria. Ozaki T, etal., Biochim Biophys Acta. 2009 Dec;1793(12):1848-59. doi: 10.1016/j.bbamcr.2009.10.002. Epub 2009 Oct 13.
19. The ultrastructural localization of calcium-activated protease "calpain" in rat brain. Perlmutter LS, etal., Synapse. 1988;2(1):79-88. doi: 10.1002/syn.890020111.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor signaling. Scalia R, etal., Circ Res. 2011 Apr 29;108(9):1102-11. doi: 10.1161/CIRCRESAHA.110.229393. Epub 2011 Mar 17.
25. Calpain expression and infiltration of activated T cells in experimental allergic encephalomyelitis over time: increased calpain activity begins with onset of disease. Schaecher K, etal., J Neuroimmunol 2002 Aug;129(1-2):1-9.
26. Primary sequences of rat mu-calpain large and small subunits are, respectively, moderately and highly similar to those of human. Sorimachi H, etal., Biochim Biophys Acta 1996 Nov 11;1309(1-2):37-41.
27. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
28. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. Taniguchi S, etal., FEBS Lett. 2001 Jan 26;489(1):46-50.
29. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Perspective on rhabdomyolysis-induced acute kidney injury and new treatment options. Ulusoy S, etal., Am J Nephrol. 2013;38(5):368-78. doi: 10.1159/000355537. Epub 2013 Oct 22.
31. Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer. Vanderklish PW, etal., Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2253-8. doi: 10.1073/pnas.040565597.
32. Differential localization of autolyzed calpains 1 and 2 in slow and fast skeletal muscles in the early phase of atrophy. Vermaelen M, etal., Am J Physiol Cell Physiol. 2007 May;292(5):C1723-31. Epub 2006 Dec 20.
33. Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons. Wang CF and Huang YS, Mol Cell Biol. 2012 Aug;32(16):3321-32. doi: 10.1128/MCB.00296-12. Epub 2012 Jun 18.
34. Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration. Wang Y, etal., J Neurosci. 2013 Nov 27;33(48):18880-92. doi: 10.1523/JNEUROSCI.3293-13.2013.
35. Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats. Yu CG, etal., J Neurotrauma. 2013 Mar 15;30(6):427-33. doi: 10.1089/neu.2012.2561. Epub 2013 Mar 26.
36. Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study. Zhao X, etal., J Cereb Blood Flow Metab. 1998 Feb;18(2):161-7. doi: 10.1097/00004647-199802000-00006.
Additional References at PubMed
PMID:2400579   PMID:2407243   PMID:8769305   PMID:8954105   PMID:9271093   PMID:12014988   PMID:12150984   PMID:12534936   PMID:14559243   PMID:14656436   PMID:15101113   PMID:15132950  
PMID:15191812   PMID:15489334   PMID:15640140   PMID:15680332   PMID:15979593   PMID:16107503   PMID:16356733   PMID:16411745   PMID:16758583   PMID:16857710   PMID:16959224   PMID:16981728  
PMID:17121855   PMID:17334225   PMID:17513494   PMID:17529984   PMID:17953355   PMID:18053648   PMID:18055215   PMID:18070881   PMID:18088374   PMID:18157632   PMID:18258589   PMID:18289510  
PMID:18395616   PMID:18420382   PMID:18493299   PMID:18495118   PMID:18590784   PMID:18627259   PMID:19022302   PMID:19056867   PMID:19162106   PMID:19199708   PMID:19295178   PMID:19318376  
PMID:19608740   PMID:20473717   PMID:20945043   PMID:21071702   PMID:21423176   PMID:21490676   PMID:21531719   PMID:21613375   PMID:21765948   PMID:22427928   PMID:22496446   PMID:22547201  
PMID:22555453   PMID:23376485   PMID:23400779   PMID:23408424   PMID:23533145   PMID:23919677   PMID:23994487   PMID:25319025   PMID:25336645   PMID:25416777   PMID:25756858   PMID:25895366  
PMID:26047104   PMID:26086870   PMID:26297661   PMID:26818429   PMID:26974309   PMID:27622212   PMID:27956030   PMID:28342779   PMID:28447745   PMID:28714350   PMID:28754591   PMID:28821652  
PMID:29249590   PMID:29772491   PMID:30423475   PMID:30796971   PMID:31278888   PMID:31815668   PMID:31904090   PMID:35597151   PMID:36382482   PMID:36430329   PMID:37325630   PMID:37602925  
PMID:38291756  


Genomics

Comparative Map Data
Capn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,705,219 - 212,736,134 (-)NCBIGRCr8
mRatBN7.21203,275,912 - 203,300,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,277,344 - 203,300,177 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,629,235 - 211,653,778 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,721,298 - 218,745,531 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,412,355 - 211,436,597 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,346,081 - 221,370,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,346,066 - 221,370,322 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01228,280,716 - 228,306,187 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,620,286 - 208,645,007 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,773,739 - 208,798,460 (-)NCBI
Celera1200,809,826 - 200,833,901 (-)NCBICelera
Cytogenetic Map1q43NCBI
CAPN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,181,373 - 65,212,006 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,180,566 - 65,212,006 (+)EnsemblGRCh38hg38GRCh38
GRCh371164,948,844 - 64,979,477 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,705,919 - 64,736,052 (+)NCBINCBI36Build 36hg18NCBI36
Build 341164,705,918 - 64,736,052NCBI
Celera1162,275,660 - 62,305,793 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,275,919 - 61,306,719 (+)NCBIHuRef
CHM1_11164,832,312 - 64,863,095 (+)NCBICHM1_1
T2T-CHM13v2.01165,174,678 - 65,205,290 (+)NCBIT2T-CHM13v2.0
Capn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,038,573 - 6,065,855 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,038,573 - 6,065,927 (-)EnsemblGRCm39 Ensembl
GRCm38195,988,545 - 6,015,825 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,988,545 - 6,015,897 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,988,545 - 6,015,825 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,988,545 - 6,015,151 (-)NCBIMGSCv36mm8
Celera195,858,975 - 5,885,371 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
Capn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,004,426 - 20,025,708 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,006,448 - 20,026,984 (-)NCBIChiLan1.0ChiLan1.0
CAPN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2966,416,231 - 66,447,116 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,459,271 - 67,490,086 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01160,545,837 - 60,576,631 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,884,451 - 63,916,731 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,886,015 - 63,916,021 (+)Ensemblpanpan1.1panPan2
CAPN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,983,266 - 52,010,831 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,983,824 - 52,010,757 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,591,530 - 50,619,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,024,769 - 53,053,236 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,941,097 - 53,053,224 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,121,242 - 52,149,446 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,694,854 - 51,723,087 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01852,489,182 - 52,517,646 (-)NCBIUU_Cfam_GSD_1.0
Capn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,736,614 - 7,759,589 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,178,901 - 4,201,052 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,178,963 - 4,201,037 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,997,985 - 7,022,684 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,997,513 - 7,024,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,129,549 - 6,155,985 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAPN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,014,087 - 9,050,389 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,014,084 - 9,049,804 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038106,399,098 - 106,431,434 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Capn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476721,146,999 - 21,169,957 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476721,146,310 - 21,169,593 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Capn1
255 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:290
Count of miRNA genes:162
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000028431
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat

Markers in Region
D1Got194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,293,397 - 203,293,528 (+)MAPPERmRatBN7.2
Rnor_6.01221,363,524 - 221,363,653NCBIRnor6.0
Rnor_5.01228,298,093 - 228,298,222UniSTSRnor5.0
RGSC_v3.41208,638,026 - 208,638,156RGDRGSC3.4
RGSC_v3.41208,638,027 - 208,638,156UniSTSRGSC3.4
RGSC_v3.11208,791,480 - 208,791,609RGD
Celera1200,827,149 - 200,827,278UniSTS
RH 3.4 Map11535.8UniSTS
RH 3.4 Map11535.8RGD
RH 2.0 Map11144.1RGD
Cytogenetic Map1q43UniSTS
RH128571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,275,935 - 203,276,143 (+)MAPPERmRatBN7.2
Rnor_6.01221,346,105 - 221,346,311NCBIRnor6.0
Rnor_5.01228,280,740 - 228,280,946UniSTSRnor5.0
RGSC_v3.41208,620,310 - 208,620,516UniSTSRGSC3.4
Celera1200,809,850 - 200,810,056UniSTS
RH 3.4 Map11538.0UniSTS
Cytogenetic Map1q43UniSTS
AU048692  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,285,403 - 203,285,685 (+)MAPPERmRatBN7.2
Rnor_6.01221,355,534 - 221,355,815NCBIRnor6.0
Rnor_5.01228,290,103 - 228,290,384UniSTSRnor5.0
RGSC_v3.41208,630,037 - 208,630,318UniSTSRGSC3.4
Celera1200,819,158 - 200,819,439UniSTS
Cytogenetic Map1q43UniSTS
MARC_2595-2596:1027009134:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,277,766 - 203,278,793 (+)MAPPERmRatBN7.2
Rnor_6.01221,347,908 - 221,348,932NCBIRnor6.0
Rnor_5.01228,282,842 - 228,283,866UniSTSRnor5.0
RGSC_v3.41208,622,533 - 208,623,557UniSTSRGSC3.4
Celera1200,811,505 - 200,812,529UniSTS
Cytogenetic Map1q43UniSTS
MARC_4751-4752:996679637:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,278,786 - 203,279,630 (+)MAPPERmRatBN7.2
Rnor_6.01221,348,926 - 221,349,769NCBIRnor6.0
Rnor_5.01228,283,860 - 228,284,703UniSTSRnor5.0
RGSC_v3.41208,623,551 - 208,624,394UniSTSRGSC3.4
Celera1200,812,523 - 200,813,366UniSTS
Cytogenetic Map1q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028431   ⟹   ENSRNOP00000028431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1203,277,344 - 203,300,177 (-)Ensembl
Rnor_6.0 Ensembl1221,346,066 - 221,370,322 (-)Ensembl
RefSeq Acc Id: NM_019152   ⟹   NP_062025
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,705,219 - 212,729,445 (-)NCBI
mRatBN7.21203,275,912 - 203,300,152 (-)NCBI
Rnor_6.01221,346,081 - 221,370,276 (-)NCBI
Rnor_5.01228,280,716 - 228,306,187 (-)NCBI
RGSC_v3.41208,620,286 - 208,645,007 (-)RGD
Celera1200,809,826 - 200,833,901 (-)RGD
Sequence:
RefSeq Acc Id: XM_063282744   ⟹   XP_063138814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,705,219 - 212,736,134 (-)NCBI
RefSeq Acc Id: XM_063282746   ⟹   XP_063138816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,705,219 - 212,729,770 (-)NCBI
RefSeq Acc Id: XM_063282747   ⟹   XP_063138817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,705,219 - 212,729,505 (-)NCBI
RefSeq Acc Id: XM_063282748   ⟹   XP_063138818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,708,971 - 212,729,528 (-)NCBI
RefSeq Acc Id: NP_062025   ⟸   NM_019152
- UniProtKB: P97571 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028431   ⟸   ENSRNOT00000028431
RefSeq Acc Id: XP_063138814   ⟸   XM_063282744
- Peptide Label: isoform X1
- UniProtKB: P97571 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063138816   ⟸   XM_063282746
- Peptide Label: isoform X1
- UniProtKB: P97571 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063138817   ⟸   XM_063282747
- Peptide Label: isoform X1
- UniProtKB: P97571 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063138818   ⟸   XM_063282748
- Peptide Label: isoform X2
- UniProtKB: P97571 (UniProtKB/Swiss-Prot)
Protein Domains
Calpain catalytic   EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97571-F1-model_v2 AlphaFold P97571 1-713 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690678
Promoter ID:EPDNEW_R1202
Type:multiple initiation site
Name:Capn1_1
Description:calpain 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01221,370,307 - 221,370,367EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2267 AgrOrtholog
BioCyc Gene G2FUF-56636 BioCyc
Ensembl Genes ENSRNOG00000020935 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055021953 UniProtKB/Swiss-Prot
  ENSRNOG00060032465 UniProtKB/Swiss-Prot
  ENSRNOG00065033912 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028431.7 UniProtKB/TrEMBL
  ENSRNOT00055037693 UniProtKB/Swiss-Prot
  ENSRNOT00060056241 UniProtKB/Swiss-Prot
  ENSRNOT00065058236 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599301 IMAGE-MGC_LOAD
InterPro C2_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calpain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calpain_cysteine_protease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calpain_domain_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calpain_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calpain_III_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C2_calpain_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29153 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72486 IMAGE-MGC_LOAD
NCBI Gene 29153 ENTREZGENE
PANTHER CALPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10183:SF284 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calpain_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Capn1 PhenoGen
PRINTS CALPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CALPAIN_CAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020935 RatGTEx
  ENSRNOG00055021953 RatGTEx
  ENSRNOG00060032465 RatGTEx
  ENSRNOG00065033912 RatGTEx
SMART calpain_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CysPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49758 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206297
UniProt A6HZB9_RAT UniProtKB/TrEMBL
  CAN1_RAT UniProtKB/Swiss-Prot
  F1LS29_RAT UniProtKB/TrEMBL
  P97571 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Capn1  calpain 1  Capn1  calpain 1, (mu/I) large subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-06 Capn1  calpain 1, (mu/I) large subunit  Capn1  calpain 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Capn1  calpain 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in experimental allergic encephalomyelitis (EAE) 634693
gene_domains contains nine putative protease inhibitor domains, four EGF repeats, and a laminin domain III homology region 632164
gene_expression expressed in inflammatory cells, activated microglia, and astrocytes 634693
gene_function Ca2+ dependent protease 70442