Slc12a3 (solute carrier family 12 member 3) - Rat Genome Database

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Gene: Slc12a3 (solute carrier family 12 member 3) Rattus norvegicus
Analyze
Symbol: Slc12a3
Name: solute carrier family 12 member 3
RGD ID: 3686
Description: Enables enzyme binding activity and sodium:chloride symporter activity. Involved in chloride transport and sodium ion transmembrane transport. Located in apical plasma membrane and vesicle. Is active in plasma membrane. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102553442; na-Cl symporter; NCC; solute carrier family 12 (sodium/chloride transporter), member 3; solute carrier family 12 (sodium/chloride transporters), member 3; solute carrier family 12 member 3-like; solute carrier family 12, member 3; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter; TSC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,636,594 - 10,690,008 (-)NCBIGRCr8
mRatBN7.21910,630,651 - 10,679,250 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,631,393 - 10,669,091 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,594,046 - 10,632,542 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,360,884 - 11,399,380 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,647,871 - 10,686,368 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,106,033 - 11,144,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,106,033 - 11,144,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,084,193 - 11,122,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,070,329 - 11,109,634 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,075,156 - 11,114,460 (-)NCBI
Celera1910,518,752 - 10,557,092 (-)NCBICelera
Cytogenetic Map19p13-p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IBA,IDA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
extracellular exosome  (IEA,ISO)
plasma membrane  (IDA,ISO)
vesicle  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. Gamba G, etal., J Biol Chem 1994 Jul 1;269(26):17713-22.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. Matayoshi T, etal., Hypertens Res. 2004 Nov;27(11):821-33.
5. G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women. Matsuo A, etal., J Hypertens. 2004 Nov;22(11):2123-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction. Monroy A, etal., Am J Physiol Renal Physiol. 2000 Jul;279(1):F161-9. doi: 10.1152/ajprenal.2000.279.1.F161.
8. Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding. Moreno E, etal., J Biol Chem. 2006 Jun 23;281(25):17266-75. Epub 2006 Apr 19.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion. Pacheco-Alvarez D, etal., J Biol Chem. 2006 Sep 29;281(39):28755-63. Epub 2006 Aug 3.
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Gitelman syndrome: genetic and expression analysis of the thiazide-sensitive sodium-chloride transporter in blood cells. Riancho JA, etal., Nephrol Dial Transplant. 2006 Jan;21(1):217-20. Epub 2005 Oct 12.
17. WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Rinehart J, etal., Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16777-82. Epub 2005 Nov 7.
18. Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet. Sandberg MB, etal., Am J Physiol Renal Physiol. 2006 Aug;291(2):F503-8. Epub 2006 Mar 22.
19. Renal tubule-specific transcription and chromosomal localization of rat thiazide-sensitive na-cl cotransporter gene. Taniyama Y, etal., J Biol Chem 2001 Jul 13;276(28):26260-8.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Interaction with grp58 increases activity of the thiazide-sensitive Na-Cl cotransporter. Wyse B, etal., Am J Physiol Renal Physiol 2002 Mar;282(3):F424-30.
22. Sodium retention in rats with liver cirrhosis is associated with increased renal abundance of NaCl cotransporter (NCC). Yu Z, etal., Nephrol Dial Transplant. 2005 Sep;20(9):1833-41. Epub 2005 Jun 14.
Additional References at PubMed
PMID:10516289   PMID:11423561   PMID:12388412   PMID:12538726   PMID:12837683   PMID:15149970   PMID:15356206   PMID:16449357   PMID:16495212   PMID:17507603   PMID:18391953   PMID:18440307  
PMID:18480177   PMID:18701621   PMID:19056867   PMID:19144688   PMID:19202345   PMID:20007345   PMID:20458365   PMID:21082674   PMID:21157372   PMID:21397062   PMID:22651238   PMID:23376485  
PMID:23533145   PMID:24668812   PMID:24920754   PMID:25587121   PMID:25925254   PMID:26608659   PMID:28003191   PMID:28356292   PMID:29767556   PMID:29846116   PMID:36961378  


Genomics

Comparative Map Data
Slc12a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,636,594 - 10,690,008 (-)NCBIGRCr8
mRatBN7.21910,630,651 - 10,679,250 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,631,393 - 10,669,091 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,594,046 - 10,632,542 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,360,884 - 11,399,380 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,647,871 - 10,686,368 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,106,033 - 11,144,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,106,033 - 11,144,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,084,193 - 11,122,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,070,329 - 11,109,634 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,075,156 - 11,114,460 (-)NCBI
Celera1910,518,752 - 10,557,092 (-)NCBICelera
Cytogenetic Map19p13-p12NCBI
SLC12A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,865,207 - 56,915,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,865,207 - 56,915,850 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,899,119 - 56,949,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,456,643 - 55,504,850 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,456,642 - 55,504,850NCBI
Celera1641,398,377 - 41,450,052 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,768,662 - 42,819,218 (+)NCBIHuRef
CHM1_11658,307,135 - 58,357,791 (+)NCBICHM1_1
T2T-CHM13v2.01662,661,526 - 62,712,168 (+)NCBIT2T-CHM13v2.0
Slc12a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,055,737 - 95,092,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,055,829 - 95,092,842 (+)EnsemblGRCm39 Ensembl
GRCm38894,329,109 - 94,366,222 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,329,201 - 94,366,214 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,853,108 - 96,890,122 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,218,355 - 97,255,092 (+)NCBIMGSCv36mm8
Celera898,660,930 - 98,697,944 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.46NCBI
Slc12a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,553,758 - 14,587,602 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543314,553,752 - 14,588,317 (+)NCBIChiLan1.0ChiLan1.0
SLC12A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,316,962 - 66,386,655 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,237,646 - 72,307,205 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,142,797 - 37,193,713 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,276,026 - 56,326,973 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,276,049 - 56,324,528 (+)Ensemblpanpan1.1panPan2
SLC12A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,413,737 - 59,449,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,413,828 - 59,449,081 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,042,573 - 56,077,948 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,952,797 - 59,988,344 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,952,888 - 59,988,297 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,783,974 - 56,819,378 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,791,053 - 57,826,469 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,685,512 - 58,720,937 (-)NCBIUU_Cfam_GSD_1.0
Slc12a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,512,705 - 50,545,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,044,106 - 9,076,307 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,044,099 - 9,076,301 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,844,600 - 18,885,476 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,844,752 - 18,885,497 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC12A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,808,773 - 42,877,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl542,811,597 - 42,862,002 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604733,488,318 - 33,536,531 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474629,098,254 - 29,132,752 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474629,087,867 - 29,132,793 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc12a3
305 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:183
Interacting mature miRNAs:207
Transcripts:ENSRNOT00000025377
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat

Markers in Region
BF391454  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,670,522 - 10,670,696 (+)MAPPERmRatBN7.2
Rnor_6.01911,146,073 - 11,146,246NCBIRnor6.0
Rnor_5.01911,124,089 - 11,124,262UniSTSRnor5.0
RGSC_v3.41911,111,066 - 11,111,239UniSTSRGSC3.4
Celera1910,558,524 - 10,558,697UniSTS
RH 3.4 Map1997.5UniSTS
Cytogenetic Map19p14-p12UniSTS
DXS1162  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,667,970 - 10,668,444 (+)MAPPERmRatBN7.2
Rnor_6.01911,143,521 - 11,143,994NCBIRnor6.0
Rnor_5.01911,121,537 - 11,122,010UniSTSRnor5.0
RGSC_v3.41911,108,514 - 11,108,987UniSTSRGSC3.4
Celera1910,555,972 - 10,556,445UniSTS
Cytogenetic Map19p14-p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 29 1
Low 3 21 20 5 19 5 52 2 28 2
Below cutoff 22 29 28 28 8 10 22 4 12 9 8

Sequence


Ensembl Acc Id: ENSRNOT00000081246   ⟹   ENSRNOP00000070064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,631,393 - 10,669,091 (-)Ensembl
Rnor_6.0 Ensembl1911,106,033 - 11,144,641 (-)Ensembl
RefSeq Acc Id: NM_019345   ⟹   NP_062218
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,636,596 - 10,675,050 (-)NCBI
mRatBN7.21910,630,651 - 10,669,108 (-)NCBI
Rnor_6.01911,106,033 - 11,144,641 (-)NCBI
Rnor_5.01911,084,193 - 11,122,657 (-)NCBI
RGSC_v3.41911,070,329 - 11,109,634 (-)RGD
Celera1910,518,752 - 10,557,092 (-)RGD
Sequence:
RefSeq Acc Id: XM_063278264   ⟹   XP_063134334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,636,594 - 10,690,008 (-)NCBI
RefSeq Acc Id: XM_063278265   ⟹   XP_063134335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,636,594 - 10,690,008 (-)NCBI
RefSeq Acc Id: XM_063278266   ⟹   XP_063134336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,636,594 - 10,690,008 (-)NCBI
RefSeq Acc Id: NP_062218   ⟸   NM_019345
- UniProtKB: P55018 (UniProtKB/Swiss-Prot),   G3V8G0 (UniProtKB/TrEMBL),   A6JY68 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070064   ⟸   ENSRNOT00000081246
RefSeq Acc Id: XP_063134334   ⟸   XM_063278264
- Peptide Label: isoform X1
- UniProtKB: P55018 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063134336   ⟸   XM_063278266
- Peptide Label: isoform X3
- UniProtKB: P55018 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063134335   ⟸   XM_063278265
- Peptide Label: isoform X2
- UniProtKB: P55018 (UniProtKB/Swiss-Prot)
Protein Domains
Amino acid permease N-terminal   Amino acid permease/ SLC12A   SLC12A transporter C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55018-F1-model_v2 AlphaFold P55018 1-1002 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700947
Promoter ID:EPDNEW_R11471
Type:single initiation site
Name:Slc12a3_1
Description:solute carrier family 12 member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01911,144,657 - 11,144,717EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3686 AgrOrtholog
BioCyc Gene G2FUF-6489 BioCyc
Ensembl Genes ENSRNOG00000057072 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055022313 UniProtKB/Swiss-Prot
  ENSRNOG00060016359 UniProtKB/Swiss-Prot
  ENSRNOG00065003778 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000081246.2 UniProtKB/TrEMBL
  ENSRNOT00055038354 UniProtKB/Swiss-Prot
  ENSRNOT00060028040 UniProtKB/Swiss-Prot
  ENSRNOT00065005526 UniProtKB/Swiss-Prot
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AA-permease/SLC12A_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AA_permease_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12A3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12A_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54300 ENTREZGENE
PANTHER PTHR11827 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11827:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AA_permease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AA_permease_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC12A3 RGD
PhenoGen Slc12a3 PhenoGen
PRINTS NACLTRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057072 RatGTEx
  ENSRNOG00055022313 RatGTEx
  ENSRNOG00060016359 RatGTEx
  ENSRNOG00065003778 RatGTEx
TIGR TC207071
UniProt A6JY68 ENTREZGENE, UniProtKB/TrEMBL
  G3V8G0 ENTREZGENE, UniProtKB/TrEMBL
  P55018 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Slc12a3  solute carrier family 12 member 3  LOC102553442  solute carrier family 12 member 3-like  Data merged from RGD:7680931 737654 PROVISIONAL
2016-02-25 Slc12a3  solute carrier family 12 member 3  Slc12a3  solute carrier family 12 (sodium/chloride transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102553442  solute carrier family 12 member 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-08-02 Slc12a3  solute carrier family 12 (sodium/chloride transporter), member 3  Slc12a3  solute carrier family 12 (sodium/chloride transporters), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc12a3  solute carrier family 12 (sodium/chloride transporters), member 3  Slc12a3  solute carrier family 12, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Slc12a3  solute carrier family 12, member 3      Symbol and Name status set to approved 70586 APPROVED
2002-02-27 Slc12a3  solute carrier family 12, member 3      Name updated to reflect Human and Mouse nomenclature 70292 APPROVED
2001-12-12 Slc12a3  Thiazide-sensitive Na-Cl cotransporter      Name updated to reflect Human and Mouse nomenclature 68673 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes Gitelman's syndrome 68673
gene_drugs is a target of thiazide diuretics 68673
gene_expression expressed specifically in the kidney 68673
gene_function acts as a sodium/chloride cotransporter 68673
gene_function acts as a sodium/chloride cotransporter 69999
gene_process may be involved in reabsorption of NaCl in the kidney 68673
gene_process may be involved in reabsorption of NaCl in the kidney 69999
gene_process may play a role in acid-base balance 68673
gene_process may play a role in acid-base balance 69999