PDIA3 (protein disulfide isomerase family A member 3) - Rat Genome Database

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Gene: PDIA3 (protein disulfide isomerase family A member 3) Sus scrofa
Analyze
Symbol: PDIA3
Name: protein disulfide isomerase family A member 3
RGD ID: 14277931
Description: ENCODES a protein that exhibits MHC class I protein binding (ortholog); peptidase activity (ortholog); protein-disulfide reductase (glutathione) activity (ortholog); INVOLVED IN cellular response to interleukin-7 (ortholog); cellular response to nonylphenol (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); asphyxia neonatorum (ortholog); autoimmune hepatitis (ortholog); FOUND IN acrosomal vesicle (ortholog); apical plasma membrane (ortholog); cell surface (ortholog); INTERACTS WITH all-trans-retinyl palmitate; phosphatidylcholine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glucose regulated protein 58; grp-58; protein disulfide-isomerase A3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1127,785,772 - 127,814,196 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11127,786,174 - 127,814,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21142,615,686 - 142,643,747 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:20152940  


Genomics

Comparative Map Data
PDIA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1127,785,772 - 127,814,196 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11127,786,174 - 127,814,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21142,615,686 - 142,643,747 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDIA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1543,746,410 - 43,773,278 (+)EnsemblGRCh38hg38GRCh38
GRCh381543,746,438 - 43,773,278 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371544,038,636 - 44,065,476 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361541,825,882 - 41,852,096 (+)NCBINCBI36hg18NCBI36
Celera1520,928,053 - 20,954,266 (+)NCBI
Cytogenetic Map15q15.3NCBI
HuRef1520,861,356 - 20,887,666 (+)NCBIHuRef
CHM1_11544,156,851 - 44,183,060 (+)NCBICHM1_1
Pdia3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392121,244,383 - 121,269,168 (+)NCBIGRCm39mm39
GRCm39 Ensembl2121,244,256 - 121,269,168 (+)Ensembl
GRCm382121,413,902 - 121,438,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2121,413,775 - 121,438,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv372121,239,638 - 121,264,423 (+)NCBIGRCm37mm9NCBIm37
MGSCv362121,105,401 - 121,129,421 (+)NCBImm8
Celera2122,564,601 - 122,589,381 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.38NCBI
Pdia3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23108,388,189 - 108,412,013 (+)NCBI
Rnor_6.0 Ensembl3113,376,983 - 113,400,707 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03113,376,983 - 113,400,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03119,916,772 - 119,940,826 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,216,414 - 108,240,138 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13108,117,203 - 108,140,928 (+)NCBI
Celera3107,289,603 - 107,313,229 (+)NCBICelera
Cytogenetic Map3q35NCBI
Pdia3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541610,198,099 - 10,220,792 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541610,197,957 - 10,221,104 (+)NCBIChiLan1.0ChiLan1.0
PDIA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11540,794,144 - 40,821,615 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1540,794,144 - 40,821,763 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01522,706,520 - 22,731,672 (+)NCBIMhudiblu_PPA_v0panPan3
PDIA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13010,487,926 - 10,513,437 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3010,487,921 - 10,513,397 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3010,546,317 - 10,571,800 (+)NCBI
ROS_Cfam_1.03010,624,436 - 10,649,938 (+)NCBI
UMICH_Zoey_3.13010,533,603 - 10,559,083 (+)NCBI
UNSW_CanFamBas_1.03010,655,339 - 10,680,999 (+)NCBI
UU_Cfam_GSD_1.03010,775,223 - 10,800,728 (+)NCBI
Pdia3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864088,961,177 - 88,986,202 (+)NCBI
SpeTri2.0NW_0049364716,809,181 - 6,834,189 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDIA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12639,273,982 - 39,300,170 (-)NCBI
ChlSab1.1 Ensembl2639,272,997 - 39,349,966 (-)Ensembl
Vero_WHO_p1.0NW_023666048101,691,336 - 101,717,748 (+)NCBI
Pdia3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480410,754,978 - 10,784,641 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005190   ⟹   ENSSSCP00000005064
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1127,785,772 - 127,814,196 (-)Ensembl
RefSeq Acc Id: NM_001195112   ⟹   NP_001182041
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11127,786,174 - 127,814,096 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001182041 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAJ11757 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001182041   ⟸   NM_001195112
- Peptide Label: precursor
- UniProtKB: E1CAJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000005064   ⟸   ENSSSCT00000005190
Protein Domains
Thioredoxin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004700 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000005064 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005190 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.30.10 UniProtKB/TrEMBL
InterPro Disulphide_isomerase UniProtKB/TrEMBL
  PDIA3_PDI_b UniProtKB/TrEMBL
  Prot_disulphide_isomerase UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
KEGG Report ssc:100156204 UniProtKB/TrEMBL
NCBI Gene PDIA3 ENTREZGENE
Pfam Thioredoxin UniProtKB/TrEMBL
PROSITE THIOREDOXIN_1 UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
TIGRFAMs ER_PDI_fam UniProtKB/TrEMBL
  pdi_dom UniProtKB/TrEMBL
UniProt E1CAJ5 ENTREZGENE, UniProtKB/TrEMBL
  F6QA08_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91272 ENTREZGENE