Knl1 (kinetochore scaffold 1) - Rat Genome Database

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Gene: Knl1 (kinetochore scaffold 1) Rattus norvegicus
Analyze
Symbol: Knl1
Name: kinetochore scaffold 1
RGD ID: 1307498
Description: Predicted to be involved in nuclear chromosome segregation; protein localization to kinetochore; and regulation of metaphase/anaphase transition of cell cycle. Predicted to be located in acrosomal vesicle; kinetochore; and nuclear body. Predicted to be part of Knl1/Spc105 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly; primary autosomal recessive microcephaly 4; and sarcoma. Orthologous to human KNL1 (kinetochore scaffold 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cancer susceptibility candidate 5; Casc5; LOC100911204; LOC102549359; LOC311327; protein CASC5-like; Rad51; RAD51 homolog; uncharacterized LOC102549359
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,483,498 - 126,545,774 (+)NCBIGRCr8
mRatBN7.23106,029,627 - 106,091,915 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,029,661 - 106,091,915 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,710,464 - 109,764,974 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,306,007 - 118,360,519 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,966,384 - 116,020,898 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,847,304 - 110,909,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,855,000 - 110,909,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,385,194 - 117,453,522 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,561,365 - 105,615,047NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3104,950,722 - 105,005,517 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-dichloroaniline  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fructose  (ISO)
furan  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
Heliotrine  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lucanthone  (ISO)
MeIQx  (ISO)
mercaptopurine  (EXP)
methotrexate  (ISO)
N-Nitrosopyrrolidine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
phenformin  (EXP)
picoxystrobin  (ISO)
progesterone  (ISO)
propanal  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Kinetochore KMN network gene CASC5 mutated in primary microcephaly. Genin A, etal., Hum Mol Genet. 2012 Dec 15;21(24):5306-17. doi: 10.1093/hmg/dds386. Epub 2012 Sep 13.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS). Veitch Z, etal., Sci Rep. 2019 May 14;9(1):7390. doi: 10.1038/s41598-019-43222-6.

Genomics

Comparative Map Data
Knl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,483,498 - 126,545,774 (+)NCBIGRCr8
mRatBN7.23106,029,627 - 106,091,915 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,029,661 - 106,091,915 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,710,464 - 109,764,974 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,306,007 - 118,360,519 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,966,384 - 116,020,898 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,847,304 - 110,909,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,855,000 - 110,909,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,385,194 - 117,453,522 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,561,365 - 105,615,047NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3104,950,722 - 105,005,517 (+)NCBICelera
Cytogenetic Map3q35NCBI
KNL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,594,249 - 40,664,342 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,594,020 - 40,664,342 (+)EnsemblGRCh38hg38GRCh38
GRCh371540,886,447 - 40,956,540 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,673,739 - 38,742,173 (+)NCBINCBI36Build 36hg18NCBI36
Celera1517,654,336 - 17,722,770 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,733,703 - 17,802,065 (+)NCBIHuRef
CHM1_11541,006,562 - 41,074,962 (+)NCBICHM1_1
T2T-CHM13v2.01538,399,974 - 38,470,044 (+)NCBIT2T-CHM13v2.0
Knl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,877,600 - 118,940,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,877,600 - 118,935,982 (+)EnsemblGRCm39 Ensembl
GRCm382119,047,119 - 119,110,497 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,047,119 - 119,105,501 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,872,855 - 118,929,857 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,738,474 - 118,795,562 (+)NCBIMGSCv36mm8
MGSCv362119,993,968 - 120,051,070 (+)NCBIMGSCv36mm8
Celera2120,199,115 - 120,256,832 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.85NCBI
Knl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,500,415 - 7,562,273 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,498,983 - 7,561,620 (+)NCBIChiLan1.0ChiLan1.0
KNL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,839,231 - 29,909,645 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,990,711 - 34,061,124 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,539,264 - 19,609,593 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,792,411 - 37,856,095 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,801,705 - 37,860,858 (+)Ensemblpanpan1.1panPan2
KNL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,753,515 - 7,825,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,753,432 - 7,821,588 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,807,365 - 7,878,953 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,879,642 - 7,951,470 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,879,704 - 7,947,949 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,803,766 - 7,875,282 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,910,285 - 7,981,708 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,039,288 - 8,110,906 (+)NCBIUU_Cfam_GSD_1.0
Knl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,231,814 - 86,262,142 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,059,995 - 4,109,413 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364714,079,877 - 4,110,205 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KNL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11130,652,493 - 130,728,989 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KNL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,342,741 - 42,409,466 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604898,564,109 - 98,634,701 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Knl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,889,689 - 7,952,384 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,884,580 - 7,952,567 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Knl1
218 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH131249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23106,084,731 - 106,084,915 (+)MAPPERmRatBN7.2
Rnor_6.03110,902,624 - 110,902,807NCBIRnor6.0
Rnor_5.03117,446,339 - 117,446,522UniSTSRnor5.0
Rnor_5.03117,440,265 - 117,440,448UniSTSRnor5.0
RGSC_v3.43105,609,613 - 105,609,796UniSTSRGSC3.4
Celera3104,998,333 - 104,998,516UniSTS
RH 3.4 Map3913.1UniSTS
Cytogenetic Map3q35UniSTS
BI278484  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23106,064,136 - 106,064,299 (+)MAPPERmRatBN7.2
Rnor_6.03110,882,030 - 110,882,192NCBIRnor6.0
Rnor_5.03117,419,673 - 117,419,835UniSTSRnor5.0
RGSC_v3.43105,588,651 - 105,588,813UniSTSRGSC3.4
Celera3104,977,745 - 104,977,907UniSTS
RH 3.4 Map3913.5UniSTS
Cytogenetic Map3q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 76 58 27 58 57 40 96
Low 21 90 103 47 42 47 24 12 128 47 49 53 12
Below cutoff 39 45 39 39 12 30 65 28 12

Sequence


Ensembl Acc Id: ENSRNOT00000041727   ⟹   ENSRNOP00000050682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3106,029,661 - 106,091,915 (+)Ensembl
Rnor_6.0 Ensembl3112,531,703 - 112,560,634 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081613   ⟹   ENSRNOP00000075477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3106,029,661 - 106,091,915 (+)Ensembl
Rnor_6.0 Ensembl3110,855,000 - 110,909,807 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102895   ⟹   ENSRNOP00000087241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3106,029,661 - 106,091,915 (+)Ensembl
RefSeq Acc Id: NM_001170594   ⟹   NP_001164065
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,490,966 - 126,545,774 (+)NCBI
mRatBN7.23106,037,108 - 106,091,915 (+)NCBI
Rnor_6.03110,855,000 - 110,909,807 (+)NCBI
Rnor_5.03117,385,194 - 117,453,522 (+)NCBI
Celera3104,950,722 - 105,005,517 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762095   ⟹   XP_008760317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,483,498 - 126,545,774 (+)NCBI
mRatBN7.23106,029,627 - 106,091,915 (+)NCBI
Rnor_6.03110,847,538 - 110,909,807 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001164065 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760317 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050682.5
  ENSRNOP00000075477.1
  ENSRNOP00000087241.1
RefSeq Acc Id: NP_001164065   ⟸   NM_001170594
- UniProtKB: D3ZNX2 (UniProtKB/TrEMBL),   A0A8I6A5F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760317   ⟸   XM_008762095
- Peptide Label: isoform X1
- UniProtKB: D3Z896 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075477   ⟸   ENSRNOT00000081613
Ensembl Acc Id: ENSRNOP00000050682   ⟸   ENSRNOT00000041727
Ensembl Acc Id: ENSRNOP00000087241   ⟸   ENSRNOT00000102895
Protein Domains
Knl1 C-terminal RWD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z896-F1-model_v2 AlphaFold D3Z896 1-1631 view protein structure
AF-D3ZNX2-F1-model_v2 AlphaFold D3ZNX2 1-2114 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307498 AgrOrtholog
BioCyc Gene G2FUF-48221 BioCyc
Ensembl Genes ENSRNOG00000026378 Ensembl
  ENSRNOG00000060100 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041727.5 UniProtKB/TrEMBL
  ENSRNOT00000081613.2 UniProtKB/TrEMBL
  ENSRNOT00000102895.1 UniProtKB/TrEMBL
InterPro Blinkin UniProtKB/TrEMBL
  KNL1_MELT_rep UniProtKB/TrEMBL
  Knl1_RWD_C UniProtKB/TrEMBL
KEGG Report rno:311327 UniProtKB/TrEMBL
NCBI Gene 311327 ENTREZGENE
PANTHER KINETOCHORE SCAFFOLD 1 UniProtKB/TrEMBL
  PTHR16520 UniProtKB/TrEMBL
Pfam Knl1_RWD_C UniProtKB/TrEMBL
  MELT UniProtKB/TrEMBL
PhenoGen Knl1 PhenoGen
RatGTEx ENSRNOG00000026378 RatGTEx
  ENSRNOG00000060100 RatGTEx
UniProt A0A8I6A5F3 ENTREZGENE, UniProtKB/TrEMBL
  D3Z896 ENTREZGENE, UniProtKB/TrEMBL
  D3ZNX2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Knl1  kinetochore scaffold 1  LOC100911204  protein CASC5-like  Data merged from RGD:6494213 737654 PROVISIONAL
2016-06-22 Knl1  kinetochore scaffold 1  Casc5  cancer susceptibility candidate 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Casc5  cancer susceptibility candidate 5  LOC102549359  uncharacterized LOC102549359  Data merged from RGD:7602599 737654 PROVISIONAL
2013-12-18 LOC102549359  uncharacterized LOC102549359      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100911204  protein CASC5-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-04 Casc5  cancer susceptibility candidate 5  Rad51_predicted  RAD51 homolog (S. cerevisiae) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Rad51_predicted  RAD51 homolog (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED