Shc4 (SHC adaptor protein 4) - Rat Genome Database

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Gene: Shc4 (SHC adaptor protein 4) Rattus norvegicus
Analyze
Symbol: Shc4
Name: SHC adaptor protein 4
RGD ID: 1583644
Description: Predicted to enable protein domain specific binding activity and receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to be active in plasma membrane. Orthologous to human SHC4 (SHC adaptor protein 4); PARTICIPATES IN chemokine mediated signaling pathway; chronic myeloid leukemia pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC296114; LOC679845; RGD1309182; SHC (Src homology 2 domain containing) family, member 4; SHC-transforming protein 4; similar to neuronal Shc; similar to rai-like protein RaLP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83133,334,026 - 133,428,404 (-)NCBIGRCr8
mRatBN7.23112,880,598 - 112,974,216 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3112,880,600 - 112,974,366 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3116,748,194 - 116,839,661 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03125,343,718 - 125,435,179 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,004,077 - 123,095,549 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03117,897,738 - 117,990,289 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3117,897,738 - 117,990,289 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03124,421,964 - 124,514,515 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43112,938,164 - 113,030,092 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3111,737,914 - 111,829,223 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090   PMID:17452444   PMID:22948967   PMID:31823725  


Genomics

Comparative Map Data
Shc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83133,334,026 - 133,428,404 (-)NCBIGRCr8
mRatBN7.23112,880,598 - 112,974,216 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3112,880,600 - 112,974,366 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3116,748,194 - 116,839,661 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03125,343,718 - 125,435,179 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,004,077 - 123,095,549 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03117,897,738 - 117,990,289 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3117,897,738 - 117,990,289 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03124,421,964 - 124,514,515 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43112,938,164 - 113,030,092 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3111,737,914 - 111,829,223 (-)NCBICelera
Cytogenetic Map3q36NCBI
SHC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381548,823,741 - 48,963,919 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1548,823,741 - 48,963,919 (-)EnsemblGRCh38hg38GRCh38
GRCh371549,115,938 - 49,256,116 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361546,903,226 - 47,042,933 (-)NCBINCBI36Build 36hg18NCBI36
Celera1526,009,561 - 26,149,272 (-)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1525,947,941 - 26,087,664 (-)NCBIHuRef
CHM1_11549,233,953 - 49,373,663 (-)NCBICHM1_1
T2T-CHM13v2.01546,631,939 - 46,772,161 (-)NCBIT2T-CHM13v2.0
Shc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392125,469,359 - 125,566,085 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2125,469,367 - 125,566,068 (-)EnsemblGRCm39 Ensembl
GRCm382125,627,439 - 125,724,148 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2125,627,447 - 125,724,148 (-)EnsemblGRCm38mm10GRCm38
MGSCv372125,453,183 - 125,549,884 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362125,318,888 - 125,415,589 (-)NCBIMGSCv36mm8
Celera2126,873,463 - 126,969,748 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Shc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554095,046,900 - 5,115,621 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554095,000,209 - 5,111,352 (+)NCBIChiLan1.0ChiLan1.0
SHC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21638,066,811 - 38,226,658 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11542,246,455 - 42,410,548 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01527,773,442 - 27,913,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11546,098,526 - 46,236,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1546,098,526 - 46,236,533 (-)Ensemblpanpan1.1panPan2
SHC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13015,056,568 - 15,188,430 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3015,058,840 - 15,188,490 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3014,978,126 - 15,109,949 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03015,190,364 - 15,322,019 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3015,185,863 - 15,322,777 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13015,113,698 - 15,245,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03015,234,640 - 15,367,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03015,341,243 - 15,473,114 (-)NCBIUU_Cfam_GSD_1.0
Shc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864093,294,400 - 93,423,610 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647111,142,429 - 11,271,557 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647111,144,635 - 11,271,673 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1122,725,904 - 122,871,426 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11122,722,745 - 122,871,424 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21136,550,750 - 136,694,425 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SHC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12634,319,831 - 34,467,072 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2634,329,322 - 34,467,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048106,660,593 - 106,799,872 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473110,781,002 - 10,890,836 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Shc4
609 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:25
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000011084
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat

Markers in Region
BE107507  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23112,924,072 - 112,924,225 (+)MAPPERmRatBN7.2
Rnor_6.03117,939,612 - 117,939,764NCBIRnor6.0
Rnor_5.03124,463,838 - 124,463,990UniSTSRnor5.0
RGSC_v3.43112,980,301 - 112,980,453UniSTSRGSC3.4
Celera3111,779,212 - 111,779,364UniSTS
RH 3.4 Map3984.5UniSTS
Cytogenetic Map3q36UniSTS
RH139161  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23112,924,500 - 112,924,635 (+)MAPPERmRatBN7.2
Rnor_6.03117,940,040 - 117,940,174NCBIRnor6.0
Rnor_5.03124,464,266 - 124,464,400UniSTSRnor5.0
RGSC_v3.43112,980,729 - 112,980,863UniSTSRGSC3.4
Celera3111,779,640 - 111,779,774UniSTS
RH 3.4 Map3985.3UniSTS
Cytogenetic Map3q36UniSTS
RH129470  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23112,924,463 - 112,924,646 (+)MAPPERmRatBN7.2
Rnor_6.03117,940,003 - 117,940,185NCBIRnor6.0
Rnor_5.03124,464,229 - 124,464,411UniSTSRnor5.0
RGSC_v3.43112,980,692 - 112,980,874UniSTSRGSC3.4
Celera3111,779,603 - 111,779,785UniSTS
RH 3.4 Map3985.3UniSTS
Cytogenetic Map3q36UniSTS
BI281881  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23112,924,071 - 112,924,225 (+)MAPPERmRatBN7.2
Rnor_6.03117,939,611 - 117,939,764NCBIRnor6.0
Rnor_5.03124,463,837 - 124,463,990UniSTSRnor5.0
RGSC_v3.43112,980,300 - 112,980,453UniSTSRGSC3.4
Celera3111,779,211 - 111,779,364UniSTS
RH 3.4 Map3984.5UniSTS
Cytogenetic Map3q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8
Low 18 9 6 7 6 5 6 74 22 32 9 5
Below cutoff 3 24 34 21 12 21 3 4 13 1 2 3

Sequence


RefSeq Acc Id: ENSRNOT00000011084   ⟹   ENSRNOP00000011084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3112,880,600 - 112,974,366 (-)Ensembl
Rnor_6.0 Ensembl3117,897,738 - 117,990,289 (-)Ensembl
RefSeq Acc Id: NM_001191065   ⟹   NP_001177994
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83133,334,034 - 133,427,627 (-)NCBI
mRatBN7.23112,880,606 - 112,974,216 (-)NCBI
Rnor_6.03117,897,738 - 117,990,289 (-)NCBI
Rnor_5.03124,421,964 - 124,514,515 (-)NCBI
Celera3111,737,914 - 111,829,223 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105836   ⟹   XP_038961764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83133,334,026 - 133,376,361 (-)NCBI
mRatBN7.23112,880,598 - 112,922,931 (-)NCBI
RefSeq Acc Id: XM_063284538   ⟹   XP_063140608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83133,334,026 - 133,428,404 (-)NCBI
RefSeq Acc Id: NP_001177994   ⟸   NM_001191065
- UniProtKB: D4A3K2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011084   ⟸   ENSRNOT00000011084
RefSeq Acc Id: XP_038961764   ⟸   XM_039105836
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140608   ⟸   XM_063284538
- Peptide Label: isoform X1
Protein Domains
PID   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3K2-F1-model_v2 AlphaFold D4A3K2 1-622 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583644 AgrOrtholog
BioCyc Gene G2FUF-48037 BioCyc
Ensembl Genes ENSRNOG00000037134 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011084 ENTREZGENE
  ENSRNOT00000011084.4 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro PH_type UniProtKB/TrEMBL
  PID_domain UniProtKB/TrEMBL
  PTyr_interaction_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SHC_SH2 UniProtKB/TrEMBL
KEGG Report rno:679845 UniProtKB/TrEMBL
NCBI Gene 679845 ENTREZGENE
PANTHER PTHR10337:SF12 UniProtKB/TrEMBL
  SHC TRANSFORMING PROTEIN UniProtKB/TrEMBL
Pfam PID UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PhenoGen Shc4 PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SHCPIDOMAIN UniProtKB/TrEMBL
PROSITE PID UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037134 RatGTEx
SMART PTB UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt D4A3K2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Shc4  SHC adaptor protein 4  Shc4  SHC (Src homology 2 domain containing) family, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-15 Shc4  SHC (Src homology 2 domain containing) family, member 4  RGD1309182  similar to neuronal Shc   Data merged from RGD:1309182 1643240 APPROVED
2008-04-30 RGD1309182  similar to neuronal Shc   RGD1309182_predicted  similar to neuronal Shc (predicted)  'predicted' is removed 2292626 APPROVED
2008-03-05 Shc4  SHC (Src homology 2 domain containing) family, member 4  LOC679845  similar to rai-like protein RaLP  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC679845  similar to rai-like protein RaLP  LOC688081  similar to rai-like protein RaLP  Data merged from RGD:1593582 1643240 APPROVED
2006-11-20 LOC688081  similar to rai-like protein RaLP      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC679845  similar to rai-like protein RaLP      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1309182_predicted  similar to neuronal Shc (predicted)  LOC296114_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296114_predicted  similar to neuronal Shc (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL