Fshb (follicle stimulating hormone subunit beta) - Rat Genome Database

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Gene: Fshb (follicle stimulating hormone subunit beta) Rattus norvegicus
Symbol: Fshb
Name: follicle stimulating hormone subunit beta
RGD ID: 2630
Description: Predicted to enable follicle-stimulating hormone activity. Predicted to be involved in follicle-stimulating hormone signaling pathway; positive regulation of steroid biosynthetic process; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including gonad development; positive regulation of bone resorption; and regulation of osteoclast differentiation. Predicted to be part of follicle-stimulating hormone complex. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in amenorrhea and hypogonadotropic hypogonadism 24 without anosmia. Orthologous to human FSHB (follicle stimulating hormone subunit beta); PARTICIPATES IN follicle-stimulating hormone signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (R)-carnitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: follicle - stimulating hormone subunit beta; follicle stimulating hormone beta; follicle stimulating hormone beta subunit; follicle stimulating hormone, beta polypeptide; follicle-stimulating hormone beta subunit; follicle-stimulating hormone beta-subunit; follicle-stimulating hormone subunit beta; follitropin beta chain; follitropin subunit beta; FSH-B; FSH-beta
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2393,548,560 - 93,552,370 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl393,548,560 - 93,552,370 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx397,074,668 - 97,078,475 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03105,673,601 - 105,677,408 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03103,471,309 - 103,475,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0398,088,321 - 98,092,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl398,088,324 - 98,092,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03104,700,141 - 104,703,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4392,569,344 - 92,571,254 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1392,465,296 - 92,467,695 (-)NCBI
Celera392,595,527 - 92,599,337 (-)NCBICelera
Cytogenetic Map3q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-Dibromo-3-chloropropane  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2-hydroxyestrone  (ISO)
2-tert-butylhydroquinone  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dihydroxybenzoic acid  (EXP)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4'-epidoxorubicin  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-Hydroxybenzophenone  (ISO)
4-nitrophenyl beta-D-xyloside  (EXP)
4-nonylphenol  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5-formyltetrahydrofolic acid  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (EXP)
acetaldehyde  (ISO)
acetate ester  (EXP)
acrylamide  (EXP)
adenosine  (ISO)
AICA ribonucleotide  (EXP)
alcohol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
aminoglutethimide  (ISO)
ammonium chloride  (EXP)
anastrozole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apocynin  (EXP)
arecoline  (EXP)
Aroclor 1254  (EXP)
aspartame  (ISO)
atrazine  (EXP,ISO)
baclofen  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
betamethasone  (EXP)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bromocriptine  (ISO)
buserelin  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (EXP)
carbaryl  (ISO)
carbendazim  (EXP)
carboplatin  (EXP)
celecoxib  (EXP)
cetrorelix  (EXP,ISO)
CGP 52608  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (EXP)
chrysin  (EXP)
cilostazol  (EXP)
cimetidine  (ISO)
cisplatin  (EXP)
clomiphene  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
crizotinib  (ISO)
curcumin  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyproterone acetate  (ISO)
danazol  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
Dicyclohexyl phthalate  (EXP)
dienogest  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethoate  (EXP)
dioxygen  (EXP)
disodium selenite  (EXP)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
Estradiol 17beta-cyclopentylpropionate  (EXP)
ethanol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenarimol  (EXP)
fenitrothion  (EXP)
fenvalerate  (EXP)
flufenamic acid  (EXP)
flutamide  (EXP,ISO)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
formestane  (EXP)
fructose  (EXP)
fulvestrant  (EXP,ISO)
furan  (EXP)
gallic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
gingerol  (ISO)
ginsenoside Rg1  (ISO)
glutathione  (EXP)
glyphosate  (EXP,ISO)
Goserelin  (ISO)
GW 1929  (ISO)
herbicide  (EXP)
hexachlorobenzene  (EXP)
hyaluronic acid  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (EXP)
iodoacetic acid  (ISO)
iprodione  (EXP)
isoprenaline  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
letrozole  (EXP,ISO)
levonorgestrel  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP)
menadione  (EXP)
mestranol  (ISO)
metformin  (EXP)
methomyl  (EXP)
methotrexate  (EXP)
methoxyacetic acid  (EXP)
methoxychlor  (EXP,ISO)
metolachlor  (EXP)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
muscimol  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N-nitrosourea  (EXP)
naltrexone  (ISO)
naringin  (EXP)
nickel atom  (EXP)
nicotine  (EXP)
nimodipine  (ISO)
octreotide  (EXP,ISO)
oxybenzone  (ISO)
ozone  (ISO)
pasireotide  (EXP,ISO)
pentobarbital  (EXP)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluoroundecanoic acid  (EXP)
perphenazine  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
potassium dichromate  (EXP)
pregnenolone  (ISO)
procymidone  (EXP)
progesterone  (EXP,ISO)
promegestone  (ISO)
propylparaben  (ISO)
pyrethrins  (EXP)
quercetin  (EXP)
resveratrol  (EXP,ISO)
risperidone  (ISO)
rolipram  (EXP,ISO)
SB 203580  (EXP)
SB 431542  (EXP,ISO)
selenium atom  (EXP)
sildenafil citrate  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium benzoate  (EXP)
sodium chlorate  (EXP)
sodium fluoride  (EXP)
sophoraflavanone B  (EXP)
spironolactone  (EXP)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (EXP,ISO)
taurine  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP,ISO)
Testosterone propionate  (EXP)
thimerosal  (ISO)
titanium dioxide  (EXP,ISO)
tributylstannane  (EXP)
trichlorfon  (ISO)
triciribine  (ISO)
triclosan  (EXP)
trilostane  (ISO)
tyrphostin AG 1478  (EXP,ISO)
uranium atom  (EXP)
valsartan  (EXP)
vinclozolin  (EXP)
vitamin E  (EXP)
vitexin  (ISO)
wortmannin  (EXP)
zearalenone  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Regulation of gonadotropin subunit gene transcription by gonadotropin-releasing hormone: measurement of primary transcript ribonucleic acids by quantitative reverse transcription-polymerase chain reaction assays. Dalkin AC, etal., Endocrinology 2001 Jan;142(1):139-46.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Isolation and characterization of the gene encoding the beta-subunit of rat follicle-stimulating hormone. Gharib SD, etal., DNA 1989 Jun;8(5):339-49.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Matthews CH, etal., Nat Genet. 1993 Sep;5(1):83-6.
6. Molecular cloning and nucleotide sequence analysis of complementary deoxyribonucleic acid for the beta-subunit of rat follicle stimulating hormone. Maurer RA Mol Endocrinol 1987 Oct;1(10):717-23.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS). Wei L, etal., Biochem Cell Biol. 2010 Aug;88(4):723-30. doi: 10.1139/O10-022.
16. Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter. Zakaria MM, etal., Mol Endocrinol 2002 Aug;16(8):1840-52.
Additional References at PubMed
PMID:2494176   PMID:9020850   PMID:11416011   PMID:11514332   PMID:12477932   PMID:12554780   PMID:12646491   PMID:14512439   PMID:14557487   PMID:14602737   PMID:14982927   PMID:15375186  
PMID:15761025   PMID:16339198   PMID:16630814   PMID:17405825   PMID:17674129   PMID:17932215   PMID:18022758   PMID:18160680   PMID:18206295   PMID:18248883   PMID:18363807   PMID:18550775  
PMID:18635654   PMID:19200975   PMID:19464343   PMID:20201104   PMID:21228211   PMID:22106407   PMID:22249524   PMID:22564408   PMID:23242526   PMID:23299500   PMID:23349233   PMID:23376485  
PMID:24692546   PMID:24739304   PMID:25635942   PMID:26853521   PMID:27030385   PMID:28402262   PMID:29534107  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2393,548,560 - 93,552,370 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl393,548,560 - 93,552,370 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx397,074,668 - 97,078,475 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03105,673,601 - 105,677,408 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03103,471,309 - 103,475,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0398,088,321 - 98,092,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl398,088,324 - 98,092,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03104,700,141 - 104,703,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4392,569,344 - 92,571,254 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1392,465,296 - 92,467,695 (-)NCBI
Celera392,595,527 - 92,599,337 (-)NCBICelera
Cytogenetic Map3q33NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381130,231,014 - 30,235,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1130,231,014 - 30,235,261 (+)EnsemblGRCh38hg38GRCh38
GRCh371130,252,561 - 30,256,741 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361130,209,139 - 30,213,400 (+)NCBINCBI36Build 36hg18NCBI36
Build 341130,210,025 - 30,211,923NCBI
Celera1130,398,958 - 30,403,219 (+)NCBICelera
Cytogenetic Map11p14.1NCBI
HuRef1129,945,298 - 29,949,559 (+)NCBIHuRef
CHM1_11130,251,554 - 30,255,815 (+)NCBICHM1_1
T2T-CHM13v2.01130,365,200 - 30,369,380 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392106,886,331 - 106,889,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2106,886,485 - 106,890,001 (-)EnsemblGRCm39 Ensembl
GRCm382107,055,986 - 107,059,651 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2107,056,140 - 107,059,656 (-)EnsemblGRCm38mm10GRCm38
MGSCv372106,896,297 - 106,899,808 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362106,856,979 - 106,860,490 (-)NCBIMGSCv36mm8
Celera2108,277,790 - 108,281,303 (-)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.02NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554768,795,351 - 8,797,244 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554768,795,354 - 8,797,244 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11132,456,189 - 32,459,515 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,204,193 - 30,208,410 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11130,095,759 - 30,100,012 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,095,486 - 30,100,167 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12150,279,320 - 50,282,843 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2150,280,208 - 50,282,680 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2149,721,618 - 49,725,189 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02151,453,974 - 51,457,558 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2151,454,924 - 51,457,395 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12150,500,112 - 50,503,675 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02150,598,794 - 50,602,364 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02151,222,316 - 51,225,896 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494734,269,268 - 34,273,598 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365337,395,206 - 7,397,266 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365337,395,206 - 7,397,266 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl230,395,018 - 30,399,274 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1230,395,769 - 30,399,282 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2232,861,492 - 32,865,005 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p1.6-p1.2NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1134,943,544 - 34,947,796 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl134,943,568 - 34,946,863 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038132,120,141 - 132,124,387 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476619,329,371 - 19,331,267 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476619,328,730 - 19,332,385 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Fshb
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:360
Count of miRNA genes:194
Interacting mature miRNAs:238
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system nervous system reproductive system respiratory system
Low 2 2
Below cutoff 6 2 10 4 5


RefSeq Acc Id: ENSRNOT00000006512   ⟹   ENSRNOP00000006512
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl393,548,560 - 93,552,370 (-)Ensembl
Rnor_6.0 Ensembl398,088,324 - 98,092,131 (-)Ensembl
RefSeq Acc Id: NM_001007597   ⟹   NP_001007598
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2393,548,560 - 93,552,370 (-)NCBI
Rnor_6.0398,088,321 - 98,092,131 (-)NCBI
Rnor_5.03104,700,141 - 104,703,954 (-)NCBI
RGSC_v3.4392,569,344 - 92,571,254 (-)RGD
Celera392,595,527 - 92,599,337 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001007598 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB60705 (Get FASTA)   NCBI Sequence Viewer  
  AAI68724 (Get FASTA)   NCBI Sequence Viewer  
  BAA00455 (Get FASTA)   NCBI Sequence Viewer  
  CCP37929 (Get FASTA)   NCBI Sequence Viewer  
  EDL79746 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006512
GenBank Protein P18427 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007598   ⟸   NM_001007597
- Peptide Label: precursor
- UniProtKB: P18427 (UniProtKB/Swiss-Prot),   B5DEM1 (UniProtKB/TrEMBL),   A6HNZ5 (UniProtKB/TrEMBL),   A0A0F7RQH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006512   ⟸   ENSRNOT00000006512
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18427-F1-model_v2 AlphaFold P18427 1-130 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:6850002
Promoter ID:EP30072
Type:single initiation site
Description:Follicle stimulating hormone-beta, FSHB gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 180; Mammalian follicle stimulating hormone
Experiment Methods:Sequencing of a full-length cDNA; Primer extension
Regulation:pituitary; (induced by or strongly expressed in) GnRH
Rat AssemblyChrPosition (strand)Source
RGSC_v3.4392,571,953 - 92,572,013EPD

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2630 AgrOrtholog
BioCyc Gene G2FUF-48502 BioCyc
Ensembl Genes ENSRNOG00000004898 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006512 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gonadotropin_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gonadotropin_bsu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11515 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fshb PhenoGen
RatGTEx ENSRNOG00000004898 RatGTEx
SMART GHB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary B5DEM1 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-07 Fshb  follicle stimulating hormone subunit beta  Fshb  follicle stimulating hormone beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 Fshb  follicle stimulating hormone beta subunit  Fshb  follicle stimulating hormone, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Fshb  follicle stimulating hormone, beta polypeptide  Fshb  follicle stimulating hormone beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-01   follicle stimulating hormone beta  Fshb  follicle-stimulating hormone subunit beta  Name updated 1299863 APPROVED
2002-06-10 Fshb  follicle - stimulating hormone subunit beta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed at high levels in pituitary 728523
gene_physical_interaction protein results from heterodimer with alpha subunit 728523
gene_process functions in reproduction 61523
gene_regulation estrogen downregulates mRNA in pituitary 728523
gene_transcript contains 3 exons of 36, 187, and 1,220 bp and 2 introns of 639 and 1,000 bp 61523