Pla2g4e (phospholipase A2, group IVE) - Rat Genome Database

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Gene: Pla2g4e (phospholipase A2, group IVE) Rattus norvegicus
Analyze
Symbol: Pla2g4e
Name: phospholipase A2, group IVE
RGD ID: 1310595
Description: Predicted to enable several functions, including calcium-dependent phospholipase A2 activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in N-acylphosphatidylethanolamine metabolic process; glycerophospholipid catabolic process; and positive regulation of endocytic recycling. Predicted to be located in early endosome membrane; lysosomal membrane; and plasma membrane. Predicted to be active in cytosol. Orthologous to human PLA2G4E (phospholipase A2 group IVE); PARTICIPATES IN alpha-linolenic acid metabolic pathway; arachidonic acid metabolic pathway; ether lipid metabolic pathway; INTERACTS WITH acrylamide; bisphenol A; 2-hydroxypropanoic acid (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytosolic phospholipase A2 epsilon; LOC296091; phospholipase A2, group 4E; RGD1310595; similar to phospholipase A2, group IVB (cytosolic)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23107,132,540 - 107,198,609 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3107,132,541 - 107,198,233 (-)Ensembl
Rnor_6.03111,952,396 - 112,018,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,952,348 - 111,994,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03118,500,163 - 118,566,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,670,159 - 106,735,089 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13106,567,403 - 106,631,517 (-)NCBI
Celera3106,041,283 - 106,107,262 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15866882   PMID:24413173   PMID:29447909  


Genomics

Comparative Map Data
Pla2g4e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23107,132,540 - 107,198,609 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3107,132,541 - 107,198,233 (-)Ensembl
Rnor_6.03111,952,396 - 112,018,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,952,348 - 111,994,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03118,500,163 - 118,566,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,670,159 - 106,735,089 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13106,567,403 - 106,631,517 (-)NCBI
Celera3106,041,283 - 106,107,262 (-)NCBICelera
Cytogenetic Map3q35NCBI
PLA2G4E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381541,981,582 - 42,050,703 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1541,981,394 - 42,051,190 (-)EnsemblGRCh38hg38GRCh38
GRCh371542,273,780 - 42,342,901 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361540,063,244 - 40,089,737 (-)NCBINCBI36hg18NCBI36
Celera1519,043,598 - 19,070,102 (-)NCBI
Cytogenetic Map15q15.1NCBI
HuRef1519,121,756 - 19,190,910 (-)NCBIHuRef
CHM1_11542,392,249 - 42,461,343 (-)NCBICHM1_1
T2T-CHM13v2.01539,787,553 - 39,856,691 (-)NCBI
Pla2g4e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,996,893 - 120,077,306 (-)NCBIGRCm39mm39
GRCm39 Ensembl2119,996,893 - 120,075,816 (-)Ensembl
GRCm382120,166,412 - 120,245,630 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2120,166,412 - 120,245,335 (-)EnsemblGRCm38mm10GRCm38
MGSCv372119,992,148 - 120,071,071 (-)NCBIGRCm37mm9NCBIm37
MGSCv362119,857,853 - 119,936,776 (-)NCBImm8
Celera2121,326,986 - 121,399,932 (-)NCBICelera
Cytogenetic Map2E5NCBI
Pla2g4e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554168,765,561 - 8,804,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554168,765,620 - 8,826,184 (-)NCBIChiLan1.0ChiLan1.0
PLA2G4E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11539,095,777 - 39,165,161 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1539,095,777 - 39,165,161 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01520,937,573 - 20,975,388 (-)NCBIMhudiblu_PPA_v0panPan3
PLA2G4E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1309,018,238 - 9,077,258 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl309,020,079 - 9,075,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha309,076,973 - 9,135,690 (-)NCBI
ROS_Cfam_1.0309,153,388 - 9,212,395 (-)NCBI
ROS_Cfam_1.0 Ensembl309,155,138 - 9,212,408 (-)Ensembl
UMICH_Zoey_3.1309,074,123 - 9,132,817 (-)NCBI
UNSW_CanFamBas_1.0309,178,334 - 9,237,062 (-)NCBI
UU_Cfam_GSD_1.0309,313,127 - 9,372,095 (-)NCBI
Pla2g4e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864087,452,829 - 87,488,718 (-)NCBI
SpeTri2.0NW_0049364715,300,932 - 5,370,150 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G4E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1129,289,732 - 129,364,021 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11129,288,727 - 129,364,034 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21144,339,794 - 144,349,251 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G4E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12640,938,730 - 41,001,787 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2640,939,712 - 41,001,217 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048100,001,209 - 100,063,250 (-)NCBIVero_WHO_p1.0
Pla2g4e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248049,140,353 - 9,227,102 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248049,142,525 - 9,227,049 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:44
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000030502
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 25 6
Low 4 4 7 39 3 7 4
Below cutoff 20 17 9 9 9 4 4 10 14 28 4 4

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_001080884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_230487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF011108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000030502   ⟹   ENSRNOP00000031380
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3107,132,541 - 107,198,233 (-)Ensembl
Rnor_6.0 Ensembl3111,952,348 - 111,994,337 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097961   ⟹   ENSRNOP00000093379
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3107,133,250 - 107,174,484 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109239   ⟹   ENSRNOP00000095683
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3107,133,250 - 107,174,484 (-)Ensembl
RefSeq Acc Id: XM_017592199   ⟹   XP_017447688
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,132,540 - 107,174,693 (-)NCBI
Rnor_6.03111,952,396 - 111,994,375 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592201   ⟹   XP_017447690
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,132,540 - 107,174,261 (-)NCBI
Rnor_6.03111,952,396 - 111,994,135 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592202   ⟹   XP_017447691
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,132,540 - 107,174,693 (-)NCBI
Rnor_6.03111,952,396 - 111,994,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592203   ⟹   XP_017447692
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,132,540 - 107,173,105 (-)NCBI
Rnor_6.03111,952,396 - 111,992,925 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592204   ⟹   XP_017447693
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,132,540 - 107,174,694 (-)NCBI
Rnor_6.03111,952,396 - 111,994,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039106510   ⟹   XP_038962438
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,132,540 - 107,174,693 (-)NCBI
RefSeq Acc Id: XM_039106511   ⟹   XP_038962439
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,132,540 - 107,174,693 (-)NCBI
RefSeq Acc Id: XM_039106512   ⟹   XP_038962440
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,132,540 - 107,174,261 (-)NCBI
RefSeq Acc Id: XM_039106513   ⟹   XP_038962441
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,134,801 - 107,174,711 (-)NCBI
RefSeq Acc Id: XM_039106514   ⟹   XP_038962442
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,137,912 - 107,174,714 (-)NCBI
RefSeq Acc Id: XM_039106515   ⟹   XP_038962443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,132,540 - 107,146,693 (-)NCBI
RefSeq Acc Id: XM_039106516   ⟹   XP_038962444
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,146,034 - 107,174,708 (-)NCBI
RefSeq Acc Id: XM_230487   ⟹   XP_230487
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,132,540 - 107,198,609 (-)NCBI
Rnor_6.03111,952,396 - 112,018,470 (-)NCBI
Rnor_5.03118,500,163 - 118,566,233 (-)NCBI
RGSC_v3.43106,670,159 - 106,735,089 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: XP_230487   ⟸   XM_230487
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017447688   ⟸   XM_017592199
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017447693   ⟸   XM_017592204
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017447691   ⟸   XM_017592202
- Peptide Label: isoform X4
- UniProtKB: F1LPY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447690   ⟸   XM_017592201
- Peptide Label: isoform X4
- UniProtKB: F1LPY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447692   ⟸   XM_017592203
- Peptide Label: isoform X4
- UniProtKB: F1LPY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031380   ⟸   ENSRNOT00000030502
RefSeq Acc Id: XP_038962439   ⟸   XM_039106511
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038962438   ⟸   XM_039106510
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962440   ⟸   XM_039106512
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038962443   ⟸   XM_039106515
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038962441   ⟸   XM_039106513
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038962442   ⟸   XM_039106514
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038962444   ⟸   XM_039106516
- Peptide Label: isoform X9
RefSeq Acc Id: ENSRNOP00000095683   ⟸   ENSRNOT00000109239
RefSeq Acc Id: ENSRNOP00000093379   ⟸   ENSRNOT00000097961
Protein Domains
C2   PLA2c

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LPY6-F1-model_v2 AlphaFold F1LPY6 1-828 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692342
Promoter ID:EPDNEW_R2863
Type:single initiation site
Name:Pla2g4e_1
Description:phospholipase A2, group IVE
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03111,994,343 - 111,994,403EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 111970540 111970541 G A snv ACI/EurMcwi (MCW), ACI/N (MCW), ACI/EurMcwi (2019), DA/OlaHsd (2019), ACI/N (2020), ACI/EurMcwi (RGD)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 118518307 118518308 G A snv ACI/EurMcwi (MCW), ACI/N (KNAW), HTX/Kyo (KyushuU), DA/BklArbNsi (KNAW), NIG-III/Hok (KyushuU), ACI/EurMcwi (KNAW)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 107150686 107150687 G A snv ACI/EurMcwi (2019), DA/OlaHsd (2019), ACI/N (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310595 AgrOrtholog
BioCyc Gene G2FUF-48181 BioCyc
Ensembl Genes ENSRNOG00000024904 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000031380 ENTREZGENE
  ENSRNOP00000031380.6 UniProtKB/TrEMBL
  ENSRNOP00000093379 ENTREZGENE
  ENSRNOP00000093379.1 UniProtKB/TrEMBL
  ENSRNOP00000095683 ENTREZGENE
  ENSRNOP00000095683.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030502 ENTREZGENE
  ENSRNOT00000030502.6 UniProtKB/TrEMBL
  ENSRNOT00000097961 ENTREZGENE
  ENSRNOT00000097961.1 UniProtKB/TrEMBL
  ENSRNOT00000109239 ENTREZGENE
  ENSRNOT00000109239.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPlipase UniProtKB/TrEMBL
  C2_Ca-dep UniProtKB/TrEMBL
  C2_cPLA2 UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  cPLA2_C2 UniProtKB/TrEMBL
  LysoPLipase_cat_dom UniProtKB/TrEMBL
NCBI Gene 296091 ENTREZGENE
Pfam cPLA2_C2 UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PLA2_B UniProtKB/TrEMBL
PhenoGen Pla2g4e PhenoGen
PROSITE PLA2C UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART PLAc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP Acyl_Trfase/lysoPlipase UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
UniProt A0A8I6AKA4_RAT UniProtKB/TrEMBL
  A0A8I6ANS2_RAT UniProtKB/TrEMBL
  A0FIP9_RAT UniProtKB/TrEMBL
  F1LPY6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-27 Pla2g4e  phospholipase A2, group IVE  RGD1310595_predicted  similar to phospholipase A2, group IVB (cytosolic) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1310595_predicted  similar to phospholipase A2, group IVB (cytosolic) (predicted)  LOC296091_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296091_predicted  similar to phospholipase A2, group IVB (cytosolic) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL