Bub1b (BUB1 mitotic checkpoint serine/threonine kinase B) - Rat Genome Database

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Gene: Bub1b (BUB1 mitotic checkpoint serine/threonine kinase B) Rattus norvegicus
Analyze
Symbol: Bub1b
Name: BUB1 mitotic checkpoint serine/threonine kinase B
RGD ID: 619791
Description: Predicted to enable protein kinase activity. Predicted to be involved in meiotic sister chromatid cohesion, centromeric; mitotic spindle assembly checkpoint signaling; and negative regulation of ubiquitin-protein transferase activity. Predicted to act upstream of or within metaphase/anaphase transition of mitotic cell cycle and protein localization to chromosome, centromeric region. Predicted to be located in cytosol; perinuclear region of cytoplasm; and spindle. Predicted to be part of mitotic checkpoint complex and outer kinetochore. Predicted to colocalize with kinetochore. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B); PARTICIPATES IN cell cycle pathway, mitotic; mitotic spindle checkpoint pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BUB1B, mitotic checkpoint serine/threonine kinase; budding uninhibited by benzimidazoles 1 beta; budding uninhibited by benzimidazoles 1 homolog beta; budding uninhibited by benzimidazoles 1 homolog beta (yeast); budding uninhibited by benzimidazoles 1 homolog, beta; budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae); LOC362192; mitotic checkpoint serine/threonine-protein kinase BUB1 beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23105,563,089 - 105,615,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,563,138 - 105,615,547 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,236,836 - 109,289,246 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03117,832,398 - 117,884,807 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03115,492,765 - 115,545,173 (+)NCBIRnor_WKY
Rnor_6.03110,367,949 - 110,420,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,367,939 - 110,420,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,912,599 - 116,965,060 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,063,018 - 105,116,145 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13104,974,011 - 104,978,578 (+)NCBI
Celera3104,480,144 - 104,532,190 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cryptolepine  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
daidzein  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
geraniol  (ISO)
glycidol  (EXP)
GW 3965  (ISO)
GW 4064  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lucanthone  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylseleninic acid  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorodecanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
Piplartine  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
SP2509  (ISO)
staurosporine  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Subcellular localization of the spindle proteins Aurora A, Mad2, and BUBR1 assessed by immunohistochemistry. Burum-Auensen E, etal., J Histochem Cytochem. 2007 May;55(5):477-86. Epub 2007 Jan 22.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Diaphragm muscle sarcopenia in aging mice. Greising SM, etal., Exp Gerontol. 2013 Sep;48(9):881-7. doi: 10.1016/j.exger.2013.06.001. Epub 2013 Jun 19.
4. Piperlongumine inhibits LMP1/MYC-dependent mouse B-lymphoma cells. Han SS, etal., Biochem Biophys Res Commun. 2013 Jul 12;436(4):660-5. doi: 10.1016/j.bbrc.2013.06.012. Epub 2013 Jun 11.
5. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Hanks S, etal., Nat Genet. 2004 Nov;36(11):1159-61. Epub 2004 Oct 10.
6. Gene expression profiles in gallbladder cancer: the close genetic similarity seen for early and advanced gallbladder cancers may explain the poor prognosis. Kim JH, etal., Tumour Biol. 2008;29(1):41-9. Epub 2008 May 23.
7. Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene. Lewis BC, etal., Mol Cell Biol 1997 Sep;17(9):4967-78.
8. BUBR1 expression in benign oral lesions and squamous cell carcinomas: correlation with human papillomavirus. Lira RC, etal., Oncol Rep. 2010 Apr;23(4):1027-36. doi: 10.3892/or_00000729.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Reactome: A Knowledgebase of Biological Processes Reactome
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:8889548   PMID:9660858   PMID:9763420   PMID:12925705   PMID:14519686   PMID:15226446   PMID:15767571   PMID:17227893   PMID:17363900   PMID:17938250   PMID:18765791   PMID:19283064  
PMID:19465021   PMID:19468067   PMID:20531406   PMID:22331848  


Genomics

Comparative Map Data
Bub1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23105,563,089 - 105,615,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,563,138 - 105,615,547 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,236,836 - 109,289,246 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03117,832,398 - 117,884,807 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03115,492,765 - 115,545,173 (+)NCBIRnor_WKY
Rnor_6.03110,367,949 - 110,420,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,367,939 - 110,420,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,912,599 - 116,965,060 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,063,018 - 105,116,145 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13104,974,011 - 104,978,578 (+)NCBI
Celera3104,480,144 - 104,532,190 (+)NCBICelera
Cytogenetic Map3q35NCBI
BUB1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,161,069 - 40,221,123 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1540,161,023 - 40,221,123 (+)EnsemblGRCh38hg38GRCh38
GRCh371540,453,270 - 40,513,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,240,530 - 38,300,629 (+)NCBINCBI36Build 36hg18NCBI36
Build 341538,240,529 - 38,300,627NCBI
Celera1517,219,190 - 17,279,313 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,296,260 - 17,356,314 (+)NCBIHuRef
CHM1_11540,573,169 - 40,633,290 (+)NCBICHM1_1
T2T-CHM13v2.01537,967,956 - 38,028,008 (+)NCBIT2T-CHM13v2.0
Bub1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,428,684 - 118,472,073 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,428,692 - 118,472,072 (+)EnsemblGRCm39 Ensembl
GRCm382118,598,202 - 118,641,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,598,211 - 118,641,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,423,947 - 118,467,328 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,289,697 - 118,333,032 (+)NCBIMGSCv36mm8
Celera2119,745,153 - 119,796,040 (+)NCBICelera
Cytogenetic Map2E5NCBI
Bub1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,105,261 - 7,160,012 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,105,302 - 7,159,121 (+)NCBIChiLan1.0ChiLan1.0
BUB1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11537,350,826 - 37,410,661 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,350,826 - 37,410,648 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01519,095,383 - 19,155,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BUB1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,361,982 - 7,410,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,322,912 - 7,438,052 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,416,730 - 7,464,873 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,490,487 - 7,538,685 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,490,458 - 7,538,459 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,412,929 - 7,461,263 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,519,268 - 7,567,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,647,445 - 7,695,793 (+)NCBIUU_Cfam_GSD_1.0
Bub1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,783,495 - 85,851,191 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,633,536 - 3,695,684 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364713,631,760 - 3,696,024 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BUB1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,092,958 - 131,143,794 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,093,026 - 131,143,840 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,217,357 - 146,249,488 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BUB1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,769,955 - 42,855,353 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,792,830 - 42,855,306 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,101,756 - 98,168,849 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bub1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,492,799 - 7,533,408 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,477,046 - 7,533,322 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bub1b
187 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:113
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000010406
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat

Markers in Region
RH129329  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,614,588 - 105,614,753 (+)MAPPERmRatBN7.2
Rnor_6.03110,419,513 - 110,419,677NCBIRnor6.0
Rnor_5.03116,964,102 - 116,964,266UniSTSRnor5.0
RGSC_v3.43105,115,952 - 105,116,116UniSTSRGSC3.4
Celera3104,531,232 - 104,531,396UniSTS
RH 3.4 Map3913.5UniSTS
Cytogenetic Map3q35UniSTS
STS-W72744  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21880,610,266 - 80,610,384 (+)MAPPERmRatBN7.2
mRatBN7.23105,557,304 - 105,557,425 (+)MAPPERmRatBN7.2
Rnor_6.01884,443,946 - 84,444,063NCBIRnor6.0
Rnor_6.03110,362,161 - 110,362,281NCBIRnor6.0
Rnor_5.01883,503,316 - 83,503,433UniSTSRnor5.0
Rnor_5.03116,906,812 - 116,906,932UniSTSRnor5.0
RGSC_v3.43105,056,989 - 105,057,109UniSTSRGSC3.4
RGSC_v3.41883,984,428 - 83,984,545UniSTSRGSC3.4
Celera1879,192,256 - 79,192,373UniSTS
Celera3104,474,311 - 104,474,431UniSTS
Cytogenetic Map18q13UniSTS
Cytogenetic Map14q21UniSTS
Cytogenetic Map3q35UniSTS
AU046934  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,608,531 - 105,608,777 (+)MAPPERmRatBN7.2
Rnor_6.03110,413,451 - 110,413,694NCBIRnor6.0
Rnor_5.03116,958,102 - 116,958,345UniSTSRnor5.0
RGSC_v3.43105,108,221 - 105,108,464UniSTSRGSC3.4
Celera3104,525,177 - 104,525,420UniSTS
Cytogenetic Map3q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 26 20 13 20 35 18 35
Low 1 10 21 14 6 14 4 4 22 12 6 11 4
Below cutoff 7 10 7 7 4 7 17 5 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010406   ⟹   ENSRNOP00000010406
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3105,563,138 - 105,615,547 (+)Ensembl
Rnor_6.0 Ensembl3110,367,939 - 110,420,458 (+)Ensembl
RefSeq Acc Id: NM_138540   ⟹   NP_612549
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23105,563,138 - 105,615,547 (+)NCBI
Rnor_6.03110,367,994 - 110,420,471 (+)NCBI
Celera3104,480,144 - 104,532,190 (+)NCBI
Sequence:
RefSeq Acc Id: XR_352538
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23105,563,089 - 105,615,547 (+)NCBI
Rnor_6.03110,367,949 - 110,420,471 (+)NCBI
Rnor_5.03116,912,599 - 116,965,060 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_612549 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB69638 (Get FASTA)   NCBI Sequence Viewer  
  EDL79866 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_612549   ⟸   NM_138540
- UniProtKB: F1LMI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010406   ⟸   ENSRNOT00000010406
Protein Domains
BUB1 N-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LMI1-F1-model_v2 AlphaFold F1LMI1 1-1055 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692317
Promoter ID:EPDNEW_R2835
Type:initiation region
Name:Bub1b_1
Description:BUB1 mitotic checkpoint serine/threonine kinase B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03110,367,993 - 110,368,053EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619791 AgrOrtholog
BioCyc Gene G2FUF-48247 BioCyc
Ensembl Genes ENSRNOG00000007906 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010406 ENTREZGENE
  ENSRNOP00000010406.7 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010406 ENTREZGENE
  ENSRNOT00000010406.7 UniProtKB/TrEMBL
InterPro Bub1 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Mad3_BUB1_I UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene 171576 ENTREZGENE
PANTHER Bub1 UniProtKB/TrEMBL
Pfam Mad3_BUB1_I UniProtKB/TrEMBL
PhenoGen Bub1b PhenoGen
PROSITE BUB1_N UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART Mad3_BUB1_I UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt F1LMI1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Bub1b  BUB1 mitotic checkpoint serine/threonine kinase B  Bub1b  BUB1B, mitotic checkpoint serine/threonine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 Bub1b  BUB1B, mitotic checkpoint serine/threonine kinase  Bub1b  BUB1 mitotic checkpoint serine/threonine kinase B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-23 Bub1b  BUB1 mitotic checkpoint serine/threonine kinase B  Bub1b  budding uninhibited by benzimidazoles 1 homolog beta (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Bub1b  budding uninhibited by benzimidazoles 1 homolog beta (yeast)  Bub1b  budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-04-28 Bub1b  budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)  Bub1b_predicted  budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) (predicted)  Data Merged 737654 APPROVED
2005-01-20 Bub1b  budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Bub1b_predicted  budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Bub1b  budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)      Symbol and Name status set to provisional 70820 PROVISIONAL