Sord (sorbitol dehydrogenase) - Rat Genome Database

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Gene: Sord (sorbitol dehydrogenase) Rattus norvegicus
Analyze
Symbol: Sord
Name: sorbitol dehydrogenase
RGD ID: 3734
Description: Exhibits identical protein binding activity and zinc ion binding activity. Involved in several processes, including response to cadmium ion; response to copper ion; and response to osmotic stress. Predicted to localize to several cellular components, including extracellular exosome; mitochondrion; and motile cilium. Used to study diabetic neuropathy. Orthologous to human SORD (sorbitol dehydrogenase); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH (+)-schisandrin B; 1,1,2-trichloroethane; 1,2,3-Trichloropropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: L-iditol 2-dehydrogenase; polyol dehydrogenase; SDH; XDH; xylitol dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23109,184,697 - 109,216,133 (+)NCBI
Rnor_6.0 Ensembl3114,176,309 - 114,207,366 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03114,176,127 - 114,207,368 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03120,716,804 - 120,746,951 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,016,830 - 109,048,446 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13108,922,464 - 108,953,299 (+)NCBI
Celera3108,082,883 - 108,113,935 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1,2-trichloroethane  (EXP)
1,2,3-Trichloropropane  (EXP)
1,2-dichlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiane  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chrysene  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cumene hydroperoxide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucitol  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextromethorphan  (ISO)
Diallyl sulfide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epalrestat  (ISO)
fenbuconazole  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
fructose  (EXP,ISO)
galactose  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
lead diacetate  (EXP)
meloxicam  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
p-toluidine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
rac-lactic acid  (ISO)
rutin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc dichloride  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:722274   PMID:1914521   PMID:3365415   PMID:6626150   PMID:6870831   PMID:7171128   PMID:8487505   PMID:12477932   PMID:12962626   PMID:14965227   PMID:15489334   PMID:16189514  
PMID:16396499   PMID:18799757   PMID:19056867   PMID:21516116   PMID:21557262   PMID:23376485   PMID:23533145   PMID:31515488  


Genomics

Comparative Map Data
Sord
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23109,184,697 - 109,216,133 (+)NCBI
Rnor_6.0 Ensembl3114,176,309 - 114,207,366 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03114,176,127 - 114,207,368 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03120,716,804 - 120,746,951 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,016,830 - 109,048,446 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13108,922,464 - 108,953,299 (+)NCBI
Celera3108,082,883 - 108,113,935 (+)NCBICelera
Cytogenetic Map3q35NCBI
SORD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1545,023,147 - 45,077,185 (+)EnsemblGRCh38hg38GRCh38
GRCh381545,023,195 - 45,077,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371545,315,393 - 45,369,383 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,102,633 - 43,154,331 (+)NCBINCBI36hg18NCBI36
Build 341543,102,643 - 43,154,330NCBI
Celera1522,206,385 - 22,258,718 (+)NCBI
Cytogenetic Map15q21.1NCBI
HuRef1522,139,528 - 22,191,494 (+)NCBIHuRef
CHM1_11545,433,621 - 45,485,599 (+)NCBICHM1_1
Sord
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,065,320 - 122,095,818 (+)NCBIGRCm39mm39
GRCm39 Ensembl2122,065,230 - 122,095,821 (+)Ensembl
GRCm382122,234,839 - 122,265,337 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,234,749 - 122,265,340 (+)EnsemblGRCm38mm10GRCm38
MGSCv372122,060,575 - 122,091,073 (+)NCBIGRCm37mm9NCBIm37
MGSCv362121,926,280 - 121,956,778 (+)NCBImm8
Celera2123,384,583 - 123,415,681 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.59NCBI
Sord
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,303,602 - 8,333,869 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,305,819 - 8,333,733 (-)NCBIChiLan1.0ChiLan1.0
SORD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11542,363,854 - 42,375,848 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01523,971,017 - 24,025,043 (+)NCBIMhudiblu_PPA_v0panPan3
SORD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,467,259 - 11,501,166 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,467,253 - 11,500,641 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,523,461 - 11,557,483 (+)NCBI
ROS_Cfam_1.03011,603,460 - 11,637,883 (+)NCBI
UMICH_Zoey_3.13011,509,757 - 11,544,158 (+)NCBI
UNSW_CanFamBas_1.03011,632,822 - 11,666,883 (+)NCBI
UU_Cfam_GSD_1.03011,751,896 - 11,786,120 (+)NCBI
Sord
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,912,015 - 89,957,526 (+)NCBI
SpeTri2.0NW_0049364717,760,097 - 7,805,475 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SORD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,655,135 - 126,700,858 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,659,198 - 126,701,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,259,120 - 141,301,021 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SORD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,129,236 - 38,173,867 (-)NCBI
ChlSab1.1 Ensembl2638,126,911 - 38,155,381 (-)Ensembl
Vero_WHO_p1.0NW_023666048102,884,429 - 102,931,888 (+)NCBI
Sord
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473114,159,439 - 14,185,960 (-)NCBI

Position Markers
RH130513  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0990,799,524 - 90,799,742NCBIRnor5.0
Rnor_5.0994,824,326 - 94,824,544NCBIRnor5.0
Rnor_5.03120,745,107 - 120,745,994NCBIRnor5.0
RGSC_v3.43109,046,603 - 109,047,489UniSTSRGSC3.4
RGSC_v3.4986,930,977 - 86,931,194UniSTSRGSC3.4
Celera3108,112,092 - 108,112,978UniSTS
Celera986,202,725 - 86,202,942UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map3q35UniSTS
RH141218  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0990,798,495 - 90,798,697NCBIRnor5.0
Rnor_5.0994,823,297 - 94,823,499NCBIRnor5.0
Rnor_5.03120,746,689 - 120,746,892NCBIRnor5.0
RGSC_v3.43109,048,185 - 109,048,387UniSTSRGSC3.4
RGSC_v3.4986,929,948 - 86,930,149UniSTSRGSC3.4
Celera3108,113,674 - 108,113,876UniSTS
Celera986,201,696 - 86,201,897UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map3q35UniSTS
BF387718  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,196,074 - 109,196,224 (+)MAPPER
Rnor_6.03114,187,310 - 114,187,459NCBIRnor6.0
Rnor_5.03120,727,982 - 120,728,131UniSTSRnor5.0
RGSC_v3.43109,027,831 - 109,027,980UniSTSRGSC3.4
Celera3108,093,882 - 108,094,031UniSTS
RH 3.4 Map3948.5UniSTS
Cytogenetic Map3q35UniSTS
PMC86057P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,191,235 - 109,191,478 (+)MAPPER
mRatBN7.210103,036,286 - 103,036,632 (+)MAPPER
Rnor_6.010106,819,088 - 106,819,433NCBIRnor6.0
Rnor_6.03114,182,471 - 114,182,713NCBIRnor6.0
Rnor_5.03120,723,143 - 120,723,385UniSTSRnor5.0
Rnor_5.010106,458,313 - 106,458,658UniSTSRnor5.0
RGSC_v3.43109,022,992 - 109,023,234UniSTSRGSC3.4
Celera10101,596,270 - 101,596,615UniSTS
Celera3108,089,043 - 108,089,285UniSTS
Cytogenetic Map3q35UniSTS
G36383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,202,714 - 109,203,305 (+)MAPPER
Rnor_6.03114,193,949 - 114,194,539NCBIRnor6.0
Rnor_5.03120,733,532 - 120,734,122UniSTSRnor5.0
RGSC_v3.43109,035,027 - 109,035,617UniSTSRGSC3.4
Celera3108,100,521 - 108,101,111UniSTS
Cytogenetic Map3q35UniSTS
UniSTS:547147  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,215,127 - 109,216,002 (+)MAPPER
Rnor_6.03114,206,363 - 114,207,237NCBIRnor6.0
Rnor_5.03120,745,946 - 120,746,820UniSTSRnor5.0
Celera3108,112,930 - 108,113,804UniSTS
Cytogenetic Map3q35UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)330114912123700444Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)339248391140271184Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)345406058127023997Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)351821836124513579Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)351822008120917851Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)354630948119830094Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)362922868127023997Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)366711607119830094Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)366711607119830094Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)372672290127023997Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)372973445127023997Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)378700444123700444Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)381136227154416635Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)383817637119509260Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)388910015133910015Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)394788365139788365Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)397009185142009185Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3100730984119830094Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3101058963146058963Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3102152812155263151Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3102466149147466149Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3106900427119830094Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:97
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000023350
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 2 2 74 35 41 11 2
Low 6 9 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000023350   ⟹   ENSRNOP00000023350
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3114,176,309 - 114,207,366 (+)Ensembl
RefSeq Acc Id: NM_017052   ⟹   NP_058748
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23109,185,074 - 109,216,133 (+)NCBI
Rnor_6.03114,176,309 - 114,207,368 (+)NCBI
Rnor_5.03120,716,804 - 120,746,951 (+)NCBI
RGSC_v3.43109,016,830 - 109,048,446 (+)RGD
Celera3108,082,883 - 108,113,935 (+)RGD
Sequence:
RefSeq Acc Id: XM_017591474   ⟹   XP_017446963
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23109,184,697 - 109,216,133 (+)NCBI
Rnor_6.03114,176,127 - 114,207,368 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104286   ⟹   XP_038960214
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23109,196,635 - 109,216,133 (+)NCBI
RefSeq Acc Id: XM_039104287   ⟹   XP_038960215
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23109,185,065 - 109,216,133 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058748   ⟸   NM_017052
- UniProtKB: P27867 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017446963   ⟸   XM_017591474
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000023350   ⟸   ENSRNOT00000023350
RefSeq Acc Id: XP_038960215   ⟸   XM_039104287
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038960214   ⟸   XM_039104286
- Peptide Label: isoform X2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692366
Promoter ID:EPDNEW_R2891
Type:initiation region
Name:Sord_1
Description:sorbitol dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03114,176,338 - 114,176,398EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3734 AgrOrtholog
Ensembl Genes ENSRNOG00000017291 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000023350 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023350 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112546 IMAGE-MGC_LOAD
  IMAGE:7373210 IMAGE-MGC_LOAD
  IMAGE:8373758 IMAGE-MGC_LOAD
InterPro ADH_C UniProtKB/Swiss-Prot
  ADH_N UniProtKB/Swiss-Prot
  ADH_Zn_CS UniProtKB/Swiss-Prot
  GroES-like_sf UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  PKS_ER UniProtKB/Swiss-Prot
KEGG Report rno:24788 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114337 IMAGE-MGC_LOAD
  MGC:156505 IMAGE-MGC_LOAD
  MGC:93504 IMAGE-MGC_LOAD
NCBI Gene 24788 ENTREZGENE
Pfam ADH_N UniProtKB/Swiss-Prot
  ADH_zinc_N UniProtKB/Swiss-Prot
PhenoGen Sord PhenoGen
PROSITE ADH_ZINC UniProtKB/Swiss-Prot
SMART PKS_ER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50129 UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
UniProt DHSO_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2VCV9 UniProtKB/Swiss-Prot
  Q4FZY4 UniProtKB/Swiss-Prot
  Q5I0F3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Sord  sorbitol dehydrogenase    Sorbitol dehydrogenase  Symbol and Name updated 629477 APPROVED
2002-06-10 Sord  Sorbitol dehydrogenase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the zinc-containing alcohol dehydrogenase family 634068