Sord (sorbitol dehydrogenase) - Rat Genome Database

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Gene: Sord (sorbitol dehydrogenase) Rattus norvegicus
Analyze
Symbol: Sord
Name: sorbitol dehydrogenase
RGD ID: 3734
Description: Enables identical protein binding activity and zinc ion binding activity. Involved in several processes, including response to cadmium ion; response to copper ion; and response to hormone. Predicted to be located in several cellular components, including extracellular exosome; mitochondrion; and motile cilium. Predicted to be active in cytosol. Used to study diabetic neuropathy. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH (+)-schisandrin B; 1,1,2-trichloroethane; 1,2,3-Trichloropropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: L-iditol 2-dehydrogenase; polyol dehydrogenase; SDH; XDH; xylitol dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,638,282 - 129,669,727 (+)NCBIGRCr8
mRatBN7.23109,184,697 - 109,216,133 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,184,676 - 109,216,133 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3112,858,692 - 112,889,823 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,454,207 - 121,485,340 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,114,585 - 119,145,718 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03114,176,127 - 114,207,368 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,176,309 - 114,207,366 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,716,804 - 120,746,951 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,016,830 - 109,048,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13108,922,464 - 108,953,299 (+)NCBI
Celera3108,082,883 - 108,113,935 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1,2-trichloroethane  (EXP)
1,2,3-Trichloropropane  (EXP)
1,2-dichlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiane  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chrysene  (ISO)
clofibrate  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cumene hydroperoxide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucitol  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextromethorphan  (ISO)
Diallyl sulfide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epalrestat  (ISO)
epoxiconazole  (ISO)
fenbuconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
fructose  (EXP,ISO)
galactose  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
hyaluronic acid  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
melamine  (ISO)
meloxicam  (ISO)
methimazole  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
rac-lactic acid  (ISO)
rutin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc dichloride  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
extracellular exosome  (IEA,ISO)
membrane  (ISO)
mitochondrial membrane  (IEA)
mitochondrion  (ISO)
motile cilium  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Sorbitol dehydrogenase: a novel target for adjunctive protection of ischemic myocardium. Hwang YC, etal., FASEB J. 2003 Dec;17(15):2331-3. Epub 2003 Oct 2.
4. Crystal structure of sorbitol dehydrogenase. Johansson K, etal., Chem Biol Interact. 2001 Jan 30;130-132(1-3):351-8.
5. Sorbitol dehydrogenase: cDNA coding for the rat enzyme. Variations within the alcohol dehydrogenase family independent of quaternary structure and metal content. Karlsson C, etal., Eur J Biochem 1991 Jun 15;198(3):761-5.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Effect of an aqueous extract of Scoparia dulcis on blood glucose, plasma insulin and some polyol pathway enzymes in experimental rat diabetes. Latha M and Pari L, Braz J Med Biol Res. 2004 Apr;37(4):577-86. Epub 2004 Mar 23.
8. Gene expression of enzymes comprising the polyol pathway in various rat tissues determined by the competitive RT-PCR method. Maekawa K, etal., Jpn J Pharmacol 2002 Jan;88(1):123-6.
9. Hepatic fructose-metabolizing enzymes and related metabolites: role of dietary copper and gender. Millo H and Werman MJ, J Nutr Biochem. 2000 Jul-Aug;11(7-8):374-81.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. A potent sorbitol dehydrogenase inhibitor exacerbates sympathetic autonomic neuropathy in rats with streptozotocin-induced diabetes. Schmidt RE, etal., Exp Neurol. 2005 Apr;192(2):407-19.
17. Effects of thyroid hormone on the sorbitol pathway in streptozotocin-induced diabetic rats. Shinohara R, etal., Biochim Biophys Acta. 1998 Nov 27;1425(3):577-86.
18. Osmoregulation of aldose reductase and sorbitol dehydrogenase in cultivated interstitial cells of rat renal inner medulla. Steffgen J, etal., Nephrol Dial Transplant. 2003 Nov;18(11):2255-61.
19. Modulation of the flux patterns in carbohydrate metabolism in the livers of streptozoticin-induced diabetic rats by dietary caloric restriction. Ugochukwu NH and Figgers CL, Pharmacol Res. 2006 Sep;54(3):172-80. Epub 2006 May 1.
20. Sorbitol dehydrogenase. Full-length cDNA sequencing reveals a mRNA coding for a protein containing an additional 42 amino acids at the N-terminal end. Wen Y and Bekhor I, Eur J Biochem 1993 Oct 1;217(1):83-7.
21. Attenuation of cadmium-induced liver injury in senescent male fischer 344 rats: role of metallothionein and glutathione. Yamano T, etal., Toxicol Appl Pharmacol. 1999 Dec 15;161(3):225-30.
Additional References at PubMed
PMID:722274   PMID:1914521   PMID:3365415   PMID:6626150   PMID:6870831   PMID:7171128   PMID:8487505   PMID:12477932   PMID:12962626   PMID:14965227   PMID:15489334   PMID:16189514  
PMID:16396499   PMID:18799757   PMID:19056867   PMID:21516116   PMID:21557262   PMID:23376485   PMID:23533145   PMID:31515488   PMID:38538210  


Genomics

Comparative Map Data
Sord
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,638,282 - 129,669,727 (+)NCBIGRCr8
mRatBN7.23109,184,697 - 109,216,133 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,184,676 - 109,216,133 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3112,858,692 - 112,889,823 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,454,207 - 121,485,340 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,114,585 - 119,145,718 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03114,176,127 - 114,207,368 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,176,309 - 114,207,366 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,716,804 - 120,746,951 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,016,830 - 109,048,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13108,922,464 - 108,953,299 (+)NCBI
Celera3108,082,883 - 108,113,935 (+)NCBICelera
Cytogenetic Map3q35NCBI
SORD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381545,023,195 - 45,077,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1545,023,147 - 45,077,185 (+)EnsemblGRCh38hg38GRCh38
GRCh371545,315,393 - 45,369,383 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,102,633 - 43,154,331 (+)NCBINCBI36Build 36hg18NCBI36
Build 341543,102,643 - 43,154,330NCBI
Celera1522,206,385 - 22,258,718 (+)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1522,139,528 - 22,191,494 (+)NCBIHuRef
CHM1_11545,433,621 - 45,485,599 (+)NCBICHM1_1
T2T-CHM13v2.01542,831,215 - 42,885,202 (+)NCBIT2T-CHM13v2.0
Sord
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,065,320 - 122,095,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2122,065,230 - 122,095,821 (+)EnsemblGRCm39 Ensembl
GRCm382122,234,839 - 122,265,337 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,234,749 - 122,265,340 (+)EnsemblGRCm38mm10GRCm38
MGSCv372122,060,575 - 122,091,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362121,926,280 - 121,956,778 (+)NCBIMGSCv36mm8
Celera2123,384,583 - 123,415,681 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.59NCBI
Sord
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,303,602 - 8,333,869 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,305,819 - 8,333,733 (-)NCBIChiLan1.0ChiLan1.0
SORD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21634,263,121 - 34,315,300 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11538,441,294 - 38,493,458 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01523,971,017 - 24,025,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11542,363,854 - 42,375,848 (+)NCBIpanpan1.1PanPan1.1panPan2
SORD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,467,259 - 11,501,166 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,467,253 - 11,500,641 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,523,461 - 11,557,483 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03011,603,460 - 11,637,883 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3011,603,473 - 11,637,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13011,509,757 - 11,544,158 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03011,632,822 - 11,666,883 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03011,751,896 - 11,786,120 (+)NCBIUU_Cfam_GSD_1.0
Sord
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,912,015 - 89,957,526 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364717,760,052 - 7,795,671 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364717,760,097 - 7,805,475 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SORD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,655,156 - 126,701,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,659,198 - 126,701,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,259,120 - 141,301,021 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SORD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,129,236 - 38,173,867 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2638,126,911 - 38,155,381 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048102,884,429 - 102,931,888 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sord
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,156,522 - 14,185,989 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,159,439 - 14,185,960 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sord
133 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:97
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000023350
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH130513  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0990,799,524 - 90,799,742NCBIRnor5.0
Rnor_5.0994,824,326 - 94,824,544NCBIRnor5.0
Rnor_5.03120,745,107 - 120,745,994NCBIRnor5.0
RGSC_v3.43109,046,603 - 109,047,489UniSTSRGSC3.4
RGSC_v3.4986,930,977 - 86,931,194UniSTSRGSC3.4
Celera3108,112,092 - 108,112,978UniSTS
Celera986,202,725 - 86,202,942UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map3q35UniSTS
RH141218  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0990,798,495 - 90,798,697NCBIRnor5.0
Rnor_5.0994,823,297 - 94,823,499NCBIRnor5.0
Rnor_5.03120,746,689 - 120,746,892NCBIRnor5.0
RGSC_v3.43109,048,185 - 109,048,387UniSTSRGSC3.4
RGSC_v3.4986,929,948 - 86,930,149UniSTSRGSC3.4
Celera3108,113,674 - 108,113,876UniSTS
Celera986,201,696 - 86,201,897UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map3q35UniSTS
BF387718  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,196,074 - 109,196,224 (+)MAPPERmRatBN7.2
Rnor_6.03114,187,310 - 114,187,459NCBIRnor6.0
Rnor_5.03120,727,982 - 120,728,131UniSTSRnor5.0
RGSC_v3.43109,027,831 - 109,027,980UniSTSRGSC3.4
Celera3108,093,882 - 108,094,031UniSTS
RH 3.4 Map3948.5UniSTS
Cytogenetic Map3q35UniSTS
PMC86057P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,191,235 - 109,191,478 (+)MAPPERmRatBN7.2
mRatBN7.210103,036,286 - 103,036,632 (+)MAPPERmRatBN7.2
Rnor_6.010106,819,088 - 106,819,433NCBIRnor6.0
Rnor_6.03114,182,471 - 114,182,713NCBIRnor6.0
Rnor_5.03120,723,143 - 120,723,385UniSTSRnor5.0
Rnor_5.010106,458,313 - 106,458,658UniSTSRnor5.0
RGSC_v3.43109,022,992 - 109,023,234UniSTSRGSC3.4
Celera10101,596,270 - 101,596,615UniSTS
Celera3108,089,043 - 108,089,285UniSTS
Cytogenetic Map3q35UniSTS
G36383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,202,714 - 109,203,305 (+)MAPPERmRatBN7.2
Rnor_6.03114,193,949 - 114,194,539NCBIRnor6.0
Rnor_5.03120,733,532 - 120,734,122UniSTSRnor5.0
RGSC_v3.43109,035,027 - 109,035,617UniSTSRGSC3.4
Celera3108,100,521 - 108,101,111UniSTS
Cytogenetic Map3q35UniSTS
UniSTS:547147  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,215,127 - 109,216,002 (+)MAPPERmRatBN7.2
Rnor_6.03114,206,363 - 114,207,237NCBIRnor6.0
Rnor_5.03120,745,946 - 120,746,820UniSTSRnor5.0
Celera3108,112,930 - 108,113,804UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000023350   ⟹   ENSRNOP00000023350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3109,184,676 - 109,216,133 (+)Ensembl
Rnor_6.0 Ensembl3114,176,309 - 114,207,366 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117801   ⟹   ENSRNOP00000084990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3109,184,692 - 109,216,131 (+)Ensembl
RefSeq Acc Id: NM_017052   ⟹   NP_058748
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,638,668 - 129,669,727 (+)NCBI
mRatBN7.23109,185,074 - 109,216,133 (+)NCBI
Rnor_6.03114,176,309 - 114,207,368 (+)NCBI
Rnor_5.03120,716,804 - 120,746,951 (+)NCBI
RGSC_v3.43109,016,830 - 109,048,446 (+)RGD
Celera3108,082,883 - 108,113,935 (+)RGD
Sequence:
RefSeq Acc Id: XM_017591474   ⟹   XP_017446963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,638,282 - 129,669,727 (+)NCBI
mRatBN7.23109,184,697 - 109,216,133 (+)NCBI
Rnor_6.03114,176,127 - 114,207,368 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063283108   ⟹   XP_063139178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,638,305 - 129,669,727 (+)NCBI
RefSeq Acc Id: NP_058748   ⟸   NM_017052
- UniProtKB: Q4FZY4 (UniProtKB/Swiss-Prot),   A2VCV9 (UniProtKB/Swiss-Prot),   Q5I0F3 (UniProtKB/Swiss-Prot),   P27867 (UniProtKB/Swiss-Prot),   A6HPS1 (UniProtKB/TrEMBL),   A0A8L2QD42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446963   ⟸   XM_017591474
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2A0 (UniProtKB/TrEMBL),   A0A8L2QD42 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023350   ⟸   ENSRNOT00000023350
Ensembl Acc Id: ENSRNOP00000084990   ⟸   ENSRNOT00000117801
RefSeq Acc Id: XP_063139178   ⟸   XM_063283108
- Peptide Label: isoform X2
Protein Domains
Alcohol dehydrogenase-like N-terminal   Enoyl reductase (ER)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27867-F1-model_v2 AlphaFold P27867 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692366
Promoter ID:EPDNEW_R2891
Type:initiation region
Name:Sord_1
Description:sorbitol dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03114,176,338 - 114,176,398EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3734 AgrOrtholog
BioCyc Gene G2FUF-48105 BioCyc
Ensembl Genes ENSRNOG00000017291 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023350.7 UniProtKB/TrEMBL
  ENSRNOT00000117801.1 UniProtKB/TrEMBL
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112546 IMAGE-MGC_LOAD
  IMAGE:7373210 IMAGE-MGC_LOAD
  IMAGE:8373758 IMAGE-MGC_LOAD
InterPro ADH-like_C UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  ADH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_Zn_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKS_ER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDH-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114337 IMAGE-MGC_LOAD
  MGC:156505 IMAGE-MGC_LOAD
  MGC:93504 IMAGE-MGC_LOAD
NCBI Gene 24788 ENTREZGENE
PANTHER SORBITOL DEHYDROGENASE UniProtKB/Swiss-Prot
  SORBITOL DEHYDROGENASE UniProtKB/Swiss-Prot
  SORBITOL DEHYDROGENASE UniProtKB/TrEMBL
  SORBITOL DEHYDROGENASE UniProtKB/TrEMBL
Pfam ADH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sord PhenoGen
PROSITE ADH_ZINC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017291 RatGTEx
SMART PKS_ER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A2A0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QD42 ENTREZGENE, UniProtKB/TrEMBL
  A2VCV9 ENTREZGENE
  A6HPS1 ENTREZGENE, UniProtKB/TrEMBL
  A6HPS2_RAT UniProtKB/TrEMBL
  A6HPS3_RAT UniProtKB/TrEMBL
  A6HPS5_RAT UniProtKB/TrEMBL
  DHSO_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4FZY4 ENTREZGENE
  Q5I0F3 ENTREZGENE
UniProt Secondary A2VCV9 UniProtKB/Swiss-Prot
  Q4FZY4 UniProtKB/Swiss-Prot
  Q5I0F3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Sord  sorbitol dehydrogenase    Sorbitol dehydrogenase  Symbol and Name updated 629477 APPROVED
2002-06-10 Sord  Sorbitol dehydrogenase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the zinc-containing alcohol dehydrogenase family 634068