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Strain Registration

Strain: F344/NSlc

Symbol: F344/NSlc
Strain: F344
Substrain: NSlc
RGD ID: 1302627
Citation ID: RRID:RGD_1302627
Ontology ID: RS:0000364
Previously known as: NBRP Rat No: 0156; MDC-01-72; F344/Slc
Type: inbred
Source: National BioResource Project for the Rat in Japan
Origin: Strain originated from Japan SLC, Inc, Shizuoka, Japan.
Coat Color: Albino
Inbred Generations: F188
Last Known Status: Live Animals





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
blood glucose level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood glucose level area under curve (AUC)
mesenteric fat pad weight
retroperitoneal fat pad weight
epididymal fat pad weight
serum insulin level
serum triglyceride level
serum total cholesterol level
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
serum free fatty acids level
plasma triglyceride level
serum adiponectin level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
retroperitoneal fat pad weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
mesenteric fat pad weight to body weight ratio
epididymal fat pad weight to body weight ratio
serum leptin level
adipocyte basal free fatty acid secretion
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Identification of a major locus for islet inflammation and fibrosis in the Spontaneously Diabetic Torii rat. Fuse M, etal., Physiol Genomics. 2008 Jul 8;.
2. Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. Kinboshi M, etal., Int J Mol Sci. 2019 Feb 26;20(5). pii: ijms20051013. doi: 10.3390/ijms20051013.
3. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
4. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
7. New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats. Sasaki D, etal., Mamm Genome. 2015 Dec;26(11-12):619-29. doi: 10.1007/s00335-015-9597-4. Epub 2015 Aug 22.
8. Chromosomal mapping of host resistance loci to Trichinella spiralis nematode infection in rats. Suzuki T, etal., Immunogenetics. 2006 Feb 8;:1-5.

Region

Cell Lines
Symbol
F344/NSlc-ES37/Nips

Strain QTL Data
Symbol Name Trait
Bw82 Body weight QTL 82 body mass   (VT:0001259)    
Gluco35 Glucose level QTL 35 blood glucose amount   (VT:0000188)    
Gluco36 Glucose level QTL 36 blood glucose amount   (VT:0000188)    
Gluco37 Glucose level QTL 37 blood glucose amount   (VT:0000188)    
Gluco38 Glucose level QTL 38 blood glucose amount   (VT:0000188)    
Tspe1 Trichinella spiralis expulsion QTL 1 parasite quantity   (VT:0010441)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
F344/NSlc (KyushuU) 1192


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_infection displays weak host response to infection by intestinal nematode parasite Trichinella spiralis 1578305

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-10 F344/NSlc    F344/NSlc    Name updated 68913 APPROVED
2012-05-10 F344/NSlc    F344/NSlc    Name updated 68913 APPROVED