Slc28a2 (solute carrier family 28 member 2) - Rat Genome Database

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Gene: Slc28a2 (solute carrier family 28 member 2) Rattus norvegicus
Analyze
Symbol: Slc28a2
Name: solute carrier family 28 member 2
RGD ID: 61840
Description: Enables nucleoside:sodium symporter activity. Involved in protein localization to cell surface and retina homeostasis. Located in coated vesicle; plasma membrane; and vesicle membrane. Orthologous to human SLC28A2 (solute carrier family 28 member 2); PARTICIPATES IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CNT 2; concentrative nucleoside transporter 2; LOC102556085; Na(+)/nucleoside cotransporter 2; rCNT2; sodium-coupled nucleoside transporter 2; sodium/nucleoside cotransporter 2; sodium/nucleoside cotransporter 2-like; sodium/purine nucleoside cotransporter; solute carrier family 28 (concentrative nucleoside transporter), member 2; solute carrier family 28 (sodium-coupled nucleoside transporter) member 2; solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; solute carrier family 28, member 2; SPNT
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23109,324,815 - 109,387,702 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,366,996 - 109,387,702 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3113,039,238 - 113,060,743 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03121,634,754 - 121,656,259 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03119,295,132 - 119,316,637 (+)NCBIRnor_WKY
Rnor_6.03114,355,003 - 114,647,382 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,355,798 - 114,647,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,897,082 - 120,921,371 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,350,531 - 109,372,027 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13109,256,103 - 109,277,600 (-)NCBI
Celera3108,262,866 - 108,284,103 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
acrylamide  (EXP)
adenosine  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
coumarin  (EXP)
D-penicillamine  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dimethylarsinic acid  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
flutamide  (EXP)
genistein  (EXP)
gentamycin  (EXP)
indole-3-methanol  (EXP)
leflunomide  (EXP)
methimazole  (EXP)
methylarsonic acid  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
permethrin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium dichromate  (EXP,ISO)
succimer  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
topotecan  (EXP)
tributylstannane  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
uridine  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Demonstration of the existence of mRNAs encoding N1/cif and N2/cit sodium/nucleoside cotransporters in rat brain. Anderson CM, etal., Brain Res Mol Brain Res 1996 Dec;42(2):358-61.
2. Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter. Che M, etal., J Biol Chem 1995 Jun 9;270(23):13596-9.
3. Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells. Fernandez-Veledo S, etal., Biochem J. 2006 Apr 15;395(2):337-44.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Characterization of the rat Na+/nucleoside cotransporter 2 and transport of nucleoside-derived drugs using electrophysiological methods. Larrayoz IM, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1395-404. Epub 2006 Jul 12.
7. Cloned blood-brain barrier adenosine transporter is identical to the rat concentrative Na+ nucleoside cotransporter CNT2. Li JY, etal., J Cereb Blood Flow Metab 2001 Aug;21(8):929-36.
8. Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum. Melani A, etal., Exp Neurol. 2012 Jan;233(1):193-204. doi: 10.1016/j.expneurol.2011.09.036. Epub 2011 Oct 6.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Study on intestinal absorption sites of mizoribine and ribavirin, substrates for concentrative nucleoside transporter(s), in rats. Mori N, etal., Eur J Pharmacol. 2010 Feb 25;628(1-3):214-9. Epub 2009 Dec 2.
11. Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier. Nagase K, etal., Biochim Biophys Acta. 2006 Jan;1758(1):13-9. Epub 2006 Feb 2.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: effect of diabetes. Rodriguez-Mulero S, etal., Kidney Int. 2005 Aug;68(2):665-72.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Transport of adenosine by recombinant purine- and pyrimidine-selective sodium/nucleoside cotransporters from rat jejunum expressed in Xenopus laevis oocytes. Yao SY, etal., Mol Pharmacol 1996 Dec;50(6):1529-35.
Additional References at PubMed
PMID:1315767   PMID:10721696   PMID:15024061   PMID:15287894   PMID:16840788   PMID:17013559   PMID:20421393   PMID:22136384   PMID:22354287   PMID:23819782   PMID:25315414   PMID:28322028  


Genomics

Comparative Map Data
Slc28a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23109,324,815 - 109,387,702 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,366,996 - 109,387,702 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3113,039,238 - 113,060,743 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03121,634,754 - 121,656,259 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03119,295,132 - 119,316,637 (+)NCBIRnor_WKY
Rnor_6.03114,355,003 - 114,647,382 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,355,798 - 114,647,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,897,082 - 120,921,371 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,350,531 - 109,372,027 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13109,256,103 - 109,277,600 (-)NCBI
Celera3108,262,866 - 108,284,103 (+)NCBICelera
Cytogenetic Map3q35NCBI
SLC28A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381545,252,234 - 45,277,846 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1545,252,234 - 45,277,846 (+)EnsemblGRCh38hg38GRCh38
GRCh371545,544,432 - 45,570,044 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,331,726 - 43,355,425 (+)NCBINCBI36Build 36hg18NCBI36
Build 341543,331,725 - 43,355,425NCBI
Celera1522,435,715 - 22,459,420 (+)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1522,368,444 - 22,392,157 (+)NCBIHuRef
CHM1_11545,662,894 - 45,686,614 (+)NCBICHM1_1
T2T-CHM13v2.01543,060,158 - 43,086,086 (+)NCBIT2T-CHM13v2.0
Slc28a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,256,836 - 122,291,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2122,256,958 - 122,291,618 (+)EnsemblGRCm39 Ensembl
GRCm382122,426,357 - 122,461,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,426,477 - 122,461,137 (+)EnsemblGRCm38mm10GRCm38
MGSCv372122,252,213 - 122,286,866 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362122,117,918 - 122,152,571 (+)NCBIMGSCv36mm8
Celera2123,576,831 - 123,613,534 (+)NCBICelera
Cytogenetic Map2E5NCBI
Slc28a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,144,304 - 8,175,360 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,145,723 - 8,175,256 (-)NCBIChiLan1.0ChiLan1.0
SLC28A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11542,554,204 - 42,577,891 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1542,554,142 - 42,578,096 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01524,199,846 - 24,223,378 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Slc28a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864090,088,338 - 90,119,863 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364717,937,490 - 7,967,568 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364717,937,490 - 7,967,568 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC28A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,472,525 - 126,511,095 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,472,500 - 126,511,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,072,725 - 141,110,169 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC28A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12637,927,200 - 37,956,729 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048103,107,096 - 103,134,707 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc28a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473113,998,505 - 14,025,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473113,999,029 - 14,051,964 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc28a2
1324 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:87
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000036435
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat

Markers in Region
RH127610  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,534,736 - 109,534,918 (+)MAPPERmRatBN7.2
Rnor_6.03114,379,146 - 114,379,328NCBIRnor6.0
Rnor_5.03120,920,944 - 120,921,126UniSTSRnor5.0
RGSC_v3.43109,199,517 - 109,199,698UniSTSRGSC3.4
RH 3.4 Map3954.4UniSTS
Cytogenetic Map3q35UniSTS
RH131217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,387,372 - 109,387,564 (+)MAPPERmRatBN7.2
Rnor_6.03114,647,053 - 114,647,244NCBIRnor6.0
Rnor_5.03121,185,952 - 121,186,143UniSTSRnor5.0
RGSC_v3.43109,350,669 - 109,350,860UniSTSRGSC3.4
Celera3108,476,193 - 108,476,389UniSTS
Celera3108,283,774 - 108,283,965UniSTS
RH 3.4 Map3953.5UniSTS
Cytogenetic Map3q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 10 25 15 18 15 27 3 4
Low 1 33 32 26 1 26 8 11 47 35 36 7 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024658   ⟹   ENSRNOP00000024658
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3109,366,996 - 109,387,702 (+)Ensembl
Rnor_6.0 Ensembl3114,355,798 - 114,647,382 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000036435   ⟹   ENSRNOP00000034564
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3114,355,814 - 114,378,941 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083380
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3114,650,518 - 114,652,214 (+)Ensembl
RefSeq Acc Id: NM_031664   ⟹   NP_113852
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23109,366,196 - 109,387,702 (+)NCBI
Rnor_6.03114,355,003 - 114,647,382 (+)NCBI
Rnor_5.03120,897,082 - 120,921,371 (+)NCBI
RGSC_v3.43109,350,531 - 109,372,027 (-)RGD
Celera3108,262,866 - 108,284,103 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105767   ⟹   XP_038961695
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23109,324,815 - 109,387,699 (+)NCBI
RefSeq Acc Id: XM_039105768   ⟹   XP_038961696
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23109,363,227 - 109,387,185 (+)NCBI
RefSeq Acc Id: XM_039105769   ⟹   XP_038961697
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23109,324,815 - 109,387,699 (+)NCBI
RefSeq Acc Id: XM_039105770   ⟹   XP_038961698
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23109,366,528 - 109,387,185 (+)NCBI
RefSeq Acc Id: XR_005501974
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23109,363,227 - 109,385,722 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_113852   ⟸   NM_031664
- UniProtKB: F1LN73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024658   ⟸   ENSRNOT00000024658
RefSeq Acc Id: ENSRNOP00000034564   ⟸   ENSRNOT00000036435
RefSeq Acc Id: XP_038961695   ⟸   XM_039105767
- Peptide Label: isoform X1
- UniProtKB: F1LN73 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961697   ⟸   XM_039105769
- Peptide Label: isoform X1
- UniProtKB: F1LN73 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961696   ⟸   XM_039105768
- Peptide Label: isoform X1
- UniProtKB: F1LN73 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961698   ⟸   XM_039105770
- Peptide Label: isoform X1
- UniProtKB: F1LN73 (UniProtKB/TrEMBL)
Protein Domains
Gate   Nucleos_tra2_C   Nucleos_tra2_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62773-F1-model_v2 AlphaFold Q62773 1-659 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692368
Promoter ID:EPDNEW_R2893
Type:single initiation site
Name:Slc28a2_1
Description:solute carrier family 28 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03114,355,796 - 114,355,856EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61840 AgrOrtholog
BioCyc Gene G2FUF-48096 BioCyc
Ensembl Genes ENSRNOG00000028668 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000052651 Ensembl
Ensembl Protein ENSRNOP00000024658 ENTREZGENE
  ENSRNOP00000024658.7 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024658 ENTREZGENE
  ENSRNOT00000024658.8 UniProtKB/TrEMBL
InterPro C_nuclsd_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_nuclsd_transpt_met_bac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNT1/CNT2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNT_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNT_N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gate_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60423 UniProtKB/Swiss-Prot
NCBI Gene 60423 ENTREZGENE
PANTHER PTHR10590 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10590:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gate UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleos_tra2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleos_tra2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC28A2 RGD
PhenoGen Slc28a2 PhenoGen
TIGR TC230283
TIGRFAMs nupC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C1PHX8_RAT UniProtKB/TrEMBL
  F1LN73 ENTREZGENE, UniProtKB/TrEMBL
  Q62773 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9QWI3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Slc28a2  solute carrier family 28 member 2  LOC102556085  sodium/nucleoside cotransporter 2-like  Data Merged 737654 PROVISIONAL
2016-02-24 Slc28a2  solute carrier family 28 member 2  Slc28a2  solute carrier family 28 (concentrative nucleoside transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-25 Slc28a2  solute carrier family 28 (concentrative nucleoside transporter), member 2  Slc28a2  solute carrier family 28 (sodium-coupled nucleoside transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-17 LOC102556085  sodium/nucleoside cotransporter 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Slc28a2  solute carrier family 28 (sodium-coupled nucleoside transporter), member 2    solute carrier family 28, member 2   Name updated 1299863 APPROVED
2002-06-10 Slc28a2  solute carrier family 28, member 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference