Atp8b4 (ATPase phospholipid transporting 8B4 (putative))

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Gene: Atp8b4 (ATPase phospholipid transporting 8B4 (putative)) Rattus norvegicus

Analyze

Symbol:

Atp8b4

Name:

ATPase phospholipid transporting 8B4 (putative)

RGD ID:

1306712

Description:

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and magnesium ion binding activity. Predicted to be involved in lipid translocation and phospholipid transport. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be part of phospholipid-translocating ATPase complex. Orthologous to human ATP8B4 (ATPase phospholipid transporting 8B4 (putative)); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ATPase, class I, type 8B, member 4; LOC311396; MGC114491; probable phospholipid-transporting ATPase IM

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	113,554,979 - 113,757,635 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	113,556,192 - 113,757,225 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	118,591,560 - 118,968,210 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	118,591,880 - 118,959,850 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	125,118,786 - 125,496,913 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	113,781,099 - 113,943,532 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	113,686,500 - 113,707,372 (-)	NCBI
Celera	3	112,402,538 - 112,609,732 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

butanal (ISO)

cadmium atom (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cytarabine (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

entinostat (ISO)

glyphosate (EXP)

lidocaine (EXP)

lipopolysaccharide (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (ISO)

N-Nitrosopyrrolidine (ISO)

O-methyleugenol (ISO)

ozone (ISO)

phenobarbital (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

testosterone (EXP,ISO)

trichloroethene (EXP)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Golgi organization (IBA)

lipid translocation (IEA)

phospholipid translocation (IBA)

phospholipid transport (IEA)

Cellular Component

Golgi apparatus (ISO)

phospholipid-translocating ATPase complex (ISO)

plasma membrane (IBA,ISO)

trans-Golgi network (IBA)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATPase-coupled intramembrane lipid transporter activity (IBA,IEA)

magnesium ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:20947505

Genomics

Comparative Map Data

Atp8b4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	113,554,979 - 113,757,635 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	113,556,192 - 113,757,225 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	118,591,560 - 118,968,210 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	118,591,880 - 118,959,850 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	125,118,786 - 125,496,913 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	113,781,099 - 113,943,532 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	113,686,500 - 113,707,372 (-)	NCBI
Celera	3	112,402,538 - 112,609,732 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

ATP8B4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	49,858,238 - 50,181,854 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	15	49,858,238 - 50,182,817 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	50,150,435 - 50,411,430 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	47,937,727 - 48,198,711 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	47,937,726 - 48,198,711	NCBI
Celera	15	27,043,704 - 27,304,104 (-)	NCBI		Celera
Cytogenetic Map	15	q21.2	NCBI
HuRef	15	26,981,828 - 27,242,532 (-)	NCBI		HuRef
CHM1_1	15	50,268,431 - 50,528,997 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	47,666,646 - 47,927,519 (-)	NCBI		T2T-CHM13v2.0

Atp8b4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	126,162,893 - 126,342,589 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	126,162,893 - 126,342,594 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	126,320,973 - 126,500,669 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	126,320,973 - 126,500,674 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	126,146,709 - 126,317,289 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	126,012,414 - 126,192,115 (-)	NCBI		MGSCv36	mm8
Celera	2	127,555,887 - 127,728,606 (-)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI

Atp8b4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	4,183,493 - 4,381,356 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	4,148,110 - 4,383,309 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATP8B4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	15	47,127,325 - 47,389,559 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	47,129,277 - 47,389,559 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	15	28,803,848 - 29,060,526 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ATP8B4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	15,885,680 - 16,122,486 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	15,887,677 - 16,122,989 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	15,812,094 - 16,048,684 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	16,030,527 - 16,266,370 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	16,030,561 - 16,258,516 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	15,953,137 - 16,188,955 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	16,068,395 - 16,306,433 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	16,174,848 - 16,412,807 (-)	NCBI		UU_Cfam_GSD_1.0

Atp8b4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	94,150,968 - 94,379,397 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	12,000,789 - 12,216,039 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936471	11,999,100 - 12,216,076 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP8B4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	121,650,951 - 121,914,712 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	121,629,072 - 121,914,633 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	135,295,195 - 135,487,660 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATP8B4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	33,190,645 - 33,510,406 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	33,256,406 - 33,446,584 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	107,701,733 - 107,959,478 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atp8b4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	9,964,909 - 10,162,739 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	9,934,010 - 10,164,530 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Atp8b4
1427 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	188
Count of miRNA genes:	135
Interacting mature miRNAs:	152
Transcripts:	ENSRNOT00000055975
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	80800231	114297550	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	96127817	115665732	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	102200529	115665732	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	112287552	135181505	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat

Markers in Region

MHAa59h6.seq

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	110,036,472 - 110,036,624 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	118,786,253 - 118,786,404	NCBI	Rnor6.0
Rnor_5.0	3	125,315,841 - 125,315,992	UniSTS	Rnor5.0
RGSC_v3.4	3	109,887,883 - 109,888,034	UniSTS	RGSC3.4
Celera	3	108,921,698 - 108,921,849	UniSTS
Cytogenetic Map	3	q36	UniSTS

AU048488

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	113,660,761 - 113,660,880 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	118,872,436 - 118,872,554	NCBI	Rnor6.0
Rnor_5.0	3	125,402,024 - 125,402,142	UniSTS	Rnor5.0
RGSC_v3.4	3	113,885,083 - 113,885,201	UniSTS	RGSC3.4
Celera	3	112,507,754 - 112,507,872	UniSTS
Cytogenetic Map	3	q36	UniSTS

px-61b6

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	113,738,398 - 113,738,527 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	118,946,592 - 118,946,720	NCBI	Rnor6.0
Rnor_5.0	3	125,478,352 - 125,478,480	UniSTS	Rnor5.0
RGSC_v3.4	3	113,964,060 - 113,964,188	UniSTS	RGSC3.4
Celera	3	112,584,590 - 112,584,718	UniSTS
Cytogenetic Map	3	q36	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium					1						6	3
Low	3	27	53	37	18	37	6	6		13	20	8	6
Below cutoff		16	4	4		4	2	5	62	22	15		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_006224605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006224606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106843	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106844	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106848	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106851	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC158638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000055975

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	118,592,389 - 118,611,578 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000086357 ⟹ ENSRNOP00000075586

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	113,556,196 - 113,577,723 (-)	Ensembl
Rnor_6.0 Ensembl	3	118,591,880 - 118,635,268 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092750 ⟹ ENSRNOP00000075998

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	113,556,192 - 113,757,225 (-)	Ensembl
Rnor_6.0 Ensembl	3	118,641,220 - 118,959,850 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104093 ⟹ ENSRNOP00000084035

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	113,556,192 - 113,757,160 (-)	Ensembl

RefSeq Acc Id:

XM_039106841 ⟹ XP_038962769

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	113,554,979 - 113,756,737 (-)	NCBI

RefSeq Acc Id:

XM_039106842 ⟹ XP_038962770

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	113,554,979 - 113,757,635 (-)	NCBI

RefSeq Acc Id:

XM_039106843 ⟹ XP_038962771

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	113,554,979 - 113,750,474 (-)	NCBI

RefSeq Acc Id:

XM_039106844 ⟹ XP_038962772

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	113,554,979 - 113,756,844 (-)	NCBI

RefSeq Acc Id:

XM_039106845 ⟹ XP_038962773

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	113,554,979 - 113,754,110 (-)	NCBI

RefSeq Acc Id:

XM_039106846 ⟹ XP_038962774

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	113,554,979 - 113,756,738 (-)	NCBI

RefSeq Acc Id:

XM_039106847 ⟹ XP_038962775

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	113,554,979 - 113,756,737 (-)	NCBI

RefSeq Acc Id:

XM_039106848 ⟹ XP_038962776

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	113,554,979 - 113,699,490 (-)	NCBI

RefSeq Acc Id:

XM_039106849 ⟹ XP_038962777

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	113,554,979 - 113,756,737 (-)	NCBI

RefSeq Acc Id:

XM_039106850 ⟹ XP_038962778

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	113,587,416 - 113,756,739 (-)	NCBI

RefSeq Acc Id:

XM_039106851 ⟹ XP_038962779

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	113,554,979 - 113,640,701 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_038962769	(Get FASTA)	NCBI Sequence Viewer
	XP_038962770	(Get FASTA)	NCBI Sequence Viewer
	XP_038962771	(Get FASTA)	NCBI Sequence Viewer
	XP_038962772	(Get FASTA)	NCBI Sequence Viewer
	XP_038962773	(Get FASTA)	NCBI Sequence Viewer
	XP_038962774	(Get FASTA)	NCBI Sequence Viewer
	XP_038962775	(Get FASTA)	NCBI Sequence Viewer
	XP_038962776	(Get FASTA)	NCBI Sequence Viewer
	XP_038962777	(Get FASTA)	NCBI Sequence Viewer
	XP_038962778	(Get FASTA)	NCBI Sequence Viewer
	XP_038962779	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98940	(Get FASTA)	NCBI Sequence Viewer
	AAI58639	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000075998 ⟸ ENSRNOT00000092750

RefSeq Acc Id:

ENSRNOP00000075586 ⟸ ENSRNOT00000086357

RefSeq Acc Id:	XP_038962770 ⟸ XM_039106842
- Peptide Label:	isoform X1
- UniProtKB:	A0A1B0GWR9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038962772 ⟸ XM_039106844
- Peptide Label:	isoform X1
- UniProtKB:	A0A1B0GWR9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038962774 ⟸ XM_039106846
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038962777 ⟸ XM_039106849
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038962775 ⟸ XM_039106847
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038962769 ⟸ XM_039106841
- Peptide Label:	isoform X1
- UniProtKB:	A0A1B0GWR9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038962773 ⟸ XM_039106845
- Peptide Label:	isoform X1
- UniProtKB:	A0A1B0GWR9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038962771 ⟸ XM_039106843
- Peptide Label:	isoform X1
- UniProtKB:	A0A1B0GWR9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038962776 ⟸ XM_039106848
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5ZYK3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038962779 ⟸ XM_039106851
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_038962778 ⟸ XM_039106850
- Peptide Label:	isoform X6

RefSeq Acc Id:

ENSRNOP00000084035 ⟸ ENSRNOT00000104093

Protein Domains

PhoLip_ATPase_C PhoLip_ATPase_N

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A1B0GWR9-F1-model_v2	AlphaFold	A0A1B0GWR9	1-590	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306712	AgrOrtholog
BioCyc Gene	G2FUF-48026	BioCyc
Ensembl Genes	ENSRNOG00000031598	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000075586.3	UniProtKB/TrEMBL
	ENSRNOP00000075998	ENTREZGENE
	ENSRNOP00000075998.2	UniProtKB/TrEMBL
	ENSRNOP00000084035	ENTREZGENE
	ENSRNOP00000084035.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000086357.3	UniProtKB/TrEMBL
	ENSRNOT00000092750	ENTREZGENE
	ENSRNOT00000092750.2	UniProtKB/TrEMBL
	ENSRNOT00000104093	ENTREZGENE
	ENSRNOT00000104093.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.1110.10	UniProtKB/TrEMBL
	3.40.50.1000	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7456884	IMAGE-MGC_LOAD
InterPro	ATP8B4	UniProtKB/TrEMBL
	ATPase_P-typ_cyto_dom_N	UniProtKB/TrEMBL
	ATPase_P-typ_P_site	UniProtKB/TrEMBL
	ATPase_P-typ_TM_dom_sf	UniProtKB/TrEMBL
	ATPase_P-typ_transduc_dom_A_sf	UniProtKB/TrEMBL
	HAD-like_sf	UniProtKB/TrEMBL
	HAD_sf	UniProtKB/TrEMBL
	P-type_ATPase_IV	UniProtKB/TrEMBL
	P-type_ATPase_N	UniProtKB/TrEMBL
	P_typ_ATPase	UniProtKB/TrEMBL
	P_typ_ATPase_c	UniProtKB/TrEMBL
	P_typ_ATPase_HD_dom	UniProtKB/TrEMBL
MGC_CLONE	MGC:187554	IMAGE-MGC_LOAD
NCBI Gene	311396	ENTREZGENE
PANTHER	PTHR24092:SF80	UniProtKB/TrEMBL
Pfam	PhoLip_ATPase_C	UniProtKB/TrEMBL
	PhoLip_ATPase_N	UniProtKB/TrEMBL
PhenoGen	Atp8b4	PhenoGen
PROSITE	ATPASE_E1_E2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56784	UniProtKB/TrEMBL
	SSF81653	UniProtKB/TrEMBL
	SSF81660	UniProtKB/TrEMBL
	SSF81665	UniProtKB/TrEMBL
TIGRFAMs	ATPase-Plipid	UniProtKB/TrEMBL
	ATPase_P-type	UniProtKB/TrEMBL
UniProt	A0A1B0GWR9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZYK3	ENTREZGENE, UniProtKB/TrEMBL
	Q4KLY5_RAT	UniProtKB/TrEMBL
UniProt Secondary	A0A0G2KAZ5	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Atp8b4	ATPase phospholipid transporting 8B4 (putative)	Atp8b4	ATPase, class I, type 8B, member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Atp8b4	ATPase, class I, type 8B, member 4	Atp8b4_predicted	ATPase, class I, type 8B, member 4 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Atp8b4_predicted	ATPase, class I, type 8B, member 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar