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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Atp8b4 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Atp8b4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ATP8B4 mRNA | CTD | PMID:36331819 | Atp8b4 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ATP8B4 mRNA | CTD | PMID:32741896 | Atp8b4 | Rat | 17beta-estradiol | increases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | Estradiol results in increased expression of ATP8B4 mRNA | CTD | PMID:39298647 | Atp8b4 | Rat | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ATP8B4 mRNA | CTD | PMID:32741896 | Atp8b4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ATP8B4 mRNA | CTD | PMID:34747641 | Atp8b4 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Atp8b4 (Mus musculus) | 6480464 | bisphenol S affects the methylation of ATP8B4 gene | CTD | PMID:31683443 | Atp8b4 | Rat | aflatoxin B1 | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of ATP8B4 mRNA | CTD | PMID:32234424 | Atp8b4 | Rat | all-trans-retinoic acid | increases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of ATP8B4 mRNA | CTD | PMID:33167477 | Atp8b4 | Rat | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of ATP8B4 mRNA | CTD | PMID:30779732 | Atp8b4 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of ATP8B4 gene | CTD | PMID:28931070 | Atp8b4 | Rat | benzo[a]pyrene | decreases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of ATP8B4 mRNA | CTD | PMID:19770486 | Atp8b4 | Rat | benzo[a]pyrene | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of ATP8B4 mRNA | CTD | PMID:32234424 | Atp8b4 | Rat | benzo[a]pyrene | increases methylation | ISO | ATP8B4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ATP8B4 3' UTR | CTD | PMID:27901495 | Atp8b4 | Rat | benzo[a]pyrene | affects methylation | ISO | ATP8B4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ATP8B4 promoter | CTD | PMID:27901495 | Atp8b4 | Rat | benzo[a]pyrene | decreases methylation | ISO | ATP8B4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of ATP8B4 5' UTR | CTD | PMID:27901495 | Atp8b4 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ATP8B4 mRNA | CTD | PMID:25181051 | Atp8b4 | Rat | bisphenol A | affects methylation | ISO | ATP8B4 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of ATP8B4 gene | CTD | PMID:31601247 | Atp8b4 | Rat | bisphenol A | increases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of ATP8B4 mRNA | CTD | PMID:38701888 | Atp8b4 | Rat | buta-1,3-diene | decreases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | 1,3-butadiene results in decreased expression of ATP8B4 mRNA | CTD | PMID:29038090 | Atp8b4 | Rat | butanal | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of ATP8B4 mRNA | CTD | PMID:26079696 | Atp8b4 | Rat | cadmium atom | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | Cadmium results in decreased expression of ATP8B4 mRNA | CTD | PMID:24376830 | Atp8b4 | Rat | carbon nanotube | increases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of ATP8B4 mRNA | CTD | PMID:25554681 | Atp8b4 | Rat | chlorpyrifos | increases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of ATP8B4 mRNA | CTD | PMID:32715474 | Atp8b4 | Rat | chromium(6+) | multiple interactions | ISO | ATP8B4 (Homo sapiens) | 6480464 | [zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression more ... | CTD | PMID:38479592 | Atp8b4 | Rat | cytarabine | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | Cytarabine results in decreased expression of ATP8B4 mRNA | CTD | PMID:21198554 | Atp8b4 | Rat | dioxygen | increases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of ATP8B4 mRNA | CTD | PMID:20880076 | Atp8b4 | Rat | dorsomorphin | multiple interactions | ISO | ATP8B4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Atp8b4 | Rat | entinostat | increases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | entinostat results in increased expression of ATP8B4 mRNA | CTD | PMID:27188386 | Atp8b4 | Rat | glyphosate | decreases methylation | EXP | | 6480464 | Glyphosate results in decreased methylation of ATP8B4 gene | CTD | PMID:31011160 | Atp8b4 | Rat | GSK-J4 | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | GSK-J4 results in decreased expression of ATP8B4 mRNA | CTD | PMID:29301935 | Atp8b4 | Rat | lidocaine | increases expression | EXP | | 6480464 | Lidocaine results in increased expression of ATP8B4 mRNA | CTD | PMID:35283115 | Atp8b4 | Rat | lipopolysaccharide | multiple interactions | ISO | ATP8B4 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of ATP8B4 mRNA | CTD | PMID:35811015 | Atp8b4 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of ATP8B4 gene | CTD | PMID:35440735 | Atp8b4 | Rat | mono(2-ethylhexyl) phthalate | decreases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of ATP8B4 mRNA | CTD | PMID:22401849 | Atp8b4 | Rat | N-nitrosodiethylamine | multiple interactions | ISO | Atp8b4 (Mus musculus) | 6480464 | MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATP8B4 mRNA] | CTD | PMID:17942915 | Atp8b4 | Rat | N-nitrosodiethylamine | decreases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | Diethylnitrosamine results in decreased expression of ATP8B4 mRNA | CTD | PMID:24535843 | Atp8b4 | Rat | N-nitrosodiethylamine | increases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of ATP8B4 mRNA | CTD | PMID:17942915 | Atp8b4 | Rat | N-Nitrosopyrrolidine | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in decreased expression of ATP8B4 mRNA | CTD | PMID:32234424 | Atp8b4 | Rat | O-methyleugenol | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of ATP8B4 mRNA | CTD | PMID:32234424 | Atp8b4 | Rat | ozone | multiple interactions | ISO | Atp8b4 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... | CTD | PMID:34911549 | Atp8b4 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Atp8b4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ATP8B4 mRNA | CTD | PMID:36331819 | Atp8b4 | Rat | phenobarbital | affects expression | ISO | Atp8b4 (Mus musculus) | 6480464 | Phenobarbital affects the expression of ATP8B4 mRNA | CTD | PMID:23091169 | Atp8b4 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | ATP8B4 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of ATP8B4 mRNA | CTD | PMID:35811015 | Atp8b4 | Rat | SB 431542 | multiple interactions | ISO | ATP8B4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Atp8b4 | Rat | silicon dioxide | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of ATP8B4 mRNA | CTD | PMID:25895662 | Atp8b4 | Rat | silicon dioxide | increases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of ATP8B4 mRNA | CTD | PMID:29341224 | Atp8b4 | Rat | sodium arsenite | decreases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of ATP8B4 mRNA | CTD | PMID:37682722 | Atp8b4 | Rat | testosterone | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of ATP8B4 mRNA | CTD | PMID:33359661 | Atp8b4 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ATP8B4 mRNA | CTD | PMID:32741896 | Atp8b4 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of ATP8B4 mRNA | CTD | PMID:33387578 | Atp8b4 | Rat | triptonide | increases expression | ISO | Atp8b4 (Mus musculus) | 6480464 | triptonide results in increased expression of ATP8B4 mRNA | CTD | PMID:33045310 | Atp8b4 | Rat | urethane | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | Urethane results in decreased expression of ATP8B4 mRNA | CTD | PMID:28818685 | Atp8b4 | Rat | valproic acid | increases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ATP8B4 mRNA | CTD | PMID:28001369 | Atp8b4 | Rat | vorinostat | decreases expression | ISO | ATP8B4 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of ATP8B4 mRNA | CTD | PMID:26272509 | Atp8b4 | Rat | vorinostat | multiple interactions | ISO | ATP8B4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | |