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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | multiple interactions | ISO | RGD:69015 | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of RYR3 mRNA | CTD | PMID:20660070 | 17beta-estradiol | decreases expression | ISO | RGD:69016 | 6480464 | Estradiol results in decreased expression of RYR3 mRNA | CTD | PMID:19484750 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:69016 | 6480464 | [AHR protein affects the susceptibility to Tetrachlorodibenzodioxin] which affects the expression of RYR3 mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of RYR3 mRNA | CTD | PMID:25975270, PMID:27163630 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RYR3 mRNA | CTD | PMID:32109520 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 3-methylcholanthrene | multiple interactions | ISO | RGD:69015 | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to RYR3 promoter] | CTD | PMID:20348232 | 8-Br-cAMP | increases expression | ISO | RGD:69015 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of RYR3 mRNA | CTD | PMID:22079614 | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of RYR3 mRNA | CTD | PMID:28606764 | Aflatoxin B2 alpha | increases methylation | ISO | RGD:69015 | 6480464 | aflatoxin B2 results in increased methylation of RYR3 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | RGD:69015 | 6480464 | Tretinoin results in increased expression of RYR3 protein | CTD | PMID:15894607 | all-trans-retinoic acid | multiple interactions | ISO | RGD:69015 | 6480464 | [Tretinoin co-treated with arsenic trioxide] results in increased expression of RYR3 protein | CTD | PMID:15894607 | arsane | affects methylation | ISO | RGD:69015 | 6480464 | Arsenic affects the methylation of RYR3 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | RGD:69015 | 6480464 | Arsenic affects the methylation of RYR3 gene | CTD | PMID:25304211 | arsenite(3-) | increases expression | ISO | RGD:69016 | 6480464 | arsenite results in increased expression of RYR3 mRNA | CTD | PMID:33053406 | arsenous acid | increases expression | ISO | RGD:69015 | 6480464 | Arsenic Trioxide results in increased expression of RYR3 protein | CTD | PMID:15894607 | arsenous acid | multiple interactions | ISO | RGD:69015 | 6480464 | [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of RYR3 protein | CTD | PMID:15894607 | benzo[a]pyrene | increases mutagenesis | ISO | RGD:69015 | 6480464 | Benzo(a)pyrene results in increased mutagenesis of RYR3 gene | CTD | PMID:25435355 | benzo[a]pyrene | decreases methylation | ISO | RGD:69015 | 6480464 | Benzo(a)pyrene results in decreased methylation of RYR3 promoter | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | RGD:69015 | 6480464 | benzo(e)pyrene results in increased methylation of RYR3 intron | CTD | PMID:30157460 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of RYR3 mRNA | CTD | PMID:25181051, PMID:34947998 | bisphenol A | increases expression | ISO | RGD:69016 | 6480464 | bisphenol A results in increased expression of RYR3 mRNA | CTD | PMID:30245210, PMID:32926169 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of RYR3 mRNA | CTD | PMID:19167457 | cadmium dichloride | increases expression | ISO | RGD:69016 | 6480464 | Cadmium Chloride results in increased expression of RYR3 mRNA | CTD | PMID:24982889 | CGP 52608 | multiple interactions | ISO | RGD:69015 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to RYR3 gene] | CTD | PMID:28238834 | clobetasol | decreases expression | ISO | RGD:69016 | 6480464 | Clobetasol results in decreased expression of RYR3 mRNA | CTD | PMID:27462272 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of RYR3 mRNA | CTD | PMID:20187946 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of RYR3 mRNA | CTD | PMID:26577399 | diarsenic trioxide | increases expression | ISO | RGD:69015 | 6480464 | Arsenic Trioxide results in increased expression of RYR3 protein | CTD | PMID:15894607 | diarsenic trioxide | multiple interactions | ISO | RGD:69015 | 6480464 | [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of RYR3 protein | CTD | PMID:15894607 | dimethylarsinic acid | multiple interactions | ISO | RGD:69016 | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of RYR3 mRNA | CTD | PMID:34876320 | dorsomorphin | multiple interactions | ISO | RGD:69015 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | RGD:69015 | 6480464 | Doxorubicin results in decreased expression of RYR3 mRNA | CTD | PMID:29803840 | entinostat | decreases expression | ISO | RGD:69015 | 6480464 | entinostat results in decreased expression of RYR3 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | RGD:69015 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA | CTD | PMID:27188386 | lead diacetate | multiple interactions | EXP | | 6480464 | [lead acetate results in increased abundance of Lead] which results in increased expression of RYR3 protein | CTD | PMID:30905827 | lead(0) | multiple interactions | EXP | | 6480464 | [lead acetate results in increased abundance of Lead] which results in increased expression of RYR3 protein | CTD | PMID:30905827 | lead(2+) | multiple interactions | EXP | | 6480464 | [lead acetate results in increased abundance of Lead] which results in increased expression of RYR3 protein | CTD | PMID:30905827 | methapyrilene | increases methylation | ISO | RGD:69015 | 6480464 | Methapyrilene results in increased methylation of RYR3 intron | CTD | PMID:30157460 | methylarsonic acid | multiple interactions | ISO | RGD:69016 | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of RYR3 mRNA | CTD | PMID:34876320 | methylmercury chloride | decreases expression | ISO | RGD:69015 | 6480464 | methylmercuric chloride results in decreased expression of RYR3 mRNA | CTD | PMID:28001369 | nickel atom | decreases expression | ISO | RGD:69015 | 6480464 | Nickel results in decreased expression of RYR3 mRNA | CTD | PMID:24768652, PMID:25583101 | panobinostat | multiple interactions | ISO | RGD:69015 | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA | CTD | PMID:27188386 | panobinostat | decreases expression | ISO | RGD:69015 | 6480464 | panobinostat results in decreased expression of RYR3 mRNA | CTD | PMID:26272509 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of RYR3 mRNA | CTD | PMID:32680482 | phenylmercury acetate | decreases expression | ISO | RGD:69015 | 6480464 | Phenylmercuric Acetate results in decreased expression of RYR3 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | RGD:69015 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA | CTD | PMID:27188386 | potassium dichromate | increases expression | ISO | RGD:69015 | 6480464 | Potassium Dichromate results in increased expression of RYR3 protein | CTD | PMID:23718831 | potassium dichromate | decreases expression | ISO | RGD:69016 | 6480464 | Potassium Dichromate results in decreased expression of RYR3 mRNA | CTD | PMID:23608068 | progesterone | multiple interactions | ISO | RGD:69015 | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of RYR3 mRNA | CTD | PMID:20660070 | SB 431542 | multiple interactions | ISO | RGD:69015 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenate | multiple interactions | ISO | RGD:69016 | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of RYR3 mRNA | CTD | PMID:34876320 | sodium arsenite | affects methylation | ISO | RGD:69015 | 6480464 | sodium arsenite affects the methylation of RYR3 gene | CTD | PMID:28589171 | sodium arsenite | multiple interactions | ISO | RGD:69016 | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of RYR3 mRNA | CTD | PMID:34876320 | sunitinib | decreases expression | ISO | RGD:69015 | 6480464 | Sunitinib results in decreased expression of RYR3 mRNA | CTD | PMID:31533062 | temozolomide | increases expression | ISO | RGD:69015 | 6480464 | Temozolomide results in increased expression of RYR3 mRNA | CTD | PMID:31758290 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of RYR3 mRNA | CTD | PMID:12734012 | thimerosal | increases expression | ISO | RGD:69015 | 6480464 | Thimerosal results in increased expression of RYR3 mRNA | CTD | PMID:27188386 | toluene | affects expression | EXP | | 6480464 | Toluene affects the expression of RYR3 mRNA | CTD | PMID:21827849 | trichostatin A | decreases expression | ISO | RGD:69015 | 6480464 | trichostatin A results in decreased expression of RYR3 mRNA | CTD | PMID:24935251, PMID:26272509 | trichostatin A | multiple interactions | ISO | RGD:69015 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA | CTD | PMID:27188386 | trimellitic anhydride | decreases expression | ISO | RGD:69016 | 6480464 | trimellitic anhydride results in decreased expression of RYR3 mRNA | CTD | PMID:19042947 | triptonide | increases expression | ISO | RGD:69016 | 6480464 | triptonide results in increased expression of RYR3 mRNA | CTD | PMID:33045310 | urethane | decreases expression | ISO | RGD:69015 | 6480464 | Urethane results in decreased expression of RYR3 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | RGD:69015 | 6480464 | Valproic Acid affects the expression of RYR3 mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | ISO | RGD:69015 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA | CTD | PMID:27188386 | valproic acid | decreases expression | ISO | RGD:69015 | 6480464 | Valproic Acid results in decreased expression of RYR3 mRNA | CTD | PMID:23179753 more ... | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of RYR3 mRNA | CTD | PMID:23869203 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of RYR3 gene | CTD | PMID:31682807 | vorinostat | multiple interactions | ISO | RGD:69015 | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RYR3 mRNA | CTD | PMID:27188386 | vorinostat | decreases expression | ISO | RGD:69015 | 6480464 | vorinostat results in decreased expression of RYR3 mRNA | CTD | PMID:26272509, PMID:27188386 | |