Ckmt1 (creatine kinase, mitochondrial 1)

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Gene: Ckmt1 (creatine kinase, mitochondrial 1) Rattus norvegicus

Analyze

Symbol:

Ckmt1

Name:

creatine kinase, mitochondrial 1

RGD ID:

61976

Description:

Exhibits creatine kinase activity and identical protein binding activity. Involved in animal organ development and digestive tract development. Localizes to mitochondrial inner-outer membrane contact site and perikaryon. Biomarker of status epilepticus. Orthologous to several human genes including CKMT1A (creatine kinase, mitochondrial 1A); PARTICIPATES IN cardiolipin metabolic pathway; INTERACTS WITH 1-bromopropane; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

acidic-type mitochondrial creatine kinase; Ckmt1b; creatine kinase U-type, mitochondrial; creatine kinase, mitochondrial 1, ubiquitous; creatine kinase, mitochondrial 1B; mia-CK; U-MtCK; ubiquitous mitochondrial creatine kinase

RGD Orthologs

Human

Mouse

Green Monkey

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CKMT1B (creatine kinase, mitochondrial 1B)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Ckmt1 (creatine kinase, mitochondrial 1, ubiquitous)	HGNC	Treefam, OMA, HomoloGene, Panther, Ensembl
Chlorocebus sabaeus (African green monkey):	LOC103246095 (creatine kinase U-type, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CKMT1A (creatine kinase, mitochondrial 1A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, Treefam
Alliance orthologs ³
Mus musculus (house mouse):	Ckmt1 (creatine kinase, mitochondrial 1, ubiquitous)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	CKMT1B (creatine kinase, mitochondrial 1B)	Alliance	DIOPT (HGNC\|TreeFam)
Homo sapiens (human):	CKMT1A (creatine kinase, mitochondrial 1A)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	ckmt1 (creatine kinase, mitochondrial 1)	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	CG30274	Alliance	DIOPT (PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	CG5144	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Caenorhabditis elegans (roundworm):	F32B5.1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	argk-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Argk	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	108,329,859 - 108,335,760 (+)	NCBI
Rnor_6.0 Ensembl	3	113,318,563 - 113,324,461 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	3	113,318,559 - 113,324,459 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	119,858,111 - 119,864,006 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	108,158,887 - 108,163,888 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	108,058,145 - 108,064,001 (+)	NCBI
Celera	3	107,232,840 - 107,237,770 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive nonsyndromic deafness 16 (ISO)

Bloom syndrome (ISO)

Brain Injuries (IEP)

colon cancer (ISO)

Sensorineural Deafness and Male Infertility (ISO)

status epilepticus (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-bromopropane (EXP)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,5-hexanedione (EXP)

2-acetamidofluorene (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP,ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

amphetamine (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

Brodifacoum (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

decabromodiphenyl ether (ISO)

dichlorine (EXP)

diethylstilbestrol (ISO)

dioxygen (ISO)

ethanol (ISO)

etoposide (ISO)

folic acid (ISO)

furan (EXP)

genistein (ISO)

isotretinoin (ISO)

methotrexate (ISO)

mitomycin C (ISO)

nicotine (ISO)

ozone (EXP)

PCB138 (EXP)

tamoxifen (ISO)

testosterone (EXP)

titanium dioxide (ISO)

tremolite asbestos (ISO)

trichloroethene (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (IEP)

cerebellum development (IEP)

digestive tract development (IEP)

kidney development (IEP)

negative regulation of apoptotic process (IEA,ISO)

negative regulation of protein binding (IEA,ISO)

phosphocreatine biosynthetic process (IBA,IEA)

phosphorylation (IEA)

skeletal muscle tissue development (IEP)

Cellular Component

mitochondrial inner membrane (IEA)

mitochondrial inner-outer membrane contact site (IDA)

mitochondrion (IBA,IDA,IEA,ISO)

perikaryon (IDA)

Molecular Function

ATP binding (IEA)

creatine kinase activity (IBA,IDA,IEA)

identical protein binding (IPI)

kinase activity (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cardiolipin metabolic pathway (ISO)

References

References - curated


1.	Briones TL, etal., Acta Neuropathol Commun. 2013 Sep 6;1:57. doi: 10.1186/2051-5960-1-57.
2.	Chen L, etal., J Comp Neurol. 1995 Dec 18;363(3):389-401.
3.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Kernec F, etal., Mol Cell Biochem. 1999 Apr;194(1-2):165-71.
5.	Kim DW, etal., BMC Neurosci. 2010 Oct 28;11:141. doi: 10.1186/1471-2202-11-141.
6.	Kottke M, etal., Biochim Biophys Acta. 1991 Jan 30;1061(2):215-25.
7.	MGD data from the GO Consortium
8.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	Payne RM and Strauss AW, Biochim Biophys Acta. 1994 Sep 13;1219(1):33-8.
10.	Payne RM, etal., Biochim Biophys Acta 1991 Jul 23;1089(3):352-61.
11.	Ren M, etal., Prog Lipid Res. 2014 Jul;55:1-16. doi: 10.1016/j.plipres.2014.04.001. Epub 2014 Apr 24.
12.	RGD automated data pipeline
13.	RGD automated import pipeline for gene-chemical interactions
14.	Shen W, etal., Biochem J 2002 Oct 15;367(Pt 2):369-80.

Additional References at PubMed

PMID:1939264	PMID:12477932	PMID:14651853	PMID:17634366	PMID:18614015	PMID:18629616	PMID:21370995	PMID:22871113	PMID:23376485	PMID:23620342	PMID:29476059

Genomics

Comparative Map Data

Ckmt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	108,329,859 - 108,335,760 (+)	NCBI
Rnor_6.0 Ensembl	3	113,318,563 - 113,324,461 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	3	113,318,559 - 113,324,459 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	119,858,111 - 119,864,006 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	108,158,887 - 108,163,888 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	108,058,145 - 108,064,001 (+)	NCBI
Celera	3	107,232,840 - 107,237,770 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

CKMT1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	15	43,593,054 - 43,604,901 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	15	43,592,857 - 43,599,406 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	15	43,885,055 - 43,891,604 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	41,672,544 - 41,678,896 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	15	41,673,545 - 41,678,874	NCBI
Celera	15	20,779,315 - 20,779,894 (+)	NCBI
Cytogenetic Map	15	q15.3	NCBI
HuRef	15	20,807,783 - 20,814,119 (+)	NCBI		HuRef
CHM1_1	15	44,003,044 - 44,009,651 (+)	NCBI		CHM1_1

Ckmt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	121,188,254 - 121,194,218 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	2	121,188,195 - 121,194,218 (+)	Ensembl
GRCm38	2	121,357,773 - 121,363,737 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	121,357,714 - 121,363,737 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	121,184,377 - 121,189,473 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	121,050,082 - 121,055,178 (+)	NCBI			mm8
Celera	2	122,509,569 - 122,514,651 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	60.37	NCBI

LOC103246095
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	39,397,797 - 39,401,046 (-)	NCBI
Vero_WHO_p1.0	NW_023666182	30,622 - 36,247 (-)	NCBI

Position Markers

MARC_3102-3103:991936731:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	108,330,997 - 108,331,718 (+)	MAPPER
Rnor_6.0	3	113,319,697 - 113,320,417	NCBI	Rnor6.0
Rnor_5.0	3	119,859,244 - 119,859,964	UniSTS	Rnor5.0
RGSC_v3.4	3	108,159,128 - 108,159,848	UniSTS	RGSC3.4
Celera	3	107,233,081 - 107,233,801	UniSTS
Cytogenetic Map	3	q35	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	30114912	123700444	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	30846101	172879276	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	39248391	140271184	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	43295930	163640485	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	43295930	163640485	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	45406058	127023997	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	45406058	177699992	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	48561928	155263151	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	48562146	115249962	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	48562146	115249962	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	51821836	124513579	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	51822008	120917851	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	54630948	119830094	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	54630948	119830094	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	54630948	119830094	Rat
1581568	Rf53	Renal function QTL 53			total urine protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	58204463	170534769	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	61241033	165369047	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	62922868	127023997	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	66711607	119830094	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	66711607	119830094	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	72672290	127023997	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	72973445	127023997	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	78700444	123700444	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	total urine protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	81136227	154416635	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	83817637	119509260	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	88910015	133910015	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	94788365	139788365	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	97009185	142009185	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	99465522	168732722	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	100730984	119830094	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	101058963	146058963	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	102152812	155263151	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	102466149	147466149	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	103141814	176418101	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	103141814	176418101	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	103141814	176418101	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	103141944	170934860	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	106900427	119830094	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	43
Count of miRNA genes:	42
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000051354
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3								56	29	4	10
Low		34	19	3	17	3	8	10	18	6	22	1	8
Below cutoff		6	18	18		18					14

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012738	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234830	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC116071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000051354 ⟹ ENSRNOP00000044253

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	113,319,456 - 113,324,457 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000089230 ⟹ ENSRNOP00000071371

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	113,318,563 - 113,324,461 (+)	Ensembl

RefSeq Acc Id:

NM_001012738 ⟹ NP_001012756

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	108,330,757 - 108,335,758 (+)	NCBI
Rnor_6.0	3	113,319,456 - 113,324,457 (+)	NCBI
Rnor_5.0	3	119,858,111 - 119,864,006 (+)	NCBI
RGSC_v3.4	3	108,158,887 - 108,163,888 (+)	RGD
Celera	3	107,232,840 - 107,237,770 (+)	RGD

Sequence:

show sequence

CTGGCCGCTTGCTTGCTGCGCTTCTCCTGCAGCCTGGTAGGCACTGGCTGCTACTTCAGCTTCA
GCCTTCGTCGCGACCCCTATTTTGGCTCCAGTCTCCGACCCTGCTCCGTCCTCTCTCTACTTGG
TTGCATCCTCCCTCCTAGTTCCAGATTTGCGCCAGATCCTGCTCCAAATCCGGTAGCCGCATCC
CCAAGCCATGGCTGGTCCCTTCTCCCGTCTGCTGTCTGCCCGCCCCGGACTCAAGCTCCTGGCT
TTGGCTGGAGCTGGGTCTCTCGCCGCCGGGATTCTGCTCCGTCCGGAATCTGTACGAGCGGCCA
CCGGTGAACGGAGGAGACTGTATCCCCCGAGCGCTGAGTACCCAGACCTCCGAAAGCACAACAA
CTGCATGGCCAGTCACCTGACCCCAGCAGTCTATGCACGGCTCTGCGACAAGACCACACCCACT
GGCTGGACACTAGATCAGTGCATCCAGACTGGAGTGGACAACCCTGGCCACCCCTTCATCAAGA
CTGTGGGCATGGTGGCTGGAGATGAGGAGACCTATGAGGTATTTGCCGAACTGTTTGACCCTGT
GATCCAAGAGCGGCATAATGGATATGACCCTAGAACAATGAAGCACACCACTGACCTTGATGCC
AGCAAAATCCGTTCTGGCTACTTTGATGAGAGGTACGTATTGTCCTCAAGAGTCAGAACTGGCC
GAAGTATCAGGGGACTCAGTCTCCCTCCAGCCTGCACTCGGGCAGAGCGACGAGAGGTGGAGCG
TGTTGTGGTGGACGCGCTGAGTGGCCTGAAGGGCGACCTGGCTGGACGGTACTACAGGCTCAGT
GAGATGACAGAGGCTGAGCAGCAGCAGCTTATTGACGACCATTTCCTGTTTGATAAACCTGTGT
CCCCATTGCTGACAGCAGCAGGCATGGCTCGAGACTGGCCAGATGCCCGAGGAATCTGGCACAA
CAATGAGAAGAGTTTCTTGATCTGGGTGAATGAGGAGGACCACACACGGGTCATCTCTATGGAG
AAAGGCGGCAACATGAAGAGAGTGTTTGAAAGATTCTGCCGGGGCCTCAAAGAGGTGGAGAAGC
TGATCCAGGAACGAGGCTGGGAGTTCATGTGGAATGAGCGTTTAGGATACATCTTGACCTGTCC
ATCTAACCTGGGCACTGGACTTCGGGCAGGAGTACACGTCAAACTGCCACTGCTAAGCAAAGAT
AGCCGCTTCCCAAAGATCCTGGAGAACCTAAGGCTGCAAAAGCGTGGGACTGGAGGAGTGGACA
CGGCTGCCACAGGCAGTGTCTTTGACATCTCTAATCTGGATCGACTTGGCAAGTCAGAGGTGGA
GCTGGTGCAGCTGGTCATCGATGGGGTGAACTATTTGATTGACTGTGAACGGCGTCTGGAGAAA
GGACAGGATATTCGAATCCCTCCACCTCTTGTCCACGGCAAACATTAACTCCCCGTTCCCAGCA
GATGAATCAAGATTCCCCAGGACTTCTGCATATTTAACAGTGGCCCATTCTACTTGCCAAGGAC
CTGCCTCTCAATCCCTGTCCTAGTAAAGACTCCACGTTCTGTTGAAAAAAAAAAAAAAAAAAAA
AAAAAAA

hide sequence

RefSeq Acc Id:

XM_006234830 ⟹ XP_006234892

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	108,329,859 - 108,335,760 (+)	NCBI
Rnor_6.0	3	113,318,559 - 113,324,459 (+)	NCBI
Rnor_5.0	3	119,858,111 - 119,864,006 (+)	NCBI

Sequence:

show sequence

TCCAGTCCAGGAACTGCCAGCTGCAGAGAAGGAAGAGAAGGAAGGAGAAACTCACCATTCCCTG
CCCAACCCCAGCCCCACACCCAGAGCAATCAACAGTTCCAGATTTGCGCCAGATCCTGCTCCAA
ATCCGGTAGCCGCATCCCCAAGCCATGGCTGGTCCCTTCTCCCGTCTGCTGTCTGCCCGCCCCG
GACTCAAGCTCCTGGCTTTGGCTGGAGCTGGGTCTCTCGCCGCCGGGATTCTGCTCCGTCCGGA
ATCTGTACGAGCGGCCACCGGTGAACGGAGGAGACTGTATCCCCCGAGCGCTGAGTACCCAGAC
CTCCGAAAGCACAACAACTGCATGGCCAGTCACCTGACCCCAGCAGTCTATGCACGGCTCTGCG
ACAAGACCACACCCACTGGCTGGACACTAGATCAGTGCATCCAGACTGGAGTGGACAACCCTGG
CCACCCCTTCATCAAGACTGTGGGCATGGTGGCTGGAGATGAGGAGACCTATGAGGTATTTGCC
GAACTGTTTGACCCTGTGATCCAAGAGCGGCATAATGGATATGACCCTAGAACAATGAAGCACA
CCACTGACCTTGATGCCAGCAAAATCCGTTCTGGCTACTTTGATGAGAGGTACGTATTGTCCTC
AAGAGTCAGAACTGGCCGAAGTATCAGGGGACTCAGTCTCCCTCCAGCCTGCACTCGGGCAGAG
CGACGAGAGGTGGAGCGTGTTGTGGTGGACGCGCTGAGTGGCCTGAAGGGCGACCTGGCTGGAC
GGTACTACAGGCTCAGTGAGATGACAGAGGCTGAGCAGCAGCAGCTTATTGACGACCATTTCCT
GTTTGATAAACCTGTGTCCCCATTGCTGACAGCAGCAGGCATGGCTCGAGACTGGCCAGATGCC
CGAGGAATCTGGCACAACAATGAGAAGAGTTTCTTGATCTGGGTGAATGAGGAGGACCACACAC
GGGTCATCTCTATGGAGAAAGGCGGCAACATGAAGAGAGTGTTTGAAAGATTCTGCCGGGGCCT
CAAAGAGGTGGAGAAGCTGATCCAGGAACGAGGCTGGGAGTTCATGTGGAATGAGCGTTTAGGA
TACATCTTGACCTGTCCATCTAACCTGGGCACTGGACTTCGGGCAGGAGTACACGTCAAACTGC
CACTGCTAAGCAAAGATAGCCGCTTCCCAAAGATCCTGGAGAACCTAAGGCTGCAAAAGCGTGG
GACTGGAGGAGTGGACACGGCTGCCACAGGCAGTGTCTTTGACATCTCTAATCTGGATCGACTT
GGCAAGTCAGAGGTGGAGCTGGTGCAGCTGGTCATCGATGGGGTGAACTATTTGATTGACTGTG
AACGGCGTCTGGAGAAAGGACAGGATATTCGAATCCCTCCACCTCTTGTCCACGGCAAACATTA
ACTCCCCGTTCCCAGCAGATGAATCAAGATTCCCCAGGACTTCTGCATATTTAACAGTGGCCCA
TTCTACTTGCCAAGGACCTGCCTCTCAATCCCTGTCCTAGTAAAGACTCCACGTTCTGTTGCA

hide sequence

RefSeq Acc Id:

XM_017591555 ⟹ XP_017447044

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	113,319,721 - 113,324,459 (+)	NCBI

Sequence:

show sequence

GCTGGGTCTCTCGCCGCCGGGATTCTGCTCCGTCCGGAATCTGTACGAGCGGCCACCGGTGAAC
GGAGGAGACTGTATCCCCCGAGGTATTTGCCGAACTGTTTGACCCTGTGATCCAAGAGCGGCAT
AATGGATATGACCCTAGAACAATGAAGCACACCACTGACCTTGATGCCAGCAAAATCCGTTCTG
GCTACTTTGATGAGAGGTACGTATTGTCCTCAAGAGTCAGAACTGGCCGAAGTATCAGGGGACT
CAGTCTCCCTCCAGCCTGCACTCGGGCAGAGCGACGAGAGGTGGAGCGTGTTGTGGTGGACGCG
CTGAGTGGCCTGAAGGGCGACCTGGCTGGACGGTACTACAGGCTCAGTGAGATGACAGAGGCTG
AGCAGCAGCAGCTTATTGACGACCATTTCCTGTTTGATAAACCTGTGTCCCCATTGCTGACAGC
AGCAGGCATGGCTCGAGACTGGCCAGATGCCCGAGGAATCTGGCACAACAATGAGAAGAGTTTC
TTGATCTGGGTGAATGAGGAGGACCACACACGGGTCATCTCTATGGAGAAAGGCGGCAACATGA
AGAGAGTGTTTGAAAGATTCTGCCGGGGCCTCAAAGAGGTGGAGAAGCTGATCCAGGAACGAGG
CTGGGAGTTCATGTGGAATGAGCGTTTAGGATACATCTTGACCTGTCCATCTAACCTGGGCACT
GGACTTCGGGCAGGAGTACACGTCAAACTGCCACTGCTAAGCAAAGATAGCCGCTTCCCAAAGA
TCCTGGAGAACCTAAGGCTGCAAAAGCGTGGGACTGGAGGAGTGGACACGGCTGCCACAGGCAG
TGTCTTTGACATCTCTAATCTGGATCGACTTGGCAAGTCAGAGGTGGAGCTGGTGCAGCTGGTC
ATCGATGGGGTGAACTATTTGATTGACTGTGAACGGCGTCTGGAGAAAGGACAGGATATTCGAA
TCCCTCCACCTCTTGTCCACGGCAAACATTAACTCCCCGTTCCCAGCAGATGAATCAAGATTCC
CCAGGACTTCTGCATATTTAACAGTGGCCCATTCTACTTGCCAAGGACCTGCCTCTCAATCCCT
GTCCTAGTAAAGACTCCACGTTCTGTTGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001012756	(Get FASTA)	NCBI Sequence Viewer
	XP_006234892	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91335	(Get FASTA)	NCBI Sequence Viewer
	EDL79988	(Get FASTA)	NCBI Sequence Viewer
	P25809	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001012756 ⟸ NM_001012738
- Peptide Label:	precursor
- UniProtKB:	Q5BJT9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGPFSRLLSARPGLKLLALAGAGSLAAGILLRPESVRAATGERRRLYPPSAEYPDLRKHNNCM ASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAELFDPVIQ ERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVV VDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNE KSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVEKLIQERGWEFMWNERLGYILTCPSN LGTGLRAGVHVKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGSVFDISNLDRLGKSEVELV QLVIDGVNYLIDCERRLEKGQDIRIPPPLVHGKH hide sequence

RefSeq Acc Id:	XP_006234892 ⟸ XM_006234830
- Peptide Label:	isoform X1
- UniProtKB:	Q5BJT9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGPFSRLLSARPGLKLLALAGAGSLAAGILLRPESVRAATGERRRLYPPSAEYPDLRKHNNCM ASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAELFDPVIQ ERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVV VDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNE KSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVEKLIQERGWEFMWNERLGYILTCPSN LGTGLRAGVHVKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGSVFDISNLDRLGKSEVELV QLVIDGVNYLIDCERRLEKGQDIRIPPPLVHGKH hide sequence

RefSeq Acc Id:

XP_017447044 ⟸ XM_017591555

- Peptide Label:

isoform X2

- Sequence:

show sequence

MKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGD
LAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEE
DHTRVISMEKGGNMKRVFERFCRGLKEVEKLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVH
VKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGSVFDISNLDRLGKSEVELVQLVIDGVNYL
IDCERRLEKGQDIRIPPPLVHGKH

hide sequence

RefSeq Acc Id:

ENSRNOP00000071371 ⟸ ENSRNOT00000089230

RefSeq Acc Id:

ENSRNOP00000044253 ⟸ ENSRNOT00000051354

Protein Domains

Phosphagen kinase C-terminal Phosphagen kinase N-terminal

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692360

Promoter ID:

EPDNEW_R2879

Type:

multiple initiation site

Name:

Ckmt1_1

Description:

creatine kinase, mitochondrial 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	113,318,577 - 113,318,637	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61976	AgrOrtholog
Ensembl Genes	ENSRNOG00000014573	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000044253	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000071371	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000051354	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000089230	UniProtKB/TrEMBL
Gene3D-CATH	1.10.135.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7314893	IMAGE-MGC_LOAD
InterPro	ATP-guanido_PTrfase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_cat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-guanido_PTrfase_N_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gln_synth/guanido_kin_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29593	UniProtKB/TrEMBL
MGC_CLONE	MGC:109333	IMAGE-MGC_LOAD
NCBI Gene	29593	ENTREZGENE
PANTHER	PTHR11547	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ATP-gua_Ptrans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-gua_PtransN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ckmt1	PhenoGen
PROSITE	PHOSPHAGEN_KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PHOSPHAGEN_KINASE_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PHOSPHAGEN_KINASE_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48034	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55931	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	KCRU_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5BJT9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-11-18	Ckmt1	creatine kinase, mitochondrial 1	Ckmt1b	creatine kinase, mitochondrial 1B	Name and Symbol changed	629549	APPROVED
2012-01-24	Ckmt1b	creatine kinase, mitochondrial 1B	Ckmt1	creatine kinase, mitochondrial 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-11-05	Ckmt1	creatine kinase, mitochondrial 1	Ckmt1	creatine kinase, mitochondrial 1, ubiquitous	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Ckmt1	creatine kinase, mitochondrial 1, ubiquitous			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expression in uterus and placenta is regulated during pregnancy	61552

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations