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Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
 Gviewer (Genome Viewer) unavailable |
 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
GViewer (Genome Viewer) |
Variant Visualizer (Damaging Variants) |
 Gene Annotator (Annotation Comparison) unavailable |
 OLGA (Gene List Generator) unavailable |
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Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
 GOLF (Gene-Ortholog Location Finder) unavailable |
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MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Imported Annotations - ClinVar | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| microcephaly and chorioretinopathy 3 | ISO | RGD:1317577 | 8554872 | ClinVar Annotator: match by term: Microcephaly and chorioretinopathy, autosomal recessive, 3 | ClinVar | PMID:24033266 more ... | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction AnnotationsGene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway AnnotationsReferences - curated| 1. | Casafont I, etal., Acta Neuropathol. 2011 Oct;122(4):481-93. doi: 10.1007/s00401-011-0869-0. Epub 2011 Sep 14. |
| 2. | Ding Y, etal., Clin Cancer Res. 2002 Oct;8(10):3290-7. |
| 3. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 4. | GOA data from the GO Consortium |
| 5. | Lu R and Wang GG, Trends Biochem Sci. 2013 Nov;38(11):546-55. doi: 10.1016/j.tibs.2013.08.002. Epub 2013 Sep 10. |
| 6. | Meloche J, etal., Circulation. 2014 Feb 18;129(7):786-97. doi: 10.1161/CIRCULATIONAHA.113.006167. Epub 2013 Nov 22. |
| 7. | MGD data from the GO Consortium |
| 8. | Panier S and Boulton SJ, Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11. |
| 9. | Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700. |
| 10. | Pospelova TV, etal., Cell Cycle. 2012 Jun 15;11(12):2402-7. doi: 10.4161/cc.20882. Epub 2012 Jun 15. |
| 11. | RGD automated data pipeline |
| 12. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 13. | RGD automated import pipeline for gene-chemical interactions |
| 14. | RGD comprehensive gene curation |
| 15. | Wen Y, etal., Cancer Res. 2001 Oct 1;61(19):7142-7. |
References - uncurated| PubMed | 8889548 9748285 11801725 11934988 14985081 15077110 15149599 15159415 15364958 17053789 17500065 17805299 19001091 20362325 21746928 22373579 23209566 23241889 23333305 23333306 23345425 23760478 24001775 24217620 24625528 28241136 |
Comparative Map Data| Tp53bp1 (Rattus norvegicus - Norway rat) |
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| TP53BP1 (Homo sapiens - human) |
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| Trp53bp1 (Mus musculus - house mouse) |
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| Tp53bp1 (Chinchilla lanigera - long-tailed chinchilla) |
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| TP53BP1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| TP53BP1 (Canis lupus familiaris - dog) |
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| Tp53bp1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| TP53BP1 (Sus scrofa - pig) |
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Position Markers| D3Rat259 |
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| BE108329 |
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| AU049532 |
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| RH68009 |
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| BI287966 |
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| RH139947 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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RNA-SEQ Expression| testis | heart | brain | ovary | uterus | skeletal muscle tissue | colon | gastrocnemius | forebrain | hindbrain | lung | spleen | liver | kidney | adrenal gland | thymus | |
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| High | ||||||||||||||||
| Medium | 19 | 33 | 23 | 15 | 4 | 1 | 1 | 26 | 25 | 11 | 11 | 6 | 33 | 8 | 8 | |
| Low | 3 | 10 | 3 | 2 | 7 | 35 | 2 | |||||||||
| Below cutoff |
Nucleotide Sequences| RefSeq Transcripts | NM_001371259 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006234865 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006234867 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008762206 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017592214 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017592215 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017601145 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHX01024687 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AAHX01024688 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01024689 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01024690 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01024691 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01024692 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01024693 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC116071 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473949 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CK840114 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | XM_006234865 ⟹ XP_006234927 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
GCACAGCTGAGGGAGGTGAGCTGCGGAGCCACGAAGGTCACTCTCTTAACTTGGTTGCCAGCAThide sequence |
| RefSeq Acc Id: | XM_006234867 ⟹ XP_006234929 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
AATTTCCTGAGTGGCAGACAACAGCAGCGAATGGGCGGCCTGATACTGCGTGACGTGACGGGAAhide sequence |
| RefSeq Acc Id: | XM_008762206 ⟹ XP_008760428 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CCGGGATGCGGTCGCTGTGCTGCGATGGGGTGGTGGCTGCAGTCGTCCACCTGCAGTTTTCCTGhide sequence |
| RefSeq Acc Id: | XM_017592214 ⟹ XP_017447703 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CCGGGATGCGGTCGCTGTGCTGCGATGGGGTGGTGGCTGCAGTCGTCCACCTGCAGTTTTCCTGhide sequence |
| RefSeq Acc Id: | XM_017592215 ⟹ XP_017447704 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
CAAACAAAAAACACGCAGGAAACAAGGAGGGAGAGTCAAGGTATTGCTCAGAACCTGAAGAAGAhide sequence |
| RefSeq Acc Id: | XM_017601145 ⟹ XP_017456634 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
ATGCACAAAGAGAACCCGGTGTTGGATATTATGTCAAATCCGGAACAAACTGTTGCAGAACAAGhide sequence |
Protein Sequences| Protein RefSeqs | NP_001358188 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006234927 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006234929 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_008760428 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017447703 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017447704 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017456634 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | EDL79980 | (Get FASTA) | NCBI Sequence Viewer |
| EDL79981 | (Get FASTA) | NCBI Sequence Viewer |
| RefSeq Acc Id: | XP_006234927 ⟸ XM_006234865 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | F1M842 (UniProtKB/TrEMBL) |
| - Sequence: |
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQALEEDAGSHFSVLSRHLPNLQMHKENPVLhide sequence |
| RefSeq Acc Id: | XP_006234929 ⟸ XM_006234867 |
| - Peptide Label: | isoform X2 |
| - Sequence: |
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQALEEDAGSHFSVLSRHLPNLQMHKENPVLhide sequence |
| RefSeq Acc Id: | XP_008760428 ⟸ XM_008762206 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | F1M842 (UniProtKB/TrEMBL) |
| - Sequence: |
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQALEEDAGSHFSVLSRHLPNLQMHKENPVLhide sequence |
| RefSeq Acc Id: | XP_017456634 ⟸ XM_017601145 |
| - Peptide Label: | isoform X3 |
| - Sequence: |
MHKENPVLDIMSNPEQTVAEQGDSNSSFSEHLKEKKASDPVESSHLGTSGPISQVIERLPQPNRhide sequence |
| RefSeq Acc Id: | XP_017447704 ⟸ XM_017592215 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | F1M842 (UniProtKB/TrEMBL) |
| - Sequence: |
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQALEEDAGSHFSVLSRHLPNLQMHKENPVLhide sequence |
| RefSeq Acc Id: | XP_017447703 ⟸ XM_017592214 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | F1M842 (UniProtKB/TrEMBL) |
| - Sequence: |
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQALEEDAGSHFSVLSRHLPNLQMHKENPVLhide sequence |
TranscriptomePromoters| RGD ID: | 13692358 | |||||||||
| Promoter ID: | EPDNEW_R2877 | |||||||||
| Type: | multiple initiation site | |||||||||
| Name: | Tp53bp1_1 | |||||||||
| Description: | tumor protein p53 binding protein 1 | |||||||||
| SO ACC ID: | SO:0000170 | |||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
| Experiment Methods: | Single-end sequencing. | |||||||||
| Position: |
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Strain Sequence Variants (Rnor 6.0)
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Damaging Variants| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 3 | 119742900 | 119742901 | C | A | snv | ACI/N (KNAW), MNS/Gib (KNAW), NIG-III/Hok (KyushuU), HTX/Kyo (KyushuU), ZF (KyushuU), MHS/Gib (KNAW), ACI/EurMcwi (KNAW), DA/BklArbNsi (KNAW), DOB/Oda (KyushuU), ACI/EurMcwi (MCW) |
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 3 | 113203099 | 113203100 | C | A | snv | ACI/EurMcwi (RGD), MHS/Gib (RGD), ACI/N (MCW), ACI/EurMcwi (MCW) |
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:1308039 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000013837 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000019025 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000019025 | ENTREZGENE, UniProtKB/TrEMBL |
| Gene3D-CATH | 2.30.30.30 | UniProtKB/TrEMBL |
| 3.40.50.10190 | UniProtKB/TrEMBL | |
| InterPro | 53-BP1_Tudor | UniProtKB/TrEMBL |
| BRCT_dom | UniProtKB/TrEMBL | |
| BRCT_dom_sf | UniProtKB/TrEMBL | |
| Rib_L2_dom2 | UniProtKB/TrEMBL | |
| KEGG Report | rno:296099 | UniProtKB/TrEMBL |
| NCBI Gene | 296099 | ENTREZGENE |
| Pfam | 53-BP1_Tudor | UniProtKB/TrEMBL |
| PhenoGen | Tp53bp1 | PhenoGen |
| PROSITE | BRCT | UniProtKB/TrEMBL |
| SMART | BRCT | UniProtKB/TrEMBL |
| Superfamily-SCOP | BRCT | UniProtKB/TrEMBL |
| UniProt | F1M842 | ENTREZGENE, UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-10-23 | Tp53bp1 | tumor protein p53 binding protein 1 | Trp53bp1 | transformation related protein 53 binding protein 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-04-30 | Trp53bp1 | transformation related protein 53 binding protein 1 | Trp53bp1_predicted | transformation related protein 53 binding protein 1 (predicted) | 'predicted' is removed | 2292626 | APPROVED |
| 2008-01-09 | Trp53bp1_predicted | transformation related protein 53 binding protein 1 (predicted) | LOC688035 | similar to transformation related protein 53 binding protein 1 | Data Merged | 1643240 | APPROVED |
| 2006-11-20 | LOC688035 | similar to transformation related protein 53 binding protein 1 | Symbol and Name status set to provisional | 70820 | PROVISIONAL | ||
| 2005-01-12 | Trp53bp1_predicted | transformation related protein 53 binding protein 1 (predicted) | Symbol and Name status set to approved | 70820 | APPROVED |
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| More on Tp53bp1 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 1308039 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2019-11-27 |
| Status: | ACTIVE |
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.
