Gene: B2m (beta-2 microglobulin) Rattus norvegicus
Analyze
Symbol:
B2m
Name:
beta-2 microglobulin
Description:
Predicted to have identical protein binding activity. Involved in response to cadmium ion and response to drug. Localizes to the extracellular space. Biomarker of acute kidney failure; pyelonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in arthritis; familial visceral amyloidosis; inflammatory bowel disease; and primary immunodeficiency disease. Orthologous to human B2M (beta-2-microglobulin); PARTICIPATES IN interleukin-12 signaling pathway; antigen processing and presentation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
Beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
B2M (beta-2-microglobulin) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
B2m (beta-2 microglobulin) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
B2m (beta-2-microglobulin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
B2M (beta-2-microglobulin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
B2M (beta-2-microglobulin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
B2m (beta-2-microglobulin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
B2M (beta-2-microglobulin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
B2m (beta-2 microglobulin)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
B2M (beta-2-microglobulin)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
zmp:0000001138
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
b2m (beta-2-microglobulin)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
b2ml (beta-2-microglobulin, like)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 3 114,087,287 - 114,093,311 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 3 120,627,499 - 120,633,523 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 3 108,927,919 - 108,932,718 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 3 108,833,491 - 108,838,291 (+) NCBI Celera 3 107,993,988 - 108,000,012 (+) NCBI Celera Cytogenetic Map 3 q35 NCBI RH 3.4 Map 3 954.3 RGD
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Colorectal Neoplasms ISO RGD:735892 8554872 ClinVar Annotator: match by term: Colorectal Neoplasms ClinVar PMID:26619011 familial visceral amyloidosis ISO RGD:735892 8554872 ClinVar Annotator: match by synonym: Ostertag type amyloidosis ClinVar PMID:22693999 gastric adenocarcinoma ISO RGD:735892 8554872 ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:26619011 head and neck squamous cell carcinoma ISO RGD:735892 8554872 ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck ClinVar PMID:26619011 Hypercatabolic Hypoproteinemia ISO RGD:735892 8554872 ClinVar Annotator: match by OMIM:241600 ClinVar PMID:25702838 Hypercatabolic Hypoproteinemia ISO RGD:735892 8554872 ClinVar Annotator: match by term: Hypoproteinemia, hypercatabolic ClinVar PMID:28492532 Hypercatabolic Hypoproteinemia ISO RGD:735892 8554872 ClinVar Annotator: match by OMIM:241600 ClinVar PMID:16549777 , PMID:4186801 lung adenocarcinoma ISO RGD:735892 8554872 ClinVar Annotator: match by term: Adenocarcinoma of lung, somatic ClinVar PMID:26619011 lung small cell carcinoma ISO RGD:735892 8554872 ClinVar Annotator: match by term: Small cell lung cancer ClinVar PMID:26619011 lung squamous cell carcinoma ISO RGD:735892 8554872 ClinVar Annotator: match by term: Squamous cell carcinoma of lung ClinVar PMID:26619011 melanoma ISO RGD:735892 8554872 ClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC ClinVar PMID:26619011 multiple myeloma ISO RGD:735892 8554872 ClinVar Annotator: match by term: Multiple myeloma ClinVar PMID:26619011 non-Hodgkin lymphoma ISO RGD:735892 8554872 ClinVar Annotator: match by term: Familial non-Hodgkin lymphoma ClinVar PMID:26619011 ovarian serous cystadenocarcinoma ISO RGD:735892 8554872 ClinVar Annotator: match by term: Ovarian Serous Cystadenocarcinoma ClinVar PMID:26619011 plasmacytoma ISO RGD:735892 8554872 ClinVar Annotator: match by term: Plasmocytoma ClinVar PMID:26619011
Imported Annotations - CTD
acute kidney failure ISO RGD:735892 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:2689182 more ... Autoimmune Diseases ISO RGD:735892 11554173 CTD Direct Evidence: therapeutic CTD PMID:21793797 diffuse large B-cell lymphoma ISO RGD:735892 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7688627 Drug-Related Side Effects and Adverse Reactions ISO RGD:735892 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28885000 heart disease ISO RGD:735892 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16844662 Hypergammaglobulinemia ISO RGD:735892 11554173 CTD Direct Evidence: therapeutic CTD PMID:21793797 kidney disease ISO RGD:735892 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:2202081 more ... peripheral T-cell lymphoma ISO RGD:735892 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24413734 Prostatic Neoplasms ISO RGD:735892 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17404077 Imported Annotations - MGI
hemochromatosis ISS RGD:10224 13592920 OMIM:231100 MouseDO Imported Annotations - OMIM
familial visceral amyloidosis ISO RGD:735892 7240710 OMIM Hypercatabolic Hypoproteinemia ISO RGD:735892 7240710 OMIM
1,1-dichloroethene increases expression ISO RGD:10224 6480464 vinylidene chloride results in increased expression of B2M mRNA CTD PMID:26682919 1,3-dinitrobenzene increases expression EXP 6480464 3-dinitrobenzene results in increased expression of B2M mRNA CTD PMID:21983209 1-chloro-2,4-dinitrobenzene affects expression ISO RGD:10224 6480464 Dinitrochlorobenzene affects the expression of B2M mRNA CTD PMID:28219650 17alpha-ethynylestradiol affects expression ISO RGD:10224 6480464 Ethinyl Estradiol affects the expression of B2M mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of B2M mRNA CTD PMID:17557909 17beta-estradiol affects expression ISO RGD:10224 6480464 Estradiol affects the expression of B2M mRNA CTD PMID:16684588 17beta-estradiol decreases expression ISO RGD:735892 6480464 Estradiol results in decreased expression of B2M mRNA CTD PMID:23019147 17beta-estradiol increases expression ISO RGD:735892 6480464 Estradiol results in increased expression of B2M mRNA CTD PMID:21185374 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression ISO RGD:735892 6480464 Metribolone results in increased expression of B2M mRNA CTD PMID:17131305 more ... 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions ISO RGD:735892 6480464 Metribolone results in increased expression of and results in increased secretion of B2M protein, resveratrol inhibits the reaction [Metribolone results in increased expression of B2M mRNA] CTD PMID:17404077 , PMID:18586690 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:735892 6480464 Dihydrotestosterone results in increased expression of B2M mRNA CTD PMID:27720946 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:735892 6480464 6-(3, 4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide analog inhibits the reaction [Dihydrotestosterone results in increased expression of B2M mRNA] CTD PMID:27720946 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10224 6480464 Tetrachlorodibenzodioxin results in decreased expression of B2M mRNA CTD PMID:19465110 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10224 6480464 Tetrachlorodibenzodioxin affects the expression of B2M mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10224 6480464 Tetrachlorodibenzodioxin results in increased expression of B2M mRNA CTD PMID:21041162 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of B2M mRNA CTD PMID:16466705 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735892 6480464 Tetrachlorodibenzodioxin results in increased expression of B2M mRNA CTD PMID:20106945 2-butoxyethanol decreases expression ISO RGD:10224 6480464 n-butoxyethanol results in decreased expression of B2M mRNA CTD PMID:19812364 2-methylcholine affects expression ISO RGD:735892 6480464 beta-methylcholine affects the expression of B2M mRNA CTD PMID:21179406 4-hydroxynon-2-enal decreases expression ISO RGD:10224 6480464 4-hydroxy-2-nonenal results in decreased expression of B2M mRNA CTD PMID:19191707 4-tert-Octylphenol increases expression EXP 6480464 4-tert-octylphenol results in increased expression of B2M mRNA CTD PMID:17011747 acetylsalicylic acid increases expression ISO RGD:735892 6480464 Aspirin results in increased expression of B2M mRNA CTD PMID:15456535 acrolein decreases expression ISO RGD:10224 6480464 Acrolein results in decreased expression of B2M mRNA CTD PMID:28482051 adefovir increases secretion EXP 6480464 adefovir results in increased secretion of B2M protein CTD PMID:27742868 aldehydo-D-ribose increases glycation ISO RGD:735892 6480464 Ribose results in increased glycation of B2M protein CTD PMID:21864514 all-trans-retinoic acid increases expression ISO RGD:10224 6480464 Tretinoin results in increased expression of B2M mRNA CTD PMID:16604517 all-trans-retinoic acid increases expression ISO RGD:735892 6480464 Tretinoin results in increased expression of B2M mRNA CTD PMID:17218384 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of B2M mRNA CTD PMID:16483693 anthocyanin multiple interactions EXP 6480464 Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of B2M protein] CTD PMID:30825423 antirheumatic drug decreases expression ISO RGD:735892 6480464 Antirheumatic Agents results in decreased expression of B2M mRNA CTD PMID:24449571 aristolochic acid multiple interactions EXP 6480464 [aristolochic acid I co-treated with aristolochic acid II] results in increased expression of B2M protein CTD PMID:23912714 arsane increases expression ISO RGD:735892 6480464 Arsenic results in increased expression of B2M protein CTD PMID:24679086 arsenic atom increases expression ISO RGD:735892 6480464 Arsenic results in increased expression of B2M protein CTD PMID:24679086 arsenic(3+) increases expression ISO RGD:735892 6480464 Arsenic results in increased expression of B2M protein CTD PMID:24679086 asbestos decreases expression ISO RGD:735892 6480464 Asbestos results in decreased expression of B2M mRNA CTD PMID:22398240 atenolol decreases expression ISO RGD:735892 6480464 Atenolol results in decreased expression of B2M protein CTD PMID:2656332 benzo[a]pyrene increases expression ISO RGD:10224 6480464 Benzo(a)pyrene results in increased expression of B2M mRNA CTD PMID:20127859 more ... bis(2-ethylhexyl) phthalate affects expression ISO RGD:10224 6480464 Diethylhexyl Phthalate affects the expression of B2M mRNA CTD PMID:27405655 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of B2M mRNA CTD PMID:25181051 bleomycin A5 decreases expression ISO RGD:735892 6480464 bleomycetin results in decreased expression of B2M mRNA CTD PMID:21040473 bortezomib decreases expression ISO RGD:735892 6480464 Bortezomib results in decreased expression of B2M protein CTD PMID:17204182 butyric acid decreases stability ISO RGD:735892 6480464 Butyric Acid results in decreased stability of B2M mRNA CTD PMID:1693837 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of B2M mRNA CTD PMID:17327699 cadmium atom affects secretion ISO RGD:735892 6480464 Cadmium affects the secretion of B2M protein CTD PMID:22995156 cadmium atom multiple interactions ISO RGD:735892 6480464 MT1A gene polymorphism affects the reaction [Cadmium affects the secretion of B2M protein] CTD PMID:22995156 cadmium atom increases expression ISO RGD:735892 6480464 Cadmium results in increased expression of B2M protein CTD PMID:22027495 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of B2M mRNA CTD PMID:17327699 calcitriol increases expression ISO RGD:735892 6480464 Calcitriol results in increased expression of B2M protein CTD PMID:8807625 carbon nanotube affects expression ISO RGD:10224 6480464 Nanotubes, Carbon affects the expression of B2M mRNA CTD PMID:25554681 carbon nanotube increases expression ISO RGD:10224 6480464 Nanotubes, Carbon analog results in increased expression of B2M mRNA CTD PMID:25554681 carbon nanotube decreases expression ISO RGD:10224 6480464 Nanotubes, Carbon results in decreased expression of B2M mRNA CTD PMID:25620056 cerium trichloride increases expression ISO RGD:735892 6480464 cerous chloride results in increased expression of B2M mRNA CTD PMID:28954213 chloropicrin affects expression ISO RGD:735892 6480464 chloropicrin affects the expression of B2M mRNA CTD PMID:26352163 chloropicrin decreases expression ISO RGD:735892 6480464 chloropicrin results in decreased expression of B2M mRNA CTD PMID:28476498 chromium(6+) affects expression ISO RGD:10224 6480464 chromium hexavalent ion affects the expression of B2M mRNA CTD PMID:28472532 cisplatin affects expression ISO RGD:735892 6480464 Cisplatin affects the expression of B2M mRNA CTD PMID:23300844 copper atom multiple interactions ISO RGD:735892 6480464 Copper binds to and results in decreased folding of and results in decreased stability of B2M protein more ... CTD PMID:16513784 , PMID:17254602 copper atom multiple interactions ISO RGD:10224 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of B2M mRNA more ... CTD PMID:15467011 , PMID:16629173 copper(0) multiple interactions ISO RGD:735892 6480464 Copper binds to and results in decreased folding of and results in decreased stability of B2M protein more ... CTD PMID:16513784 , PMID:17254602 copper(0) multiple interactions ISO RGD:10224 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of B2M mRNA more ... CTD PMID:15467011 , PMID:16629173 copper(2+) multiple interactions ISO RGD:735892 6480464 Copper binds to and results in decreased folding of and results in decreased stability of B2M protein more ... CTD PMID:16513784 , PMID:17254602 copper(2+) multiple interactions ISO RGD:10224 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of B2M mRNA more ... CTD PMID:15467011 , PMID:16629173 coumestrol increases expression ISO RGD:735892 6480464 Coumestrol results in increased expression of B2M mRNA CTD PMID:19167446 cytarabine increases expression ISO RGD:735892 6480464 Cytarabine results in increased expression of B2M protein CTD PMID:11096300 D-ribofuranose increases glycation ISO RGD:735892 6480464 Ribose results in increased glycation of B2M protein CTD PMID:21864514 dexamethasone decreases expression ISO RGD:735892 6480464 Dexamethasone results in decreased expression of B2M protein CTD PMID:3047540 dexamethasone increases expression ISO RGD:10224 6480464 Dexamethasone results in increased expression of B2M mRNA CTD PMID:21041162 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of B2M mRNA CTD PMID:21266533 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of B2M mRNA CTD PMID:21266533 dicrotophos decreases expression ISO RGD:735892 6480464 dicrotophos results in decreased expression of B2M mRNA CTD PMID:28302478 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of B2M mRNA CTD PMID:17011747 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of B2M mRNA CTD PMID:21658437 diethylstilbestrol increases expression ISO RGD:10224 6480464 Diethylstilbestrol results in increased expression of B2M mRNA CTD PMID:21041162 diuron decreases expression EXP 6480464 Diuron results in decreased expression of B2M mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:735892 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases secretion EXP 6480464 Doxorubicin results in increased secretion of B2M protein CTD PMID:28885000 doxorubicin decreases expression ISO RGD:735892 6480464 Doxorubicin results in decreased expression of B2M mRNA CTD PMID:29803840 entinostat increases expression ISO RGD:735892 6480464 entinostat results in increased expression of B2M mRNA CTD PMID:27188386 ethanol decreases response to substance ISO RGD:10224 6480464 B2M gene mutant form results in decreased susceptibility to Ethanol CTD PMID:21309947 ethanol increases expression ISO RGD:10224 6480464 Ethanol results in increased expression of B2M mRNA CTD PMID:30319688 eugenol increases expression ISO RGD:735892 6480464 Eugenol results in increased expression of B2M mRNA CTD PMID:17936526 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of B2M mRNA CTD PMID:24136188 folic acid affects expression ISO RGD:735892 6480464 Folic Acid affects the expression of B2M mRNA CTD PMID:17868486 formaldehyde increases expression EXP 6480464 Formaldehyde results in increased expression of B2M mRNA CTD PMID:12679049 furan decreases expression EXP 6480464 furan results in decreased expression of B2M mRNA CTD PMID:26194646 genistein increases expression EXP 6480464 Genistein results in increased expression of B2M mRNA CTD PMID:21782745 gentamycin increases expression ISO RGD:735892 6480464 Gentamicins results in increased expression of B2M protein CTD PMID:2218653 gentamycin multiple interactions EXP 6480464 Sodium Fluoride inhibits the reaction [Gentamicins results in increased expression of B2M protein] CTD PMID:26779593 gentamycin increases secretion EXP 6480464 Gentamicins results in increased secretion of B2M protein CTD PMID:20816719 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of B2M mRNA, Gentamicins results in increased expression of B2M protein CTD PMID:22061828 , PMID:26779593 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of B2M mRNA CTD PMID:24136188 Hexachloro-1,3-butadiene increases expression EXP 6480464 hexachlorobutadiene results in increased expression of B2M protein CTD PMID:21259293 , PMID:2202081 hydrogen peroxide affects expression ISO RGD:735892 6480464 Hydrogen Peroxide affects the expression of B2M mRNA CTD PMID:21179406 ifosfamide increases expression ISO RGD:735892 6480464 Ifosfamide results in increased expression of B2M protein CTD PMID:8625085 , PMID:9261752 irinotecan increases expression EXP 6480464 Irinotecan results in increased expression of B2M mRNA CTD PMID:20097248 iron atom multiple interactions ISO RGD:735892 6480464 [HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron CTD PMID:16841247 iron atom affects metabolic processing ISO RGD:10224 6480464 B2M protein affects the metabolism of Iron CTD PMID:17194590 iron(0) affects metabolic processing ISO RGD:10224 6480464 B2M protein affects the metabolism of Iron CTD PMID:17194590 iron(0) multiple interactions ISO RGD:735892 6480464 [HFE protein binds to B2M protein binds to SLC11A2 protein] which results in decreased uptake of Iron CTD PMID:16841247 L-ascorbic acid increases expression EXP 6480464 Ascorbic Acid results in increased expression of B2M mRNA CTD PMID:15372504 lead(0) affects expression ISO RGD:735892 6480464 Lead affects the expression of B2M mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:735892 6480464 Lead affects the expression of B2M mRNA CTD PMID:28903495 mercury dichloride multiple interactions ISO RGD:10224 6480464 B2M protein affects the reaction [Mercuric Chloride results in increased expression of IFNG mRNA], B2M protein affects the reaction [Mercuric Chloride results in increased expression of IL4 mRNA] CTD PMID:21793797 methylmercury chloride increases expression ISO RGD:735892 6480464 methylmercuric chloride results in increased expression of B2M mRNA CTD PMID:28001369 muramyl dipeptide increases activity ISO RGD:735892 6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of B2M protein CTD PMID:15905553 muramyl dipeptide increases activity ISO RGD:10224 6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of B2M protein CTD PMID:15905553 N-acetyl-L-cysteine decreases response to substance ISO RGD:735892 6480464 Acetylcysteine results in decreased susceptibility to B2M protein modified form CTD PMID:21864514 N-acetyl-L-cysteine multiple interactions ISO RGD:735892 6480464 Acetylcysteine inhibits the reaction [B2M protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:21864514 N-nitrosodiethylamine increases expression ISO RGD:10224 6480464 Diethylnitrosamine results in increased expression of B2M mRNA CTD PMID:17942915 N-nitrosodiethylamine multiple interactions ISO RGD:10224 6480464 MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of B2M mRNA] CTD PMID:17942915 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of B2M mRNA CTD PMID:24136188 nickel atom increases expression ISO RGD:735892 6480464 Nickel results in increased expression of B2M mRNA CTD PMID:24768652 , PMID:25583101 nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of B2M mRNA CTD PMID:24136188 nitric oxide increases expression ISO RGD:735892 6480464 Nitric Oxide results in increased expression of B2M protein CTD PMID:15764486 nitroglycerin affects expression ISO RGD:735892 6480464 Nitroglycerin affects the expression of B2M protein CTD PMID:8350464 ozone decreases expression ISO RGD:10224 6480464 Ozone results in decreased expression of B2M mRNA CTD PMID:12763052 p-toluidine decreases expression EXP 6480464 4-toluidine results in decreased expression of B2M mRNA CTD PMID:27638505 pamidronate decreases expression ISO RGD:735892 6480464 pamidronate results in decreased expression of B2M protein CTD PMID:11683535 paracetamol increases expression ISO RGD:735892 6480464 Acetaminophen results in increased expression of B2M mRNA, Acetaminophen results in increased expression of B2M protein CTD PMID:17642144 , PMID:22230336 perfluorooctanoic acid decreases expression ISO RGD:735892 6480464 perfluorooctanoic acid results in decreased expression of B2M protein CTD PMID:26879310 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of B2M mRNA CTD PMID:12082028 phenylmercury acetate increases expression ISO RGD:735892 6480464 Phenylmercuric Acetate results in increased expression of B2M mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:735892 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA CTD PMID:27188386 phlorizin increases expression ISO RGD:10224 6480464 Phlorhizin results in increased expression of B2M mRNA CTD PMID:22538082 phosphoramide mustard decreases expression EXP 6480464 phosphoramide mustard results in decreased expression of B2M mRNA CTD PMID:27888070 pirinixic acid multiple interactions ISO RGD:10224 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of B2M mRNA CTD PMID:20813756 pirinixic acid decreases expression ISO RGD:10224 6480464 pirinixic acid results in decreased expression of B2M mRNA CTD PMID:17426115 , PMID:20813756 potassium chromate decreases expression ISO RGD:735892 6480464 potassium chromate(VI) results in decreased expression of B2M mRNA CTD PMID:22714537 reactive oxygen species increases abundance ISO RGD:735892 6480464 B2M protein modified form results in increased abundance of Reactive Oxygen Species CTD PMID:21864514 reactive oxygen species multiple interactions ISO RGD:735892 6480464 Acetylcysteine inhibits the reaction [B2M protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:21864514 resveratrol multiple interactions ISO RGD:735892 6480464 resveratrol inhibits the reaction [Metribolone results in increased expression of B2M mRNA] CTD PMID:18586690 sarin decreases expression ISO RGD:735892 6480464 Sarin results in decreased expression of B2M mRNA CTD PMID:19522546 SB 431542 multiple interactions ISO RGD:735892 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:10224 6480464 Silicon Dioxide results in decreased expression of B2M mRNA CTD PMID:19073995 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of B2M mRNA CTD PMID:18685790 sodium chromate increases expression EXP 6480464 sodium chromate(VI) results in increased expression of B2M protein CTD PMID:2202081 sodium dichromate decreases expression ISO RGD:10224 6480464 sodium bichromate results in decreased expression of B2M mRNA CTD PMID:22155349 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of B2M protein CTD PMID:23933529 sodium fluoride multiple interactions EXP 6480464 Sodium Fluoride inhibits the reaction [Gentamicins results in increased expression of B2M protein] CTD PMID:26779593 tacrolimus hydrate increases expression ISO RGD:10224 6480464 Tacrolimus results in increased expression of B2M mRNA CTD PMID:29362864 tamoxifen increases expression ISO RGD:735892 6480464 Tamoxifen results in increased expression of B2M mRNA CTD PMID:19155303 tamoxifen affects expression ISO RGD:10224 6480464 Tamoxifen affects the expression of B2M mRNA CTD PMID:17555576 testosterone increases expression ISO RGD:10224 6480464 Testosterone results in increased expression of B2M mRNA CTD PMID:19693291 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of B2M protein CTD PMID:30825423 tetrachloromethane multiple interactions EXP 6480464 Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of B2M protein] CTD PMID:30825423 titanium dioxide increases expression ISO RGD:10224 6480464 titanium dioxide results in increased expression of B2M mRNA CTD PMID:23557971 , PMID:27760801 tobramycin increases expression ISO RGD:735892 6480464 Tobramycin results in increased expression of B2M protein CTD PMID:2218653 trichostatin A increases expression ISO RGD:735892 6480464 trichostatin A results in increased expression of B2M mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:735892 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA CTD PMID:27188386 trovafloxacin multiple interactions ISO RGD:10224 6480464 [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of B2M mRNA CTD PMID:18930950 uranium atom affects expression ISO RGD:735892 6480464 Uranium affects the expression of B2M mRNA CTD PMID:15672453 urea multiple interactions ISO RGD:735892 6480464 Urea promotes the reaction [Copper promotes the reaction [B2M protein binds to B2M protein]] CTD PMID:17254602 valproic acid decreases methylation ISO RGD:735892 6480464 Valproic Acid results in decreased methylation of B2M gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:735892 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of B2M mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:735892 6480464 Valproic Acid results in increased expression of B2M mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:735892 6480464 Valproic Acid affects the expression of B2M mRNA CTD PMID:25979313 vancomycin decreases expression ISO RGD:10224 6480464 Vancomycin results in decreased expression of B2M mRNA CTD PMID:18930951 vorinostat increases expression ISO RGD:735892 6480464 vorinostat results in increased expression of B2M mRNA CTD PMID:27188386
Biological Process amyloid fibril formation ISO RGD:735892 1624291 RGD PMID:28468825 amyloid fibril formation IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 antibacterial humoral response ISO RGD:735892 1624291 RGD PMID:23144825 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 antigen processing and presentation of endogenous peptide antigen via MHC class I ISO RGD:735892 1624291 UniProtKB:P01892 RGD PMID:24643698 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent ISO RGD:10224 1624291 RGD MGI:MGI:3611636 , PMID:16299293 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 antimicrobial humoral immune response mediated by antimicrobial peptide ISO RGD:735892 1624291 RGD PMID:23144825 cellular response to iron ion ISO RGD:735892 1624291 UniProtKB:P02787 more ... RGD PMID:18353247 cellular response to iron(III) ion ISO RGD:10224 1624291 MGI:MGI:1927183 RGD MGI:MGI:1203460 , PMID:9531620 cellular response to iron(III) ion IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to lipopolysaccharide ISO RGD:735892 1624291 RGD PMID:23144825 cellular response to nicotine IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to nicotine ISO RGD:735892 1624291 RGD PMID:28213472 defense response to Gram-negative bacterium ISO RGD:735892 1624291 RGD PMID:23144825 defense response to Gram-positive bacterium ISO RGD:735892 1624291 RGD PMID:23144825 immune response IEA InterPro:IPR015707 1600115 GO_REF:0000002 InterPro GO_REF:0000002 innate immune response ISO RGD:735892 1624291 RGD PMID:23144825 iron ion homeostasis ISO RGD:10224 1624291 RGD MGI:MGI:1931896 , PMID:11113132 iron ion homeostasis IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 iron ion transport ISO RGD:10224 1624291 MGI:MGI:1927183 RGD MGI:MGI:1203460 , PMID:9531620 iron ion transport IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 learning or memory IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 learning or memory ISO RGD:735892 1624291 RGD PMID:26147761 learning or memory ISO RGD:10224 1624291 RGD MGI:MGI:5708430 more ... learning or memory IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 modulation of age-related behavioral decline IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 modulation of age-related behavioral decline ISO RGD:735892 1624291 RGD PMID:26147761 modulation of age-related behavioral decline ISO RGD:10224 1624291 RGD MGI:MGI:5708430 , PMID:26147761 modulation of age-related behavioral decline IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 multicellular organism development ISO RGD:10224 1624291 RGD MGI:MGI:1860385 , PMID:10912502 negative regulation of epithelial cell proliferation IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of epithelial cell proliferation ISO RGD:735892 1624291 RGD PMID:28213472 negative regulation of forebrain neuron differentiation IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of forebrain neuron differentiation ISO RGD:735892 1624291 RGD PMID:26147761 negative regulation of forebrain neuron differentiation ISO RGD:10224 1624291 RGD MGI:MGI:5708430 , PMID:26147761 negative regulation of forebrain neuron differentiation IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of neurogenesis ISO RGD:735892 1624291 RGD PMID:26147761 negative regulation of neurogenesis ISO RGD:10224 1624291 RGD MGI:MGI:5708430 , PMID:26147761 negative regulation of neuron projection development ISO RGD:10224 1624291 MGI:MGI:95896 RGD MGI:MGI:4442543 , PMID:20018625 negative regulation of neuron projection development IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of receptor binding IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of receptor binding ISO RGD:735892 1624291 RGD PMID:9465039 positive regulation of cellular senescence IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cellular senescence ISO RGD:735892 1624291 RGD PMID:28213472 positive regulation of ferrous iron binding IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of ferrous iron binding ISO RGD:735892 1624291 UniProtKB:P02786 more ... RGD PMID:18353247 positive regulation of protein binding ISO RGD:735892 1624291 UniProtKB:P02787 more ... RGD PMID:18353247 positive regulation of receptor binding ISO RGD:735892 1624291 UniProtKB:P02787 more ... RGD PMID:18353247 positive regulation of receptor-mediated endocytosis IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of receptor-mediated endocytosis ISO RGD:735892 1624291 UniProtKB:P02787 more ... RGD PMID:18353247 positive regulation of T cell cytokine production IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of T cell cytokine production ISO RGD:735892 1624291 RGD PMID:24643698 positive regulation of T cell mediated cytotoxicity ISO RGD:10224 1624291 RGD MGI:MGI:3611636 , PMID:16299293 positive regulation of T cell mediated cytotoxicity IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transferrin receptor binding IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transferrin receptor binding ISO RGD:735892 1624291 UniProtKB:P02786 more ... RGD PMID:18353247 protein homotetramerization ISO RGD:735892 1624291 RGD PMID:28468825 protein homotetramerization IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein refolding ISO RGD:10224 1624291 RGD MGI:MGI:3808676 , PMID:16920948 protein refolding IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of erythrocyte differentiation ISO RGD:10224 1624291 MGI:MGI:1927183 RGD MGI:MGI:1203460 , PMID:9531620 regulation of erythrocyte differentiation IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of iron ion transport IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of iron ion transport ISO RGD:735892 1624291 UniProtKB:P02786 more ... RGD PMID:18353247 regulation of membrane depolarization ISO RGD:735892 1624291 RGD PMID:23144825 response to cadmium ion IEP 2293801 RGD response to drug IEP 1599430 tibolone RGD response to molecule of bacterial origin ISO RGD:10224 1624291 RGD MGI:MGI:3611636 , PMID:16299293 response to molecule of bacterial origin IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 T cell differentiation in thymus ISO RGD:10224 1624291 MGI:MGI:95663 RGD MGI:MGI:3817343 , PMID:18776904 T cell differentiation in thymus IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cytosol IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:735892 1624291 RGD GO_REF:0000052 external side of plasma membrane ISO RGD:10224 1624291 RGD MGI:MGI:50291 , PMID:1538753 external side of plasma membrane IEA UniProtKB:P01887 , ensembl:ENSMUSP000000995341600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular space IDA 1599431 RGD extracellular space ISO RGD:8991054 1624291 RGD RGD:11556285 Golgi apparatus IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 Golgi apparatus ISO RGD:735892 1624291 RGD GO_REF:0000052 HFE-transferrin receptor complex IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 HFE-transferrin receptor complex ISO RGD:735892 1624291 RGD PMID:9990067 MHC class I peptide loading complex IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 MHC class I peptide loading complex ISO RGD:735892 1624291 RGD PMID:21263072 MHC class I protein complex IEA UniProtKB-KW:KW-0490 1600115 GO_REF:0000037 UniProt GO_REF:0000037 plasma membrane ISO RGD:735892 1624291 RGD GO_REF:0000052 Molecular Function identical protein binding ISO RGD:735892 1624291 UniProtKB:P61769 RGD PMID:17108084 more ... molecular_function ND 1598407 01/2007: no relevant rat data RGD protein binding ISO RGD:10224 1624291 UniProtKB:P14427 more ... RGD MGI:MGI:3037219 more ... protein binding ISO RGD:735892 1624291 UniProtKB:P01892 more ... RGD PMID:12118248 more ... protein homodimerization activity IEA UniProtKB:P61769 , ensembl:ENSP000004979101600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein homodimerization activity ISO RGD:735892 1624291 RGD PMID:28468825
Gene-Chemical Interaction Annotations
