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Gene: B2m (beta-2 microglobulin) Rattus norvegicus
Symbol: B2m
Name: beta-2 microglobulin
RGD ID: 2189
Description: Predicted to have protein homodimerization activity. Involved in response to cadmium ion and response to drug. Localizes to extracellular space. Biomarker of acute kidney failure; pyelonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in arthritis; familial visceral amyloidosis; immunodeficiency 43; and inflammatory bowel disease. Orthologous to human B2M (beta-2-microglobulin); PARTICIPATES IN interleukin-12 signaling pathway; antigen processing and presentation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA)
Homo sapiens (human) : B2M (beta-2-microglobulin)  HGNC  Alliance
Mus musculus (house mouse) : B2m (beta-2 microglobulin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : B2m (beta-2-microglobulin)
Pan paniscus (bonobo/pygmy chimpanzee) : B2M (beta-2-microglobulin)
Canis lupus familiaris (dog) : B2M (beta-2-microglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : B2m (beta-2-microglobulin)
Sus scrofa (pig) : B2M (beta-2-microglobulin)
Chlorocebus sabaeus (African green monkey) : B2M (beta-2-microglobulin)
Heterocephalus glaber (naked mole-rat) : B2m (beta-2-microglobulin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03114,087,287 - 114,093,311 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,087,287 - 114,093,309 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,627,499 - 120,633,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,927,919 - 108,932,718 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13108,833,491 - 108,838,291 (+)NCBI
Celera3107,993,988 - 108,000,012 (+)NCBICelera
Cytogenetic Map3q35NCBI
RH 3.4 Map3954.3RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on B2m
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2189
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.