B2m (beta-2 microglobulin) - Rat Genome Database

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Gene: B2m (beta-2 microglobulin) Rattus norvegicus
Analyze
Symbol: B2m
Name: beta-2 microglobulin
RGD ID: 2189
Description: Predicted to enable MHC class II protein complex binding activity and protein homodimerization activity. Involved in response to cadmium ion and response to xenobiotic stimulus. Located in extracellular space. Biomarker of acute kidney failure; pyelonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in arthritis; familial visceral amyloidosis; immunodeficiency 43; and inflammatory bowel disease. Orthologous to human B2M (beta-2-microglobulin); PARTICIPATES IN interleukin-12 signaling pathway; antigen processing and presentation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23109,095,740 - 109,101,764 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,095,729 - 109,101,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3112,769,695 - 112,775,711 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03121,365,215 - 121,371,231 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03119,025,591 - 119,031,607 (+)NCBIRnor_WKY
Rnor_6.03114,087,287 - 114,093,311 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,087,287 - 114,093,309 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,627,499 - 120,633,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,927,919 - 108,932,718 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13108,833,491 - 108,838,291 (+)NCBI
Celera3107,993,988 - 108,000,012 (+)NCBICelera
RH 3.4 Map3954.3RGD
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
AGAT deficiency  (ISO)
Albuminuria  (ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
autoimmune disease  (ISO)
Bloom syndrome  (ISO)
carotid artery disease  (ISO)
cataract  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
diffuse large B-cell lymphoma  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
encephalomyelitis  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (IEP)
familial visceral amyloidosis  (ISO)
gastric adenocarcinoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
hemochromatosis  (ISS)
hereditary spastic paraplegia 11  (ISO)
Hypergammaglobulinemia  (ISO)
hypertension  (ISO)
Hypoproteinemia  (ISO)
immunodeficiency 43  (ISO)
inflammatory bowel disease  (ISO)
kidney disease  (ISO)
Knee Osteoarthritis  (ISO)
lung adenocarcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoproliferative syndrome  (ISO)
measles  (ISO)
melanoma  (ISO)
multiple myeloma  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
Paraproteinemias  (ISO)
Parkinson's disease  (ISO)
peripheral artery disease  (ISO)
peripheral T-cell lymphoma  (ISO)
plasma cell neoplasm  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
pyelonephritis  (IEP)
skin melanoma  (ISO)
Spondylarthritis  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3-phenylprop-2-enal  (ISO)
4-hydroxynon-2-enal  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
adefovir  (EXP)
aldehydo-D-ribose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
anthocyanin  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
atenolol  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP,ISO)
cytarabine  (ISO)
D-ribofuranose  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
eugenol  (ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (EXP)
gallic acid  (ISO)
genistein  (EXP)
gentamycin  (EXP,ISO)
glafenine  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
irinotecan  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
muramyl dipeptide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
nitroglycerin  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
p-toluidine  (EXP)
pamidronate  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phosphoramide mustard  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pyrimidifen  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium chromate  (EXP)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tobramycin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trovafloxacin  (ISO)
uranium atom  (ISO)
urea  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid fibril formation  (ISO)
antibacterial humoral response  (ISO)
antigen processing and presentation of endogenous peptide antigen via MHC class I  (ISO)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (IBA)
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent  (ISO)
antigen processing and presentation of peptide antigen via MHC class I  (IEA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
cellular response to iron ion  (ISO)
cellular response to iron(III) ion  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nicotine  (ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
immune response  (IEA)
innate immune response  (ISO)
iron ion transport  (ISO)
learning or memory  (ISO)
multicellular organismal-level iron ion homeostasis  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of forebrain neuron differentiation  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of receptor binding  (ISO)
obsolete iron ion homeostasis  (ISO)
obsolete modulation of age-related behavioral decline  (ISO)
peptide antigen assembly with MHC class II protein complex  (IBA)
positive regulation of cellular senescence  (ISO)
positive regulation of ferrous iron binding  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of receptor binding  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of T cell activation  (IBA)
positive regulation of T cell cytokine production  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
positive regulation of transferrin receptor binding  (ISO)
protein homotetramerization  (ISO)
protein refolding  (ISO)
regulation of erythrocyte differentiation  (ISO)
regulation of iron ion transport  (ISO)
regulation of membrane depolarization  (ISO)
response to cadmium ion  (IEP)
response to molecule of bacterial origin  (ISO)
response to xenobiotic stimulus  (IEP)
retina homeostasis  (ISO)
sensory perception of smell  (ISO)
T cell differentiation in thymus  (ISO)
T cell mediated cytotoxicity  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Beta2-microglobulin and cystatin C in type 2 diabetes: assessment of diabetic nephropathy. Aksun SA, etal., Exp Clin Endocrinol Diabetes. 2004 Apr;112(4):195-200.
2. Beta 2 microglobulin and the risk for cardiovascular events in patients with asymptomatic carotid atherosclerosis. Amighi J, etal., Stroke. 2011 Jul;42(7):1826-33. Epub 2011 May 5.
3. Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive population. Baekken M, etal., Nephrol Dial Transplant. 2008 Oct;23(10):3130-7. Epub 2008 May 9.
4. Effect of childhood obesity and obesity-related cardiovascular risk factors on glomerular and tubular protein excretion. Csernus K, etal., Eur J Pediatr. 2005 Jan;164(1):44-9. Epub 2004 Oct 28.
5. Deletion of Beta-2-Microglobulin Ameliorates Spinal Cord Lesion Load and Promotes Recovery of Brainstem NAA Levels in a Murine Model of Multiple Sclerosis. Denic A, etal., Brain Pathol. 2012 Feb 15. doi: 10.1111/j.1750-3639.2012.00576.x.
6. Characterization of diabetic nephropathy by urinary proteomic analysis: identification of a processed ubiquitin form as a differentially excreted protein in diabetic nephropathy patients. Dihazi H, etal., Clin Chem. 2007 Sep;53(9):1636-45. Epub 2007 Jul 18.
7. Clinical and immunologic aspects of B chronic lymphocytic leukemia associated with autoimmune disorders. Duek A, etal., Isr Med Assoc J. 2006 Dec;8(12):828-31.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Immune activation during measles: beta 2-microglobulin in plasma and cerebrospinal fluid in complicated and uncomplicated disease. Griffin DE, etal., J Infect Dis. 1992 Nov;166(5):1170-3.
10. Effect of tibolone on cytochrome c oxidase I, beta-2-microblobulin and vascular endothelial growth factor gene expression in the lower urinary tract of castrated rats. Hamerski MG, etal., Clin Exp Obstet Gynecol. 2006;33(4):233-7.
11. Transgenic rescue implicates beta2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice. Hamilton-Williams EE, etal., Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11533-8.
12. beta2-microglobulin, a novel biomarker of peripheral arterial disease, independently predicts aortic stiffness in these patients. Kals J, etal., Scand J Clin Lab Invest. 2011 Jul;71(4):257-63. Epub 2011 Feb 14.
13. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Koller BH, etal., Science 1990 Jun 8;248(4960):1227-30.
14. Mechanism of hypoalbuminemia in rodents. Koltun M, etal., Am J Physiol Heart Circ Physiol 2004 Nov 11;.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. EAE in beta-2 microglobulin-deficient mice: axonal damage is not dependent on MHC-I restricted immune responses. Linker RA, etal., Neurobiol Dis. 2005 Jun-Jul;19(1-2):218-28.
17. Detection of a serum class I molecule in rat with anti-rat liver beta-2-microglobulin. Matsumoto K, etal., Biochem Genet. 1986 Feb;24(1-2):93-102.
18. Nucleotide sequence of rat beta 2-microglobulin cDNA. Mauxion F and Kress M, Nucleic Acids Res 1987 Sep 25;15(18):7638.
19. Relationship between radiographic grading of osteoarthritis and serum beta-2 microglobulin. Melikoglu MA, etal., Ir J Med Sci. 2009 Jun;178(2):151-4. Epub 2008 Sep 16.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Evidence for the prevention of enthesitis in HLA-B27/hbeta(2)m transgenic rats treated with a monoclonal antibody against TNF-alpha. Milia AF, etal., J Cell Mol Med. 2011 Feb;15(2):270-9. doi: 10.1111/j.1582-4934.2009.00984.x.
22. Brain beta 2-microglobulin levels are elevated in the striatum in Parkinson's disease. Mogi M, etal., J Neural Transm Park Dis Dement Sect. 1995;9(1):87-92.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Comparison of markers for fetal inflammatory response syndrome: fetal blood interleukin-6 and neonatal urinary beta(2)-microglobulin. Nishimaki S, etal., J Obstet Gynaecol Res. 2009 Jun;35(3):472-6.
25. Transcriptome analysis of rat kidney cells continuously exposed to cadmium using DNA microarray. Ohba K, etal., J Toxicol Sci. 2007 Feb;32(1):103-5.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Can cystatin C be a better marker for the early detection of renal damage in primary hypertensive patients? Ozer BA, etal., Ren Fail. 2005;27(3):247-53.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Comprehensive gene review and curation RGD comprehensive gene curation
34. Increased beta 2-microglobulin (B2M) is useful in the detection of post-transplant lymphoproliferative disease (PTLD). Sasaki TM, etal., Clin Transplant. 1997 Feb;11(1):29-33.
35. Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat. Smyth R, etal., Cell Biol Toxicol. 2009 Oct;25(5):499-512. Epub 2008 Sep 7.
36. Skin graft rejection elicited by beta 2-microglobulin as a minor transplantation antigen involves multiple effector pathways: role of Fas-Fas ligand interactions and Th2-dependent graft eosinophil infiltrates. Surquin M, etal., J Immunol 2002 Jul 1;169(1):500-6.
37. A model of experimental acute hematogenous pyelonephritis in the rat. Tancheva S, etal., Folia Med (Plovdiv). 2011 Apr-Jun;53(2):63-8.
38. Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. Tarakanova VL, etal., J Virol. 2005 Dec;79(23):14668-79.
39. Additional human beta2-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats. Tran TM, etal., Arthritis Rheum. 2006 Apr;54(4):1317-27.
40. Discrepancy between serum levels of low molecular weight proteins in acute kidney injury model rats with bilateral ureteral obstruction and bilateral nephrectomy. Tsuda H, etal., Clin Exp Nephrol. 2009 Dec;13(6):567-70. Epub 2009 Jun 18.
41. Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. Wani MA, etal., Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5084-9. Epub 2006 Mar 20.
42. A study of factors related to the incidence of cataract in patients with non-insulin dependent diabetes mellitus. Xia X, etal., Yan Ke Xue Bao. 2001 Sep;17(3):180-2.
43. Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation. Young HY, etal., Transplantation. 2004 Aug 27;78(4):509-15.
44. Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis. Zumrutdal A, etal., Nephrology (Carlton). 2005 Oct;10(5):453-8.
Additional References at PubMed
PMID:1538753   PMID:2689174   PMID:2911353   PMID:7969498   PMID:9465039   PMID:9493268   PMID:9531620   PMID:9990067   PMID:10912502   PMID:11113132   PMID:11163232   PMID:12847084  
PMID:15505791   PMID:16299293   PMID:16502470   PMID:16920948   PMID:17108084   PMID:17929129   PMID:18353247   PMID:18579777   PMID:18776904   PMID:19056867   PMID:19172750   PMID:19199708  
PMID:19564620   PMID:19565478   PMID:19946888   PMID:20018625   PMID:20826442   PMID:21131979   PMID:21220305   PMID:21263072   PMID:21423176   PMID:21569201   PMID:22289140   PMID:22575645  
PMID:22664934   PMID:23144825   PMID:23376485   PMID:23533145   PMID:23580065   PMID:24006456   PMID:24643698   PMID:25187167   PMID:25766467   PMID:25865156   PMID:26147761   PMID:28213472  
PMID:28468825   PMID:28864206   PMID:33472168  


Genomics

Comparative Map Data
B2m
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23109,095,740 - 109,101,764 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,095,729 - 109,101,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3112,769,695 - 112,775,711 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03121,365,215 - 121,371,231 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03119,025,591 - 119,031,607 (+)NCBIRnor_WKY
Rnor_6.03114,087,287 - 114,093,311 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,087,287 - 114,093,309 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,627,499 - 120,633,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,927,919 - 108,932,718 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13108,833,491 - 108,838,291 (+)NCBI
Celera3107,993,988 - 108,000,012 (+)NCBICelera
RH 3.4 Map3954.3RGD
Cytogenetic Map3q35NCBI
B2M
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381544,711,517 - 44,718,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1544,711,358 - 44,718,851 (+)EnsemblGRCh38hg38GRCh38
GRCh371545,003,715 - 45,010,343 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361542,790,977 - 42,797,649 (+)NCBINCBI36Build 36hg18NCBI36
Build 341542,790,976 - 42,797,649NCBI
Celera1521,893,442 - 21,900,114 (+)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1521,827,296 - 21,833,968 (+)NCBIHuRef
CHM1_11545,121,781 - 45,128,453 (+)NCBICHM1_1
T2T-CHM13v2.01542,519,493 - 42,526,121 (+)NCBIT2T-CHM13v2.0
B2m
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392121,978,168 - 121,983,563 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2121,978,167 - 121,983,564 (+)EnsemblGRCm39 Ensembl
GRCm382122,147,687 - 122,153,082 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,147,686 - 122,153,083 (+)EnsemblGRCm38mm10GRCm38
MGSCv372121,973,423 - 121,978,818 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362121,839,128 - 121,844,523 (+)NCBIMGSCv36mm8
Celera2123,294,935 - 123,300,323 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.55NCBI
B2m
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541611,204,849 - 11,215,568 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541611,205,503 - 11,211,325 (+)NCBIChiLan1.0ChiLan1.0
B2M
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11541,836,321 - 41,842,991 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1541,836,345 - 41,842,991 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01523,668,108 - 23,674,791 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
B2M
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,331,574 - 11,337,991 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,331,569 - 11,337,997 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,388,144 - 11,392,829 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03011,468,141 - 11,474,563 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13011,375,114 - 11,379,792 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03011,497,731 - 11,502,419 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03011,616,856 - 11,621,737 (+)NCBIUU_Cfam_GSD_1.0
B2m
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,798,404 - 89,807,593 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364717,646,373 - 7,655,778 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364717,646,504 - 7,655,656 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
B2M
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,835,143 - 126,981,582 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,837,721 - 126,844,043 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
B2M
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,331,818 - 38,338,785 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2638,331,442 - 38,338,809 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048102,721,246 - 102,728,233 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
B2m
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480411,514,728 - 11,521,625 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in B2m
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:126
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000023017
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat

Markers in Region
RH127442  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,098,610 - 109,098,799 (+)MAPPERmRatBN7.2
Rnor_6.03114,090,158 - 114,090,346NCBIRnor6.0
Rnor_5.03120,630,370 - 120,630,558UniSTSRnor5.0
RGSC_v3.43108,930,777 - 108,930,965UniSTSRGSC3.4
Celera3107,996,859 - 107,997,047UniSTS
Cytogenetic Map3q35UniSTS
RH94575  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,100,346 - 109,100,532 (+)MAPPERmRatBN7.2
Rnor_6.03114,091,894 - 114,092,079NCBIRnor6.0
Rnor_5.03120,632,106 - 120,632,291UniSTSRnor5.0
RGSC_v3.43108,932,513 - 108,932,698UniSTSRGSC3.4
Celera3107,998,595 - 107,998,780UniSTS
RH 3.4 Map3954.3UniSTS
Cytogenetic Map3q35UniSTS
PMC18810P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01206,487,422 - 206,487,559NCBIRnor5.0
RGSC_v3.41187,303,086 - 187,303,222UniSTSRGSC3.4
Celera1180,278,983 - 180,279,119UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map3q35UniSTS
Cytogenetic Map1q22UniSTS
Cytogenetic Map8q24UniSTS
PMC350564P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01206,487,427 - 206,487,551NCBIRnor5.0
RGSC_v3.41187,303,091 - 187,303,214UniSTSRGSC3.4
Celera1180,278,988 - 180,279,111UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map3q35UniSTS
Cytogenetic Map1q22UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4 1 14 9 13 9 5 9
Medium 1 42 44 32 6 32 8 11 74 35 36 2 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB714511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM032790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM042487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM080788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y08531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000023017   ⟹   ENSRNOP00000023017
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3109,095,729 - 109,101,766 (+)Ensembl
Rnor_6.0 Ensembl3114,087,287 - 114,093,309 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098012   ⟹   ENSRNOP00000088125
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3109,097,839 - 109,101,766 (+)Ensembl
RefSeq Acc Id: NM_012512   ⟹   NP_036644
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23109,095,740 - 109,101,764 (+)NCBI
Rnor_6.03114,087,287 - 114,093,311 (+)NCBI
Rnor_5.03120,627,499 - 120,633,523 (+)NCBI
RGSC_v3.43108,927,919 - 108,932,718 (+)RGD
Celera3107,993,988 - 108,000,012 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036644 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA34830 (Get FASTA)   NCBI Sequence Viewer  
  CAA68498 (Get FASTA)   NCBI Sequence Viewer  
  CAA69847 (Get FASTA)   NCBI Sequence Viewer  
  EDL80017 (Get FASTA)   NCBI Sequence Viewer  
  P07151 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036644   ⟸   NM_012512
- Peptide Label: precursor
- UniProtKB: P07151 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023017   ⟸   ENSRNOT00000023017
RefSeq Acc Id: ENSRNOP00000088125   ⟸   ENSRNOT00000098012
Protein Domains
Ig-like   Ig-like C1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07151-F1-model_v2 AlphaFold P07151 1-119 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692364
Promoter ID:EPDNEW_R2889
Type:multiple initiation site
Name:B2m_1
Description:beta-2 microglobulin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03114,087,275 - 114,087,335EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2189 AgrOrtholog
BioCyc Gene G2FUF-48108 BioCyc
Ensembl Genes ENSRNOG00000017123 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023017 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000088125.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023017 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000098012.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B2Microglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24223 UniProtKB/Swiss-Prot
NCBI Gene 24223 ENTREZGENE
PANTHER PTHR19944:SF62 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB B2M RGD
PhenoGen B2m PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_MHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A949_RAT UniProtKB/TrEMBL
  B2MG_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 B2m  Beta-2-microglobulin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process mouse homolog is required for the normal expression of T cells 631787
gene_process mouse homolog is required for the assembly and surface expression of MHC class I molecules 631788